Digital Commons Network^™

Cytolytic Toxin Production By Staphylococcus Aureus Is Dependent Upon The Activity Of The Protoheme Ix Farnesyltransferase, Emily Stevens, Maisem Laabei, Stewart Gardner, Greg A. Somerville, Ruth C. Massey

School of Veterinary and Biomedical Sciences: Faculty Publications

Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase signal independent of Agr. As part of a recent genome wide association study (GWAS) to identify novel loci that alter the expression of cytolytic toxins, a polymorphism in the cyoE gene, which encodes a protoheme IX farnesyltransferase, was identified. This enzyme is essential for processing heme into the electron transport chain for use …

Valuing And Managing The Philippines’ Marine Resources Toward A Prosperous Ocean-Based Blue Economy, Rhodora V. Azanza, Porfirio M. Aliño, Reniel B. Cabral, Marie Antonette Juinio-Meñez, Ernesto M. Pernia, Ronald U. Mendoza, Charles S. Siriban

Ateneo School of Government Publications

The ocean-based “blue economy” is a significant part of the Philippine economy that has largely been taken for granted despite its enormous potential. It is of critical importance to a substantial segment of our population dependent on the seas and coastal resources for their livelihood and sustenance, appreciably enlarge the country’s wealth, and significantly contribute to its gross domestic product. This paper attempts to review the major issues concerning marine ecosystems in relation to the country’s pursuit of the blue economy. It discusses the economic and social activities in relation to the seas and coastal areas, and provides updated estimates …

Consensual Sexual Dysphoria: A Challenge For Campus Life, Robin West

Georgetown Law Faculty Publications and Other Works

This article ultimately suggests one way to address the problem of nonconsensual sex, assault, and rape on college campuses, but it does so by focusing on a topic that our conversations about nonconsensual sex have often marginalized: harms occasioned by consensual but unwanted sex. I argue that the party who does not physically desire, does not emotionally welcome, and does not take pleasure in sex, has sometimes been harmed by that sex by virtue of its unwelcomeness, and that the harm is serious enough that we need to attend to it. Further, the harms caused by this sex are not …

Development Of An Excel® Rocket Simulator For Application In Middle School, High-School, And University Stem Education, Melvin Lee Hortman

All Master's Theses

Water rocket activities are one of the most popular STEM activities used in primary, secondary, and higher education yet are void of engineering, though engineering is heavily implied in the STEM acronym. This study investigated the amount of engineering present in water rocket activities, and options for emphasizing engineering more in water rocket activities using an open-platform flight simulator for use by educators to enable students to predict flight parameters of a water rocket they designed, and test those predictions against experimental data. The simulator was constructed in Excel® with many functions, but the function validated in this study was …

Image-Based Collection And Measurements For Construction Pay Items, Chul Min Yeum, Anup Mohan, Shirley J. Dyke, Mohammad Jahanshahi, Jongseong Choi, Ziyi Zhao, Ali Lenjani, Julio A. Ramirez

JTRP Technical Reports

Prior to each payment to contractors and suppliers, measurements are made to document the actual amount of pay items placed at the site. This manual process has substantial risk for personnel, and could be made more efficient and less prone to human errors. In this project a customized software tool package has been developed to address these concerns. The Pay Item Measurement (PIM) tool package is provided as two complementary tools, the Orthophoto Generation Tool and the Graphical Measurement Tool. PIM has been developed in close cooperation with the advisory committee and field engineers from INDOT, and is specifically designed …

Making It Up: Lessons For Equal Protection Doctrine From The Use And Abuse Of Hypothesized Purposes In The Marriage Equality Litigation, Steve Sanders

Articles by Maurer Faculty

To survive rational basis scrutiny under the Equal Protection Clause, a law must serve a governmental purpose which is at least legitimate. It is well established that legitimate purposes can sometimes be found through speculation and conjecture-that is, they may be hypothesized-in order to avoid the difficulties of identifying actual purpose or the specter of courts second-guessing legislative judgments. But hypothesized purposes can be abused, and such abuse was rampant in the states' defenses of their bans on same-sex marriage, bans which were ultimately invalidated in Obergefell v. Hodges.

This Article draws on the federal marriage litigation as a lens …

Fate And Impacts Of Triclosan, Sulfamethoxazole, And 17Β-Estradiol During Nutrient Recovery Via Ion Exchange And Struvite Precipitation, Yiran Tong, Patrick J. Mcnamara, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

Increasing emphasis on resource recovery from wastewater highlights the importance of capturing valuable products, e.g., nutrients such as nitrogen and phosphorus, while removing contaminants, e.g., organic micropollutants. The objective of this research was to evaluate the fate of the micropollutants triclosan (present as a mixture of neutral and anionic species at neutral pH), 17β-estradiol (neutral at neutral pH), and sulfamethoxazole (anionic at neutral pH) during nutrient recovery using ion exchange-precipitation. Adsorption of the three micropollutants to the phosphate-selective ion exchange resins LayneRT and DOW-HFO-Cu ranged from 54% to 88% in Milli-Q water tests and 50% to 71% in …

Playing Together : A Clinician's Perspective On The Use And Value Of Play In Therapy With Couples, Teresa Musick

Theses, Dissertations, and Projects

The purpose of this study was to examine couples therapists perceptions of their use and value of play in the therapeutic encounter. Secondary to the main hypothesis, this thesis also solicited couples therapists to comment on their experience in couples therapy as a client and how this impacted their sense of relationship satisfaction. Forty-four couples’ therapists representing a variety of licensing credentials (psychologists, LPC’s, MSW/LMSW/LICSW, MFT’s) and time in practice completed a brief online questionnaire. The questionnaire asked participants to rate their use, value, and experience of play in the therapeutic encounter. Results indicate that clinicians who participated in this …

Parenting One's Birth Child After Adoption Plans Dissolve, Elise Trujillo

Theses, Dissertations, and Projects

I come to this work as someone who as a potential birth mother withdrew from an open adoption plan after giving birth. During my training as a clinical social worker, I have found little literature and research which speaks to the aftermath of the adoption process on the prospective birth parent. For the purpose of this thesis, I am interested in exploring the lasting impacts on birth mothers of creating and withdrawing from an adoption plan after giving birth. I hope through this thesis I will be able explore resources available to potential birth mothers and parents who sever their …

Fall 2017

University of Richmond Magazine

No abstract provided.

Winter 2017

University of Richmond Magazine

No abstract provided.

Predictors Of Modern Contraceptive Usage Among Women In Rural Pakistan: Physical Access To Services Stills A Major Barrier, Sumera Aziz Ali, Zafar Fatmi

Community Health Sciences

Background: The predictors of contraceptive use may vary in urban and rural areas. Studies have largely focused on the factors predicting contraceptive usage in urban areas. We studied the predictors of contraceptives in one of the rural districts of Pakistan.
Methods: A nested case-control design was used on The Global Network’s Maternal Newborn Health Registry (MNHR) in district Thatta Pakistan between June 2011 to July 2012. Pregnant women before their index pregnancy, who did not use (n = 200 cases) and those used any modern contraceptive method (n = 600 controls), were compared. Logistic regression was used to as certain …

A Formal Approach To Discovering Simultaneous Additive Masking Between Auditory Medical Alarms, Bassam Hasanain, Andrew D. Boyd, Judy Edworthy, Matthew L. Bolton

School of Psychology

No abstract provided.

Treatment Outcomes In Schizophrenia: Qualitative Study Of The Views Of Family Carers, J Lloyd, H Lloyd, Ray Fitzpatrick, Michele Peters

School of Psychology

No abstract provided.

Participants' Experience Of A Web-Based Physiotherapy Programme For People With Multiple Sclerosis (Ms): Does It Impact Physical Activity Levels?, R Dennett, E Coulter, L Paul, J Freeman

School of Health Professions

No abstract provided.

Channelling Passion For The Ocean Towards Plastic Pollution, Sabine Pahl, Kayleigh J. Wyles, Richard C. Thompson

School of Psychology

Plastic pollution is caused exclusively by humans. It poses growing global threats to the ocean and to society and requires urgent action. Using psychological principles can motivate and implement change by connecting symptoms and sources.

Neural Signatures Of Spatial Statistical Learning: Characterizing The Extraction Of Structure From Complex Visual Scenes, Elisabeth A. Karuza, Lauren L. Emberson, Matthew E. Roser, Daniel Cole, Richard N. Aslin, Jozsef Fiser

School of Psychology

No abstract provided.

"So Close, Yet So Far": The United States Follows The Lead Of The European Union In Mandating Gmo Labeling. But Did It Go Far Enough?, Courtney Begley

Fordham International Law Journal

No abstract provided.

Completion Characteristics Of Non-Hispanic Blacks With Tuberculosis And Hiv, Vernard Darrell Green

Walden Dissertations and Doctoral Studies

Tuberculosis (TB) and human immunodeficiency virus (HIV) are difficult conditions to manage, in tandem they pose even more challenges to public health programs in identifying coinfection to ensure that all TB cases are treated to completion of therapy (COT). The purpose of this study was to test variables that predicted COT among the HIV/TB coinfected population of non-Hispanic, U.S.-born Blacks alive at the time of diagnosis. Social determinants of health were the theoretical foundation used to guide the study based on data from the Report of Verified Cases of TB (RVCT) between 2009 and 2014. Relationships were tested between ethnic/racial …

Development And Evaluation Of Quercetin Nanoparticles And Hot Melt Cast Films For Retinal Neuroprotection, Chau Truong

Honors Theses

The aim of this study was to prepare optimized nanoparticles and hot melt cast films of quercetin and to investigate the release and permeability profile across corneal membranes. The results demonstrate that all formulations can be successfully employed for delivery of quercetin into the eye through the topical route of administration, with films showing significantly better transcorneal permeability.

Everybody's Story: Gertrude Stein's Career As A Nexus Connecting Writers And Painters In Bohemian Paris, Elizabeth F. Milam

Honors Theses

My thesis examines how the combination of Gertrude Stein's career, Paris, and the time period before, during, and after The Great War conflated to create the Lost Generation and affected the work of Sherwood Anderson and Ernest Hemingway. Five different sections focus on: the background of Stein and how her understanding of expression came into existence, Paris and the unique environment it provided for experimentation at the beginning of the twentieth century (and how that compared to the environment found in America), Modernism existing in Paris prior to World War One, the mass culture of militarization in World War One …

We The People: An Analysis Of The Supreme Court's Jurisprudence Relating To Constitutional Personhood, Emma Jennings

Honors Theses

This thesis studies the Supreme Court's jurisprudence on the issue of constitutional personhood and its historical lack of clarity and uniformity. I focus on three groups of persons who historically and frequently bring claims of constitutional protection before the Court: aliens, children, and felons. Across these three classes of claimants, case analysis shows that the Court lacks a clear framework for answering questions of constitutional personhood, instead relying on an individualistic approach in their decision-making, rendering a defined understanding of constitutional personhood impossible. I argue that the Court's current methods of decision- making produce inequality and second-class citizenship, and further, …

An Analysis Of Stimuli Responsive Biomaterials Using Raman Spectroscopy And Computational Studies, Gretchen Harknett

Honors Theses

This thesis involves the computational and spectroscopic exploration of the linear dendritic block copolymer, poly(L-lactide)-poly(amido-amine), (PLA-PAMAM), under different environmental conditions using Raman spectroscopy, in hopes to utilize it in future effective and cost-efficient drug delivery systems. Janus dendrimers, a material made up of two different dendrimer portions, are currently being studied in great detail, as they possess many attractive features for materials scientists looking to develop ways for drugs to be delivered in more efficient manners than currently available to physicians. The instrumentation used to conduct this thesis is a high resolution Raman spectrometer. Computationally, Gaussian 09 was employed to …

Memory Retention Rates Of Gossip-Related Information, Hannah R. Rogers

Honors Theses

The aim of this study is to determine if gossip-related information produces higher memory retention rates than scientific information. Participants completed a two-part survey. During the first part of the survey, participants read nine paragraphs, separated into three categories. Three were scientific, three were non-celebrity gossip, and three were celebrity gossip. After reading each article, participants rated each on a scale of 1-10 based on both personal relevance and how interesting they found each article. After a week delay, participants completed a multiple-choice memory test about the articles read the week before. The study found that while scientific articles were …

Culture-Independent Analysis Of Microbial Communities Associated With Hydroponically Grown Living Lettuce, Abby Matthews

Honors Theses

The bacteria associated on and within a plant make up that plant's microbiome. Given recent interest in how microbes can affect human health, as well as developments in DNA sequencing that allow us to examine microbial communities without culture techniques, a number of recent studies have investigated the composition of the microbial communities on edible plants. Leafy green salad vegetables pose an added interest, since they are consumed without sterilization or cooking. This study investigated the bacterial composition of endophytic and epiphytic communities of hydroponically grown green leaf lettuce that is sold with the roots intact and referred to as …

Synthesis Of Znse@Zns Core-Shell Quantum Dots (Qds) For Bioimaging Applications, Yang He

Graduate Theses, Dissertations, and Problem Reports (ETD)

To date, malignancies have been categorized as one of the leading life-threatening diseases worldwide, mainly because of lack of imaging devices for detection of cancers at its early stage of development. In this case, the emergence of novel strategies which can be effectively used in early stage cancer detection and therapy continue to become an inevitable need and indispensable scope of and cancer field researchers, for which implementation of new technologies are required to advance the early detection and management of cancers. The biomedical imaging of the organs in the living system offers a viable approach to label and image …

Exposure Monitoring And Controlling Hazards In Additive Manufacturing Processes, Tyler John Kusich

Graduate Theses, Dissertations, and Problem Reports (ETD)

Additive manufacturing (AM) is a relatively new field that promises advancement in various disciplines such as medical, aerospace, and consumer products. One of the recent developments in additive manufacturing is with the use of metal powders, such as aluminum, nickel, and chromium. AM processes are projected to become more common as the technology advances and the applications spread into a variety of different industries. There are several health and safety risks that have been identified with the use of these powders, including combustible dust and health exposure issues. This study was aimed at looking at some of the issues with …

Is Major League Baseball Striking Out? In-Game Advertising And Its Effects On America's Pastime, Ashley M. Anderson

Honors Theses

The purpose of this thesis is to determine the effectiveness of in-game advertisements at Major League Baseball games. Average attendance at Major League Baseball games has been steadily declining for years. Simultaneously, the average length of a professional baseball game has increased significantly. Secondary research has shown that just a few minutes of advertising per game could add up to hours of extra playing time per season. There is ample research available on the evolution and frequency of in-game advertisement, but little has been done to study the actual effectiveness of in-game advertising. Therefore, I conducted primary research in the …

Examination Of Electroglottography (Egg) And Surface Electromyography (Semg) As Techniques To Assess Oral Motor Activity During Consumption Of Four Forms Of Chocolate, Taylor Patterson

Honors Theses

The study assessed individual oral motor activity while eating different types of chocolates through the use of electroglottography (EGG) and surface electromyography (sEMG). I hypothesized that chocolate samples with higher milk solids and cocoa composition would be preferred by subjects as assessed by subject evaluation of textural attributes for the four chocolate samples. I predicted that preference will be significantly and positively correlated with oral motor events [e.g. sEMG activity of master and suprahyoid muscles, total number of chewing actions, and time to last swallow (EGG)]. The experiment used a subject group of 40 students enrolled at the University of …

Psammaplins Selectively Target Triple-Negative Metastatic Breast Tumor Cells That Are Genetically Programmed To Colonize Specific Organs, Thuy Phuong Le

Honors Theses

Five bromotyrosine-derived marine sponge metabolites, four psammaplins (1 — 4) and the psammaplin dimer, bisaprasin (5) were isolated from a lipid extract sample of the marine sponge Dendrilla lacunosa. Â Psammaplins act as histone deacetylase (HDAC) inhibitors that alter cellular gene expression. Â The D. lacunosa psammaplins activated the oxygen regulated transcription factor HIF-1 (hypoxia-inducible factor-1) in T47D human breast tumor cells and displayed cell line specific effects against aggressive organotropic metastatic cell lines that were derived from triple-negative MDA-MB-231 human breast tumor cells.