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2017

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The Unregulated Certification Mark(Et), Jeanne C. Fromer Jan 2017

The Unregulated Certification Mark(Et), Jeanne C. Fromer

Faculty Articles

Certification mark law — a branch of trademark law — itself enables consequences that undermine the law’s own goals through inadequate regulation or oversight. Because the law allows certification standards to be kept vague, high-level, and underdeveloped, a certifier can choose to exclude certain businesses inconsistently or arbitrarily, even when those businesses’ goods or services would seem to qualify for the certification mark (particularly to consumers). Moreover, even when a certification standard is clear and complete, certifiers can wield their marks anticompetitively. They can do so through redefinition — something certification mark law currently allows without oversight — to ensure …


Limitless Worker Surveillance, Ifeoma Ajunwa, Kate Crawford, Jason M. Schultz Jan 2017

Limitless Worker Surveillance, Ifeoma Ajunwa, Kate Crawford, Jason M. Schultz

Faculty Articles

From the Pinkerton private detectives of the 1850s, to the closed-circuit cameras and email monitoring of the 1990s, to new apps that quantify the productivity of workers, and to the collection of health data as part of workplace wellness programs, American employers have increasingly sought to track the activities of their employees. Starting with Taylorism and Fordism, American workers have become accustomed to heightened levels of monitoring that have only been mitigated by the legal counterweight of organized unions and labor laws. Thus, along with economic and technological limits, the law has always been presumed as a constraint on these …


Coral Gardening: Issues And Challenges, Michelle Z. Reyes, Darwin J. C. Raymundo, Sameen J. Rizwan, Wilfredo Y. Licuanan Jan 2017

Coral Gardening: Issues And Challenges, Michelle Z. Reyes, Darwin J. C. Raymundo, Sameen J. Rizwan, Wilfredo Y. Licuanan

Angelo King Institute for Economic and Business Studies (AKI)

Coral gardening is the process of restoring cover of a damaged reef by affixing live coral fragments. This method of reef rehabilitation has been gaining popularity in the Philippines, and while it has its applications, it should be the last option for bringing a reef back to a healthy state. Proper management of reef resources through marine protected areas, removal of stressors, and easing of fishing pressure provides a broader and more holistic approach while allowing the reef to recover by itself. If coral gardening is the only viable option available for rehabilitating a certain reef, careful consideration must be …


“To Nurture Something That Nurtures You”: Care, Creativity, Class, And The Production Of Urban Environments In Deindustrial Michigan, Megan L. Maurer Jan 2017

“To Nurture Something That Nurtures You”: Care, Creativity, Class, And The Production Of Urban Environments In Deindustrial Michigan, Megan L. Maurer

Theses and Dissertations--Anthropology

In this dissertation I investigate how gardeners and beekeepers in a small, deindustrial city in Michigan used their activities to produce their environments. Drawing on fourteen months of ethnographic fieldwork, I consider what kind of labor gardening is. For residents of Elmwood, gardening was a way to care for households, communities, and ecosystems. Furthermore, this care was performed through a type of creative, material labor that served to address forms of alienation experienced by these individuals. While all sorts of Elmwoodites gardened, they did so in ways that were specific to their experiences of race and class. These experiences, in …


A Mixed-Method Study Examining The Intersection Of Race And Sexual Violence Among Lgbtq Prisoners, Sarah J. Aftab Jan 2017

A Mixed-Method Study Examining The Intersection Of Race And Sexual Violence Among Lgbtq Prisoners, Sarah J. Aftab

Theses, Dissertations, and Projects

The current mixed-method study examined the intersection of race and sexual violence among LGBTQ prisoners while incarcerated. The study used secondary data from a survey of LGBTQ prisoners collected by an organization in 2014 (N=1093). Historically, the criminal justice system has criminalized and discriminated against LGBTQ persons, and reports show a prevalence of abuse occurs during incarceration. Quantitatively, the study aimed to determine a relationship between race and sexual violence; qualitatively, it aimed to understand how prisoners in this study experienced sexual violence. Findings suggested: Black, Latinx/Hispanic, and Mixed race prisoners had significantly lower likelihood of unwanted touching …


An Exploration Of The Relationship Between Religion And Spirituality And Acculturation Stress Among International Students In The Western Massachusetts, Mun Ying Kennis Cheng Jan 2017

An Exploration Of The Relationship Between Religion And Spirituality And Acculturation Stress Among International Students In The Western Massachusetts, Mun Ying Kennis Cheng

Theses, Dissertations, and Projects

This quantitative study examined the relationship between religion and spirituality and acculturative stress among international students (n=38) in two colleges in Western Massachusetts. This study utilized three well-validated tools to measure acculturative stress for international students, religion and spirituality, and intrinsic religious motivation to test the hypothesis that religion and spirituality can help international students lessen their acculturative stress. The findings suggested no significant correlation between the variables, possibly due to a small sample size. The results showed that over 55% of students had some type of religious affiliation, and over 63% indicated they either attended churches or practiced meditation …


Do Characteristics Of Children And Families Influence Reported Caregiver Burden? : A Secondary Data Analysis Of The 2009-2010 National Survey Of Children With Special Health Care Needs, Chelsea Davies Jan 2017

Do Characteristics Of Children And Families Influence Reported Caregiver Burden? : A Secondary Data Analysis Of The 2009-2010 National Survey Of Children With Special Health Care Needs, Chelsea Davies

Theses, Dissertations, and Projects

Children with special health care needs (CSHCN) make up 15% of U.S. children 18 and under. They require increased specialized care, which may pose unique challenges to families. Prior research suggests families from historically disenfranchised groups may experience greater burden due to systems of structural oppression. This quantitative secondary data analysis of the 2009-2010 National Survey of CSHCN (N=40,242) uses a cross-sectional design, testing whether family characteristics (race/ethnicity, caregiver’s gender or education level, and number of CSHCN in the home) or a child’s functional difficulty (chronic pain, behavior, anxiety/depression) are significantly associated with caregiver burden. Results suggest significantly greater time, …


Kinship Diversion : Exploring Experiences Of Relative Probate Guardianship In Los Angeles, Ca., Alison Davies Jan 2017

Kinship Diversion : Exploring Experiences Of Relative Probate Guardianship In Los Angeles, Ca., Alison Davies

Theses, Dissertations, and Projects

This qualitative study explored the characteristics and experiences of relative caregivers in Los Angeles County who were involved in a child welfare practice called “kinship diversion.” It specifically examined cases in which caregivers were diverted to probate court to obtain legal guardianship of their relatives' children as an alternative to opening a case with the child welfare system due to allegations of abuse or neglect against the biological parents. Five kinship caregivers were interviewed with a focus on answering the questions of who is diverted to legal guardianship, and why?

The findings of this study showed that diversion occurred …


Perinatal Depression Screening : Using Antenatal Depression Screens And Patient Demographics To Predict Risk For Postpartum Depression :, Jackson Doyle Jan 2017

Perinatal Depression Screening : Using Antenatal Depression Screens And Patient Demographics To Predict Risk For Postpartum Depression :, Jackson Doyle

Theses, Dissertations, and Projects

This study examined the relationship between antenatal depression and postpartum depression in pregnant women at a family health clinic. The aim was to determine whether antenatal depression screens predicted postpartum depression. The Edinburgh Postnatal Depression Screen (EPDS) was used to screen for depression in 411 pregnant women during the first trimester, third trimester and postpartum phases of pregnancy. Risk factors including patient body mass index, socioeconomic status and marital status were considered predictors of perinataldepression. EPDS scores were analyzed over the three time periods and were compared to body mass index, socioeconomic status and marital status. Results indicated that third …


A Correlative Analysis Of Mystical Experiences And Lasting Symptom Improvement From Mdma-Assisted Psychotherapy For Treatment-Resistant Ptsd : A Project Based Upon An Investigation Sponsored By Multidisciplinary Association For Psychedelic Studies (Maps), Michiko A. Mitsunaga-Whitten Jan 2017

A Correlative Analysis Of Mystical Experiences And Lasting Symptom Improvement From Mdma-Assisted Psychotherapy For Treatment-Resistant Ptsd : A Project Based Upon An Investigation Sponsored By Multidisciplinary Association For Psychedelic Studies (Maps), Michiko A. Mitsunaga-Whitten

Theses, Dissertations, and Projects

Before the Controlled Substance Act of 1985 categorized psychedelic substances as criminalized schedule I drugs, psychiatrists used ±3,4-methylenedioxymethamphetamine (MDMA) as a catalyst to psychotherapy. Over two decades later, this project seeks to contribute to the renaissance of psychedelic research. Specifically, this study focuses on participants’ experience of treatment in the recent FDA approved Phase 2 clinical study, “A Randomized, Triple-Blind Phase 2 Pilot Study Comparing 3 Different Doses of MDMA in conjunction with manualized psychotherapy in 24 Veterans, Firefighters, and Police Officers with Chronic, Treatment-resistant PTSD.” The current study presents results from correlation analyses of the Mystical Experience Questionnaire …


The Troubling Turn In State Preemption: The Assault On Progressive Cities And How Cities Can Respond, Richard Briffault, Nestor M. Davidson, Paul A. Diller, Olatunde Johnson, Richard C. Schragger Jan 2017

The Troubling Turn In State Preemption: The Assault On Progressive Cities And How Cities Can Respond, Richard Briffault, Nestor M. Davidson, Paul A. Diller, Olatunde Johnson, Richard C. Schragger

Faculty Scholarship

No abstract provided.


Exploring Experiences Of, And Responses To, Microaggressions As Disrespect From Teachers In High School Classrooms : A Person-Centered Approach, Emily Ann Peck Jan 2017

Exploring Experiences Of, And Responses To, Microaggressions As Disrespect From Teachers In High School Classrooms : A Person-Centered Approach, Emily Ann Peck

Theses, Dissertations, and Projects

The present study examined the relationship among high school students’ experiences of microaggressions and disrespect perpetrated by teachers and their perceptions of school connectedness and projections of their own bystander intervention behaviors. There is reason to believe that peer bystanding behavior, defined as either intervention in the moment, or active supporting after the event, are protective in terms of the otherwise cumulative impact of microaggressions. Using interviews from seventeen high school students, and quantitative data from nine participants, this research prioritized the voices of students, their narratives, and their meaning making process after such events occur. Findings suggest that participants …


Unequal Treatment : Sociocultural Identities And Their Effects On Eating Diorder Treatment Access And Efficacy, Hannah NoëL Smith Jan 2017

Unequal Treatment : Sociocultural Identities And Their Effects On Eating Diorder Treatment Access And Efficacy, Hannah NoëL Smith

Theses, Dissertations, and Projects

The purpose of this study is to explore ways in which eating disorder treatment can be made not only more accessible, but more effective for clients who identify as people of color, lower-socioeconomic status (SES), trans and gender nonconforming, and people whose Body Mass Index (BMI) normal or higher at the time of treatment.

Data was collected using a survey, which was completed by 28 participants recruited through Facebook eating disorder recovery groups and Instagram. Participants were asked to describe their racial identity, gender identity, SES, and BMI, then reflect on the experience of seeking eating disorder treatment.

The findings …


"Without Roofs Are The Houses" : An Exploration Of Ceremonies In Indigenous Communities, A Pathway To Healing And To The Forgotten, Denis C. Vidal Jan 2017

"Without Roofs Are The Houses" : An Exploration Of Ceremonies In Indigenous Communities, A Pathway To Healing And To The Forgotten, Denis C. Vidal

Theses, Dissertations, and Projects

Settler colonialism is often cited as the foundation for a myriad of social problems such as psychopathological stress in Indigenous communities. This research study explores how culturally syntonic interventions such as sacred ancestral ceremonies can alleviate acute symptoms of anxiety and depression. The experiences of eleven people of Indigenous heritage who live in the Southwest and had participated in sacred ancestral ceremonies were interviewed in an attempt to better understand the potential healing properties of these ceremonies. The participants all self-reported a reduction in anxiety and depression symptoms as measured before and after participating in the ceremonies.


Mind, Body, & Spirit : An Ecological Community-Based Approach To Healthy Aging, Emily Widra Jan 2017

Mind, Body, & Spirit : An Ecological Community-Based Approach To Healthy Aging, Emily Widra

Theses, Dissertations, and Projects

Based on the biopsychosocial approach of the ecological theory of aging, the present study examined the health status and social engagement of participants in an osteoporosis-prevention exercise class for adults over the age of 65 in two counties in Western Massachusetts. A self-rated health survey was developed and administered in each of the Healthy Bones & Balance classes with 226 responses in total.

Participants in this study had higher self-rated health scores than have been found in a national epidemiological study. In particular, participants who live alone were engaging in more social activities – at senior centers and places of …


Psychedelic Psychotherapy : Existential And Neuroscience Perspectives On The Therapeutic Journey, Arthur W. Seelig Jan 2017

Psychedelic Psychotherapy : Existential And Neuroscience Perspectives On The Therapeutic Journey, Arthur W. Seelig

Theses, Dissertations, and Projects

Psychotherapy with the use of high-dose psychedelic drugs shows immense promise in treating a myriad of debilitating psychiatric conditions. After a three-decade long suspension, regulators have allowed for new studies and re-awakened interest in the potential of psychedelics. However, while research on the topic has quickly progressed, little has been done to reinvigorate our clinical understanding of the psychedelic healing process. This thesis interprets the psychedelic state through the twin perspectives of existentialism and neuroscience with the goal of starting to develop a theoretical language.

The subjective experience of high-dose psychedelics under therapeutic conditions often results in a loss-of-self referred …


Biochemical And Molecular Assessment Of Toxicity Of Primaquine Metabolites On Erythrocytes, Jagrati Jain Jan 2017

Biochemical And Molecular Assessment Of Toxicity Of Primaquine Metabolites On Erythrocytes, Jagrati Jain

Electronic Theses and Dissertations

The 8-aminoquinoline (8AQ) antimalarial drug primaquine (PQ) is the only drug for prevention of malaria relapse. Moreover, PQ also has gametocytocidal activity against Plasmodium falciparum. However, clinical use of PQ has been limited due to its hemolytic toxicity, especially in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals. Phenolic and quinone metabolites generated via cytochrome P450-dependent pathways appear to be responsible for hemolytic effects of PQ. However, the mechanism for the hemolytic toxicity of PQ is still poorly understood. To explore the mechanism, targets, and pathways for toxicity of PQ, normal and G6PDd human erythrocytes were treated with the potential hemotoxic metabolites of …


Nucleic Acid Clamp-Mediated Transcriptional And Translational Modulation Of Oncogenes Via The Stabilization Of G-Quadruplexes, Taisen Hao Jan 2017

Nucleic Acid Clamp-Mediated Transcriptional And Translational Modulation Of Oncogenes Via The Stabilization Of G-Quadruplexes, Taisen Hao

Electronic Theses and Dissertations

G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures that exit in various biologically important regions within a cell, such as the promoters of DNA, 5’-Untranslated regions (UTR) of mRNA and telomeres. These secondary structures tend to cluster around 1 kb from transcriptional start sites across all human chromosomes in addition to at telomeric regions. Extensive efforts from many research groups have been dedicated to targeting G4s in oncogenic promoters, telomeres, and 5’-UTRs with traditional small molecules. However, most small molecules recognizing multiple G4s raising potential issues in terms of utilizing these small molecules clinically. Therefore, we developed a novel nucleic …


Historical Refuges And Recolonization Routes In The Southern Appalachian Mountains, Inferred Through Phylogeographic Analysis Of The Spotted Wintergreen (Chimaphila Maculata), John Daniel Banusiewicz Jan 2017

Historical Refuges And Recolonization Routes In The Southern Appalachian Mountains, Inferred Through Phylogeographic Analysis Of The Spotted Wintergreen (Chimaphila Maculata), John Daniel Banusiewicz

Electronic Theses and Dissertations

Phylogeography has recently benefited from incorporation of coalescent modeling to test competing scenarios of population history of a species. Ecological niche modeling has also been useful in inferring areas of likely suitable habitat during past climate conditions. Several studies have examined the population history of biota in the Southern Appalachian Mountains and how they responded to climate change associated with the end of the Last Glacial Maximum (~18,000 years ago), though few studies have focused on understory plants. This study redressed that knowledge gap thorough examination of the phylogeographic history of the understory plant Chimaphila maculata, which is native to …


Contribution Of Specific Amino Acids To Calcium-Dependent Dimerization Of Epithelial Cadherin, Xiaoyun Z. Howard Jan 2017

Contribution Of Specific Amino Acids To Calcium-Dependent Dimerization Of Epithelial Cadherin, Xiaoyun Z. Howard

Electronic Theses and Dissertations

Cadherins are calcium-dependent molecules that play essential roles in embryonic development, tissue morphogenesis, and cancer progression. Epithelial (E-) cadherin is present at adherens junctions, structures that are important for maintaining tissue integrity. At adherens junctions, cell–cell adhesion complexes are formed as clusters of cadherin dimers through strand-swapped dimerization between two interacting protomers from adherent cells. Recently, a number of studies of dimer formation of E-cadherin supported a two-step adhesive binding model. First, an inter-molecular initial encounter complex (X-dimer) forms at the linker region of the first two extracellular domains, EC1 and EC2. Next, strand-swap dimerization occurs via exchange or ''swap'' …


One Or Two Things I Know About Us: Narrative Strategies For Autoethnography, Self-Representation And Healing In Four Memoirs By Poor-White Women From The U.S. South, Joseph Aaron Farmer Jan 2017

One Or Two Things I Know About Us: Narrative Strategies For Autoethnography, Self-Representation And Healing In Four Memoirs By Poor-White Women From The U.S. South, Joseph Aaron Farmer

Electronic Theses and Dissertations

This dissertation examines autobiographical writings by formerly poor white Southern women, who are rarely considered as a group and are more typically studied with “rough South” male writers, which would suggest that few women have contributed their own gendered experience to discussions of class, race, and sexuality vis-à-vis Southern poverty. Correcting this assumption, I examine formative statements by women from poor white backgrounds, including Roxanne Dunbar-Ortiz’s Red Dirt, Janisse Ray’s Ecology of a Cracker Childhood and Wild Card Quilt, Dorothy Allison’s Trash, and Jeannette Walls’s The Glass Castle. Each of these writers engage in narrative strategies that do not defend …


Quantitative Analysis Of Tobacco-Specific Nitrosamines And Their Precursor Alkaloids In Tobacco Extracts, Celeste T. Wilkinson Jan 2017

Quantitative Analysis Of Tobacco-Specific Nitrosamines And Their Precursor Alkaloids In Tobacco Extracts, Celeste T. Wilkinson

Theses and Dissertations

Tobacco-specific nitrosamines (TSNA) are carcinogenic constituents derived from alkaloids in tobacco. Researchers are actively exploring several avenues to reduce TSNA levels in tobacco products like moist snuff tobacco. The focus of the research presented within is the quantitative analysis of TSNA in tobacco, specifically N’-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1(3-pyridyl)-1-butanone (NNK), N’-nitrosoanatabine (NAT), and N’-nitrosoanabasine (NAB).

Tobacco alkaloids and nitrosamines in tobacco are currently analyzed by different instrumentation due to orders of magnitude difference in their concentrations, chromatographic separation challenges due to structural similarities, and similar mass fragmentation patterns. An analytical column using silica and 1,2-bis(siloxy)ethane hybrid particles of 1.7 µm size is …


Pebbles Is A Girl That Doesn't Know Anything, Grace A. Kubilius Jan 2017

Pebbles Is A Girl That Doesn't Know Anything, Grace A. Kubilius

Theses and Dissertations

I am not quite sure how to be a woman. It’s complicated, contradictory and highly surveilled. I make videos, sculptures and wearable objects that attempt to rationalize my female identity. The body is a sustained fixture in my work: as an armature, as an absent actor for constructed environments, as fragment and as the literal inclusion of my image. It is through these various modes of dis/embodiment that I negotiate the complexities of gendered existence. Crumbling ceramic and paper objects, pieced fabric forms, videos, beauty products, and delicate flowers reference splintered narratives and unwieldy terrains. I consider the idea of …


Bioelectrohydrogenesis And Inhibition Of Methanogenic Activity In Microbial Electrolysis Cells - A Review, Rengasamy Karthikeyan, Ka Yu Cheng, Ammaiyappan Selvam, Arpita Bose, Jonathan W.C. Wong Jan 2017

Bioelectrohydrogenesis And Inhibition Of Methanogenic Activity In Microbial Electrolysis Cells - A Review, Rengasamy Karthikeyan, Ka Yu Cheng, Ammaiyappan Selvam, Arpita Bose, Jonathan W.C. Wong

Biology Faculty Research

Microbial electrolysis cells (MECs) are a promising technology for biological hydrogen production. Compared to abiotic water electrolysis, a much lower electrical voltage (~0.2V) is required for hydrogen production in MECs. It is also an attractive waste treatment technology as a variety of biodegradable substances can be used as the process feedstock. Underpinning this technology is a recently discovered bioelectrochemical pathway known as "bioelectrohydrogenesis". However, little is known about the mechanism of this pathway, and numerous hurdles are yet to be addressed to maximize hydrogen yield and purity. Here, we review various aspects including reactor configurations, microorganisms, substrates, electrode materials, and …


Lessons Learned From A 10-Year Collaboration Between Biomedical Engineering And Industrial Design Students In Capstone Design Projects, Jay R. Goldberg, Pascal Malassigné Jan 2017

Lessons Learned From A 10-Year Collaboration Between Biomedical Engineering And Industrial Design Students In Capstone Design Projects, Jay R. Goldberg, Pascal Malassigné

Biomedical Engineering Faculty Research and Publications

Engineers and industrial designers have different approaches to problem solving. Both place heavy emphasis on identification of customer needs, manufacturing methods, and prototyping. Industrial designers focus on aesthetics, ergonomics, ease of use, manufacturing methods, and the user’s experience. They tend to be more visual and more concerned with the interaction between users and products. Engineers focus on functionality, performance requirements, analytical modeling, and design verification and validation. They tend to be more analytical and more concerned with the design of internal components and product performance. Engineers and industrial designers often work together on project teams in industry. Collaboration between the …


The Church Is Familial And Is Built On Spiritually Strong Families, Yat Lau Jan 2017

The Church Is Familial And Is Built On Spiritually Strong Families, Yat Lau

Doctoral Dissertations and Projects

Christ’s headship of the church has strong parallels to the husband’s headship of the family unit. As postmodernism, socio-economic factors, egalitarianism, globalization and shifts in the communicational processes drive inter-generational issues to greater heights, insidiously tear families apart—relationally, intellectually and spiritually. On the other hand, the church models the world through its discipleship programs, organization structures and has asserted itself as the spiritual head of the home. This paper will survey Christian young adults to identify key influences on their spiritual formation and family ministries the church provide to support families. The paper will provide a critique on family-equipping ministries …


Electron Impact Excitation-Ionization Of Molecules, Esam Abobakr A. Ali Jan 2017

Electron Impact Excitation-Ionization Of Molecules, Esam Abobakr A. Ali

Doctoral Dissertations

"In the last few decades, the study of atomic collisions by electron-impact has made significant advances. The most difficult case to study is electron impact ionization of molecules for which many approximations have to be made and the validity of these approximations can only be checked by comparing with experiment.

In this thesis, I have examined the Molecular three-body distorted wave (M3DW) or Molecular four-body distorted wave (M4DW) approximations for electron-impact ionization. These models use a fully quantum mechanical approach where all particles are treated quantum mechanically and the post collision interaction (PCI) is treated to all orders of perturbation. …


Gamma Spectroscopy By Artificial Neural Network Coupled With Mcnp, Huseyin Sahiner Jan 2017

Gamma Spectroscopy By Artificial Neural Network Coupled With Mcnp, Huseyin Sahiner

Doctoral Dissertations

"While neutron activation analysis is widely used in many areas, sensitivity of the analysis depends on how the analysis is conducted. Even though the sensitivity of the techniques carries error, compared to chemical analysis, its range is in parts per million or sometimes billion. Due to this sensitivity, the use of neutron activation analysis becomes important when analyzing bio-samples. Artificial neural network is an attractive technique for complex systems. Although there are neural network applications on spectral analysis, training by simulated data to analyze experimental data has not been made. This study offers an improvement on spectral analysis and optimization …


Optimization Of Solvent Suppression Sequences For Nmr Analysis Of Aqueous Solutions, Annalise Rose Pfaff Jan 2017

Optimization Of Solvent Suppression Sequences For Nmr Analysis Of Aqueous Solutions, Annalise Rose Pfaff

Doctoral Dissertations

"When the use of deuterated solvents is precluded in the NMR analysis of biomolecules in their natural environment, pre-saturation solvent suppression pulse sequences are frequently employed to avoid interference from the overbearing solvent signal. However, these sequences generally require extensive re-adjustment of NMR parameters between samples. For this reason, the EXCEPT (EXponentially Converging Eradication Pulse Train) solvent suppression sequence was developed, which exhibits a tolerance of over an order of magnitude in sample T₁ variation. EXCEPT uses an innovative version of "inversion-recovery nulling" with frequency-selective, low-power adiabatic pulses and exponentially decreasing interpulse delays that effectively reduce solvent net magnetization by …


The Maculoprotective Effect Of A Thiol Antioxidant In Retinal Degeneration Models, Hsiu-Jen Wang Jan 2017

The Maculoprotective Effect Of A Thiol Antioxidant In Retinal Degeneration Models, Hsiu-Jen Wang

Doctoral Dissertations

"Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among adults, age 60 and older, in developed countries. While oxidative stress is implicated in the pathogenesis of AMD, clinical studies have shown that dietary antioxidants can delay progression of AMD. Currently, there is no FDA-approved treatment for AMD. Therefore, we hypothesized that N-acetylcysteine amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD models. To achieve this, we …