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It's Divine, Krysten Godfrey Maddocks

UNH Today Archive

No abstract provided.

Improved Survival And Tumor Control With Interleukin-2 Is Associated With The Development Of Immune-Related Adverse Events: Data From The Proclaim, Brendan Curti, Gregory A Daniels, David F Mcdermott, Joseph I Clark, Howard L Kaufman, Theodore F Logan, Jatinder Singh, Meenu Kaur, Theresa L Luna, Nancy Gregory, Michael A Morse, Michael K K Wong, Janice P Dutcher

Articles, Abstracts, and Reports

BACKGROUND: Immune related adverse events (irAEs) are associated with immunotherapy for cancer and while results suggest improvement in tumor control and overall survival in those experiencing irAEs, the long-term impact is debated. We evaluated irAE reports related to high dose interleukin-2 therapy (IL-2) documented in the PROCLAIM

METHODS: Reports on 1535 patients, including 623 with metastatic melanoma (mM) and 919 with metastatic renal cell cancer (mRCC) (7 patients had both diseases), were queried for irAEs. The timing of the event was categorized as occurring before, during or after IL-2 or related to any checkpoint inhibitor (CPI). mM patients and mRCC …

Evaluation Of A Field-Deployable Reverse Transcription-Insulated Isothermal Pcr For Rapid And Sensitive On-Site Detection Of Zika Virus, Mariano Carossino, Yanqiu Li, Pei-Yu A. Lee, Chuan-Fu Tsai, Pin-Hsing Chou, Dennis Williams, Ashley Skillman, R. Frank Cook, Grayson Brown, Hsiao-Fen G. Chang, Hwa-Tang T. Wang, Udeni B. R. Balasuriya

Maxwell H. Gluck Equine Research Center Faculty Publications

Background: The recent emergence of Zika virus (ZIKV) in Brazil and its precipitous expansion throughout the Americas has highlighted the urgent need for a rapid and reliable on-site diagnostic assay suitable for viral detection. Such point-of-need (PON), low-cost diagnostics are essential for ZIKV control in vulnerable areas with limited resources.

Methods: We developed and evaluated a ZIKV-specific field-deployable RT-iiPCR reagent set targeting the E gene for rapid detection of ZIKV in ZIKV-spiked human and mosquito specimens, and compared its performance to the Center for Disease Control and Prevention (CDC) and Pan American Health Organization (PAHO) RT-qPCR assays targeting the E …

Food Waste In The United States: Issues, Ethics, And Solutions, Patrick Erickson

Honors College Theses

One-third of all food produced for human consumption is lost or wasted globally. In North America and Europe, 280-300 kg of food is wasted per capita each year, with more than 40% of the losses occurring at the retail and consumer level. In this paper, I compare the amount of food wasted in the United States to the amounts wasted by different societies around the world, and discuss the reasons for the food waste, and the consequences that the waste has on our society, in terms of resource consumption and production of pollution. The pragmatic philosophy of Richard Rorty states …

Dna Base Excision Repair And Double Strand Break Repair In Human Fibroblast, Mingyang Li

LSU Doctoral Dissertations

In eukaryotes, DNA repair mechanisms detect and repair damaged DNA. DNA damage is primarily caused by a variety of exogenous and endogenous sources. Several types of damage to DNA are repaired by different kinds of DNA repair pathways. This dissertation focused on repair of N-methylpurines (NMPs) and double-strand breaks (DSBs) in human fibroblasts.

NMPs, including N⁷-methylguanine (7MeG) and N³-methyladenine (3MeA), can be induced by environmental methylating agents (e.g. the soil fumigant methyl bromide), chemotherapeutics (e.g. nitrogen mustards), and natural cellular methyl donors like S-adenosylmethionine. In human cells, NMPs are repaired by the multi-step …

Sequence Data And Association Statistics From 12,940 Type 2 Diabetes Cases And Controls, Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M. Teslovich, Vineeta Agarwala, Kyle J. Gaulton, Lizz Caulkins, Rector Arya, Ravi Duggirala, Joanne E. Curran, Satish Kumar, John Blangero

School of Medicine Publications

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1–5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency …

From Ground Pools To Treeholes: Convergent Evolution Of Habitat And Phenotype In Aedes Mosquitoes, John Soghigian, Theodore G. Andreadis, Todd P. Livdahl

Biology

Background: Invasive mosquito species are responsible for millions of vector-borne disease cases annually. The global invasive success of Aedes mosquitoes such as Aedes aegypti and Aedes albopictus has relied on the human transport of immature stages in container habitats. However, despite the importance of these mosquitoes and this ecological specialization to their widespread dispersal, evolution of habitat specialization in this group has remained largely unstudied. We use comparative methods to evaluate the evolution of habitat specialization and its potential influence on larval morphology, and evaluate whether container dwelling and invasiveness are monophyletic in Aedes. Results: We show that habitat specialization …

Um Youth Summer Camps Release 2018 Schedule, Pam Starling

University of Mississippi News

Outreach offers special option for holiday gifts, several new camps for K-12 students

A Functional Near-Infrared Spectroscopic Investigation Of Speech Production During Reading, Nick Wan, Allison S. Hancock, Todd K. Moon, Ronald B. Gillam

Psychology Faculty Publications

This study was designed to test the extent to which speaking processes related to articulation and voicing influence Functional Near Infrared Spectroscopy (fNIRS) measures of cortical hemodynamics and functional connectivity. Participants read passages in three conditions (oral reading, silent mouthing, and silent reading) while undergoing fNIRS imaging. Area under the curve (AUC) analyses of the oxygenated and deoxygenated hemodynamic response function concentration values were compared for each task across five regions of interest. There were significant region main effects for both oxy and deoxy AUC analyses, and a significant region x task interaction for deoxy AUC favoring the oral reading …

Information Literacy In Ghanaian Academic Institutions: Case Of Kwame Nkrumah University Of Science And Technology (K.N.U.S.T), Ghana, Lilian Atta-Obeng Miss, Ernest Boakye Mr., Fynn Paapa Kwamena Mr.

Library Philosophy and Practice (e-journal)

A case of a credit bearing information literacy skills class, offered to first year undergraduate students though not across all colleges at the Kwame Nkrumah University of Science and Technology (KNUST), Ghana was analysed. The survey research methodology was used and questionnaire was distributed to 136 students. The findings indicated that the course was relevant and should be maintained though students’ knowledge on ethical use of information, citation skills, and information searching skills were poor. The study recommends a collaborative partnership between librarians and faculty for the teaching and learning of information literacy skills.

Constraining The Deforestation History Of Europe: Evaluation Of Historical Land Use Scenarios With Pollen-Based Land Cover Reconstructions, Jed O. Kaplan, Kristen M. Krumhardt, Marie José Gaillard, Shinya Sugita, Anna Kari Trondman, Ralph Fyfe, Laurent Marquer, Florence Mazier, Anne Birgitte Nielsen

School of Geography, Earth and Environmental Sciences

No abstract provided.

Population-Level Plasticity In Foraging Behavior Of Western Gulls (Larus Occidentalis), Scott A. Shaffer, Sue Cockerham, Pete Warzybok, Russell Bradley, Jaime Jahncke, Corey Clatterbuck, Magali Lucia, Jennifer Jelincic, Anne Cassell, Emma Kelsey, Josh Adams

Faculty Publications, Biological Sciences

Background Plasticity in foraging behavior among individuals, or across populations may reduce competition. As a generalist carnivore, western gulls (Larus occidentalis) consume a wide range of marine and terrestrial foods. However, the foraging patterns and habitat selection (ocean or land) of western gulls is not well understood, despite their ubiquity in coastal California. Here, we used GPS loggers to compare the foraging behavior and habitat use of western gulls breeding at two island colonies in central California. Results Gulls from offshore Southeast Farallon Island (SFI; n = 41 gulls) conducted more oceanic trips (n = 90) of …

Relationship Between Physical Activity And Stress Among Junior High School Students In The Physical Education Environment, David C. Barney, Frank Pleban, Terrance Lewis

Faculty Publications

The study purpose was to explore grade level differences (7^th, 8^th, and 9^th) among junior high school students’ perception of participation in physical education class on individual environmental stress. Physical activity’s role as a stress reduction tool has been well documented. However, physical activity as a stressful event in the school and physical education environment has been less established; particularly in junior high school students. Study participants were comprised of 872 junior high school students, 585 males (67%) and 287 females (33%), enrolled in four junior high schools. Stratified by grade, 315 7^{th …}

Gene Master Regulators Of Papillary And Anaplastic Thyroid Cancers, Dumitru Iacobas, Neha Tuli, Sanda Iacobas, John Rasamny, Augustine Moscatello, Jan Geliebter, Raj Tiwari

NYMC Faculty Publications

We hypothesize that distinct cell phenotypes are governed by different sets of gene master regulators (GMRs) whose strongly protected (by the homeostatic mechanisms) abundance modulates most cell processes by coordinating the expression of numerous genes from the corresponding functional pathways. Gene Commanding Height (GCH), a composite measure of gene expression control and coordination, is introduced to establish the gene hierarchy in each phenotype. If the hypothesis is true, than one can selectively destroy cancer nodules from a heterogeneous tissue by altering the expression of genes whose GCHs are high in cancer but low in normal cell phenotype. Here, we test …

Correction To “Tailoring The Electrochemical Properties Of Carbon Nanotube Modified Indium Tin Oxide Via In Situ Grafting Of Aryl Diazonium”, Jm Hicks, Zy Wong, Dj Scurr, N Silman, Sk Jackson, Pm Mendes, Jw Aylott, Fj Rawson

School of Biomedical Sciences

No abstract provided.

The Blurred Line Between Photic And Aphotic Environments: A Large Mexican Cave With Almost No Dark Zone, Luis M. Mejía-Ortíz, Tanja Pipan, David C. Culver, Peter Sprouse

International Journal of Speleology

Sistema Muévelo Rico is a 1.2 km long cave in Quintana Roo, less than 2 km from the Caribbean Sea. We measured illuminance to a level of 0.1 lux, organic matter (weight loss on ignition), temperature, and relative humidity. The last two were measured at hourly intervals for nearly one year. Approximately one-third of the cave has illuminance values greater than 0.01 lux, and most of the rest of the cave has light as well. Temperature and relative humidity were relatively constant, but they showed a daily cycle at all stations, albeit with different strengths. Organic matter averaged 8%, intermediate …

Testing The Underlying Chemical Principles Of The Biotic Ligand Model (Blm) To Marine Copper Systems: Measuring Copper Speciation Using Fluorescence Quenching, Tara N. Tait, James C. Mcgeer, Scott Smith

Chemistry Faculty Publications

Speciation of copper in marine systems strongly influences the ability of copper to cause toxicity. Natural organic matter (NOM) contains many binding sites which provides a protective effect on copper toxicity. The purpose of this study was to characterize copper binding with NOM using fluorescence quenching techniques. Fluorescence quenching of NOM with copper was performed on nine sea water samples. The resulting stability con- stants and binding capacities were consistent with literature values of marine NOM, show- ing strong binding with log K values from 7.64 to 10.2 and binding capacities ranging from 15 to 3110 nmole mg C ^{−1 …}

Қишлоқ Хўжалиги Инфратузилмасини Инновацион Ривожлантиришнинг Иқтисодий Самарадорликка Таъсири, С. Н. Хамраева

Irrigation and Melioration

The article scientifically substantiates the innovative development of rural infrastructure in the context of the activation of innovative processes in agriculture. A conceptual model of the formation and development of the innovative infrastructure of the agricultural sector has been developed, taking into account the conditions and factors of innovation policy in Uzbekistan. And also, the effect of innovation infrastructure in agriculture has been examined from the point of view of the state and the local government, economic entities of agriculture, and also objects of innovation infrastructure and assessed by types of strategic, economic and social effects. Based on the types …

Philippine Aquatic Food Production Afs 450, Michael Cerbo

Library Impact Statements

No abstract provided.

New Generation Of Biomedicine, Dave Larsen

College of Arts and Sciences Newsroom

Converging biology, physics, mathematics and engineering research could create innovative solutions to major health issues such as cancer and Alzheimer's disease. The University of Dayton is well-suited to model such a transition, a former National Cancer Institute deputy director said during a campus visit.

Consequences Of Fatigue And Sleep Deficiency In The Workplace: Implications For The Construction Industry, Karen Phegley

Master of Public Health Program Student Publications

Background: This study was a review of the (1) consequences that fatigue and sleep deficiency have on the human body, personal safety and safety in the workplace with implications for the construction industry; and (2) factors in the workplace that contribute to worker fatigue.

Methods: A systematic search and review of peer-reviewed articles and gray literature was conducted for sources describing common industry policies, standards and/or recommendations addressing sleep related problems in the workplace.

Results: The contributing factors of fatigue include work-related mental exertion, sleep deficiency and work-related physical exertion. Major work-related effects stem from circadian rhythm disruptions due to …

Happy Beginnings: Kim Kraus Broadens Grad School Plans To Include Medicine And Research, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Establishes New Consumer Privacy Rights; Expands Liability For Consumer Data Breaches. Initiative Statute.

Initiatives

Gives consumers right to learn categories of personal information that businesses collect, sell, or disclose about them, and to whom information is sold or disclosed. Gives consumers right to prevent businesses from selling or disclosing their personal information. Prohibits businesses from discriminating against consumers who exercise these rights. Allows consumers to sue businesses for security breaches of consumers’ data, even if consumers cannot prove injury. Allows for enforcement by consumers, whistleblowers, or public agencies. Imposes civil penalties. Applies to online and brick-and-mortar businesses that meet specific criteria. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact …

A Preliminary Study: Comparative Toxicity Of Extracts From Tinospora Tuberculata Beumee And Lumnitzera Racemosa Willd On Aedes Aegypti Linnaeus Larvae (Diptera: Culicidae), Wahizatul A. A., Shasita R.

ASEAN Journal on Science and Technology for Development

Research has been widely made on the potential use of herbal plants as effective agents for mosquito vector control. However, only a few studies have been carried out to investigate the potential insecticidal activity of mangrove plants against these dengue vectors. This study was carried out to examine the comparative toxicity of two mangrove plants, Tinospora tuberculata and Lumnitzera racemosa against the Aedes aegypti larvae. The leaf and stem of T. tuberculata and L. racemosa, were extracted using 95% methanol and these extracts bioassayed against the 3rd instar larvae of aegypti under laboratory conditions. The LC50 values of the crude …

Ros-Enabled Framework For A Miniature Hexapod As A Mobile Robot Research Platform, Joseph Michael Kloeppel

Electrical and Computer Engineering ETDs

The purpose of this thesis is to investigate and develop a framework for connected six-legged robots which can be used as a Robotic Operating System (ROS) based research platform. The research presented aims to purvey the necessary engineering and scientific steps needed to evolve a consumer-grade connected toy into a fully functioning and highly capable robotic system. Such a platform can be used to simulate and implement novel biologically inspired swarm research. Crawling robots have the advantage of being able to scale terrains which wheeled mobile robots may not and possess many interesting characteristics. The miniROaCH, miniature ROS-enabled and Crawling …

Week Of December 18, 2017, New York Medical College

InTouch

• Prominent Trauma Surgeon Addresses 14th Annual Louis R.M. DelGuercio Professorship and Research Day
• GSA Organizes Successful Second Annual Snowman Project
• SOM P2P Committee Recognizes Role Models at NYMC

Maternal Depressive Symptoms And Child Behavior Among Mexican Women And Their Children., Emily P Flynn, Esther O Chung, Emily J Ozer, Lia C H Fernald

Articles, Abstracts, and Reports

Over 50% of mothers in rural Mexico have high depressive symptoms, and their children's health and development are likely to be negatively affected. A critical question is whether children vary in their vulnerability to the effects of high maternal depressive symptoms according to their indigenous ethnicity, maternal education, or household wealth. Our sample included 4442 mothers and 5503 children from an evaluation of Mexico's social welfare program. Maternal depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) Scale, and child behavior was measured using an adapted version of the Behavior Problems Index (BPI). Multiple linear regression models …

Mapping Genetic Variations To Three-Dimensional Protein Structures To Enhance Variant Interpretation: A Proposed Framework., Gustavo Glusman, Peter W Rose, Andreas Prlić, Jennifer Dougherty, José M Duarte, Andrew S Hoffman, Geoffrey J Barton, Emøke Bendixen, Timothy Bergquist, Christian Bock, Elizabeth Brunk, Marija Buljan, Stephen K Burley, Binghuang Cai, Hannah Carter, Jianjiong Gao, Adam Godzik, Michael Heuer, Michael Hicks, Thomas Hrabe, Rachel Karchin, Julia Koehler Leman, Lydie Lane, David L Masica, Sean D Mooney, John Moult, Gilbert S Omenn, Frances Pearl, Vikas Pejaver, Sheila M Reynolds, Ariel Rokem, Torsten Schwede, Sicheng Song, Hagen Tilgner, Yana Valasatava, Yang Zhang, Eric W Deutsch

Articles, Abstracts, and Reports

The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may be unclear. Many diseases are caused by genetic variants affecting important protein features, such as enzyme active sites or interaction interfaces. The scientific community has catalogued millions of genetic variants in genomic databases and thousands of protein structures in the Protein Data Bank. Mapping mutations onto three-dimensional (3D) structures enables atomic-level analyses of protein positions that may be important for the stability …

Objective Measures Of Electrophysiological Responses Of Children With Idiopathic Autism Spectrum Disorder And Phelan-Mcdermid Syndrome To A Contrast-Reversing Checkerboard, Chloe Brittenham

Theses and Dissertations

The heterogeneity of autism presents many challenges in understanding the disorder. The current study employs objective measures to examine visual evoked potential (VEP) responses of children with idiopathic autism (iASD) and Phelan-Mcdermid syndrome (PMS) to a contrast-reversing checkerboard in both long (60-second) and short (2-second) duration conditions.

Una Sensibilità Scientifica: Giacomo Balla’S Painting Of Light, 1900-1914, Luise Mahler

Theses and Dissertations

This thesis examines how science shaped Giacomo Balla’s pioneering style of abstraction. A reconsideration of his oeuvre from 1900 to the advent of Italian Futurism demonstrates that his artistic vision of light—indebted to popular scientific imagery and what might be called "prosthetic" visual technologies—anticipated the emergent Futurist aesthetics.