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2017

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Fluvial Archives Of Nw African Climate And Tectonic Evolution, Atlas Mountains, Central Morocco, Jr Zondervan, M Stokes, Ae Mather, Sj Boulton Jan 2017

Fluvial Archives Of Nw African Climate And Tectonic Evolution, Atlas Mountains, Central Morocco, Jr Zondervan, M Stokes, Ae Mather, Sj Boulton

School of Geography, Earth and Environmental Sciences

The Atlas mountains in Morocco are a natural laboratory at the junction between the Atlantic Ocean (passive margin), the Mediterranean (subduction) and the African Craton. Here, interactions between the mantle and lithosphere, crustal compression and uplift have been recorded in river terraces, alluvial fans, drainage patterns, river long profiles, and in wedge-top & foreland sediments. Limited work on terraces in one of the catchments crossing the south Atlas thrust front has shown rates of incision are low and have been sustained since the Pleistocene. Dating of terraces using Optically Stimulated Luminescence, together with field sedimentology, links the formation of terraces …


Response To ‘Pathway To Driverless Cars: Consultation On Proposals To Support Advanced Driver Assistance Systems And Automated Vehicles’., M Channon, H Stones Jan 2017

Response To ‘Pathway To Driverless Cars: Consultation On Proposals To Support Advanced Driver Assistance Systems And Automated Vehicles’., M Channon, H Stones

School of Law, Humanities and Social Sciences

No abstract provided.


Youth Incarceration, Health, And Length Of Stay, Thalia Gonzalez Jan 2017

Youth Incarceration, Health, And Length Of Stay, Thalia Gonzalez

Faculty Scholarship

For youth from marginalized communities, the pathway into the juvenile justice system occurs against a backdrop of disproportionately high levels of stress, complex trauma, and adverse childhood experiences. Despite overall reductions in the percentage of youth in confinement from recent state-level reforms, the lengths of stay for many youth often exceed evidence-based timelines, as well as a state’s own guidelines and criteria. This occurs despite a large and growing body of empirical research that documents the health status of system-involved youth and the association between incarceration during adolescence and the range of subsequent health and mental health outcomes in adulthood. …


Discovering Forensic Fraud, Jennifer D. Oliva, Valena E. Beety Jan 2017

Discovering Forensic Fraud, Jennifer D. Oliva, Valena E. Beety

Faculty Scholarship

This Essay posits that certain structural dynamics, which dominate criminal proceedings, significantly contribute to the admissibility of faulty forensic science in criminal trials. The authors believe that these dynamics are more insidious than questionable individual prosecutorial or judicial behavior in this context. Not only are judges likely to be former prosecutors, prosecutors are “repeat players” in criminal litigation and, as such, routinely support reduced pretrial protections for defendants. Therefore, we argue that the significant discrepancies between the civil and criminal pretrial discovery and disclosure rules warrant additional scrutiny. In the criminal system, the near absence of any pretrial discovery means …


Fool's Gold? Equity Compensation & The Mature Startup, Abraham Cable Jan 2017

Fool's Gold? Equity Compensation & The Mature Startup, Abraham Cable

Faculty Scholarship

No abstract provided.


Trading Safety For Innovation And Access: An Empirical Evaluation Of The Fda’S Premarket Approval Process, George Horvath Jan 2017

Trading Safety For Innovation And Access: An Empirical Evaluation Of The Fda’S Premarket Approval Process, George Horvath

Faculty Scholarship

Congress created the premarket approval process (PMA) to provide a rigorous safety evaluation of high-risk medical devices before they may be sold on the U.S. market. Evaluating a PMA application requires the Food and Drug Administration (FDA) to conduct a lengthy, complex, and costly assessment of the extensive data a manufacturer must submit. But other policy concerns, notably a fear of hampering innovation and a desire to assure timely access to new technologies, have led Congress to relax some of the rigorous data requirements the PMA process imposes on manufacturers. Congress mandates that the FDA employ the “least burdensome” approach …


The Development Of The Tenora, N Bonet Jan 2017

The Development Of The Tenora, N Bonet

School of Law, Humanities and Social Sciences

The tenora is a type of tenor shawm from Catalonia, an area in both northern Spain and southern France (see Figure 1), and its invention is usually attributed to Andreu Toron (1815–1886) of Perpignan in North Catalonia. Like members of the shawm family, it has ‘a conical bore, wider than that of oboes, and a broad double reed of cane placed on a metal staple which is partly enclosed in a wooden pirouette,’ to which Toron added a sophisticated key system and a flaring metal bell. While Toron’s design has six finger holes and 13 keys, however, surviving examples have …


The Effect Of Hospital Biocide Sodium Dichloroisocyanurate On The Viability And Properties Of Clostridium Difficile Spores., L. T. Joshi, A. Welsch, J. Hawkins, L. Baillie Jan 2017

The Effect Of Hospital Biocide Sodium Dichloroisocyanurate On The Viability And Properties Of Clostridium Difficile Spores., L. T. Joshi, A. Welsch, J. Hawkins, L. Baillie

Peninsula Dental School

UNLABELLED: Clostridium difficile is the primary cause of healthcare-associated diarrhoea globally and produces spores which are resistant to commonly used biocides and are able persist on contaminated surfaces for months. This study examined the effect of sublethal concentrations of the biocide sodium dichloroisocyanurate (NaDCC) on the viability of spores produced by 21 clinical isolates of C. difficile representing a range of PCR ribotypes. Spores exposed to 500 ppm NaDCC for 10 min exhibited between a 4-6 log10 reduction in viability which was independent of spore PCR ribotype. The effect of sublethal concentrations of biocide on the surface properties of exosporium …


Differential Presynaptic Atp Supply For Basal And High-Demand Transmission, Courtney Sobieski, Michael J. Fitzpatrick, Steven Mennerick Jan 2017

Differential Presynaptic Atp Supply For Basal And High-Demand Transmission, Courtney Sobieski, Michael J. Fitzpatrick, Steven Mennerick

Open Access Publications

No abstract provided.


A New Chicken Genome Assembly Provides Insight Into Avian Genome Structure, Wesley C. Warren, Ladeana W. Hillier, Chad Tomlinson, Patrick Minx, Milinn Kremitzki, Tina Graves, Chris Markovic, Et Al Jan 2017

A New Chicken Genome Assembly Provides Insight Into Avian Genome Structure, Wesley C. Warren, Ladeana W. Hillier, Chad Tomlinson, Patrick Minx, Milinn Kremitzki, Tina Graves, Chris Markovic, Et Al

Open Access Publications

No abstract provided.


Multi-Institutional Analysis Shows That Low Pcat-14 Expression Associates With Poor Outcomes In Prostate Cancer, Nicole M. White, Shuang G. Zhao, Jin Zhang, Emily B. Rozycki, Ha X. Dang, Sandra D. Mcfadden, Abdallah M. Eteleeb, Mohammed Alshalalfa, Ismael A. Vergara, Nicholas Erho, Jeffrey M. Arbeit, Robert Jeffrey Karnes, Robert B. Den, Elai Davicioni, Christopher A. Maher Jan 2017

Multi-Institutional Analysis Shows That Low Pcat-14 Expression Associates With Poor Outcomes In Prostate Cancer, Nicole M. White, Shuang G. Zhao, Jin Zhang, Emily B. Rozycki, Ha X. Dang, Sandra D. Mcfadden, Abdallah M. Eteleeb, Mohammed Alshalalfa, Ismael A. Vergara, Nicholas Erho, Jeffrey M. Arbeit, Robert Jeffrey Karnes, Robert B. Den, Elai Davicioni, Christopher A. Maher

Open Access Publications

No abstract provided.


A Rab5 Endosomal Pathway Mediates Parkin-Dependent Mitochondrial Clearance, Babette C. Hammerling, Rita H. Najor, Melissa Q. Cortez, Sarah E. Shires, Leonardo J. Leon, Eileen R. Gonzalez, Daniela Boassa, Sébastien Phan, Andrea Thor, Rebecca E. Jimenez, Hong Li, Richard N. Kitsis, Gerald W. Dorn Ii, Junichi Sadoshima, Mark H. Ellisman, Åsa B. Gustafsson Jan 2017

A Rab5 Endosomal Pathway Mediates Parkin-Dependent Mitochondrial Clearance, Babette C. Hammerling, Rita H. Najor, Melissa Q. Cortez, Sarah E. Shires, Leonardo J. Leon, Eileen R. Gonzalez, Daniela Boassa, Sébastien Phan, Andrea Thor, Rebecca E. Jimenez, Hong Li, Richard N. Kitsis, Gerald W. Dorn Ii, Junichi Sadoshima, Mark H. Ellisman, Åsa B. Gustafsson

Open Access Publications

No abstract provided.


Potential Molecular Consequences Of Transgene Integration: The R6/2 Mouse Example, Jessie C. Jacobsen, Serken Erdin, Colby Chiang, Carrie Hanscom, Renee R. Handley, Douglas D. Barker, Alex Stortchevoi, Ian Blumenthal, Suzanne J. Reid, Russell G. Snell, Marcy E. Macdonald, A. Jennifer Morton, Carl Ernst, James F. Gusella, Michael E. Talkowski Jan 2017

Potential Molecular Consequences Of Transgene Integration: The R6/2 Mouse Example, Jessie C. Jacobsen, Serken Erdin, Colby Chiang, Carrie Hanscom, Renee R. Handley, Douglas D. Barker, Alex Stortchevoi, Ian Blumenthal, Suzanne J. Reid, Russell G. Snell, Marcy E. Macdonald, A. Jennifer Morton, Carl Ernst, James F. Gusella, Michael E. Talkowski

Open Access Publications

No abstract provided.


Esterase Mutation Is A Mechanism Of Resistance To Antimalarial Compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg Jan 2017

Esterase Mutation Is A Mechanism Of Resistance To Antimalarial Compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg

Open Access Publications

No abstract provided.


Rapid Generation Of Hypomorphic Mutations, Laura L. Arthur, Joyce J. Chung, Preetam Jankirama, Kathryn M. Keefer, Igor Kolotilin, Slavica Pavlovic-Djuranovic, Douglas L. Chalker, Vojislava Grbic, Rachel Green, Rima Menassa, Heather L. True, James B. Skeath, Sergej Djuranovic Jan 2017

Rapid Generation Of Hypomorphic Mutations, Laura L. Arthur, Joyce J. Chung, Preetam Jankirama, Kathryn M. Keefer, Igor Kolotilin, Slavica Pavlovic-Djuranovic, Douglas L. Chalker, Vojislava Grbic, Rachel Green, Rima Menassa, Heather L. True, James B. Skeath, Sergej Djuranovic

Open Access Publications

No abstract provided.


Perceived Barriers To Achieving A Healthy Weight: A Qualitative Study Using Focus Groups At Public And Private Schools In Guatemala City, Luisa Madrigal, Inez Adams, Violeta Chacon, Joaqin Barnoya Jan 2017

Perceived Barriers To Achieving A Healthy Weight: A Qualitative Study Using Focus Groups At Public And Private Schools In Guatemala City, Luisa Madrigal, Inez Adams, Violeta Chacon, Joaqin Barnoya

Open Access Publications

No abstract provided.


A Novel Method For The Quantification Of Fatty Infiltration In Skeletal Muscle, Nicole K. Blitz, Gretchen A. Meyer Jan 2017

A Novel Method For The Quantification Of Fatty Infiltration In Skeletal Muscle, Nicole K. Blitz, Gretchen A. Meyer

Open Access Publications

No abstract provided.


Knockout Of Lysosomal Enzyme-Targeting Gene Causes Abnormalities In Mouse Pup Isolation Calls, Terra D. Barnes, Timothy E. Holy Jan 2017

Knockout Of Lysosomal Enzyme-Targeting Gene Causes Abnormalities In Mouse Pup Isolation Calls, Terra D. Barnes, Timothy E. Holy

Open Access Publications

No abstract provided.


Trojan Horse Transit Contributes To Blood-Brain Barrier Crossing Of A Eukaryotic Pathogen, Felipe H. Santiago-Tirado, Michael D. Onken, John A. Cooper, Robyn S. Klein, Tamara L. Doering Jan 2017

Trojan Horse Transit Contributes To Blood-Brain Barrier Crossing Of A Eukaryotic Pathogen, Felipe H. Santiago-Tirado, Michael D. Onken, John A. Cooper, Robyn S. Klein, Tamara L. Doering

Open Access Publications

No abstract provided.


Novel Treatment Of Chronic Graft-Versus-Host Disease In Mice Using The Er Stress Reducer 4-Phenylbutyric Acid, Shin Mukai, Yoko Ogawa, Fumihiko Urano, Chie Kudo-Saito, Yutaka Kawakami, Kazuo Tsubota Jan 2017

Novel Treatment Of Chronic Graft-Versus-Host Disease In Mice Using The Er Stress Reducer 4-Phenylbutyric Acid, Shin Mukai, Yoko Ogawa, Fumihiko Urano, Chie Kudo-Saito, Yutaka Kawakami, Kazuo Tsubota

Open Access Publications

No abstract provided.


Cell-Free Measurements Of Brightness Of Fluorescently Labeled Antibodies, Haiying Zhou, George Tourkakis, Dennis Shi, David M. Kim, Hairong Zhang, Tommy Du, William C. Eades, Mikhail Y. Berezin Jan 2017

Cell-Free Measurements Of Brightness Of Fluorescently Labeled Antibodies, Haiying Zhou, George Tourkakis, Dennis Shi, David M. Kim, Hairong Zhang, Tommy Du, William C. Eades, Mikhail Y. Berezin

Open Access Publications

No abstract provided.


Animal Models Of Zika Virus Infection, Pathogenesis, And Immunity, Thomas E. Morrison, Michael S. Diamond Jan 2017

Animal Models Of Zika Virus Infection, Pathogenesis, And Immunity, Thomas E. Morrison, Michael S. Diamond

Open Access Publications

No abstract provided.


The Nuclear Receptor Hizr-1 Uses Zinc As A Ligand To Mediate Homeostasis In Response To High Zinc, Kurt Warnhoff, Hyun C. Roh, Zuzana Kocsisova, Chieh-Hsiang Tan, Andrew Morrison, Damari Croswell, Daniel L. Schneider, Kerry Kornfeld Jan 2017

The Nuclear Receptor Hizr-1 Uses Zinc As A Ligand To Mediate Homeostasis In Response To High Zinc, Kurt Warnhoff, Hyun C. Roh, Zuzana Kocsisova, Chieh-Hsiang Tan, Andrew Morrison, Damari Croswell, Daniel L. Schneider, Kerry Kornfeld

Open Access Publications

No abstract provided.


Exacerbated Leishmaniasis Caused By A Viral Endosymbiont Can Be Prevented By Immunization With Its Viral Capsid, Patrick Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzxchneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Nicolas Fasel, Catherine Ronet Jan 2017

Exacerbated Leishmaniasis Caused By A Viral Endosymbiont Can Be Prevented By Immunization With Its Viral Capsid, Patrick Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzxchneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Nicolas Fasel, Catherine Ronet

Open Access Publications

No abstract provided.


Osteoarthritis: Toward A Comprehensive Understanding Of Pathological Mechanism, Di Chen, Jie Shen, Weiwei Zhao, Tingyu Wang, Lin Han, John L. Hamilton, Hee-Jeong Im Jan 2017

Osteoarthritis: Toward A Comprehensive Understanding Of Pathological Mechanism, Di Chen, Jie Shen, Weiwei Zhao, Tingyu Wang, Lin Han, John L. Hamilton, Hee-Jeong Im

Open Access Publications

No abstract provided.


Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader Jan 2017

Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader

Open Access Publications

No abstract provided.


Interrater Reliability Of Surveillance For Ventilator-Associated Events And Pneumonia, Meeta Prasad Kerlin, William E. Trick, Deverick J. Anderson, Hilary M. Babcock, Ebbing Lautenbach, Renaud Gueret, Michael Klompas Jan 2017

Interrater Reliability Of Surveillance For Ventilator-Associated Events And Pneumonia, Meeta Prasad Kerlin, William E. Trick, Deverick J. Anderson, Hilary M. Babcock, Ebbing Lautenbach, Renaud Gueret, Michael Klompas

Open Access Publications

No abstract provided.


Computational Assessment Of Potassium And Magnesium Ion Binding To A Buried Pocket In Gtpase-Associating Center Rna, Hamed S. Hayatshahi, Daniel R. Roe, Rodrigo Galindo-Murillo, Kathleen B. Hall, Thomas E. Chetham Iii Jan 2017

Computational Assessment Of Potassium And Magnesium Ion Binding To A Buried Pocket In Gtpase-Associating Center Rna, Hamed S. Hayatshahi, Daniel R. Roe, Rodrigo Galindo-Murillo, Kathleen B. Hall, Thomas E. Chetham Iii

Open Access Publications

No abstract provided.


Best Anthropometric Discriminators Of Incident Type 2 Diabetes Among White And Black Adults: A Longitudinal Aric Study, Dale S. Hardy, Devita T. Stallings, Jane T. Garvin, Hongyan Xu, Susan B. Racette Jan 2017

Best Anthropometric Discriminators Of Incident Type 2 Diabetes Among White And Black Adults: A Longitudinal Aric Study, Dale S. Hardy, Devita T. Stallings, Jane T. Garvin, Hongyan Xu, Susan B. Racette

Open Access Publications

No abstract provided.


In Vivo Two-Photon Imaging Of Astrocytes In Gfap-Gfp Transgenic Mice, Dongjun Guo, Jia Zou, Nicholas Rensing, Michael Wong Jan 2017

In Vivo Two-Photon Imaging Of Astrocytes In Gfap-Gfp Transgenic Mice, Dongjun Guo, Jia Zou, Nicholas Rensing, Michael Wong

Open Access Publications

No abstract provided.