Preclinical Evaluation Of Ag10 For Therapeutic Use Against Familial Amyloid Cardiomyopathy And Its Application In Various Other Technologies, Mark Russell Miller

University of the Pacific Theses and Dissertations

Transthyretin (TTR) amyloidosis is a progressive, fatal disease in which deposition of amyloid derived from either mutant or wild-type TTR causes severe organ damage and dysfunction. TTR cardiomyopathy is an infiltrative, restrictive cardiomyopathy characterized by progressive left and right heart failure. Familial amyloid cardiomyopathy (FAC) is driven by pathogenic point mutations in the TTR gene that destabilize the TTR tetramer, prompting its dissociation into dimers and monomers, with subsequent misfolding, aggregation and deposition of toxic TTR amyloid aggregates in the myocardium. The most prevalent mutation that causes FAC is the V122I variant, carried by 3.4% of African Americans, that increases …

Synthetic Methods For Ester Bond Formation And Conformational Analysis Of Ester-Containing Carbohydrates, Sven Hackbusch

University of the Pacific Theses and Dissertations

This dissertation encompasses work related to synthetic methods for the formation of ester linkages in organic compounds, as well as the investigation of the conformational influence of the ester functional group on the flexibility of inter-saccharide linkages, specifically, and the solution phase structure of ester-containing carbohydrate derivatives, in general.

Stereoselective reactions are an important part of the field of asymmetric synthesis and an understanding of their underlying mechanistic principles is essential for rational method development. Here, the exploration of a diastereoselective O-acylation reaction on a trans-2-substituted cyclohexanol scaffold is presented, along with possible reasons for the observed reversal of stereoselectivity …

Improving Performance Portability And Productivity Of Parallel Scientific Applications For Exascale, Hadia M R M Ahmed

All ETDs from UAB

The continuous emergence of new hardware architectures and software libraries create new opportunities and challenges for existing applications. While they promise better performance for applications, most of the times these applications' source code have to be modified to achieve the promised improvements. These modifications are labor intensive, error prone, and costly. Hence, users of applications either abandon the use of newer hardware and/or software and lose potential improvements, or abandon their application to build new one and lose time and effort spent on building them. Many tools are built to aid users in adapting their current application, in particular HPC …

The Evaluation Of Perampanel As A Neuroprotective Pharmacotherapy In Traumatic Brain Injury, Virginia Aida

All ETDs from UAB

In the United States, 2.5 million people experience a traumatic brain injury (TBI) every year and an estimated 5.3 million are living with a TBI-related disability. A TBI alters the function of the brain and the brain pathology often resulting in long-lasting cognitive impairment, motor function impairments, and emotional changes. In conjunction with the physical changes a victim of TBI experiences, the injury can take a financial toll. It is estimated that 76.3 billion dollars is attributed to the direct and indirect costs of sustaining a TBI every year in the United States. Despite improvements in managing TBI, there are …

The Role Of Rig-I And Mda5 In Alphavirus Replication, Ivan Viachaslavavich Akhrymuk

All ETDs from UAB

Evolution of vertebrates has resulted in the development of a wide range of cellular pattern recognition receptors (PRRs), which detect the presence of virus-specific molecules termed pathogen-associated molecular patterns (PAMPs). Sensing of the incoming viruses and/or their replication by PRRs activates the cascade of cellular pathways that ultimately result in activation of antiviral response. Such response is determined by hundreds of cellular genes, whose products either directly interfere with virus replication or are released from the cells and activate antiviral state in yet uninfected cells. Consequently, the latter cell signaling prevents development of the next rounds of infection both in …

Leading Ladies: A Mixed-Method Study Of The Influence Of Gender Bias On Leadership Styles For Women Who Lead Secondary Schools, Angela S. Coaxum-Young

College of Graduate Studies: Theses & Dissertations

The purpose of this mixed method study is to determine if women who lead secondary schools have gender bias experiences that might influence their leadership styles. The study focused on the accounts of five women who lead secondary schools, their gender bias experiences, their perceived leadership style and whether or not they believed the experience influences how they lead. Through in-depth interviews and survey completion, the data from both sources revealed the common leadership styles and gender bias experiences among the research participants. When examining the shared experiences three salient themes emerged: (a) A belief that gender bias still exists …

Silver Nanoparticle Fate And Accumulation In The Aquatic Food Web Of Stream Microcosms, Stefan J. Petersen

College of Graduate Studies: Theses & Dissertations

Silver nanoparticles (AgNPs) are used in 25% of all nano-enabled products and applied for anti-microbial properties. Silver nanoparticles are discharged into aquatic environments through wastewater discharge, runoff, and chemical spills. Once in aquatic environments silver nanoparticles have the potential to harm aquatic organisms. While the fate of silver nanoparticles in lentic systems has been investigated, limited information is available for the fate of silver nanoparticles in flowing environments. The purpose of this study was to compare the fate of AgNPs following a one-time pulsed application simulating a chemical spill, or small repetitive applications simulating effluent discharge, in artificial stream communities …

Neon Nature, Jessamy G. Mcmanus Ms.

College of Graduate Studies: Theses & Dissertations

The goal of this work is to explore my painting of nature in our contemporary time, considering the current geological epoch termed the Anthropocene, an era I think of as postnatural. Neon Nature is a collection of portraits of hypernatural creatures I call “pseudo-specimens”. These pseudo-specimens symbolize hypernature, which describes manufactured nature as better than authentic nature. These specimens are painted in vanitas-inspired still life scenes to act as a reminder of our changing nature, or new-nature.

Influenced by living in suburbia where nature is manicured and controlled, I am interested in the divide between the “born” and the “made,” …

Quantification And Characterization Of Net Precipitation Bacterial Flux From A Subtropical Epiphyte-Laden Oak Forest, Preston Pound

College of Graduate Studies: Theses & Dissertations

Transport pathways of microbes between ecosystem spheres (atmosphere, phyllosphere, and pedosphere) represent major fluxes in nutrient cycles and have the potential to significantly affect microbially-mediated biogeochemical processes. We quantified a previously unexamined microbial flux from the phyllosphere to the pedosphere during rainfall via throughfall (rainfall dripping from the canopy and through gaps) and stemflow (rainwater funneled down the stem). Bacterial concentrations were quantified using flow cytometry and validated with quantitative Polymerase Chain Reaction (qPCR) assays for samples from a Quercus virginiana (oak)- forest with heavy epiphyte cover (Tillandsia usneoides, Spanish moss) in coastal Georgia (Southeastern USA). Bacteria concentrations …

The Effect Of An Increase In Lead In The Water System On Fertility And Birth Outcomes: The Case Of Flint, Michigan, Daniel Grossman, David J.G. Slutsky

Economics Faculty Working Papers Series

Flint changed its public water source in April 2014, increasing lead exposure. The effects of lead in water on fertility and birth outcomes are not well established. Exploiting variation in the timing of births we find fertility rates decreased by 12%, fetal death rates increased by 58% (a selection effect from a culling of the least healthy fetuses), and overall health at birth decreased (from scarring), compared to other cities in Michigan. Given recent efforts to establish a registry of residents exposed, these results suggests women who miscarried, had a stillbirth or had a newborn with health complications should register.

Reducing Substance Abuse Stigma In Employment Application, Timothy W. Curran

College of Graduate Studies: Theses & Dissertations

A history of substance use and having a history of legal charges can be a barrier to employment. Available research shows individuals with a criminal history of substance related charges have greater difficulty obtaining employment due to the presence of substance abuse stigma and criminal history stigma. Research also shows that employers with higher levels of fundamentalism and conservativism are more likely to negatively evaluate applicants with a criminal history of substance charges. Furthermore, available research demonstrates employers in rural areas are more likely to deny employment to an individual with a legal history of substance charges based upon higher …

Persistence And Achievement In Academics, Robert L. Altman

College of Graduate Studies: Theses & Dissertations

One of the most valuable commodities in modern society is a college education. According to the National Center for Education Statistics (NCES, 2016), an estimated 20.5 million students enrolled in American colleges and universities during the fall of 2016, with the majority enrolled in undergraduate programs. When assessing undergraduate success, many studies focus on academic achievement, with grade-point average (GPA) serving as the most common measure. Other studies utilize persistence to graduation as the primary measure of success. Based on the available literature, college success can be predicted by several domains, including personality, motivational influences, and social variables. In the …

Investigating Individual Pathways To Recovery, Mackenzie R. Mcbride

College of Graduate Studies: Theses & Dissertations

Drug use is most prevalent among young adults between ages 18 and 24; this is just one factor that contributes to the high rates of substance use on college campuses. Collegiate recovery programs (CRPs) have been growing in number, awakening the “youth in recovery” movement. This paper presents literature on various tools and elements of recovery, with a focus on CRPs and their significance. This study aims to fill the knowledge gap by examining individual pathways to recovery and learning about the characteristics of students participating in CRPs, including their life events and decisions to seek treatment. Semi-structured interviews were …

Examining What Factors Affect High School Students’ Educational Aspirations, Kalle T. Pray

College of Graduate Studies: Theses & Dissertations

This study sought to examine the factors that influenced a high school student’s educational aspirations. This study used data collected by the High School Longitudinal Study (HSLS) 2009-2013 to examine how a student’s engagement, interest, attitudes toward math teacher, counselors helping with college materials, and meeting with a counselor influence a student’s educational aspirations. The findings suggest that student engagement, student interest and meeting with a counselor were significant predictors of higher educational aspirations even after controlling for being white, female, academic track, and family income. Counselors helping with college material was also a predictor of higher educational aspirations, however …

Producing A College Graduate Using Retention, Progression, And Graduation (Rpg) Initiatives: A University Systems’ Approach, Deborah N. Kittrell-Mikell

College of Graduate Studies: Theses & Dissertations

ABSTRACT

Complete College Georgia (CCG) is an initiative that has the University System of Georgia institutions strategizing ways to develop plans that will increase the number of college graduates by the year 2020. Governor Nathan Deal has indicated that graduation rates need to increase from 42% to 60% within the next 7 years. With the anticipation of approximately 20% more students graduating to meet the 250,000 target, a closer look is needed at how an additional 50,000 graduates can be produced to make this goal a reality. To fulfill this goal, there needs to be an increase of approximately 7,143 …

Romantic Interest Selection From An Imago Relationship Therapy Perspective, Lauren O. Patterson

College of Graduate Studies: Theses & Dissertations

Imago Relationship Therapy (IRT) is a model of couples therapy that is not empirically validated (Jakubowski et al., 2004). IRT proposes that individuals select Romantic Interests (Interests) that are similar to their Childhood Caregivers (Caregivers) in an effort to heal childhood wounding (Hendrix, 1988). The current study sought to evaluate the IRT proposition of romantic interest selection by evaluating patterns in romantic interest selection, particularly the relationship between Caregiver and Interest personality characteristics, adult attachment dimensions, gender, and geographical location of origin. In addition, the study considers similarities in participant narratives of positive and negative experiences with Caregivers and Interests. …

Examining The Effects Of Enclosure Size At Training And At Test In Spatial Reorientation, Zebulon K. Bell

College of Graduate Studies: Theses & Dissertations

Previous research has begun to shed light on the differentiated influence of enclosure size on cue use during reorientation (Sturz, Forloines, & Bodily, 2012). Namely, the question remains of why both feature (i.e., objects or landmarks in the enclosure) and geometric (i.e., shape of the enclosure) cues are differentially affected by enclosure size, and the extent to which local (i.e., wall lengths and corner angles) and global (i.e., principal axis of space) geometric cues are affected by enclosure size. Further, it remains unclear whether training size, testing size, or the relationship between training and testing size influences the use of …

The Role Of Habitat Management In Shaping Predation, Animal Color, And Gene Flow In A Metapopulation Of Florida Scrub Lizards (Sceloporus Woodi), Richard William Orton

College of Graduate Studies: Theses & Dissertations

Anthropogenic disturbance is known to affect biological diversity at the community, species, and genetic levels. Habitat fragmentation, in particular, has been shown to impact predator abundance and distribution, impede dispersal, and augment genetic drift. In small populations, which often result from habitat fragmentation, the effects of human disturbance may be disproportionately expressed. Small populations are more susceptible to selection pressures and random drift because genetic and phenotypic frequencies can become rapidly fixed, in comparison to larger populations. In turn, fixation of maladaptive alleles or morphs can accelerate extinction. For example, cryptic color polymorphism can be maintained by apostatic selection, where …

A Population Genetic Investigation Of The Reticulated Flatwoods Salamander (Ambystoma Bishopi) On Eglin Air Force Base, Alexander S. Wendt

College of Graduate Studies: Theses & Dissertations

The reticulated flatwoods salamander (RFS) is an endangered salamander with a unique life history. One of the largest known, best studied refuges for RFS is found on Eglin Air Force Base, and these RFS have been sampled and managed extensively since 2010. My thesis seeks to better understand RFS by using genetic techniques to address several unknowns, including: 1) determining the population structuring of RFS and the manageable units for species conservation, 2) estimating the size and status of populations, 3) understanding dispersal of RFS and factors that influence this, 4) exploring the breeding biology and recruitment patterns of RFS …

Corticospinal Excitability During Locomotion In Humans, Lisa Kogan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The coordination between signals from cortical structures and spinal segmental pathways responsible for the control of locomotion remains a contentious issue in human motor control. The signals are known to be integrated, but the nature of these neural calculations is unknown. To understand these interactions in humans, noninvasive cortical stimulation techniques can be combined with detailed analyses of muscle activity patterns in locomotor tasks.;In this study, I tested the relationship between corticospinal inputs and the forward velocity of each limb. Transcranial magnetic stimulation (TMS) was used to elicit motor evoked potentials (MEPs) in 12 healthy human volunteers during locomotion on …

Common Data Set, 2016-2017, Planning, Research, And Policy Analysis

Common Data Set (2001-present)

Common Data Set 2016-2017 for Illinois State University

Electron Impact Excitation-Ionization Of Molecules, Esam Abobakr A. Ali

Doctoral Dissertations

"In the last few decades, the study of atomic collisions by electron-impact has made significant advances. The most difficult case to study is electron impact ionization of molecules for which many approximations have to be made and the validity of these approximations can only be checked by comparing with experiment.

In this thesis, I have examined the Molecular three-body distorted wave (M3DW) or Molecular four-body distorted wave (M4DW) approximations for electron-impact ionization. These models use a fully quantum mechanical approach where all particles are treated quantum mechanically and the post collision interaction (PCI) is treated to all orders of perturbation. …

Biomarker Discovery Using Urinary Metabolomics For Noninvasive Early Cancer Detection, Casey Franklin Burton

Doctoral Dissertations

"The development of new screening methods for the early detection of cancer remains one of the foremost challenges facing modern cancer research. The emergence of new analytical technologies and their application to 'omics'-based approaches has provided researchers with powerful new tools for molecular biomarker discovery that may benefit early screening of cancer. This dissertation outlines several key advances made toward the application of urinary metabolomics to cancer biomarker discovery. The term urinary metabolomics here refers to the investigation of small metabolites in urine as potential disease biomarkers. The advantage of using this approach lies in its noninvasive sampling characteristics and …

Rapid Quantification Of Trypsin Inhibitors In Food And Feed Formulations With Electrospray Ionization Mass Spectrometry, Radheshyam Panta

Doctoral Dissertations

"Presence of anti- nutrients deteriorate the nutritional value of animal foods and feed formulations. The important one being trypsin inhibitors. Trypsin inhibitors in food and feed formulations lower the protein supplement and hence the ultimate consequence is the decrease in growth and development of animals. It is therefore, crucial to monitor trypsin inhibitors in animal food and feed formulations. Research work mentioned in this dissertation is based on the development of rapid, more accurate and robust method for determination of trypsin inhibitor in food and feed formulations. The developed method includes extraction of trypsin inhibitor from food and feed formulation …

Event-Triggered Near Optimal Adaptive Control Of Interconnected Systems, Vignesh Narayanan

Doctoral Dissertations

"Increased interest in complex interconnected systems like smart-grid, cyber manufacturing have attracted researchers to develop optimal adaptive control schemes to elicit a desired performance when the complex system dynamics are uncertain. In this dissertation, motivated by the fact that aperiodic event sampling saves network resources while ensuring system stability, a suite of novel event-sampled distributed near-optimal adaptive control schemes are introduced for uncertain linear and affine nonlinear interconnected systems in a forward-in-time and online manner.

First, a novel stochastic hybrid Q-learning scheme is proposed to generate optimal adaptive control law and to accelerate the learning process in the presence of …

Long-Range Interatomic Interactions: Oscillatory Tails And Hyperfine Perturbations, Chandra Mani Adhikari

Doctoral Dissertations

"We study the long-range interaction between two hydrogen atoms, in both the van der Waals and Casimir-Polder regimes. The retardation regime is reached when the finiteness of the speed of light becomes relevant. Provided that both atoms are in the ground states, the retardation regime is achieved when the interatomic distance, R, is larger than 137 a₀, where a₀ is the Bohr radius.

To study the interaction between two hydrogen atoms in 1S and 2S states, we differentiate three different ranges for the interatomic distance: van der Waals range (a₀ « R « a₀/α, where α is the fine structure …

Event-Triggering Architectures For Adaptive Control Of Uncertain Dynamical Systems, Ali Talib Oudah Albattat

Doctoral Dissertations

"In this dissertation, new approaches are presented for the design and implementation of networked adaptive control systems to reduce the wireless network utilization while guaranteeing system stability in the presence of system uncertainties. Specifically, the design and analysis of state feedback adaptive control systems over wireless networks using event-triggering control theory is first presented. The state feedback adaptive control results are then generalized to the output feedback case for dynamical systems with unmeasurable state vectors. This event-triggering approach is then adopted for large-scale uncertain dynamical systems. In particular, decentralized and distributed adaptive control methodologies are proposed with reduced wireless network …

The Maculoprotective Effect Of A Thiol Antioxidant In Retinal Degeneration Models, Hsiu-Jen Wang

Doctoral Dissertations

"Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among adults, age 60 and older, in developed countries. While oxidative stress is implicated in the pathogenesis of AMD, clinical studies have shown that dietary antioxidants can delay progression of AMD. Currently, there is no FDA-approved treatment for AMD. Therefore, we hypothesized that N-acetylcysteine amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD models. To achieve this, we …

Continuous Focusing And Separation Of Microparticles With Acoustic And Magnetic Fields, Ran Zhou

Doctoral Dissertations

"Microfluidics enables a diverse range of manipulations (e.g., focusing, separating, trapping, and enriching) of micrometer-sized objects, and has played an increasingly important role for applications that involve single cell biology and the detection and diagnosis of diseases. In microfluidic devices, methods that are commonly used to manipulate cells or particles include the utilization of hydrodynamic effects and externally applied field gradients that induce forces on cells/particles, such as electrical fields, optical fields, magnetic fields, and acoustic fields.

However, these conventional methods often involve complex designs or strongly depend on the properties of the flow medium or the interaction between the …

Drinking Water Disinfection By-Products Detection, Formation And The Precursors Removal Study, Runmiao Xue

Doctoral Dissertations

"Haloacetic acids (HAAs) and trihalomethanes (THMs) are two groups of commonly found disinfection by-products (DBPs). Iodinated THMs and HAAs were observed after disinfection of water containing high level of iodide and are proved to be more toxic than their corresponding chlorinated and brominated species. In the presented dissertation, a novel rapid and sensitive high performance ion chromatography-tandem mass spectrometry (HPIC-MS/MS) method has been developed for simultaneous analysis of all these HAAs, bromate, bromide, iodide, and iodate, seventeen compounds in total, without any tedious sample preparation. Besides an efficient analytical method for the detection of DBPs, seeking for a green disinfectant …