Digital Commons Network^™

Angptl4 Promotes The Progression Of Cutaneous Melanoma To Brain Metastasis., Sivan Izraely, Shlomit Ben-Menachem, Orit Sagi-Assif, Tsipi Meshel, Diego M Marzese, Shuichi Ohe, Inna Zubrilov, Metsada Pasmanik-Chor, Dave S B Hoon, Isaac P Witz

Articles, Abstracts, and Reports

In an ongoing effort to identify molecular determinants regulating melanoma brain metastasis, we previously identified Angiopoietin-like 4 (ANGPTL4) as a component of the molecular signature of such metastases. The aim of this study was to determine the functional significance of ANGPTL4 in the shaping of melanoma malignancy phenotype, especially in the establishment of brain metastasis. We confirmed that ANGPTL4 expression is significantly higher in cells metastasizing to the brain than in cells from the cutaneous (local) tumor from the same melanoma in a nude mouse xenograft model, and also in paired clinical specimens of melanoma metastases than in primary melanomas …

The Influence Of A Kdt501, A Novel Isohumulone, On Adipocyte Function In Humans, Brian S. Finlin, Beibei Zhu, Bernard P. Kok, Cristina Godio, Philip M. Westgate, Neile Grayson, Robert Sims, Jeffrey S. Bland, Enrique Saez, Philip A. Kern

Clinical and Translational Science Faculty Publications

Objective: In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whether KDT501 increased adiponectin secretion from subcutaneous white adipose tissue (SC WAT) and the underlying mechanism(s).

Methods: Nine obese participants with either prediabetes or with normal glucose tolerance plus three features of metabolic syndrome were part of the study. SC WAT biopsies were performed before and after 28 days of KDT501 treatment in a clinical research setting. In addition, a cold stimulus was used …

University Honors Program News, Georgia Southern University

Honors College: News & Publications (2008-2020)

• Competition in the Community
• Honors Art Receives a Standing Ovation

Dean's Perceptions Of Leadership Strategies Used To Manage A Multicultural Faculty Environment In Saudi Arabia, Sanaa Awwad Alsulami, Gwen D. Sherwood

Biennial Convention (CONV)

Majority of nursing faculty in Saudi Arabia are expatriates. Because leading an academic multicultural environment in Saudi Arabia has not been examined, five interviews were conducted via Skype with Saudi deans of Schools of Nursing to explore how they lead their multicultural environments and improve school performance.

Stochastic Resonance In A Proton Pumping Complex I Of Mitochondria Membranes, Davneet Kaur, Ilan Filonenko, Lev Mourokh, Cornelius Fendler, Robert H. Blick

Publications and Research

We make use of the physical mechanism of proton pumping in the so-called Complex I within mitochondria membranes. Our model is based on sequential charge transfer assisted by conformational changes which facilitate the indirect electron-proton coupling. The equations of motion for the proton operators are derived and solved numerically in combination with the phenomenological Langevin equation describing the periodic conformational changes. We show that with an appropriate set of parameters, protons can be transferred against an applied voltage. In addition, we demonstrate that only the joint action of the periodic energy modulation and thermal noise leads to efficient uphill proton …

State V. Cota-Medina Appellant's Reply Brief Dckt. 44940

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Controlling Water Exchange Kinetics And Improving Paracest Imaging, Jacqueline R. Slack

Dissertations and Theses

Generating MR image contrast from exogenous contrast media through chemical exchange saturation transfer (CEST) offers several exciting new possibilities, such as multicolored imaging, the interleaving of pre- and post-contrast images, and the potential to perform ratiometric metabolic imaging. The major limitation of the deployment of CEST imaging is the comparatively high detection limits of exogenous agents and particularly at the low B_¹ power levels required to meet SAR requirements. The large chemical shifts afforded by paramagnetic (paraCEST) agents permit more rapid exchange kinetics and therefore potentially more effective contrast agents. Despite comparatively large chemical shifts, many Ln³⁺ DOTA-tetraamide …

Mutsβ Abundance And Msh3 Atp Hydrolysis Activity Are Important Drivers Of Ctg•Cag Repeat Expansions, Norma Keogh, Kara Y. Chan, Guo-Min Li, Robert S. Lahue

Toxicology and Cancer Biology Faculty Publications

CTG•CAG repeat expansions cause at least twelve inherited neurological diseases. Expansions require the presence, not the absence, of the mismatch repair protein MutSβ (Msh2-Msh3 heterodimer). To evaluate properties of MutSβ that drive expansions, previous studies have tested under-expression, ATPase function or polymorphic variants of Msh2 and Msh3, but in disparate experimental systems. Additionally, some variants destabilize MutSβ, potentially masking the effects of biochemical alterations of the variations. Here, human Msh3 was mutated to selectively inactivate MutSβ. Msh3^−/− cells are severely defective for CTG•CAG repeat expansions but show full activity on contractions. Msh3^−/− cells provide a single, isogenic system …

Palliative Care Need For Hiv Adolescents Using Maxwell Model: A Qualitative Study, Iqbal Pramukti, Nai-Ying Ko, Ai Mardhiyah, Ahmad Yamin

Biennial Convention (CONV)

Palliative care for HIV adolescents is urgently needed since adolescents itself are a group of young people who have a unique responds to their illnesses. The approach in delivering palliative care for adolescents is a quite different, so it need a comprehensive need assessment as an initial step.

The Influence Of A Kdt501, A Novel Isohumulone, On Adipocyte Function In Humans, Brian S. Finlin, Beibei Zhu, Bernard P. Kok, Cristina Godio, Philip M. Westgate, Neile Grayson, Robert Sims, Jeffrey S. Bland, Enrique Saez, Philip A. Kern

Internal Medicine Faculty Publications

Objective: In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whether KDT501 increased adiponectin secretion from subcutaneous white adipose tissue (SC WAT) and the underlying mechanism(s).

Methods: Nine obese participants with either prediabetes or with normal glucose tolerance plus three features of metabolic syndrome were part of the study. SC WAT biopsies were performed before and after 28 days of KDT501 treatment in a clinical research setting. In addition, a cold stimulus was used …

Evidence-Based Practice: Introduction Of A Gluten-Free And Casein-Free Diet To Alleviate Psychotic Symptoms, Yolanta Kreklow

Biennial Convention (CONV)

Introduction of a GFCF diet helps reduce psychotic symptoms, and gives another option for patients resistant to traditional treatment methods. Additionally, this diet provides a more holistic approach to treatment (augmenting medication therapy), reduces hospital stays, and improves outcomes.

Fort Hays State University Tiger Weekly, September 29, 2017, University Relations

Tiger Weekly Newsletters

No abstract provided.

The Cosm Aggregate, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

No abstract provided.

Range Extension Of The Northern Naked-Tailed Armadillo (Cabassous Centralis) In Southern Mexico, Rugieri Juárez-López, Mariana Pérez-López, Yaribeth Bravata-De La Cruz, Alejandro Jesús-De La Cruz, Fernando M. Contreras-Moreno, Daniel Thornton, Mircea G. Hidalgo-Mihart

Western North American Naturalist

The northern naked-tailed armadillo (Cabassous centralis) is one of the least known armadillo species. Due to its restricted distribution in Mexico and the few known records of the species, the northern naked-tailed armadillo is considered endangered by Mexican law. Using camera traps, we obtained a new record in Portaceli, Chiapas, an area where the species was not previously recorded. The record was located 75 km north of the previously known range of the species in Mexico, and thus constitutes a range expansion of the species in the country. This record suggests that the species could be present in …

Decorin-Evoked Paternally Expressed Gene 3 (Peg3) Is An Upstream Regulator Of The Transcription Factor Eb (Tfeb) In Endothelial Cell Autophagy., Thomas Neill, Catherine Sharpe, Rick T. Owens, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Macroautophagy is a fundamental and evolutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organelles in eukaryotic cells. Decorin, an archetypical small leucine-rich proteoglycan, initiates a protracted autophagic program downstream of VEGF receptor 2 (VEGFR2) signaling that requires paternally expressed gene 3 (PEG3). We have discovered that PEG3 is an upstream transcriptional regulator of transcription factor EB (TFEB), a master transcription factor of lysosomal biogenesis, for decorin-evoked endothelial cell autophagy. We found a functional requirement of PEG3 for TFEB transcriptional induction and nuclear translocation in human umbilical vein endothelial and PAER2 cells. Mechanistically, inhibiting VEGFR2 or AMP-activated protein …

A Shiftwork Education Program: Translating Non-Healthcare Evidence To Improve Nurse And Patient Safety, Mary Lawson Carney

Biennial Convention (CONV)

A significant nurse and patient safety risk, shift-work and its resultant fatigue, is seldom addressed in the classroom or the workplace. Using evidence from non-healthcare industries, this session will describe a proactive shift-work education program suitable for both students and practicing professionals.

Exploring The Role Of Nurses As Antimicrobial Stewards, Junel Amarado Padigos, Anecita Gigi Lim, Stephen Robert Ritchie

Biennial Convention (CONV)

The role of nurses in antimicrobial stewardship (AMS), or safe antimicrobial management is not well defined. In this New Zealand research, potential nursing roles in AMS were identified. Educational foci and learning strategies were formulated to address learning needs of nurses to effectively embed AMS in clinical practice.

September 29, 2017 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

SWOSU Faculty Senate September 29, 2017 Approved Minutes.

The Kinetic Mechanism Of Bacterial Ribosome Recycling., Yuanwei Chen, Akira Kaji, Hideko Kaji, Barry S. Cooperman

Department of Biochemistry and Molecular Biology Faculty Papers

Bacterial ribosome recycling requires breakdown of the post-termination complex (PoTC), comprising a messenger RNA (mRNA) and an uncharged transfer RNA (tRNA) cognate to the terminal mRNA codon bound to the 70S ribosome. The translation factors, elongation factor G and ribosome recycling factor, are known to be required for recycling, but there is controversy concerning whether these factors act primarily to effect the release of mRNA and tRNA from the ribosome, with the splitting of the ribosome into subunits being somewhat dispensable, or whether their main function is to catalyze the splitting reaction, which necessarily precedes mRNA and tRNA release. Here, …

Structural Basis For Selective Inhibition Of Cyclooxygenase-1 (Cox-1) By Diarylisoxazoles Mofezolac And 3-(5-Chlorofuran-2-Yl)-5-Methyl-4-Phenylisoxazole (P6)., Gino Cingolani, Andrea Panella, Maria Grazia Perrone, Paola Vitale, Giuseppe Di Mauro, Cosimo G G. Fortuna, Roger S. Armen, Savina Ferorelli, William L. Smith, Antonio Scilimati

Department of Biochemistry and Molecular Biology Faculty Papers

The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we have determined the structural basis for COX-1 binding to two diarylisoxazoles: mofezolac, which is polar and ionizable, and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) that has very low polarity. X-ray analysis of the crystal structures of COX-1 bound to mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole allowed the identification of specific binding determinants within the enzyme active site, relevant to generate structure/activity relationships for diarylisoxazole NSAIDs.

Range Expansion Of A Locally Endangered Mustelid (Eira Barbara) In Southern Mexico, Fernando Ruiz-Gutiérrez, Enrique Vázquez-Arroyo, Cuauhtémoc Chávez

Western North American Naturalist

We documented the occurrence of Eira barbara in the municipalities of Tecpán de Galeana and Petatlán, state of Guerrero, Mexico. Our records represent a 450-km range expansion from the most recent northern occurrences of this species in the Mexican Pacific coast states.


Se documentó la presencia del viejo de monte (Eira barbara) en los municipios de Tecpán de Galeana y Petatlán, Guerrero, México. Estos registros representan un aumento de su área de distribución al norte en 450-km de los registros más recientes de la especie en la costa del Pacífico Mexicano.

A Systems Biology Approach To The Development Of Commercial Bioprocesses: 1,4-Butanediol And Beyond, Stephen Van Dien

Amgen Seminar Series in Chemical Engineering

Production of biobased chemicals by fermentation at competitive titer, rate, and yield involves optimizing the cellular resources normally devoted to biomass formation and directing them towards product formation. Systems and synthetic biology tools are the key to surmounting these challenges. As an example success of this approach, Genomatica has developed a complete bioprocess for commercial scale production of 1,4-butanediol (BDO) from carbohydrate feedstocks. BDO is a chemical intermediate (> 3B lbs/yr) that goes into a variety of products including automotive parts and apparel, and is currently produced commercially through energy-intensive petrochemical processes. Systems biology, diagnostic ‘omics’ experiments, and novel synthetic …

09-28-2017 Zach Jones Is New Chair Of Swosu Biological Sciences Department, Southwestern Oklahoma State University

THE BARK ARCHIVE 2017

Dr. Zach Jones is the new chair of the Biological Sciences Department at Southwestern Oklahoma State University in Weatherford.

You, Me And Life In The Sea Ocg 106g, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Enzyme Shielding In A Soft Organo-Silica Layer – Pharma/Biopharma Applications, Yves Dudal, Federica Richina, Lucas Durandi, Rita Correro, Patrick Shahgaldian

Enzyme Engineering XXIV

Enzymes, or biocatalysts, are specialty proteins. Like antibodies to antigens, enzymes exhibit remarkable specificity for their substrate and naturally facilitate many chemical conversions. However, the use of enzymes in the biotech industry ($2.3bn) is strongly limited by the fact that enzymes are highly sensitive like most proteins and usually not fitted to in vivo and process conditions. Many expensive genetically engineered or biosourced enzymes show remarkable properties but need to be made more robust for deployment in the health industry.

We have developed a unique procedure to fit enzymes to in vivo and process conditions. The process is initiated by …

Spartan Daily, September 28, 2017, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2017

Volume 149, Issue 16

Validation And Optimization Of Capturetm: Rapid Diagnosis Of Pathogens Causing Urinary Tract Infections, Elizabeth Marie Richards Gates

Honors Capstone Projects and Theses

No abstract provided.

Additive Negative Effects Of Anthropogenic Sedimentation And Warming On The Survival Of Coral Recruits, Francesca Fourney, Joana Figueiredo

Marine & Environmental Sciences Faculty Articles

Corals worldwide are facing population declines due to global climate change and local anthropogenic impacts. Global climate change effects are hard to tackle but recent studies show that some coral species can better handle climate change stress when provided with additional energy resources. The local stressor that most undermines energy acquisition is sedimentation because it impedes coral heterotrophic feeding and their ability to photosynthesize. To investigate if reducing local sedimentation will enable corals to better endure ocean warming, we quantitatively assessed the combined effects of increased temperature and sedimentation (concentration and turbidity) on the survival of coral recruits of the …

Neosho Smallmouth Bass Movement, Spawning, And Associated Environmental Conditions In A Seasonally Discontinuous Stream: The Illinois Bayou, Arkansas, Jacob Herbert Martin

Theses and Dissertations from 2017

The Neosho Smallmouth Bass Micropterus dolomieu velox is a top predator and popular sportfish in Arkansas’ Boston Mountain streams. In this ecoregion, Smallmouth Bass are common in headwater streams that are prone to drying during the summer months. My objectives were to characterize longitudinal movements of adult Smallmouth Bass and to determine the timing of spawning events along with associated environmental variables during the likely spawning months of June and July. Thirty Smallmouth Bass were captured and implanted with radio transmitters in March, and tracked weekly in the Middle Fork of Illinois Bayou until August 2016. Age-0 Smallmouth Bass were …

Student Movement - Issue 4, Andrews University

Student Movement v. 102 (2017-2018)

Student Movement, Issue 4, 2017