Digital Commons Network^™

A Phenotypic Comparison Between Hiv Positive And Hiv Negative Tuberculous Meningitis Patients, Ita Anggraini, Yovita Hartantri, Ahmad Rizal

Makara Journal of Health Research

Background: Tuberculous meningitis (TBM) is the most common type of meningitis found in humans and the Human Immunodeficiency Virus (HIV) is a major risk factor of TBM. This study aimed to identify phenotype differences, such as clinical manifestations, cerebrospinal fluid (CSF) findings, and chest x-ray results between HIV positive and HIV negative TBM patients. Methods: This was a comparative analytical study of 123 TBM patients. The patients were divided into two groups based on their HIV status, and their phenotypes were compared. A retrospective cross sectional designed study was carried out in case report form using a TBM cohort and …

Surveying The Circular Rep Encoding Single Stranded (Cress) Dna Viral Consortium Found In Invasive Quagga Mussels (Dreissena Rostriformis Bugensis) And Sediments Of The Central Lake Michigan Benthos, Nicholas Gezon

Masters Theses

Globalization and resulting increases in international trade has allowed for the movement of species between almost all ecosystems on Earth. The Great Lakes in particular has seen a number of high impact invasive species that have moved in following the opening of the lakes to intercontinental shipping trade. This research specifically focuses on the benthic community of Lake Michigan which has seen significant community shifts including declines of the amphipods Diporeia spp. and the expansion of invasive quagga mussels (Dreissena rostriformis bugensis). Little is known about the viral community in the benthos of Lake Michigan and how …

The Effect Of Dietary Specialism And Generalism On Evolutionary Longevity In An Early Paleogene Mammalian Community, Samantha Glonek

Masters Theses

This study examines the relationship between relief index (RFI) on first and second mandibular molars and longevity of the genus. The molars were extracted from small-bodied, arboreal mammals during the late-Paleocene, early-Eocene in the Bighorn Basin in Wyoming. This study site is a well-known location to research and study fossil mammals of this time period. The study was conducted and analyzed at the genus level due to the relatively small number of specimens available and identifiable at the species level. Dietary breadth, or how broad or narrow a dietary preference is for a mammal, is an area of concentration within …

Sex Differences In Collateral Remodeling Following Hindlimb Arterial Occlusion, Laura Burckhardt

Master's Theses

Clinical evidence indicates a higher incidence of peripheral arterial occlusive disease and associated likelihood of critical limb ischemia in women, as well as worse prognosis and decreased survival post myocardial infarction. Therefore, understanding the possible differences in underlying vascular compensation mechanisms is crucial. With arterial occlusions, necrosis and tissue injury can be naturally mitigated by the collateral circulation, improving patient prognosis. Previous sex-comparison studies describing differences in vascular remodeling are inconsistent. Therefore, the aim of this study was to describe the effect of arterial occlusion on collateral remodeling in healthy male and healthy reproductive-stage female mice. At 7 days following …

Effect Of Undergraduate Research Output On Faculty Scholarly Research Impact, Adriana Popescu, Radu Popescu

Library Scholarship

Objective – In the context of the ongoing discourse about the role of Institutional Repositories (IRs), the objective of the study is to investigate if there is any evidence of a relation between undergraduate student activity in an IR and the impact of faculty research.

Methods – The data used for the study is representative of six academic departments of the College of Science and Mathematics (CSM) at California Polytechnic State University (Cal Poly). Digital Commons@Cal Poly (DC) is the IR supported by the library. Regression analysis was used to investigate the interdependence between faculty research impact (dependent variable) and …

A Phenomenological Analysis Of God Attachment, Romantic Attachment, And Relationship Satisfaction In Christian Couples Completing An Emotionally-Focused Marital Intensive, Shanon Roberts

Doctoral Dissertations and Projects

With professional counseling ethics and organizations moving to more spiritual and cultural sensitivity on behalf of their clients, there is limited research on Christian couples in the area of marital intervention. This phenomenological study examined the shared experiences of five Christian couples who participated in a Christian emotionally-focused therapy marital intensive and who reported maintaining relationship satisfaction one year later. The study assessed the effectiveness of this Christian marital counseling intervention; and identified emergent processes and themes that occurred specific to Christian couples in a marital intervention setting; and added to the God attachment and romantic attachment literature through a …

Anna He Purnabramha: Deorukhe Women’S Agency In The Making Of Bodies, Cuisines, And Culture In Maharashtra, India, Gauri Anilkumar Pitale

Dissertations

The world is changing. India is changing. Food is changing. Bodies are changing. What does this mean for the women of Maharashtra, India? Globalization and modernity manifest in new and interesting ways the world over. As people establish networks of global commodity, capital, and human circulation, anthropologists raise pertinent concerns. While some are apprehensive about cultural loss and western cultural imperialism, others make a case for the rise of glocalization. While some espouse the positives of a free market economy, others are critical of the nutrition transition in developing countries and what this means for the health of the people …

Survival And Capture Efficiency Of River Otters In Southern Illinois, Andrew U. Rutter

Theses

River otter (Lontra canadensis) populations in Illinois have rebounded considerably after >80 years of harvest protection and a successful reintroduction program. However, few studies of river otter ecology exist in the Midwestern U.S. where river otter numbers have increased in recent decades. Capturing study animals safely and efficiently is a critical part of wildlife research, and difficulties associated with live capture of river otters have contributed to the dearth of research on the species. Furthermore, estimating survival rates and identifying causes of mortality are important in effectively managing river otters. To address these knowledge gaps, my objectives were determine survival …

Effect Of Ppo-Inhibiting Herbicides On Male-To-Female Sex Ratio Of Amaranthus Palmeri, Mafia Mahabub Rumpa

Theses

TITLE: EFFECT OF PPO-INHIBITING HERBICIDES ON MALE-TO-FEMALE SEX RATIO OF AMARANTHUS PALMERI Background: Amaranthus palmeri S. Wats. (Palmer amaranth) is a dicotyledonous, dioecious species having separate male and female plants that forces outcrossing, ensures genetic diversity, and is recognized as one of the most noxious, invasive agricultural weed pests in the Mid-West. It can be characterized by extended emergence periodicity, aggressive growth habit, high fecundity, and high water use efficiency as well as high competitive ability. Fisher (1930) predicted 1: 1 primary sex ratios after the period of parental investment, but initial field studies indicated that A. palmeri populations were …

The Public’S Perception Of Humanlike Robots: Online Social Commentary Reflects An Appearance-Based Uncanny Valley, A General Fear Of A “Technology Takeover”, And The Unabashed Sexualization Of Female-Gendered Robots, Megan K. Strait, Cynthia Aguillon, Virginia Contreras, Noemi Garcia

Computer Science Faculty Publications

Towards understanding the public’s perception of humanlike robots, we examined commentary on 24 YouTube videos depicting social robots ranging in human similarity – from Honda’s Asimo to Hiroshi Ishiguro’s Geminoids. In particular, we investigated how people have responded to the emergence of highly humanlike robots (e.g., Bina48) in contrast to those with more prototypically-“robotic” appearances (e.g., Asimo), coding the frequency at which the uncanny valley versus fears of replacement and/or a “technology takeover” arise in online discourse based on the robot’s appearance. Here we found that, consistent with Masahiro Mori’s theory of the uncanny valley, people’s commentary reflected an aversion …

Oystower | Oystown Multi-Scalar Biomimetic Design For Resilient Coastal Inhabitation, Christopher William James

Honors Capstones

No abstract provided.

Short Communication: Massive Erosion In Monsoonal Central India Linked To Late Holocene Land Cover Degradation, Liviu Giosan, Camilo Ponton, Muhammed Usman, Jerzy Glusztajn, Dorian Q. Fuller, Valier Galy, Negar Haghipour, Joel E. Johnson, Cameron Mcintyre, Lukas Wacker, Timothy I. Eglinton

Faculty Publications

Soil erosion plays a crucial role in transferring sediment and carbon from land to sea, yet little is known about the rhythm and rates of soil erosion prior to the most recent few centuries. Here we reconstruct a Holocene erosional history from central India, as integrated by the Godavari River in a sediment core from the Bay of Bengal. We quantify terrigenous fluxes, fingerprint sources for the lithogenic fraction and assess the age of the exported terrigenous carbon. Taken together, our data show that the monsoon decline in the late Holocene significantly increased soil erosion and the age of exported …

Growing In Favor With God And Man: Attachment To God And Psychological Separation Of Christian, Millennial College Students, David Allen Gregory

Doctoral Dissertations and Projects

The purpose of this quantitative, correlational study was to examine whether Christian, Millennial college students’ secure attachment to God relationship could contribute to their psychological separation. This question was addressed by examining (a) the correlation between attachment to parents and psychological separation, (b) the correlation between attachment to parents and attachment to God, and (b) the correlation between attachment to God and psychological separation. Bowlby’s (1969, 1973, 1982) attachment theory was used as the theoretical foundation to explore both the students’ relationships with parents and God. Attachment to parents of Christian, Millennial college students attending a Southern Christian college was …

Teacher Efficacy Of Secondary Special Education Science Teachers, Celeste Bonton

Doctoral Dissertations and Projects

Students with disabilities are a specific group of the student population that are guaranteed rights that allow them to receive a free and unbiased education in an environment with their non-disabled peers. The importance of this study relates to providing students with disabilities with the opportunity to receive instruction from the most efficient and prepared educators. The purpose of this study is to determine how specific factors influence special education belief systems. In particular, educators who provide science instruction in whole group or small group classrooms in a large metropolitan area in Georgia possess specific beliefs about their ability to …

Achievement Gap In United States History End Of Course Assessment Scores In Ga High Schools, Kris Watkins

Doctoral Dissertations and Projects

The purpose of this dissertation study, which employed a quantitative correlational research design, was to determine if the school-level variables of percentage of African American students, the percentage of economically disadvantaged students, and type of school scheduling significantly influence student performance on the Georgia Milestones U.S. History end-of-course assessments (EOCs) for the school years 2014-15 and 2015-16. The study utilized a sample of 163 high schools located in the Atlanta metropolitan statistical area (MSA). Results from simultaneous linear regression analyses showed that school-level percentage of economically disadvantaged students was significantly associated with school-level Georgia Department of Education (GADOE) U.S. History …

A Phenomenological Study Of Elementary General Education Teachers' Experiences Teaching Students With Autism Spectrum Disorder, Patricia Massengale

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the experiences of elementary general education teachers instructing students diagnosed with Autism Spectrum Disorder (ASD) in a suburban North Georgia inclusion setting. The four research questions that guided this study included (a) How do elementary general education teachers describe their experiences teaching students with ASD in their classrooms? (b) In what ways do teachers describe how the presence of students with ASD influence their beliefs regarding inclusion? (c) How do teachers describe the challenges they faced with students with ASD in the inclusion setting? and (d) How do teachers describe the …

A Study Of Fatherlessness In The African-American Community In Relationship To The Positive Role Of Christianity, Kevin Smith

Doctoral Dissertations and Projects

The following study is a qualitative investigation into the issue of fatherlessness among African Americans and its relation to the positive role of Christianity. The primary objective of the study is to determine, understand, and describe the circumstances that brought about fatherlessness and what role Christians may play to help address the problem. Also, the study focuses on developing a deep understanding of the consequences of fatherlessness and what role Christians may play to help mitigate these consequences. The results of this research will reconnect, revitalize, recover trust, ease the pain, and implement healing for fathers, children, and all involved. …

The Effectiveness Of High Frequency Word List Instruction On Star Reading Test Scores, Michael Foster

Doctoral Dissertations and Projects

The purpose of this quantitative, quasi-experimental study was to test the theory of using high frequency word list (HFWL)-based instruction when teaching beginning reading instruction. This study compared the reading fluency changes of eight classes across three different grades containing 115 students over 5 months as measured by the Standardized Test for the Assessment in Reading (STAR) when intervention students are given identical instruction using different popular HFWLs. One control group received no such intervention. The Fry HFWL was used. The resulting scores were analyzed using an independent-samples t test. The comparisons determined the effectiveness of teaching beginning reading using …

Mitochondrial Fission After Traumatic Brain Injury, Tara Fischer

Dissertations and Theses (Open Access)

Mitochondrial dysfunction is a central feature in the pathophysiology of Traumatic Brain Injury (TBI). Loss of mitochondrial function disrupts normal cellular processes in the brain, as well as impedes the ability for repair and recovery, creating a vicious cycle that perpetuates damage after injury. To maintain metabolic homeostasis and cellular health, mitochondria constantly undergo regulated processes of fusion and fission and functionally adapt to changes in the cellular environment. An imbalance of these processes can disrupt the ability for mitochondria to functionally meet the metabolic needs of the cell, therefore resulting in mitochondrial damage and eventual cell death. Excessive fission, …

Computational Identification Of Noncoding Driver Mutations Based On Impact On Rna Processing, Kevin Zhu

Dissertations and Theses (Open Access)

Despite the prevalence of mutations in the noncoding regions of the DNA, their effects on cancer development remain largely uninvestigated. This is especially evident when compared to coding mutations, which have been relatively well-studied and, in certain cases, been identified as driver mutations for cancer. Recent studies, however, have identified noncoding mutations that frequently appear in certain types of cancer, which may be evidence that those mutations are important to cancer development. Nonetheless, the role of noncoding mutations in cancer remains unclear. A potential vector for understanding this mechanism is through observing the relation between noncoding mutations and functional RNA …

Integrative Cancer Immunogenomic Analysis Of Serial Melanoma Biopsies Reveals Correlates Of Response And Resistance To Sequential Ctla-4 And Pd-1 Blockade Treatment, Whijae Roh

Dissertations and Theses (Open Access)

Melanoma is the most malignant form of skin cancer. The five-year survival rate for metastatic melanoma is 19.9%. Although targeted therapy of BRAF and MEK inhibitors were developed for melanoma, resistance to therapy is inevitable. Immune checkpoint blockade, which reverses the suppression of the immune system, on the other hand, has shown a durable response in 20-30% of patients with metastatic melanoma. However, more predictive and robust biomarkers of response to this therapy are still needed, and resistance mechanisms remain incompletely understood. To address this, we examined a cohort of metastatic melanoma patients treated with sequential checkpoint blockade against cytotoxic …

Memory Potential, Molecular Characterization, And Translational Applications Of The Novel Theo/Tceo T Cell Phenotype, Todd Bartkowiak, Todd Bartkowiak

Dissertations and Theses (Open Access)

T cells comprise a substantial arm of the immune system and are exquisitely adapted to combat pathogens and tumors. The inflammatory environment largely dictates the nature of T cell response. A hallmark of T cell-mediated immunity is formation of immunological memory; the ability to respond more potently to re-encounter with pathogens. The immune system is also capable of recognizing tumors as foreign, much like viral or bacterial pathogens. Tumors have evolved, though, to generate an immunosuppressive environment to avoid destruction. The field of immunotherapy seeks to overcome immune suppression, in part by targeting T cell co-receptors on the cell surface …

Impact Of Kras/Nras Mutational Heterogeneity On Clinical Outcomes In Colorectal Cancer, Jonathan M. Loree

Dissertations and Theses (Open Access)

Introduction: Mutations in KRAS/NRAS (RAS) predict a lack of benefit from anti-EGFR agents in metastatic colorectal cancer (mCRC). As next generation sequencing (NGS) has advanced, we are discovering atypical and low allele frequency mutations. We aimed to evaluate how NGS can optimally define RAS mutant CRC and the role of relative mutant allele frequency (rMAF) as a biomarker.

Methods: Using institutional and public cohorts of mCRC patients with NGS results, we described the prevalence and clinical impact of atypical (not in current guidelines) and low rMAF RAS mutations (RAS MAF by the MAF of the mutated gene with …

Quality Of Life: Socio-Demographic And Genetic Determinants As Well As Links With Cancer Outcomes, Jeanne Pierzynski

Dissertations and Theses (Open Access)

Quality of life (QOL) is an independent prognostic factor for cancer. Lung cancer is the leading cause of cancer death. Breast cancer is the most diagnosed. Bladder cancer is the most expensive cancer to treat because of its high recurrence rate. We set to perform comprehensive analyses of predictors of QOL in these cancer sites with the future goal of improving QOL and outcomes.

In 6,456 newly diagnosed lung cancer patients, we investigated the relationship between baseline patient characteristics and QOL to identify determinants of QOL. A QOL questionnaire (SF-12v1) measured patients’ physical component summary (PCS) and mental component summary …

Dynamic Assessment Of Nk Cell Interactions With Pediatric Tumor Cells To Predict Response To Immunotherapy, Arianexys Aquino Lopez

Dissertations and Theses (Open Access)

Due to Natural Killer (NK) cells’ capacity to target tumor cells without prior sensitization, adoptive NK cell therapy represents a promising immunotherapy approach for pediatric cancer patients. Our laboratory has developed an NK cell expansion protocol that generates large quantities of NK cells for therapeutic infusion. Given that NK cells are heterogeneous, with variable receptor expression and potential to target tumor cells, the purpose of my study was to determine whether subpopulations of NK cells with enhanced anti-tumor potential could be identified for increased potency of the NK cell infusion product. In addition, we previously showed that our expanded NK …

Characterization Of Notch1 And Pi3k-Pten-Akt/Mtor Pathway Interaction In Head And Neck Squamous Cell Carcinoma, Kyriante' Henry

Dissertations and Theses (Open Access)

Head and neck squamous cell carcinoma (HNSCC) affects various mucosal sites of the upper aerodigestive tract, including the nasal and oral cavities, the nasopharynx, and the oropharynx. More than five hundred thousand new cases of HNSCC occurred in 2011 alone, with 50,000 reported cases in the United States. This trend made HNSCC the seventh most common non-skin cancer worldwide (Ferlay et al., 2015). Although significant epidemiological and pathological advancements have been made, survival rates have not improved much over the last 40 years, leaving a mortality rate that remains at approximately 50%. An unbiased drug screen demonstrated that HNSCC cell …

The Functions Of Setd5 And Mir-221 In Embryonic Stem Cell Differentiation, Tsai-Yu Chen

Dissertations and Theses (Open Access)

Embryonic stem cells (ESCs) are a widely used model system to study cellular differentiation because of their pluripotent characteristics, and ESC differentiation is an epigenetic process. In an effort to identify a new epigenetic factor that is required for ESC differentiation, the function of SETD5 in ESCs was studied for this thesis. Results show that SETD5 is essential for retinoic acid (RA)-induced differentiation of mouse ESCs and for RA-induced expression of critical developmental genes (e.g., Hoxa1 and Hoxa2) and neuron-related genes (e.g., Nestin and Pax6). SETD5 was upregulated during ESC differentiation. Additional results demonstrated that SETD5 bound to …

Circulating Autoantibodies In Human Traumatic Spinal Cord Injury Subjects And Their Relationship To The Development Of Neuropathic Pain, Georgene Hergenroeder

Dissertations and Theses (Open Access)

Background:

Approximately 17,500 spinal cord injuries (SCI) occur yearly in the U.S. causing considerable morbidity and mortality. Neuropathic pain (NP) ensues in 40-70% of SCI. An autoimmune response resulting from disruption of the blood-spinal cord-barrier may be a contributor to NP. However, the relationship between autoantibodies and NP after SCI in humans has not been thoroughly characterized nor have autoantigens been identified. Glial fibrillary acidic protein (GFAP) and collapsin response mediator protein2 (CRMP2) were identified as candidate autoantigens. The hypothesis is that proteins from the injured spinal cord released by SCI trigger autoantibody production which can lead to the development …

Insights Into The Therapeutic Potential Of Salt Inducible Kinase 1: A Novel Mechanism Of Metabolic Control, Randi Fitzgibbon

Dissertations and Theses (Open Access)

Salt inducible kinase 1 (SIK1) has been considered a stress-inducible kinase since it was first cloned in 1999. Continued efforts since this time have been dedicated to characterizing the structure and function of SIK1. Such research has laid the ground work for our understanding of SIK1 action and regulation in tissue and stimuli dependent manners. The fundamental findings of this dissertation continue in this tradition and include investigations of SIK1 regulatory mechanisms in skeletal muscle cells, the cellular and physiological effects of SIK1 loss of function in vitro and in vivo, and intracellular metabolic and mitochondrial regulation by this …

Cytoplasmic Cyclin E Mediates Resistance To Aromatase Inhibitors In Breast Cancer, Iman Doostan

Dissertations and Theses (Open Access)

Almost seventy percent of patients with breast cancer have tumors that express hormone receptors and need hormonal therapy. Aromatase inhibitors (AIs) block estrogen biosynthesis and are considered as the first line hormonal therapy for ER⁺ post-menopausal patients. However, resistance to these drugs remains a major challenge in clinic and the biology of such resistance is not completely understood. Cyclin E is deregulated in breast cancer through generation of low molecular weight isoforms that renders patients to a poor survival. Herein, we show that HR+ patients with LMW-E expressing tumors show diminished early response to neo-adjuvant AIs as well as …