Digital Commons Network^™

Leadership Strategies For Addressing U.S. Pharmaceutical Drug Shortages And Supply Chain Disruptions, Adrian Grant Scioli

Walden Dissertations and Doctoral Studies

Health care providers in the United States expend more than $400 million in unnecessary direct costs annually managing the effects of widespread drug shortages. Based on the theory of complexity and complex adaptive systems, the purpose of this exploratory multiple case study was to identify the strategies that health care pharmaceutical procurement leaders from the Eastern region of the United States use to address widespread drug shortages. Data were collected from 5 semistructured interviews with pharmaceutical procurement leaders, recorded field notes, and a review of public documents from company websites. Data analysis included deductive and open coding techniques. Emergent themes …

Leadership Attributes And Behaviors As Predictors Of Organizational Resilience In Academic Health Care Systems, Patti Lynn Besuner

Walden Dissertations and Doctoral Studies

Research intentionally addressing how leadership attributes and behaviors collectively contributed to the socioecological perspective of organizational resilience were not found. This is a problem for organizations who must hire without benefit of how a collective leadership effect might influence their psychological capital. The purpose of this study was to explore whether or not self-efficacy, psychological empowerment, personal resilience, and leadership style were associated with or predicted organizational resilience among clinical managers in an academic medical center setting. Metatheory of resilience and resiliency was used to frame the study. A quantitative correlational design was used. Self-reported data was collected via the …

Examining Parental Involvement In Impoverished Schools, Tara Lynn Broadus

Walden Dissertations and Doctoral Studies

A decline in parent participation in one impoverished Pre-K through Grade 5 school in Texas over recent years has been an ongoing concern for school administrators. The purpose of this instrumental case study was to investigate parent perceptions of the school's efforts to involve parents in the school. Research questions focused on identifying factors that inhibited parental involvement concentrating on parent perceptions of school efforts. Constructivist theory and the advocacy/liberatory framework formed the conceptual framework for this study. A triangulation method for data collection included parent interviews, teacher questionnaires, and observations of parental involvement activities over 12 weeks. Participants were …

Sentence Recall In Children With Autism Spectrum Disorder, Brett Wallace

UNF Graduate Theses and Dissertations

There is an age-shift in neurotypical children: younger children tend to remember information in a verbatim manner so they store item-specific surface characteristics; between nine and ten children engage in gist recall where they store meanings of presented information. The aim of the present study was to explore false memory in children with Autistic Spectrum Disorder (ASD), as some research suggests that they develop gist recall at a later age than neurotypical children. We are also interested in the role of working memory.

One approach to understanding false memory creation is activation-monitoring (AM) theory. Working memory can play a role …

Morphological Variation In The Monardella Odoratissima – Monardella Villosa Complex, Monica Estiandan

University of the Pacific Theses and Dissertations

In this study, morphological characters were investigated to better characterize the species boundaries between members of the Monardella odoratissima – M. villosa complex (Lamiaeceae). Traditionally, it has been very difficult to identify and separate members of this complex. Monardella linoides, M. purpurea, and M. sheltonii populations are distributed in the overlapping boundaries of these two species (M. odoratissima and M. villosa) and considered within the complex as well. Previous studies and floral manuals have found that the vegetative plant parts from these five Monardella species intergrade with the other taxa in the complex throughout their distribution in California and in …

Monitoring Insecticide Resistance Mechanisms In Culex Tarsalis From Sutter County, California, Bridgette Danielle Hughes

University of the Pacific Theses and Dissertations

Culex mosquitoes are known for carrying several harmful viruses in the United States. Culex tarsalis is found in rural as well as some residential areas in the Western United States, so they are under insecticide pressure from both agricultural spraying and vector control. In response to insecticide pressure, mosquitoes can evolve two primary resistance mechanisms: target site insensitivity, as a result of DNA mutation, and elevated levels of detoxifying enzymes (GST, alpha and beta esterases, and P450 oxidases). The two types of target site insensitivity studied here in Cx. tarsalis are kdr, which is a mutation in the para-type voltage …

Auranofin Targets Thioredoxin Reductases In Trichomonas Vaginalis, Jose Jauregui

University of the Pacific Theses and Dissertations

Trichomonas vaginalis is an anaerobic, parasitic protozoan, responsible for trichomoniasis, the world’s most common, non-viral sexually transmitted infection. Lacking many of the defenses present in other organisms to combat oxidative stress, Trichomonas vaginalis relies extensively on the thioredoxin system—NADPH, thioredoxin reductase, and thioredoxin—as a means to protect against exposure to excess oxygen. Current trichomoniasis treatment relies exclusively on the 5-nitroimidazole drugs, but fear of drug-resistant strains and allergic reactions to 5-nitroimidazole treatment necessitate the discovery of a new treatment method for trichomoniasis. Previous research has shown that auranofin, an FDA-approved drug, was effective at inhibiting activity of one of Trichomonas …

Examining The Relationship Between Exercise Induced Fatigue And Postural Stability Among Geriatric Patients With Vestibular Disorders, Alexis Christine King

University of the Pacific Theses and Dissertations

Purpose: This study examined: (1) the relationship between exercise induced fatigue and postural balance amongst geriatric patients with vestibular disorders. (2) Assessed the duration for postural stability to return to baseline measurements upon induced fatigue.

Methods: A controlled pre-post test experimental design method was used during this study. This study incorporated a quantitative analysis to explore the relationship between exercise induced fatigue and postural balance with a sample of 24 subjects. The subjects were randomly assigned to either an experimental or control group. Baseline postural stability measurements were conducted prior to all subject testing and were accounted for again once …

Studies On Development In Euphilomedes Ostracods: Embryology, Nervous System Development, And The Genetics Of Sexually Dimorphic Eye Development, Kristina Koyama

University of the Pacific Theses and Dissertations

Model organism studies have been fundamental in understanding evolutionary and developmental biology. However, non-model organisms present opportunities to study unique characteristics and as comparisons to model organisms, leading us toward broader and more relevant perspectives on diversity. The Euphilomedes genus of ostracods is an example of a non-model group with potential for evolutionary and developmental studies.

Ostracoda is an ancient, basally branching lineage of Crustaceans with a complete and prodigious fossil record. Despite the group’s promise for evolutionary studies, much remains unknown about the basic biology of this clade. There are a limited number of embryogenesis studies in Ostracoda; here, …

Fragment-Based Excitonic Coupled-Cluster Theory For Large Chemical Systems, Yuhong Liu

University of the Pacific Theses and Dissertations

Accurate energetic modeling of large molecular systems is always desired by chemists. For example, ligand-protein binding simulations and enzymatic catalysis studies all involve with a small energy difference. The energetic accuracy depends largely on a proper handling of electronic correlations. Molecular mechanics (MM) methods deliver a parameterized Newtonian treatment to these problems. They show great capability in handling large calculations but give only qualitatively good results. Quantum mechanics (QM) methods solve Schrödinger equations and exhibit much better energy accuracy, though the computational cost can be prohibitive if directly applied to very large systems.

Fragment-based methods have been developed to decompose …

Investigating Secondary Structure Features Of Yap1 Protein Fragments Using Molecular Dynamics (Md) And Steered Molecular Dynamics (Smd) Simulations, Ferdiemar Cardenas Guinto Jr.

University of the Pacific Theses and Dissertations

Molecular dynamics (MD) is a powerful tool that can be applied to protein folding and protein structure. MD allows for the calculation of movement, and final position, of atoms in a biomolecule. These movements can be used to investigate the pathways that allow proteins to fold into energetically favorable structures. While MD is very useful, it still has its limitations. Most notable, computing power and time are of constant concern.

Protein structure is inherently important due to the direct link between the structure of a protein and its function. One of the four levels of protein structure, the secondary structure, …

Solubility Enhancement Of Model Compounds, Lavanya Pitani

University of the Pacific Theses and Dissertations

Solubility is the amount of solute in the solvent system at phase equilibrium with certain temperature and pressure. Many of the new chemical entities are lipophilic molecules that require techniques to enhance solubility. Solubility enhancement can be achieved by either physical and/or chemical modification of the drug. Various techniques are available for solubility enhancement of poorly soluble drugs include particle size reduction, salt formation, solid dispersions, use of surfactants, prodrug, crystal modification, etc.

In this study, the three model drugs belong to BCS class II and IV having low solubility with a certain range of physicochemical properties were studies in …

Liposome-Coated Magnesium Phosphate Nanoparticle For Delivery Of Cytochrome C Into Lung Cancer Cells A549, Weizhou Yue

University of the Pacific Theses and Dissertations

Proteins are large biomolecules that have great therapeutic potential in treating many human diseases. However, chemical/enzymatic degradation, denaturation, and poor penetration into cells are some of the challenges for clinical use of intracellular proteins.

Previously, our group has developed cationic lipid-coated magnesium phosphate nanoparticle (LP MgP NP-CAT) formulations to enhance the intracellular delivery of the negatively charged protein catalase. The goal of the current research is to develop a formulation to deliver cytochrome c (CytC), a positively charged protein into lung cancer cells A549. Specifically, this thesis research prepares and tests liposome-coated magnesium phosphate nanoparticle for delivery of cytochrome c …

Qualitative Examination Of Strategies To Overcome Resistance To Change In Lean Manufacturing, Elizabeth Burmester

Walden Dissertations and Doctoral Studies

Approximately 80% of lean manufacturing program initiatives are abandoned in the first year of implementation. Only 2% of organizations that embark on the lean journey complete it with the results and the sustainability they expected. There is a gap in past research regarding, the leadership strategies organizations can use to overcome resistance to change during lean manufacturing program implementations. The problem in this study was that leaders have limited information to overcome resistance to change when implementing these programs. The purpose of this study was to explore how leaders within manufacturing organizations may overcome resistance to change through leadership strategy. …

Liberian Educational Stakeholders' Perceptions Of Overcrowding In An Urban Public Elementary School In Monrovia, Franklin T. Dalieh

Walden Dissertations and Doctoral Studies

In post-conflict Liberia, more students are returning to schools and moving to urban areas resulting in overcrowding and class sizes that surpassed recommended and legally-sanctioned limits. The purpose of this qualitative case study was to explore educational stakeholders' perceptions of the factors (e.g., organizational leadership, social, and environmental) contributing to overcrowding and the challenges and opportunities of overcrowding. The conceptual framework was based on Bolman and Deal's theory of reframing organization and Bertalanffy's theory of general systems. The research questions centered on educational stakeholders' perceptions of the effects overcrowding has on elementary school students' achievement and the opportunities available for …

Employee Perceptions Of Merit Pay And Its Influence On Work Performance, Michael John Mcknight, Sr.

Walden Dissertations and Doctoral Studies

The work performance of employees remains a vital factor both in an organization's viability as well as in the prosperity of its employees. Merit pay can influence employee performance and is one of the most frequently used monetary reward incentives for motivating employees to achieve a higher level of performance. The problem is the limited knowledge on how state employees in a southern state perceive merit pay and how those perceptions may influence employee work performance. Using a conceptual framework built from elements of various motivational theories including Maslow's hierarchy of needs and Herzberg's 2 factor theory, the purpose of …

Resistance, Resonance And Restoration: How Generative Stories Shape Organisational Futures, Michelle Lebaron, Nadja Marie Alexander

All Faculty Publications

Stories are powerful. They reflect our past and shape our futures, but are never complete. Stories connect us to people in organisations – present and past – with whom we feel belonging, and disconnect us from others. Always abstractive, they give incomplete pictures of what was, weaving past accounts into what is and what will be. Because choice-points in storytelling are mostly unconscious, biases and perceptions are always part of narration, tending to reinforce preferred images, identities and trajectories. Storytelling habits, in turn, often accent negative histories and escalate conflict.

Because stories are so powerful, it is essential to critically …

The Use And Abuse Of Mutual Support Programs In Drug Courts, Sara Gordon

All Faculty Publications

There is a large gap between what we know about the disease of addiction and its appropriate treatment, and the treatment received by individuals who are ordered into treatment as a condition of participation in drug court. Most medical professionals are not appropriately trained about addiction and most addiction treatment providers do not have the education and training necessary to provide appropriate evidence-based services to individuals who are referred by drug courts for addiction treatment. This disconnect between our understanding of addiction and available addiction treatment has widereaching impact for individuals who attempt to receive medical care for addiction in …

Equality And The Defence Of Provocation: Irreconcilable Differences, Isabel Grant, Debra Parkes

All Faculty Publications

Recent amendments to the defence of provocation have limited access to the defence to those who are provoked by conduct that, if prosecuted, would have been an indictable offence punishable by at least five years imprisonment. The paper argues that these amendments are both over- and under-inclusive and fail to confront the central problem surrounding provocation which is that it privileges loss-of-control rage often in the context of male violence against women or in response to same-sex advances. The paper supports the abolition of the defence of provocation but only if mandatory minimum sentences for murder are abolished providing trial …

Shinrin-Yoku (Forest Bathing) And Nature Therapy: A State-Of-The-Art Review, Margaret M. Hansen Edd, Msn, Rn, Reo Jones, Kirsten Tocchini

Nursing and Health Professions Faculty Research and Publications

Background: Current literature supports the comprehensive health benefits of exposure to nature and green environments on human systems. The aim of this state-of-the-art review is to elucidate empirical research conducted on the physiological and psychological effects of Shinrin-Yoku (or Forest Bathing) in transcontinental Japan and China. Furthermore, we aim to encourage healthcare professionals to conduct longitudinal research in Western cultures regarding the clinically therapeutic effects of Shinrin-Yoku and, for healthcare providers/students to consider practicing Shinrin-Yoku to decrease undue stress and potential burnout. Methods: A thorough review was conducted to identify research published with an initial open date range …

Mammary Extracellular Matrix Directs Differentiation Of Testicular And Embryonic Stem Cells To Form Functional Mammary Glands In Vivo, Robert D. Bruno, Jodie M. Fleming, Andrea L. George, Corinne A. Boulanger, Pepper Schedin, Gilbert H. Smith

School of Medical Diagnostics & Translational Sciences Publications

Previously, we demonstrated the ability of the normal mammary microenvironment (niche) to direct non-mammary cells including testicular and embryonic stem cells (ESCs) to adopt a mammary epithelial cell (MEC) fate. These studies relied upon the interaction of transplanted normal MECs with non-mammary cells within the mammary fat-pads of recipient mice that had their endogenous epithelium removed. Here, we tested whether acellular mammary extracellular matrix (mECM) preparations are sufficient to direct differentiation of testicular-derived cells and ESCs to form functional mammary epithelial trees in vivo. We found that mECMs isolated from adult mice and rats were sufficient to redirect testicular derived …

High-Throughput Single-Molecule Mapping Links Subtelomeric Variants And Long-Range Haplotypes With Specific Telomeres, Eleanor Young, Steven Pastor, Ramakrishnan Rajagopalan, Jennifer Mccaffrey, Justin Sibert, Angel C. Y. Mak, Pui-Yan Kwok, Harold Riethman, Ming Xiao

School of Medical Diagnostics & Translational Sciences Publications

Accurate maps and DNA sequences for human subtelomere regions, along with detailed knowledge of subtelomere variation and long-range telomereterminal haplotypes in individuals, are critical for understanding telomere function and its roles in human biology. Here, we use a highly automated whole genome mapping technology in nano-channel arrays to analyze large terminal human chromosome segments extending from chromosome-specific subtelomere sequences through subtelomeric repeat regions to terminal (TTAGGG) n repeat tracts. We establish detailed maps for subtelomere gap regions in the human reference sequence, detect many new large subtelomeric variants and demonstrate the feasibility of long-range haplotyping through segmentally duplicated subtelomere regions. …

Tissue Specific Microenvironments: A Key Tool For Tissue Engineering And Regenerative Medicine, Patrick C. Sachs, Peter A. Mollica, Robert D. Bruno

School of Medical Diagnostics & Translational Sciences Publications

The accumulated evidence points to the microenvironment as the primary mediator of cellular fate determination. Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and signaling molecules, the microenvironment is a complex and synergistic edifice that varies tissue to tissue. Furthermore, it has become increasingly clear that the microenvironment plays crucial roles in the establishment and progression of diseases such as cardiovascular disease, neurodegeneration, cancer, and ageing. Here we review the historical perspectives on the microenvironment, and how it has directed current explorations in tissue engineering. By thoroughly understanding the role of the microenvironment, we can begin to correctly …

A Comparative Study To Assess The Level Of Pain During Nursing Procedures In Ventilated, Unconscious And/Or Sedated Patients, Betbhalin Mukhim Ms, Manashi Sengupta Ms, Rikupar Iawin

Manipal Journal of Nursing and Health Sciences

Introduction: Pain is developed, when there is certain illness or injury. Patients under mechanical ventilator commonly experience pain, which is often overlooked. Factors such as stage of illness, invasive-procedures, and surgical interventions often aggravate pain in critical patients. Objective: The objective of this study was to assess pain levels among mechanically ventilated patients during routine nursing procedures by using the behavioral pain scale (BPS). Method: Non-experimental study was conducted among 30 mechanically ventilated patients admitted in ICU (Intensive Care Unit), in Down Town hospital Guwahati, Assam during different nursing interventions, fifteen patients were assessed during turning and fifteen patients were …

Librarian Joint Mediated Outreach On Health And Legal Information Provision In Select Communities In Akwa Ibom State, Nigeria., Kathryn James Philip

Library Philosophy and Practice (e-journal)

Health information activities essentially are geared towards raising people’s awareness on good health and holistic living, thereby reducing the risks of opportunistic illness. In this regard, a related health promotional activity was undertaken in four local communities in Southern Nigeria. The purpose was gingered by the compelling efforts made by various government bodies and NGOs to curb the scourging HIV/AIDS pandemic, particularly in local communities. This Paper is therefore based on a three-day health and legal information outreach programme spearheaded by this author as a volunteer librarian in one of the communities. Planning and implementation of this endeavour undertook participatory …

Preclinical Evaluation Of Ag10 For Therapeutic Use Against Familial Amyloid Cardiomyopathy And Its Application In Various Other Technologies, Mark Russell Miller

University of the Pacific Theses and Dissertations

Transthyretin (TTR) amyloidosis is a progressive, fatal disease in which deposition of amyloid derived from either mutant or wild-type TTR causes severe organ damage and dysfunction. TTR cardiomyopathy is an infiltrative, restrictive cardiomyopathy characterized by progressive left and right heart failure. Familial amyloid cardiomyopathy (FAC) is driven by pathogenic point mutations in the TTR gene that destabilize the TTR tetramer, prompting its dissociation into dimers and monomers, with subsequent misfolding, aggregation and deposition of toxic TTR amyloid aggregates in the myocardium. The most prevalent mutation that causes FAC is the V122I variant, carried by 3.4% of African Americans, that increases …

Synthetic Methods For Ester Bond Formation And Conformational Analysis Of Ester-Containing Carbohydrates, Sven Hackbusch

University of the Pacific Theses and Dissertations

This dissertation encompasses work related to synthetic methods for the formation of ester linkages in organic compounds, as well as the investigation of the conformational influence of the ester functional group on the flexibility of inter-saccharide linkages, specifically, and the solution phase structure of ester-containing carbohydrate derivatives, in general.

Stereoselective reactions are an important part of the field of asymmetric synthesis and an understanding of their underlying mechanistic principles is essential for rational method development. Here, the exploration of a diastereoselective O-acylation reaction on a trans-2-substituted cyclohexanol scaffold is presented, along with possible reasons for the observed reversal of stereoselectivity …

Improving Performance Portability And Productivity Of Parallel Scientific Applications For Exascale, Hadia M R M Ahmed

All ETDs from UAB

The continuous emergence of new hardware architectures and software libraries create new opportunities and challenges for existing applications. While they promise better performance for applications, most of the times these applications' source code have to be modified to achieve the promised improvements. These modifications are labor intensive, error prone, and costly. Hence, users of applications either abandon the use of newer hardware and/or software and lose potential improvements, or abandon their application to build new one and lose time and effort spent on building them. Many tools are built to aid users in adapting their current application, in particular HPC …

The Evaluation Of Perampanel As A Neuroprotective Pharmacotherapy In Traumatic Brain Injury, Virginia Aida

All ETDs from UAB

In the United States, 2.5 million people experience a traumatic brain injury (TBI) every year and an estimated 5.3 million are living with a TBI-related disability. A TBI alters the function of the brain and the brain pathology often resulting in long-lasting cognitive impairment, motor function impairments, and emotional changes. In conjunction with the physical changes a victim of TBI experiences, the injury can take a financial toll. It is estimated that 76.3 billion dollars is attributed to the direct and indirect costs of sustaining a TBI every year in the United States. Despite improvements in managing TBI, there are …

The Role Of Rig-I And Mda5 In Alphavirus Replication, Ivan Viachaslavavich Akhrymuk

All ETDs from UAB

Evolution of vertebrates has resulted in the development of a wide range of cellular pattern recognition receptors (PRRs), which detect the presence of virus-specific molecules termed pathogen-associated molecular patterns (PAMPs). Sensing of the incoming viruses and/or their replication by PRRs activates the cascade of cellular pathways that ultimately result in activation of antiviral response. Such response is determined by hundreds of cellular genes, whose products either directly interfere with virus replication or are released from the cells and activate antiviral state in yet uninfected cells. Consequently, the latter cell signaling prevents development of the next rounds of infection both in …