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Characterization Of The Immune Response To Lipopolysaccharide In Early Pregnant Ewes As A Model To Study Bacterial Infection Induced Embryonic Loss, Jessalyn Marie Hadfield

Graduate Theses, Dissertations, and Problem Reports (ETD)

An immunological balance has to be established during pregnancy that protects the mother yet tolerates the semi-allogenic fetus. To understand the innate immune response during bacterial infections that may cause early embryonic loss, a lipopolysaccharide (LPS) treated sheep model was used. Two objectives of this study were to examine if omega-3 PUFAs in the form of supplementary whole flaxseed could reduce the inflammatory response to an LPS challenge and to examine if there is a differential immune response to LPS in Suffolk and Dorset ewes. A total of 3 experiments were conducted; two investigating the effect of supplement and one …

Provenance Of The Hamilton Group: A Study Of Source-To-Sink Relationships Within The Middle Devonian Central Appalachian Basin, Brittany N. Hupp

Graduate Theses, Dissertations, and Problem Reports (ETD)

Little is known of the provenance of detrital clays in the Hamilton Group, which contains one of the most lucrative unconventional shale gas plays in the world. The Hamilton Group consists of both the organic-rich Marcellus Shale and the overlying, clay-rich Mahantango Formation. This research, in collaboration with the Marcellus Shale Energy and Environmental Laboratory (MSEEL) project, aims to constrain the provenance of the two units within the Hamilton Group and evaluate paleoclimate indicators in order to better understand the role of clastic influx on organic-matter production and preservation within the Middle Devonian Acadian foreland basin.;Geochemical and petrographic analysis of …

The Effects Of Aerobic Exercise And Lipolytic Stimulation On Skeletal Muscle And Adipose Expression Of Perilipin 3 (Plin3) In Individuals With Type 2 Diabetes And Women With Polycystic Ovary Syndrome, Jeffrey Daniel Covington

LSU Doctoral Dissertations

Ectopic lipid accumulation in skeletal muscle is linked with insulin resistance and type 2 diabetes (T2D). Neutral lipid is stored as lipid droplets, which are coated by lipid droplet coat proteins. One important class of these proteins are the perilipins. Little research has focused on perilipin 3 (PLIN3) and coatomer gtp-ases, theorized to be involved in PLIN3 directed lipid oxidation. Under lipolytic stimulation with epinephrine or palmitate, forskolin, and ionomysin (PFI), primary human myotubes taken from health non-T2D donors showed increased protein content levels of PLIN3. Concordantly, following endurance exercise in non-T2D males—an experimental paradigm shown to increase lipolysis—levels of …

Assessing The Effects Of The Smartphone As A Learning Tool On The Academic Achievement And Motivation Of High School Agriculture Students In Louisiana, Henry Eric Smith

LSU Doctoral Dissertations

Perhaps the most influential device in modern society is the smartphone. Over 90% of Americans aged 18-29 own a smartphone and 74% of teenagers reported using a smartphone as their primary internet connection. Students perceived that using smartphones in the classroom aided learning. However, two-thirds of American high schools ban students from using phones in the classroom. Secondary science curriculum focuses on subjects that regard the biodiversity of plant and animal species, but disregard the student’s ability to identify species. Consequently, secondary students in general are very poor at identifying species of trees. Previous research supports the idea that advanced …

Characterization Of Dehalogenimonas Strains From A Louisiana Superfund Site That Reductively Dehalogenate Polychlorinated Alkanes, Trent Anthony Key

LSU Doctoral Dissertations

The research described in this dissertation was aimed at expanding understanding of the diversity and functional roles of microorganisms able to anaerobically transform chlorinated compounds. During the course of the research, a novel strictly anaerobic bacterial isolate originating from chlorinated solvent contaminated groundwater at a Superfund Site in south Louisiana (USA) was characterized. Phylogenetic analysis based on 16S rRNA gene sequencing placed the newly isolated strain, designated as NSZ-14 T, within the genus Dehalogenimonas but within a separate lineage from previously described species. Like previously described species within the genus Dehalogenimonas (i.e., D. lykanthroporepellens and D. alkenigignens), strain NSZ-14T was …

Gender Bias In Leadership: Do Gender Of Leader, Type Of Error, Diversity Climate, And Gender Of Subordinate Affect Faculty Perceptions Of Academic Leaders' Effectiveness?, Adriana Alfaro

LSU Doctoral Dissertations

The cyphers don’t lie: women remain significantly underrepresented in positions of authority across the United States, despite their nearly equal representation in the labor force. Gender bias has been proposed as one of the major reasons for the disparity in leadership roles between men and women. Therefore, the primary purpose of this study was to investigate whether gender bias influenced faculty’s perceptions of leadership effectiveness at a Research 1 (R1) Doctoral institution in the southeastern United States when high-ranking university leaders made mistakes, and how type of error, diversity climate, and gender of subordinate affected this relationship. Two scenarios were …

Structure-Based Prediction Of Protein-Protein Interaction Networks Across Proteomes, Surabhi Maheshwari

LSU Doctoral Dissertations

Protein-protein interactions (PPIs) orchestrate virtually all cellular processes, therefore, their exhaustive exploration is essential for the comprehensive understanding of cellular networks. Significant efforts have been devoted to expand the coverage of the proteome-wide interaction space at molecular level. A number of experimental techniques have been developed to discover PPIs, however these approaches have some limitations such as the high costs and long times of experiments, noisy data sets, and often high false positive rate and inter-study discrepancies. Given experimental limitations, computational methods are increasingly becoming important for detection and structural characterization of PPIs. In that regard, we have developed a …

Activity Of Benzobicyclon Herbicide In Common Louisiana Rice Production Practices, Benjamin M. Mcknight

LSU Doctoral Dissertations

A study was conducted at the LSU AgCenter H. Rouse Caffey Rice Research Station (RRS) to evaluate benzobicyclon herbicide application timing on water-seeded rice. Benzobicyclon was applied at seven different timings, at 246 g ai ha-1 in a water-seeded rice production system. Benzobicyclon controlled ducksalad above 90% when applied into the pinpoint flood. Barnyardgrass control was greater than 90% from applications made on pegging rice and immediately following pinpoint flood establishment. At 49 days after treatment (DAT), yellow nutsedge control exceeded 90% following benzobicyclon treatment with a pegging rice or pinpoint flood timing. Ducksalad control was greater than 90% following …

Digital Osteology: 3d Surface Scanning The Os Coxa, Victoria Harrington

LSU Doctoral Dissertations

ABSTRACT This research was designed to isolate a standard 3D scanning methodology using a popular 3D scanner (NextEngine®) used in biological anthropology to reproduce research-quality human skeletal remains. Settings using NextEngine® hardware were determined through three successive studies. The first study used minimum settings to create a topography of nine postcranial bones excavated from a Maya archaeological site, Moho Cay, Belize. The research was conducted in Louisiana State University’s (LSU) Digital Imaging and Visualization in Archaeology (DIVA) Lab. The resulting 3D scans were visually compared to the original bone specimens for similarities in five categories. The similarity ratings were used …

A Graph-Based Taxonomic Intelligent Tutoring System Utilizingbloom’S Taxonomy And Item-Response Theoretic Assessment, Dennis Gordon Castleberry Ii

LSU Doctoral Dissertations

This dissertation details an intelligent tutoring system which aims to raise student trait abilities across concepts and levels of Blooms taxonomy within an educational program. The system utilizes Item Response Theory, a probabilistic theory of assessment which accounts for item discrimination, difficulty, and probability of guessing in its assessment of student trait ability. A modification to Item Response Theory which accounts for question dependencies is used to assess the probability that a student will answer a given question correctly given prior responses on the dependency questions. It also draws from theories of memory and forgetting present in the ACT-R model …

Termite Gut Microbes As Tools And Targets For Termite Control, Chinmay Vijay Tikhe

LSU Doctoral Dissertations

The Formosan subterranean termite (FST), Coptotermes formosanus, is an invasive urban pest in the United States. Colonies of the FST are dependent on the symbiotic gut protozoa for cellulose digestion in the workers’ guts, and the gut bacterial community is known to provide essential nutrients to the termite. The objectives of this PhD research were to develop and evaluate paratransgenesis and phage therapy for termite control. During this study, a termite gut bacterium: Trabulsiella odontotermitis was genetically engineered and was evaluated as a ‘Trojan horse’ for paratransgenesis. We proved that T. odontotermitis can tolerate 50 times more concentration of ligand-Hecate …

A System Dynamic Transmission Model (Systrans) To Simulate Epidemic Dengue Environment, Rifat Anwar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Dengue is the most significant arthropod-borne virus in terms of human morbidity and mortality. Geographic expansion of dengue and intensity of outbreak has amplified significantly during the last few decades. Thus, the understanding of the dynamic of the large outbreaks has become indispensable for planning of control interventions in future epidemics. In this regard, local entomological, meteorological and epidemiological parameters based dengue models can be an essential tool for better interpretation of dengue-climate relationship at a regional scale. Process based modelling is resourceful in combining the vector and host dynamic along with the response to the meteorological factors for dengue …

Associations Between Sleep, Infant Feeding Methods, Brain Development And Behavior: A Multimodal Approach To Assess Plasticity In The Brain, Christopher Edward Bauer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: Sleep-disordered breathing (SDB) is a spectrum disorder that is estimated to effect a significant proportion of the pediatric population (1-3% in USA). SDB is able to disrupt and fragment sleep through frequent arousals and intermittent hypoxia. In addition, the long term effects of SDB in pediatrics have been well-documented; decreases in intelligence quotient (IQ), executive function, school performance, and alertness have all been observed. Although surgical treatments can be quite effective, there are no widely accepted prophylactic measures to prevent SDB development. Recently, breastfeeding duration in infancy has been demonstrated to be correlated with reduced SDB (lower AHI, RAI, …

Interactions Between Euwallacea Ambrosia Beetles, Their Fungal Symbionts And The Native Trees They Attack In The Eastern United States, Matthew C. Berger

Graduate Theses, Dissertations, and Problem Reports (ETD)

In a globalized world, wood products are constantly being shipped from one location to another, along with tiny hitchhikers in the form of insects and microorganisms. Euwallacea validus is a fungus-farming ambrosia beetle native to East Asia that likely made its way to the United States in wood packaging materials in the latter half of the twentieth century. E. validus cultivates two fungal symbionts in the U.S., an unnamed Fusarium sp. (AF-4) and Raffaelea subfusca. Fusarium symbionts of Euwallacea ambrosia beetles as well as Raffaelea symbionts of closely related ambrosia beetles have incited widespread disease on more than one-hundred hosts …

Evaluating Steam Conditioning Manipulations And Grain Expressed Enzymes Effects On Feed Manufacturing Metrics, Feed Hygiene, Broiler Performance, And Bone Mineralization, John William Boney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Animal well-being, evolving feed manufacturing regulatory programs, and consumer perception drive the continued need to provide safe feed to animals. Considering the performance benefits associated with feeding pelleted feed, the concepts of hygienic feed production and production of highly durable pellets may interact to benefit the broiler chicken. In addition to hygienic and physical attributes, poultry nutrition may be enhanced by cereal grains expressing enzymatic activity. These additives may provide additional opportunities to support dietary phosphorus (P) requirements in growing broilers, further contributing to improved animal welfare conditions in an economically favorable manner. In order to study the effects of …

Survivorship And Growth Among Three Developmental Stages Of Black Mangrove (Avicennia Germinans) Seedlings In Southernmost Texas, Frank W. Judd, Kenneth R. Sunny, Robert I. Lonard, Ruben A. Mazariegos

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Black mangrove is useful for shoreline stabilization in Texas and Mexico but there is insufficient information regarding propagule survivorship and seedling growth. We compared survivorship and growth of three develop-mental groups of black mangrove seedlings planted on three dredge spoil islands in the Lower Laguna Madre of Texas, to better understand optimum planting strategy. Each spoil island had 100 seedlings without emergent radicles, 100 seedlings with emergent radicles, and 75 head-started seedlings. Survivorship of seedlings with and with-out emergent radicles was low, (0-16%). Survivorship of head-started seedlings was higher, (60 – 62.7%). Varia-tion in survivorship among developmental categories was significant …

Non-Traditional Examination: A Study To Improve Academic And Research Performance Of Undergraduate Organic Chemistry Students#, Bimal K. Banik, Ram Naresh Yadav, Sunena Chandra

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

An investigation of conducting a presentation examination instead of a classical written examination method on academic and research performance of undergraduate chemistry students was performed at the University of Texas-Pan American. The results suggest that chemistry students do much better in the presentation examination compared to the written examination at the advanced organic chemistry course. But, the performances of the students in the lower level courses are mixed. However, students do much better in research work when presentation examination was conducted.

Carbon Dioxide-Mediated Preparation Of Pyrroles In Water Following Paal Knorr Method, Ram Naresh Yadav, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Carbon dioxide-mediated new reaction of 2,5-hexanedione and primary amino compounds in water-THF produced N-substituted pyrroles in excellent yield. This method for the preparation of pyrroles is novel, simple, and efficient.

Ammonium Chloride-Induced Synthesis Of Pyrroles Via Paalknorr Reaction, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Reaction of commercially available 2,5-hexanedione and primary amino compounds in the presence of ammonium chloride produced N-substituted pyrroles in excellent yield. In contrast to other available methods, this current procedure for the preparation of pyrroles is exceedingly simple, efficient, and eco-friendly and therefore, may find numerous applications in this field.

Dihydropyridines As Calcium Channel Blockers: An Overview, Thelma Salazar, Andres Gonzalez, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Cardiovascular disease remains one of the leading causes of death in the United States. It is estimated that 1 in every 3 American adults suffer from high blood pressure. Hypertension, a precursor to most cardiovascular diseases, continues to grow at an alarming rate and is seldom managed carefully. Attempts have been made to manage hypertension and reduce the morbidity and mortality of the cardiovascular organ through methods including diets, increased amount of exercise, and medications. Many commercial drugs have been derived from dihydropyridine due to its antihypertensive property. Dihydropyridine derivatives work by acting as calcium channel blockers blocking the intake …

Identification And Characterization Of A Chemical Compound That Inhibits Methionyl-Trna Synthetase From Pseudomonas Aeruginosa, Sara Robles, Yanmei Hu, Tahyra Resto, Frank Dean, James M. Bullard

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Background: Pseudomonas aeruginosa is an opportunistic pathogen problematic in causing nosocomial infections and is highly susceptible to development of resistance to multiple antibiotics. The gene encoding methionyl-tRNA synthetase (MetRS) from P. aeruginosa was cloned and the resulting protein characterized.

Methods: MetRS was kinetically evaluated and the KM for its three substrates, methionine, ATP and tRNAMet were determined to be 35, 515, and 29 μM, respectively. P. aeruginosaMetRS was used to screen two chemical compound libraries containing 1690 individual compounds.

Results: A natural product compound (BM01C11) was identified that inhibited the aminoacylation function. The compound inhibited P. aeruginosa MetRS with an …

Efectos Del Cambio Climático En La Interacción Planta-Hormiga: Una Mini Revisión Sobre La Tolerancia Térmica, Florencio Luna Castellanos, Mariana Cuautle, Teresa Patricia Feria-Arroyo, Citlalli Castillo Guevara

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Sin duda alguna el clima está cambiando debido al aumento de la concentración de gases de efecto invernadero en la atmósfera provocado por la acción humana. Dichos cambios van a tener un efecto importante en algunas actividades humanas tales como la agricultura y también pueden afectar enormemente la distribución geográfica de los organismos vivos y por tanto sus interacciones. Las hormigas y las plantas tienen una larga historia evolutiva de interacción. La actividad de las hormigas y su relación con las plantas en los últimos años ha tenido un número creciente de estudios que están poniendo de relieve su papel …

Assessing The Genetic Status And Factors Leading To The Decline Of The Roanoke Bass (Ambloplites Cavifrons), Jackman C. Eschenroeder

College of Graduate Studies: Theses & Dissertations

Although numerous factors have led to the staggering declines in freshwater biodiversity throughout the United States and the world, habitat alteration and introduced species pose some of the greatest challenges to conservation efforts. Learning more about how these two factors lead to the decline of an endemic organism could help prevent the future loss of unique species and the premature conclusion of evolutionary trajectories. Roanoke bass (Ambloplites cavifrons) is a sport fish endemic to portions of the Roanoke, Chowan, Tar, and Neuse river basins of North Carolina and Virginia. This species has been in decline for many years, …

Psychopathy And The Effect Of Imitation On Empathetic Pain, Emily N. Lasko

College of Graduate Studies: Theses & Dissertations

Psychopathy is a disorder largely characterized by a marked deficit in empathy, however, the specificity and extent of the deficit is currently unclear. While it has been well-established in the literature that individuals higher in psychopathy tend to have intact Theory of Mind abilities and exhibit a deficient ability for affective empathy (Blair, 2005), the contribution of motor empathy to these abilities, particularly in regard to empathy for pain, has yet to be experimentally examined. Additionally, the possibility of imitation increasing motor empathic abilities has not been tested in this capacity. The goal of the current study was to further …

Home Healthcare And Performance: Development And Application Of A Typology For Home Health Agencies, Ronique Nechelle Evans

All ETDs from UAB

This three-paper dissertation sought to examine the existence of strategic groups in the home health industry, the application of Porter’s generic strategies (cost leader, differentiator, “stuck-in-the-middle” and both cost leader/differentiator) in identifying these groups, and the association of group membership with agency performance. The findings of this study will provide researchers and managers with a highlight of the current strategic makeup of the home health industry and its relationship with quality and financial performance. The results of this dissertation provide some evidence that strategic groups do exist in the home health industry and can be described along the basis of …

Role Of Calmodulin In Death Receptor 5-Mediated Apoptosis In Breast Cancer, Romone Markel Fancy

All ETDs from UAB

Drug resistant estrogen receptor positive (ER-positive) and triple-negative (TN) breast cancers, are prolific breast cancers with poor clinical outcome. TRA-8 is a death receptor-5 (DR5) specific agonistic antibody with tumoricidal activity in vitro and in vivo, without inducing normal hepatocyte apoptosis. ER-positive and TN breast cancers have a range of sensitivity to TRA-8 mediated cytotoxicity. TRA-8 activation of DR5 leads to DR5 oligomerization that is critical for formation of the death inducing signaling complex (DISC) at the death domain of DR5 and initiation of apoptotic signaling. Calmodulin (CaM) is overexpressed in breast cancer and is involved in regulating breast cancer …

Neuroanatomical Correlates Of Antisocial Traits In Adolescent Males, Emma Sartin Goodman

All ETDs from UAB

Prior research suggests that antisocial traits and behaviors often found in psychopathy are also present during childhood and adolescence. Thus, understanding the neurobiology of children and adolescents who are displaying early-signs of antisocial behavior can enhance the pace of diagnosis, allow for earlier and more effective intervention, and allow for researchers to record the developmental trajectory of these traits more accurately. This project used magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) to examine the neuroanatomy of gray and white matter in 25 adolescent males, which were further analyzed using a regression model and the Youth Psychopathic Traits Inventory …

Non-Markovian Investigation Of An Autonomous Quantum Heat Engine, Ketan Goyal Goyal

All ETDs from UAB

A systematic study of a quantum heat engine is presented in this thesis. In particular, we study heat conduction through a two-two level composite system, which is then connected to a photon cavity to extract work, forming an autonomous quantum heat engine. The question as to what extent quantum effects such as quantum coherence and correlations impact thermodynamic properties of such a system is addressed. The investigated heat engine has been previously studied using the popular Born-Markovian quantum master equation under weak internal coupling approximation. However, we show that the used approach is quite limited in addressing such problems as …

Reducing Acute Cardiovascular Hospitalizations With A Weight Management Program (Reach), Laura A. Graham

All ETDs from UAB

Reducing cardiovascular (CVD) risk factors such as obesity through lifestyle and behavioral interventions like weight management programs should result in better cardiovascular health. However, there is conflicting evidence on the effectiveness of these interventions in reducing long-term CVD outcomes such as acute myocardial infarction or stroke. This reflects an important gap in our understanding about factors affecting recruitment and engagement in these programs and how these factors relate to improvement in long-term cardiovascular health. To address this gap, we will use a retrospective study with up to 11 years of follow up data from the nation’s largest health care system-associated …

Evaluating The Genotype Phenotype Correlations In Cleidocranial Dysplasia, Stephen Lamar Greene

All ETDs from UAB

Cleidocranial dysplasia (CCD, OMIM 119600) is a rare (1 in 1,000,000) human autosomal dominant skeletal disorder with unique craniofacial and dental features caused by mutations the gene coding for transcription factor RUNX2. RUNX2 is a key master regulator of osteoblast differentiation, chondrocyte maturation and tooth formation. CCD is commonly diagnosed based on bone defects with ~90% of cases presenting with supernumerary teeth or a “third dentition”. Mouse Runx2 null models (Runx2+/-), although having similar CCD skeletal defects, do not mimic the human dental phenotype of supernumerary teeth. Instead, Runx2-/- mouse have arrested tooth formation at the cap stage. Furthermore, based …