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2017

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Source For Gloxinia (Sinningia Spp.) And Potato (Solanum Tuberosum) Micropropagation, Tan Nhut Duong, Ngoc Huong Mai Thi Nov 2017

Source For Gloxinia (Sinningia Spp.) And Potato (Solanum Tuberosum) Micropropagation, Tan Nhut Duong, Ngoc Huong Mai Thi

ASEAN Journal on Science and Technology for Development

An efficient lighting system (Compact 3U) was successfully applied to the micropropagation of gloxinia and potato plants. To compare the in vitro growth of plantlets under Neon and Compact 3U lighting systems, gloxinia and potato shoots were cultured on suitable media at different light intensities: (1) 45 µmol m-2s-1 (under Neon lighting system as a control); (2) 45 µmol m-2s-1, (3) 60µmol m-2s-1, and (4) 75 µmol m-2s-1 (under Compact 3U lighting systems). The results obtained after 3 weeks of in vitro culture and 6 weeks of acclimatization in a greenhouse showed that the growth of plantlets cultured under the …


Onshore Wind Speed Modulates Microbial Aerosols Along An Urban Waterfront, M. Elias Drucker, Gregory D. O'Mullan, Joaquín Martínez Martínez, Andrew R. Juhl, Kathleen C. Weathers Nov 2017

Onshore Wind Speed Modulates Microbial Aerosols Along An Urban Waterfront, M. Elias Drucker, Gregory D. O'Mullan, Joaquín Martínez Martínez, Andrew R. Juhl, Kathleen C. Weathers

Publications and Research

Wind blowing over aquatic and terrestrial surfaces produces aerosols, which include microbial aerosols. We studied the effect of onshore wind speeds on aerosol concentrations as well as total and culturable microbial aerosols (bacterial and viral) at an urban waterfront (New York, NY, USA). We used two distinct methods to characterize microbial aerosol responses to wind speed: A culture-based exposure-plate method measuring viable bacterial deposition near-shore (CFU accumulation rate); and a culture-independent aerosol sampler-based method measuring total bacterial and viral aerosols (cells m−3 air). While ambient coarse (>2 µm) and fine (0.3–2 µm) aerosol particle number concentrations (regulated indicators of …


Polyclonal Pulmonary Tuberculosis Infections And Risk For Multidrug Resistance, Lima, Peru, Ruvandhi R. Nathavitharana, Cynthia X. Shi, Leonid. Chindelevitch, Roger Calderon, Zibiao Zhang, Jerome T. Galea, Carmen C. Contreras, Rosa Yataco, Leonid Lecca, Mercedes C. Becerra, Megan B. Murray, Ted Cohen Nov 2017

Polyclonal Pulmonary Tuberculosis Infections And Risk For Multidrug Resistance, Lima, Peru, Ruvandhi R. Nathavitharana, Cynthia X. Shi, Leonid. Chindelevitch, Roger Calderon, Zibiao Zhang, Jerome T. Galea, Carmen C. Contreras, Rosa Yataco, Leonid Lecca, Mercedes C. Becerra, Megan B. Murray, Ted Cohen

Social Work Faculty Publications

Because within-host Mycobacterium tuberculosis diversity complicates diagnosis and treatment of tuberculosis (TB), we measured diversity prevalence and associated factors among 3,098 pulmonary TB patients in Lima, Peru. The 161 patients with polyclonal infection were more likely than the 115 with clonal or the 2,822 with simple infections to have multidrug-resistant TB.


The Glocal Hiv/Aids Epidemic And The Need For An Extended Theory Of Power In International Relations, Annika Hughes Nov 2017

The Glocal Hiv/Aids Epidemic And The Need For An Extended Theory Of Power In International Relations, Annika Hughes

International Dialogue

This paper argues for an extended theory of power in International Relations (IR), using the example of the glocal HIV/AIDS epidemic. It will argue that world power relations depend not only on military, economic, social and cultural power, but also on the power of the human body itself. This argument builds on the author’s own theory of glocalised world power, which combines a Foucaultian with a structurationist approach to argue for the existence of four-faced power relationships across the following twelve interdependent sites of power: 1) time; 2) space; 3) knowledge and aesthetics; 4) morality and emotion; 5) identities; 6) …


Human Rights And Cultural Diversity. Core Issues And Cases, Stener Ekern Nov 2017

Human Rights And Cultural Diversity. Core Issues And Cases, Stener Ekern

International Dialogue

As clearly explained on the very first page, this book is about “the troubled relationship between the promotion of human rights and the promotion of cultural diversity.” Its purpose is to discuss (and overcome, I presume) some of the “core areas of anxiety” that this trouble speaks of. Anyone working with human rights, academically or in more applied ways, will be familiar with the anxieties that arise from trying to reconcile individual and collective rights in a consistent and convincing manner. A book holding the promise of taking you one step further towards simultaneously handling the issues of individual moral …


Research & Strategic Partnerships: Quarterly Review, Volume 4, Issue 2, Portland State University. Research & Strategic Partnerships Nov 2017

Research & Strategic Partnerships: Quarterly Review, Volume 4, Issue 2, Portland State University. Research & Strategic Partnerships

Portland State Research Magazine

This issue highlights some of the innovative work PSU faculty members and graduate students are doing around campus, work aimed at producing:

  • New nanotechnologies for medical researchers seeking novel therapies to treat diseases
  • A solution to the problem of unregulated contaminants in water supplies
  • A powerful new tool for forecasting droughts and drought recovery times
  • Three-dimensional maps of molecules associated with memory formation, cognition, and learning, and
  • Innovations in physics education that will impact students entering health-related fields

Additionally, this issue takes a close look at two recent grants received by PSU faculty members, one of which will improve our …


Smarcb1 Is Required For Widespread Baf Complex-Mediated Activation Of Enhancers And Bivalent Promoters., Robert T Nakayama, John L Pulice, Alfredo M Valencia, Matthew J Mcbride, Zachary M Mckenzie, Mark A Gillespie, Wai Lim Ku, Mingxiang Teng, Kairong Cui, Robert T Williams, Seth H Cassel, He Qing, Christian J Widmer, George D Demetri, Rafael A Irizarry, Keji Zhao, Jeffrey A Ranish, Cigall Kadoch Nov 2017

Smarcb1 Is Required For Widespread Baf Complex-Mediated Activation Of Enhancers And Bivalent Promoters., Robert T Nakayama, John L Pulice, Alfredo M Valencia, Matthew J Mcbride, Zachary M Mckenzie, Mark A Gillespie, Wai Lim Ku, Mingxiang Teng, Kairong Cui, Robert T Williams, Seth H Cassel, He Qing, Christian J Widmer, George D Demetri, Rafael A Irizarry, Keji Zhao, Jeffrey A Ranish, Cigall Kadoch

Articles, Abstracts, and Reports

Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) complexes contribute to more than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor, an aggressive pediatric cancer characterized by biallelic inactivation of the core BAF complex subunit SMARCB1 (BAF47). However, the mechanism by which this alteration contributes to tumorigenesis remains poorly understood. We find that BAF47 loss destabilizes BAF complexes on chromatin, absent significant changes in complex assembly or integrity. Rescue of BAF47 in BAF47-deficient sarcoma cell lines results in increased genome-wide BAF complex occupancy, facilitating widespread enhancer activation and opposition of Polycomb-mediated repression at bivalent promoters. We …


Life Cycle Analysis For Algae Biofuels-Using Local Situations To Factor In The Cost/Benefit Of High-End Products Along With Nutrient Remediation And Co2 Sequestration, John Korstad, Joe T. Moore Nov 2017

Life Cycle Analysis For Algae Biofuels-Using Local Situations To Factor In The Cost/Benefit Of High-End Products Along With Nutrient Remediation And Co2 Sequestration, John Korstad, Joe T. Moore

College of Science and Engineering Faculty Research and Scholarship

Algae as a feedstock for commercial biofuels is best suited for sunny and warm areas with abundant fresh, salt, or brackish water. Optimum areas worldwide are in the tropics. Logical areas in North America include the Southeast Gulf coast and perhaps New Mexico. Additional practical areas on smaller scale probably lie in metropolitan locations, especially near international airports. The cost-benefit of these endeavors can be enhanced when factors such as high-end products alongside collaboration with sewage treatment or other waste water remediation, industrial carbon dioxide sequestration, reduced transport distance of fuels, and other aspects of the local economy are taken …


Department Of Surgery Update, November 2017, Wright State University Department Of Surgery Nov 2017

Department Of Surgery Update, November 2017, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, and more.


Interactive Effects Of Ovarian Steroid Hormones On Alcohol Use And Binge Drinking Across The Menstrual Cycle, Michelle M. Martel, Tory Eisenlohr-Moul, Bethan A. Roberts Nov 2017

Interactive Effects Of Ovarian Steroid Hormones On Alcohol Use And Binge Drinking Across The Menstrual Cycle, Michelle M. Martel, Tory Eisenlohr-Moul, Bethan A. Roberts

Psychology Faculty Publications

Patterns and features of substance use and abuse vary across the menstrual cycle in humans. Yet, little work has systematically examined the within-person relationships between ovarian hormone changes and alcohol use across the menstrual cycle. Our study was the first to examine the roles of within-person levels of estradiol (E2) and progesterone (P4) in relation to daily alcohol use and binge drinking in young women. Participants were 22 naturally cycling women, ages 18-22, recruited through a university subject pool who reported any alcohol use and who completed a screening visit assessing study eligibility, followed by 35 subsequent days of data …


Jaci Ullrich Honors Portfolio, Jaci Danielle Ullrich Nov 2017

Jaci Ullrich Honors Portfolio, Jaci Danielle Ullrich

Honors Capstone Portfolios

Jaci Ullrich's honors portfolio captured in November 2017.


Targeting Mitoneet With Pioglitazone For Therapeutic Neuroprotection After Spinal Cord Injury, Alexander G. Rabchevsky, Samir P. Patel, Patrick G. Sullivan Nov 2017

Targeting Mitoneet With Pioglitazone For Therapeutic Neuroprotection After Spinal Cord Injury, Alexander G. Rabchevsky, Samir P. Patel, Patrick G. Sullivan

Spinal Cord and Brain Injury Research Center Faculty Publications

No abstract provided.


Linking Tuberous Sclerosis Complex, Excessive Mtor Signaling, And Age-Related Neurodegeneration: A New Association Between Tsc1 Mutation And Frontotemporal Dementia, Nicholas T. Olney, Carolina Alquezar, Eliana Marisa Ramos, Alissa L. Nana, Jamie C. Fong, Anna M. Karydas, Joanne B Taylor, Melanie L. Stephens, Andrea R. Argouarch, Victoria A. Van Berlo, Deepika R. Dokuru, Elliott H. Sherr, Gregory A. Jicha, William P. Dillon, Rahul S. Desikan, Mary De May, William W. Seeley, Giovanni Coppola, Bruce L. Miller, Aimee W. Kao Nov 2017

Linking Tuberous Sclerosis Complex, Excessive Mtor Signaling, And Age-Related Neurodegeneration: A New Association Between Tsc1 Mutation And Frontotemporal Dementia, Nicholas T. Olney, Carolina Alquezar, Eliana Marisa Ramos, Alissa L. Nana, Jamie C. Fong, Anna M. Karydas, Joanne B Taylor, Melanie L. Stephens, Andrea R. Argouarch, Victoria A. Van Berlo, Deepika R. Dokuru, Elliott H. Sherr, Gregory A. Jicha, William P. Dillon, Rahul S. Desikan, Mary De May, William W. Seeley, Giovanni Coppola, Bruce L. Miller, Aimee W. Kao

Neurology Faculty Publications

No abstract provided.


Optimal Hemoglobin Extinction Coefficient Data Set For Near-Infrared Spectroscopy, Yue Zhao, Lina Qiu, Yunlong Sun, Chong Huang, Ting Li Nov 2017

Optimal Hemoglobin Extinction Coefficient Data Set For Near-Infrared Spectroscopy, Yue Zhao, Lina Qiu, Yunlong Sun, Chong Huang, Ting Li

Biomedical Engineering Faculty Publications

Extinction coefficient (ε) is a critical parameter for quantification of oxy-, deoxy-, and total-hemoglobin concentrations (Δ[HbO2], Δ[Hb], Δ[tHb]) from optical measurements of Near-infrared spectroscopy (NIRS). There are several different ε data sets which were frequently used in NIRS quantification. A previous study reported that even a small variation in ε could cause a significant difference in hemodynamic measurements. Apparently the selection of an optimal ε data set is important for NIRS. We conducted oxygen-state-varied and blood-concentration-varied model experiments with 57 human blood samples to mimic tissue hemodynamic variations. Seven reported ε data sets were evaluated by comparisons between …


Techno-Economic Implications Of Fed-Batch Enzymatic Hydrolysis, Ellen Emanuel Nov 2017

Techno-Economic Implications Of Fed-Batch Enzymatic Hydrolysis, Ellen Emanuel

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

As ethanol production continues to increase in the United States, cellulosic ethanol continues to gain traction as a viable option for meeting ethanol demands. In this work, a literature review of techno-economic analyses for cellulosic ethanol was conducted. It was found that pretreatment methods greatly affect the ethanol production costs. There is a lack of techno-economic data comparing a batch enzymatic hydrolysis to a fed-batch enzymatic hydrolysis for a separate hydrolysis and fermentation production process. Consequently, a techno-economic analysis comparing cellulosic ethanol production using batch versus fed-batch enzymatic hydrolysis was conducted. SuperPro Designer software (Intelligen, Scotch Plains, New Jersey), a …


In The Crosshairs Of The White Nationalist Movement: Is Bridgewater State Ready?, Carolyn Petrosino Nov 2017

In The Crosshairs Of The White Nationalist Movement: Is Bridgewater State Ready?, Carolyn Petrosino

Bridgewater Review

No abstract provided.


Bridgewater Review, Vol. 36, No. 2, November 2017 Nov 2017

Bridgewater Review, Vol. 36, No. 2, November 2017

Bridgewater Review

No abstract provided.


The Effectiveness And Effects Of Alcohol Regulation: Evidence From India, Dara Lee Luca, Emily Owens, Gunjan Sharma Nov 2017

The Effectiveness And Effects Of Alcohol Regulation: Evidence From India, Dara Lee Luca, Emily Owens, Gunjan Sharma

WCBT Faculty Publications

We provide quasi-experimental evidence on the effects of alcohol regulation on alcohol consumption and associated public health outcomes using detailed individual level and aggregate data from India, where state level laws generate substantial variation in the availability of commercially produced alcohol across people of different ages. We find that despite significant law evasion, men who are legally allowed to drink are substantially more likely to consume alcohol. Further, men who are legally allowed to drink are significantly more likely to commit violence against their partners, suggesting a causal channel between alcohol consumption and domestic violence. We also examine the effects …


Filamentation Involves Two Overlapping, But Distinct, Programs Of Filamentation In The Pathogenic Fungus Candida Albicans, Jahaun Azadmanesh, Austin M. Gowen, Paul E. Creger, Nicole D. Shafer, Jill R. Blankenship Nov 2017

Filamentation Involves Two Overlapping, But Distinct, Programs Of Filamentation In The Pathogenic Fungus Candida Albicans, Jahaun Azadmanesh, Austin M. Gowen, Paul E. Creger, Nicole D. Shafer, Jill R. Blankenship

Biology Faculty Publications

The ability of the human pathogenic fungus Candida albicans to switch between yeast-like and filamentous forms of growth has long been linked to pathogenesis. Numerous environmental conditions, including growth at high temperatures, nutrient limitation, and exposure to serum, can trigger this morphological switch and are frequently used in in vitro models to identify genes with roles in filamentation. Previous work has suggested that differences exist between the various in vitro models both in the genetic requirements for filamentation and transcriptional responses to distinct filamentation-inducing media, but these differences had not been analyzed in detail. We compared 10 in vitro models …


Contemporary Issues Of Open Data In Information Systems Research: Considerations And Recommendations, Georg J.P. Link, Kevin Lumbard, Kieran Conboy, Michael Feldman, Joseph Feller, Jordana George, Matt Germonprez, Sean Goggins, Debora Jeske, Gaye Kiely, Kristen Schuster, Matt Willis Nov 2017

Contemporary Issues Of Open Data In Information Systems Research: Considerations And Recommendations, Georg J.P. Link, Kevin Lumbard, Kieran Conboy, Michael Feldman, Joseph Feller, Jordana George, Matt Germonprez, Sean Goggins, Debora Jeske, Gaye Kiely, Kristen Schuster, Matt Willis

Information Systems and Quantitative Analysis Faculty Publications

Researchers, governments, and funding agencies are calling on research disciplines to embrace open data - data that is publicly accessible and usable beyond the original authors. The premise is that research efforts can draw and generate several benefits from open data, as such data might provide further insight, enabling the replication and extension of current knowledge in different contexts. These potential benefits, coupled with a global push towards open data policies, brings open data into the agenda of research disciplines – including Information Systems (IS). This paper responds to these developments as follows. We outline themes in the ongoing discussion …


Prevalence And Risk Of Hepatitis E Virus Infection In The Hiv Population Of Nepal, Ananta Shrestha, Anurag Adhikar, Manjula Bhattarai, Ramanuj Rauniyar, Jose D. Debes, André Boonstra, Thupten K. . Lama, Mamun Al Mahtab, Amna Subhan Butt, Sheikh Mohammad Fazle Akbar Nov 2017

Prevalence And Risk Of Hepatitis E Virus Infection In The Hiv Population Of Nepal, Ananta Shrestha, Anurag Adhikar, Manjula Bhattarai, Ramanuj Rauniyar, Jose D. Debes, André Boonstra, Thupten K. . Lama, Mamun Al Mahtab, Amna Subhan Butt, Sheikh Mohammad Fazle Akbar

Section of Gastroenterology

Background: Infection with the hepatitis E virus (HEV) can cause acute hepatitis in endemic areas in immune-competent hosts, as well as chronic infection in immune-compromised subjects in non-endemic areas. Most studies assessing HEV infection in HIV-infected populations have been performed in developed countries that are usually affected by HEV genotype 3. The objective of this study is to measure the prevalence and risk of acquiring HEV among HIV-infected individuals in Nepal.

Methods: We prospectively evaluated 459 Human Immunodeficiency Virus (HIV)-positive individuals from Nepal, an endemic country for HEV, for seroprevalence of HEV and assessed risk factors associated with HEV infection. …


Premedical Programs Newsletter, November-December 2017, University Of Dayton Nov 2017

Premedical Programs Newsletter, November-December 2017, University Of Dayton

Pre-Health Resource Center Campus Communications

Newsletter for students, staff, and faculty in the premedical and predental programs.


Book Review: Why We Do What We Do, Michael Carson Nov 2017

Book Review: Why We Do What We Do, Michael Carson

Bridgewater Review

Review of Behave: The Biology of Humans at Our Best and Worst by Robert M. Sapolsky. (New York: Penguin Random House, 2017).


Dynamic Range Of Frontoparietal Functional Modulation Is Associated With Working Memory Capacity Limitations In Older Adults, Jonathan G. Hakun, Nathan F. Johnson Nov 2017

Dynamic Range Of Frontoparietal Functional Modulation Is Associated With Working Memory Capacity Limitations In Older Adults, Jonathan G. Hakun, Nathan F. Johnson

Physical Therapy Faculty Publications

Older adults tend to over-activate regions throughout frontoparietal cortices and exhibit a reduced range of functional modulation during WM task performance compared to younger adults. While recent evidence suggests that reduced functional modulation is associated with poorer task performance, it remains unclear whether reduced range of modulation is indicative of general WM capacity-limitations. In the current study, we examined whether the range of functional modulation observed over multiple levels of WM task difficulty (N-Back) predicts in-scanner task performance and out-of-scanner psychometric estimates of WM capacity. Within our sample (60–77 years of age), age was negatively associated with frontoparietal modulation range. …


Wmu Board Of Trustees Formal Session November 1, 2017, Wmu Board Of Trustees Nov 2017

Wmu Board Of Trustees Formal Session November 1, 2017, Wmu Board Of Trustees

WMU Board of Trustees Meetings

  • Acceptance of the Agenda
  • Approval of the Minutes
  • Remarks by the Chair
  • Remarks by the President
  • Comments by the Faculty Senate Vice President
  • Comments by the Western Student Association President
  • Comments by the Graduate Student Association President
  • Research, Discovery, and Student Engagement Presentation
  • Smart Zone Update
  • WMU Presentation
  • Public Comments Regarding Action Items


The Antelope, University Of Nebraska At Kearney Nov 2017

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.


Special Issue Of Applied Mechanics Reviews In Collaboration With The Journal Of Tribology, Harry Dankowicz, Michael Khonsari Nov 2017

Special Issue Of Applied Mechanics Reviews In Collaboration With The Journal Of Tribology, Harry Dankowicz, Michael Khonsari

Faculty Publications

No abstract provided.


Mtor Kinase Inhibition Effectively Decreases Progression Of A Subset Of Neuroendocrine Tumors That Progress On Rapalog Therapy And Delays Cardiac Impairment, Melissa A. Orr-Asman, Zhengtao Chu, Min Jiang, Mariah Worley, Kathleen Lesance, Sheryl E. Koch, Vinicius S. Carreira, Hanan M. Dahche, David R. Plas, Kakajan Komurov, Xiaoyang Qi, Carol A. Mercer, Lowell B. Anthony, Jack Rubinstein, Hala E. Thomas Nov 2017

Mtor Kinase Inhibition Effectively Decreases Progression Of A Subset Of Neuroendocrine Tumors That Progress On Rapalog Therapy And Delays Cardiac Impairment, Melissa A. Orr-Asman, Zhengtao Chu, Min Jiang, Mariah Worley, Kathleen Lesance, Sheryl E. Koch, Vinicius S. Carreira, Hanan M. Dahche, David R. Plas, Kakajan Komurov, Xiaoyang Qi, Carol A. Mercer, Lowell B. Anthony, Jack Rubinstein, Hala E. Thomas

Internal Medicine Faculty Publications

Inhibition of mTOR signaling using the rapalog everolimus is an FDA-approved targeted therapy for patients with lung and gastroenteropancreatic neuroendocrine tumors (NET). However, patients eventually progress on treatment, highlighting the need for additional therapies. We focused on pancreatic NETs (pNET) and reasoned that treatment of these tumors upon progression on rapalog therapy, with an mTOR kinase inhibitor (mTORKi), such as CC-223, could overcome a number of resistance mechanisms in tumors and delay cardiac carcinoid disease. We performed preclinical studies using human pNET cells in vitro and injected them subcutaneously or orthotopically to determine tumor progression and cardiac function in mice …


Superficial Soft-Tissue Sarcomas Rarely Require Advanced Soft-Tissue Reconstruction Following Resection, William C. Eward, Alexander L. Lazarides, Anthony M. Griffin, Patrick W. O'Donnell, Amir Sternheim, Anne O'Neill, Stefan O. Hofer, Peter C. Ferguson, Jay S. Wunder Nov 2017

Superficial Soft-Tissue Sarcomas Rarely Require Advanced Soft-Tissue Reconstruction Following Resection, William C. Eward, Alexander L. Lazarides, Anthony M. Griffin, Patrick W. O'Donnell, Amir Sternheim, Anne O'Neill, Stefan O. Hofer, Peter C. Ferguson, Jay S. Wunder

Markey Cancer Center Faculty Publications

Objective: Soft-tissue sarcomas are most frequently located deep within myofascial compartments. Superficial soft-tissue sarcomas (S-STS) are relatively less common and may be managed differently than deep sarcomas because generous resection margins are often possible without sacrificing critical structures. We sought to investigate the frequency and types of soft-tissue reconstructive procedures that are required following excision of S-STS.

Methods: We reviewed 457 consecutively treated patients with S-STS with a minimum 2-year follow-up from our prospectively maintained database between 1989 and 2009.

Results: Mean follow-up was 10.5 years (range, 2–23). Four hundred twenty-one tumors (91%) were excised with negative margins, 38 (8.3%) …


Design And Prototyping Of A Shape-Changing Rigid-Body Human Foot In Gait, Tanner N. Rolfe Nov 2017

Design And Prototyping Of A Shape-Changing Rigid-Body Human Foot In Gait, Tanner N. Rolfe

Honors Theses

Traditional ankle-foot prostheses often replicate the physiological change in shape of the foot during gait via compliant mechanisms. In comparison, rigid-body feet tend to be simplistic and largely incapable of accurately representing the geometry of the human foot. Multi-segment rigid-body devices offer certain advantages over compliant mechanisms which may be desirable in the design of ankle-foot devices, including the ability to withstand greater loading, the ability to achieve more drastic shape-change, and the ability to be synthesized from their kinematics, allowing for realistic functionality without prior accounting of the complex internal kinetics of the foot. This work focuses on applying …