Digital Commons Network^™

Diagnosis And Treatment Of Cd20 Negative B Cell Lymphomas, Tasleem Katchi, Delong Liu

NYMC Faculty Publications

CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, aggressive clinical behaviour, resistance to standard chemotherapy and poor prognosis. The most common types of these include plasmablastic lymphoma, primary effusion lymphoma, large B-cell lymphoma arising from HHV8-associated multicentric Castleman's disease, and ALK+ large B cell lymphoma. This review provides an overview of the diagnostic and treatment modalities for CD20 negative B cell NHL.

Whole Genome Expression Profiling Associates Activation Of Unfolded Protein Response With Impaired Production And Release Of Epinephrine After Recurrent Hypoglycemia, J Kim, Edmund La Gamma, T Estabrook, N Kudrick, Bistra Nankova

NYMC Faculty Publications

Recurrent hypoglycemia can occur as a major complication of insulin replacement therapy, limiting the long-term health benefits of intense glycemic control in type 1 and advanced type 2 diabetic patients. It impairs the normal counter-regulatory hormonal and behavioral responses to glucose deprivation, a phenomenon known as hypoglycemia associated autonomic failure (HAAF). The molecular mechanisms leading to defective counter-regulation are not completely understood. We hypothesized that both neuronal (excessive cholinergic signaling between the splanchnic nerve fibers and the adrenal medulla) and humoral factors contribute to the impaired epinephrine production and release in HAAF. To gain further insight into the molecular mechanism(s) …

Protocol For The Development Of A Core Domain Set For Hidradenitis Suppurativa Trial Outcomes, Linnea Thorlacius, J Ingram, A Garg, B Villumsen, S Esmann, J Kirby, Alice Gottlieb, J Merola, R Dellavalle, R Christensen, G Jemec

NYMC Faculty Publications

INTRODUCTION: Randomised controlled trials (RCTs) should have well-defined primary and secondary outcomes to answer questions generated by the main hypotheses. However, for the chronic, inflammatory skin disease hidradenitis suppurativa (HS), the reported outcome measures are numerous and diverse. A recent systematic review found a total of 30 outcome measure instruments in 12 RCTs. This use of a broad range of outcome measures can increase difficulties in interpretation and comparison of results and may potentially obstruct appropriate evidence synthesis by causing reporting bias. One strategy for dealing with these problems is to develop a core outcome set (COS). A COS is …

February 2017 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Amoebozoans Are Secretly But Ancestrally Sexual: Evidence For Sex Genes And Potential Novel Crossover Pathways In Diverse Groups Of Amoebae, Yonas I. Tekle, Fiona C. Wood, Laura A. Katz, Mario A. Cero ́ N-Romero, Lydia A. Gorfu

Biological Sciences: Faculty Publications

Sex is beneficial in eukaryotes as it can increase genetic diversity, reshuffle their genomes, and purge deleterious mutations. Yet, its evolution remains a mystery. The eukaryotic clade supergroup Amoebozoa encompasses diverse lineages of polymorphic amoeboid forms, including both free-living and parasitic lineages. The group is generally believed to be asexual, though recent studies show that some of its members are implicated in cryptic forms of sexual cycles. In this study, we conduct a comprehensive inventory and analysis of genes involved in meiosis and related processes, in order to investigate the evolutionary history of sex in the clade. We analyzed genomic …

Beyond The Mhc: A Canine Model Of Dermatomyositis Shows A Complex Pattern Of Genetic Risk Involving Novel Loci, Jacquelyn M. Evans, Rooksana E. Noorai, Kate L. Tsai, Alison N. Starr-Moss, Cody M. Hill, Kendall J. Anderson, Thomas R. Famula, Leigh Anne Clark

Publications

Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01), particularly in homozygosity (P-val = 0.0001). However, the high incidence of the haplotype among healthy dogs indicated that additional genetic risk factors are likely involved in disease progression. We conducted genome-wide association studies in two modern breeds having common …

Changes In Temporal Variability Of Precipitation Over Land Due To Anthropogenic Forcings, Goutam Konapala, Ashok Mishra, L. Ruby Leung

Publications

This study investigated the anthropogenic influence on the temporal variability of annual precipitation for the period 1950–2005 as simulated by the CMIP5 models. The temporal variability of both annual precipitation amount (PRCPTOT) and intensity (SDII) was first measured using a metric of statistical dispersion called the Gini coefficient. Comparing simulations driven by both anthropogenic and natural forcing (ALL) with simulations of natural forcing only (NAT), we quantified the anthropogenic contributions to the changes in temporal variability at global, continental and sub-continental scales as a relative difference of the respective Gini coefficients of ALL and NAT. Over the period of 1950–2005, …

Hormone Receptor Status And Survival Of Medullary Breast Cancer Patients: A Turkish Cohort, Asude Aksoy, Hatice Odabas, Serap Kaya, Oktay Bozkurt, Mustafa Degirmenci, Turkan O. Topcu, Aydın Aytekin, Erkan Arpaci, Nilufer Avci, Kezban N. Pilanci, Havva Y. Cinkir, Yakup Bozkaya, Yalcin Cirak, Mahmut Gumus

Saudi Medical Journal

Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, …

Further Advances For The Sequential Multiple Assignment Randomized Trial (Smart), Tianjiao Dai

Dissertations and Theses (Open Access)

ABSTRACT

FURTHER ADVANCES FOR THE SEQUENTIAL MULTIPLE ASSIGNMENT RANDOMIZED TRIAL (SMART)

Tianjiao Dai, M.S.

Advisory Professor: Sanjay Shete, Ph.D.

Sequential multiple assignment randomized trial (SMART) designs have been developed these years for studying adaptive interventions. In my Ph.D. study, I mainly investigate how to further improve SMART designs and optimize the interventions for each individual in the trial. My dissertation has focused on two topics of SMART designs.

1) Developing a novel SMART design that can reduce the cost and side effects associated with the interventions and proposing the corresponding analytic methods. I have developed a time-varying SMART design in …

How Should Justice Policy Treat Young Offenders?, Owen D. Jones, B. J. Casey, Richard J. Bonnie, Et Al .

Vanderbilt Law School Faculty Publications

The justice system in the United States has long recognized that juvenile offenders are not the same as adults, and has tried to incorporate those differences into law and policy. But only in recent decades have behavioral scientists and neuroscientists, along with policymakers, looked rigorously at developmental differences, seeking answers to two overarching questions: Are young offenders, purely by virtue of their immaturity, different from older individuals who commit crimes? And, if they are, how should justice policy take this into account?

A growing body of research on adolescent development now confirms that teenagers are indeed inherently different from adults, …

The K-Sf-42: A New Short Form Of The Arizona Life History Battery, Aurelio José Figueredo, Rafael Antonio Garcia, J Michael Menke, Norman P. Li

Research Collection School of Social Sciences

The purpose of the present article is to propose an alternative short form for the 199-item Arizona Life History Battery (ALHB), which we are calling the K-SF-42, as it contains 42 items as compared with the 20 items of the Mini-K, the short form that has been in greatest use for the past decade. These 42 items were selected from the ALHB, unlike those of the Mini-K, making direct comparisons of the relative psychometric performance of the two alternative short forms a valid and instructive exercise. A series of secondary data analyses were performed upon a recently completed five-nation cross- …

Feb2017, Robert Kelly

Robert Kelly Manuscripts

From the February 2017 Robert Kelly archive.

Estimating Biomass Of Berries Consumed By Gray Wolves, Thomas Gable, Steve K. Windels, John G. Bruggink

Journal Articles

Gray wolves (Canis lupus) consume berries and other wild fruits seasonally when available or abundant. However, a method to convert percent frequency of occurrence or percent volume of berries in wolf scats to percent biomass has not yet been developed. We used estimates of the average number of blueberry (Vaccinium spp.) seeds in 10 individual wolf scats collected in and adjacent to Voyageurs National Park, Minnesota, USA, along with published values of the number of seeds per blueberry and blueberry masses to estimate that a wolf scat containing only berries equated to an average of 0.468 kg …

High School Earth And Space Science Should Be Taught By Geoscientists, Elizabeth Lewis

Department of Teaching, Learning, and Teacher Education: Faculty Publications

A recent survey of U.S. science teachers’ understanding, perspectives and teaching of climate change — an important earth and space science (ESS) standard included in the new Next Generation Science Standards (NGSS) — revealed that teachers spend an average of only one to two hours per year teaching students about climate change. The survey study’s authors concluded that “[science] teachers may not be very knowledgeable about a wide range of evidence and how climate models work.” However, the authors did not distinguish between qualified ESS teachers and other teachers, like biology, physics or chemistry teachers who might be charged with …

Legislative Comment: Family Property Division Under The Family Law Act 2011

UBC Law Review

No abstract provided.

Mineral Estate Conservation Easements: A New Policy Instrument To Address Hydraulic Fracturing And Resource Extraction, Robert B. Jackson, Jessica Owley, James Salzman

Journal Articles

In a few short years, hydraulic fracturing has transformed the oil and natural gas industries and changed the landscape of energy policy, while generating major conflicts over local land use decisions. Individuals and communities have turned to the law to restrict oil and natural gas production with mixed success. While little explored, there is also potential for private efforts to restrict fracking.

We propose a novel tool, the Mineral Estate Conservation Easement (MECE), to provide landowners with the ability to restrict hydraulic fracturing and other oil and gas subsurface activities in areas of particular social or ecological vulnerability. The article …

Moderating Effects Of Immunosuppressive Medications And Risk Factors For Post-Operative Joint Infection Following Total Joint Arthroplasty In Patients With Rheumatoid Arthritis Or Osteoarthritis, Elizabeth G. Salt, Amanda T. Wiggins, Mary Kay Rayens, Brent J. Morris, David M. Mannino, Andrew Hoellein, Ryan P. Donegan, Leslie J. Crofford

Nursing Faculty Publications

Objective—Inconclusive findings about infection risks, importantly the use of immunosuppressive medications, in patients who have undergone large-joint total joint arthroplasty challenge efforts to provide evidenced-based perioperative total joint arthroplasty recommendations to improve surgical outcomes. Thus, the aim of this study was to describe risk factors for developing a postoperative infection in patients undergoing TJA of a large joint [total hip arthroplasty, total knee arthroplasty, or total shoulder arthroplasty] by identifying clinical and demographic factors, including the use of high risk medications (i.e., prednisone and immunosuppressive medications) and diagnoses (i.e., rheumatoid arthritis [RA], osteoarthritis [OA], gout, obesity, diabetes mellitus), that …

A Randomized Controlled Pilot Trial Of Different Mobile Messaging Interventions For Problem Drinking, Frederick Muench, Katherine Van Stolk-Cooke, Alexis Kuerbis, Gertraud Stadler, Amit Baumel, Sijing Shao, James R. Mckay, Jon Morgenstern

Publications and Research

Introduction
Recent evidence suggests that text messaging may help to reduce problem drinking as an extension to in-person services, but very little is known about the effectiveness of remote messaging on problem drinking as a stand-alone intervention, or how different types of messages may improve drinking outcomes in those seeking to moderate their alcohol consumption.

Methods
We conducted an exploratory, single-blind randomized controlled pilot study comparing four different types of alcohol reduction-themed text messages sent daily to weekly drink self-tracking texts in order to determine their impact on drinking outcomes over a 12-week period in 152 participants (≈ 30 per …

At Lunch With A Killer: The Effect Of Weaver Ants On Host-Parasitoid Interactions On Mango, Valentina Migani, Sunday Ekesi, Katharina Merkel, Thomas Hoffmeister

All Peer-Reviewed Publications

Predator-prey interactions can affect the behaviour of the species involved, with consequences for population distribution and competitive interactions. Under predation pressure, potential prey may adopt evasive strategies. These responses can be costly and could impact population growth. As some prey species may be more affected than others, predation pressure could also alter the dynamics among species within communities. In field cages and small observation cages, we studied the interactions between a generalist predator, the African weaver ant, Oecophylla longinoda, two species of fruit flies that are primary pests of mango fruits, Ceratitis cosyra and Bactrocera dorsalis, and their two exotic …

Impedance Optimized Electric Pulses For Enhancing Cutaneous Gene Electrotransfer, Reginald Morley Atkins

USF Tampa Graduate Theses and Dissertations

Electric field mediated gene delivery modalities have preferable safety profiles with the ability to rapidly transfect cells in vitro and in vivo with high efficiency. However, the current state of the art has relied on trial and error studies that target the average cell within a population present in treated tissue to derive electric pulse parameters. This results in fixed gene electrotransfer (GET) parameters that are not universally optimum. Slow progress towards the validation of a mechanism that explains this phenomena has also hindered its advancement in the clinic. To date, GET methods utilizing feedback control as a means to …

Porous Magnesium-Based Scaffolds For Tissue Engineering, Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Keyvan Moharamzadeh, Aldo R. Boccaccini, Lobat Tayebi

Chemical and Biochemical Engineering Faculty Research & Creative Works

Significant amount of research efforts has been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments. They are often used to replace and regenerate the damaged bones or to provide structural support …

2017 February, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for February of 2017.

Multiple Mating By Females In The Chesapeake Bay Blue Crab Callinectes Sapidus Population, S. Wells, J. Mcconaugha, L. Horth

OES Faculty Publications

Mature females of the Chesapeake Bay (USA) blue crab Callinectes sapidus population mate multiple times. Microsatellite DNA analysis of sperm stored in the spermathecae has shown that virtually all (~97%, 104 out of 107) females collected in a 2009−2010 study mated with at least 2 males. Enumeration of stored sperm revealed that despite multiple mating, some females did not have enough sperm to fulfill their lifetime reproductive potential, suggesting that female blue crabs may experience varying levels of sperm limitation. This could result from multiple factors. The average body size of males in the population has decreased, which reduces the …

Experimental Impacts Of Climate Warming And Ocean Carbonation On Eelgrass Zostera Marina, Richard C. Zimmerman, Victoria J. Hill, Malee Jinuntuya, Billur Celebi, David Ruble, Miranda Smith, Tiffany Cedeno, W. Mark Swingle

OES Faculty Publications

CO₂ is a critical and potentially limiting substrate for photosynthesis of both terrestrial and aquatic ecosystems. In addition to being a climate-warming greenhouse gas, increasing concentrations of CO₂ will dissolve in the oceans, eliciting both negative and positive responses among organisms in a process commonly known as ocean acidification. The dissolution of CO₂ into ocean surface waters, however, also increases its availability for photosynthesis, to which the highly successful, and ecologically important, seagrasses respond positively. Thus, the process might be more accurately characterized as ocean carbonation. This experiment demonstrated that CO₂ stimulation of primary production enhances …

Talk About Toy Models, Joshua Luczak

Research Collection School of Social Sciences

Scientific models are frequently discussed in philosophy of science. A great deal of the discussion is centred on approximation, idealisation, and on how these models achieve their representational function. Despite the importance, distinct nature, and high presence of toy models, they have received little attention from philosophers. This paper hopes to remedy this situation. It aims to elevate the status of toy models: by distinguishing them from approximations and idealisations, by highlighting and elaborating on several ways the Kac ring, a simple statistical mechanical model, is used as a toy model, and by explaining why toy models can be used …

Body Size And Symbiotic Status Influence Gonad Development In Aiptasia Pallida Anemones, Judith F. Carlisle, Grant K. Murphy, Alison M. Roark

Biology Publications

Pale anemones (Aiptasia pallida) coexist with dinoflagellates (primarily Symbiodinium minutum) in a mutualistic relationship. The purpose of this study was to investigate the role of these symbionts in gonad development of anemone hosts. Symbiotic and aposymbiotic anemones were subjected to light cycles that induced gametogenesis. These anemones were then sampled weekly for nine weeks, and gonad development was analyzed histologically. Anemone size was measured as mean body column diameter, and oocytes or sperm follicles were counted for each anemone. Generalized linear models were used to evaluate the influence of body size and symbiotic status on whether gonads …

Openline Newsletter, February 2017, Civil Service Council

OpenLine Newsletter

A monthly newsletter for Civil Service employees, February 2017.

On Forgiveness: Phenomenon And Norms, Wassim Abdelmasseh

Theses and Dissertations

This paper takes a close look at forgiveness. As the title suggests, this paper is divided in two sections. The first section provides a description and an understanding of the phenomenon of forgiveness. This is done first by considering how various philosophical accounts have done so. This is then followed by a phenomenological description of what forgiveness is and what forgiveness does. For this purpose the paper also considers other concepts that are related to forgiveness, namely those of guilt and resentment. In the second section of the paper the norms of forgiveness are investigated. Two elementary normative conditions of …

A Whole New Wurld? How Unusual Brand Name Spelling Negatively Affects Sensory Perceptions Of New Products Through Cognitive And Affective Processing, Ann E. Mcneel

Dissertations, Theses, and Capstone Projects

Introducing the importance of unusual brand name spelling to sensory marketing, this research shows that utilizing the linguistic device of unique brand name spelling can lead to differences in sensory perceptions and actual consumption of a variety of consumer products. Across five studies, we explore how perceptions of the uniqueness of a brand name can be achieved by varying one letter in the spelling of the brand name, and that such a small variation can result in less favorable sensory perceptions of taste (studies 1 and 3), scent (study 2), and vision (studies 4 and 5) as a result of …

The Effects Of Parametrically Manipulating The Ratio Of Complimentary To Constructive Feedback Statements On Performance, Amanda Mentzer

Dissertations, Theses, and Capstone Projects

Performance feedback is frequently discussed and implemented. Although shown to be quite effective, the characteristics of feedback have yet to be fully explored. Feedback ratio was explored in this study. While participants evaluated the postural safety of body positions presented on a computer screen, researchers measured the (a) number of s that it took participants to evaluate body positions (i.e., response time), (b) percent of correctly evaluated body positions (i.e., percent correct), and (c) extent to which participants appreciated the statements they received after responding (i.e., rating). Using a mixed-factorial design, researchers manipulated feedback within groups and feedback ratio between …