Digital Commons Network^™

Identification And Characterization Of A Chemical Compound That Inhibits Methionyl-Trna Synthetase From Pseudomonas Aeruginosa, Sara Robles, Yanmei Hu, Tahyra Resto, Frank Dean, James M. Bullard

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Background: Pseudomonas aeruginosa is an opportunistic pathogen problematic in causing nosocomial infections and is highly susceptible to development of resistance to multiple antibiotics. The gene encoding methionyl-tRNA synthetase (MetRS) from P. aeruginosa was cloned and the resulting protein characterized.

Methods: MetRS was kinetically evaluated and the KM for its three substrates, methionine, ATP and tRNAMet were determined to be 35, 515, and 29 μM, respectively. P. aeruginosaMetRS was used to screen two chemical compound libraries containing 1690 individual compounds.

Results: A natural product compound (BM01C11) was identified that inhibited the aminoacylation function. The compound inhibited P. aeruginosa MetRS with an …

How Strange The Change From Major To Minor, Peter Goodrich

Articles

No abstract provided.

Knowledge Activation For Patient Centered Care: Bridging The Health Information Technology Divide, Sajda Qureshi, Cherie Noteboom

Research & Publications

The provision of healthcare is a collaborative process. It follows evidence based treatments which are becoming increasingly data driven and focusing on the best clinical outcomes. Patient centered care requires participation of patients in the decision making of the best treatment options. Healthcare provision requires both evidence based and patient centered care. In practice, these two perspectives conflict with each other due to the use of an information technology designed primarily for billing purposes. Using the knowledge activation framework developed by Qureshi and Keen [25], we analyze data from two hospitals in the Midwest that aim to achieve quality of …

An Exploration Of Anchoring Female Millennial Students To An It Career Path: The Class Model, Cherie Noteboom, Pamela Rowland

Research & Publications

There has been much research conducted on the under-representation of women in Science, Technology, and Engineering & Math (STEM). Looking specifically at the area of Information Systems and Information Technology (IS/IT), women are largely under-represented in degree programs and the workforce. With the growth in the IS/IT workforce and the future demands of IS/IT career growth, the importance of understanding the perceptions and influences on the female IS/IT students grows. While there is research investigating the demographics of the IS/IT workforce, the relationship between female students and millennial influences has not been investigated. This research contends that addressing the demographic …

Antecedents To Managerial Preference For Agile Software Development Methods – A Research Plan, David Bishop, Pam Rowland, Cherie Noteboom

Research & Publications

Agile development methods are widely used and continue to grow in their adoption. A theoretical understanding of agile is needed. This research plan uses a Grounded Theory approach to develop antecedents to managerial preference for agile development methods. First, we provide the motivation for the research. Next, we provide a brief literature review to orient the research to the domain. Finally, we discuss the research methodology and research plan.

Speaking Out & Speaking Up: Xinjiao Perspectives, Eng Fong Pang, Arnoud De Meyer

Research Collection Lee Kong Chian School Of Business

Contents: A Singaporean in Xinjiang by Wong Ee Vin; Sex for Sale and Second Wives by Xue Jiarong; Singapore Families: Mixed Salad or New Rojak? by Darren Lim; Singaporean-Burmese, Burmese-Singaporean or Both? by In Jin Zaw; Foreign Workers: Seen but not Heard by Mohammad Muzhaffar & Rohith Misir; Wheel You Ride? by Khew Pei Xuan; Gaelic Kallang Roar by Kate Whyte; Gaming Virtual Reality, Seriously by Lin Junkang & Low Kai Loon; Cyber Vigilantes: Mobs or Cops? by Timothy Lim & Hermanth Kumar; Online Dating: Waiting for the Stars to Align by Alex Cherucheril & Muhammed Ismail; Tying the Knot, …

Perspectives From 22 Countries On The Legal Environment For Selection, Brett Myors, Filip Lievens, Eveline Schollaert, Greet Van Hoye, Steven F. Cronshow, Antonio Mladinic, Viviana Rodriguez, Herman Aguinis, Dirk D. Steiner, Florence Rolland, Heinz Schuler, Andreas Frintrup, Ioannis Nikolaou, Maria Tomprou, S. Subramony, Shabu B. Raj, Shay Tzafrir, Peter Bamberger, Marilena Bertolino, Marco Mariani

Research Collection Lee Kong Chian School Of Business

In the United States, the legal context plays a major role in how industrial/organizational (I/O) psychologists approach selection system development. The set of protected groups, the approaches to making an a priori case of discrimination (e.g., differential treatment vs. adverse impact), the key court cases influencing selection, and the prohibitions against preferential treatment (e.g., the 1991 ban on score adjustment or within-group norming) are well known. Selection texts (e.g., Guion, 1998) and human resource management texts (e.g., Cascio & Aguinis, 2008) give prominent treatment to the legal context. In recent years, there has been a growing internationalization of I/O psychology …

Organizational Image/Reputation, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Organizational image refers to people’s global impressions of an organization and is defined as people’s loose structures of knowledge and beliefs about an organization. Organizational image represents the net cognitive reactions and associations of customers, investors, employees, and applicants to an organization’s name. Accordingly, it serves as a template to categorize, store, and recall organization-related information.

How Future Work Selves Guide Feedback Seeking And Feedback Responding At Work, Frederik Anseel, Karoline Strauss, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Providing feedback is one of the most widely accepted psychological interventions for learning and development. The belief that giving feedback to employees is beneficial for individual and organizational performance is also strongly held in organizations. Therefore, providing feedback to employees lies at the heart of a wide range of often costly and time-intensive performance management tools in organizations. However, contrary to these beliefs, meta-analytic evidence shows that feedback interventions do not produce unequivocal positive effects on performance (Kluger & DeNisi, 1996).

How Crisis Managers Define Ethical Crisis Communication In Singapore: Identifying Organizational Factors That Influence Adoption Of Ethical Stances, Augustine Pang, Yan Jin, Benjamin Meng-Keng Ho

Research Collection Lee Kong Chian School Of Business

This study explores the veracity of the six ethical variables proposed in the contingency theory of strategic conflict management – the role of PR practitioner, the role of top management, nature of the crisis, the activism of stakeholders; government regulation/intervention; diversity to different cultures and exposure external business environments. In-depth interviews with 10 communication professionals in Singapore were conducted. In line with the patriarchal management structure, the top management plays a critical role in determining ethical stances, with practitioners playing important consultative positions. Also, the role of the relevant government almost predisposes the organization toward certain ethical stances. The study …

The Phantom Segregationist: Kentucky's 1996 Desegregation Amendment And The Limits Of Direct Democracy, D. Stephen Voss

Commonwealth Review of Political Science

Decades after Kentucky abolished de jure racial distinctions in education, the state legislature asked voters to strip segregationist language from their venerable constitution. Political elites were stunned when a third of the state's voters, and majorities in five countries, rejected the change. However, the prime culprit for Kentucky's 1996 constitutional amendment vote was not white racism, because African-American voters endorsed segregation at rates similar to whites. Rather, the Kentucky vote offers a particularly clear and particularly dramatic example of the limits of ballot-box policy making. It should alert scholars that highly publicized referenda in high-profile states - the focus of …

“Young Men Of Erin, Our Dead Are Calling”: Death, Immortality And The Otherworld In Modern Irish Republican Ballads, Seán Ó Cadhla

Articles

Irish physical-force Republicanism has long been noted for its tendency to promote the tropes of martyrdom and immortality as core tenets of its ideological belief system. This essay sets out to examine the genre of Republican death ballads so as to identify how such essentialist concepts are represented and promoted within the attendant song tradition. Particular attention will be paid to works that deploy overtly supernatural tropes in order to articulate the key Republican concept of heroic immortality. The present research will demonstrate the consistency with which such narrative devices have been retained within the Republican song tradition into the …

Rrh Library Newsletter, January 2017, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: Human Trafficking

Moore Kinship: Foreword, R.A. Lenhardt, Clare Huntington

Faculty Scholarship

Forty years ago, Mrs. Inez Moore, a widowed black mother and grandmother of little means, secured a victory that likely seemed improbable to many. Without any money, but with the assistance of a team of dedicated Legal Aid attorneys, she took her lawsuit challenging an East Cleveland, Ohio, zoning ordinance that made it a crime for her to live with her grandson all the way to the U.S. Supreme Court and won. The ordinance permitted certain extended family configurations to reside together within the city’s limits, but it prohibited Inez’s family arrangement. Just by bringing her infant grandson John Jr., …

Simplexity: Plain Language And The Tax Law, Joshua D. Blank, Leigh Osofsky

Articles

In recent years, federal government agencies have increasingly attempted to use plain language in written communications with the public. The Plain Writing Act of 2010, for instance, requires agencies to incorporate "clear and simple" explanations of rules and regulations into their official publications. In the tax context, as part of its "customer service" mission, the Internal Revenue Service bears a "duty to explain" the tax law to hundreds of millions of taxpayers who file tax returns each year. Proponents of the plain language movement have heralded this form of communication as leading to simplicity in tax compliance, more equitable access …

A Tale Of Two Clinics: Similarities And Differences In Evidence Of The Clinic Effect On The Development Of Law Students' Ethical And Altruistic Professional Identities, Jonel Newman, Donald Nicolson

Articles

No abstract provided.

How Should The E.U. Respond To Brexit And Trump?: The Lessons From Trade Wars, John C. Coffee Jr.

Faculty Scholarship

The U.K.’s decision to exit the E.U. (popularly known as “Brexit”) sets the stage for a potential retaliatory trade war. Similarly, the aggressive nationalism of U.S. President Donald Trump does also. In both cases, game theory suggests how such a conflict might be resolved. This paper first examines three standard game theory models – the Chicken Game, the Prisoner’s Dilemma, and the Stag-Hunt Game – and then turns to the strong incentives for rent-seeking by special interests and considers how rent-seeking likely affects how these games might play out. Although the conventional wisdom expects that the U.K. will suffer retaliation …

The Separation Of Corporate Law And Social Welfare, William Wilson Bratton

Articles

No abstract provided.

Supermarket Pricing Model Impact On Private Label Brands Versus National Brands Among Millennial Consumers, Jeffrey Hendrix, Vinny Caraballo

AMTP Proceedings 2017

National Brands (NBs) and private label brands (PLBs) play a vital role in manufacturing and retailing strategies. Market share growth of PLBs over the past few decades continues to level the playing field; altering go-to-market strategies for both NB and PLB manufacturers and retailers. A quantitative examination compared purchase data between NB versus PLB using panel data from 100,000 households. Consumer metrics; trip conversion, buyer conversion, and dollar loyalty served as dependent variables interacting with a multivariate grouping of branding (NB vs. PLB), grocery pricing model (Hi-Lo vs. EDLP vs. Hybrid) and age-cohort (Millennial vs. Generation X). A MANOVA provided …

Art By Jerks, Bernard Wills, Jason Holt

Contemporary Aesthetics (Journal Archive)

Is it wrong to enjoy art created by immoral people? Some people express discomfort with listening to or reading the works of artists who have been abusive to others in their personal lives. In this paper, the authors argue that, generally speaking, moral and aesthetic judgment should be kept distinct, as authors and their works formally differ. Indeed, works by morally dubious artists may well contain crucial acts of moral imagination we should not deprive ourselves of as ethical beings. Nonetheless, the authors argue there are limits to how far the ethical and aesthetic can be divorced. Art that is …

On The Front: Aesthetics Vs. Popular Arts And Mass Culture - I, Ken-Ichi Sasaki

Contemporary Aesthetics (Journal Archive)

The popular arts and mass culture represent our environment. The flood of their products reduces high art to minority status. This situation leads us to reconsider the privileged status of high art and the role of aesthetics as its theory, which is my main focus here. I take up three different cultural eras: early modern times, when the notions of art and aesthetics as a philosophical discipline were founded; our own day as the time of mass culture; and, lastly, the popular culture in the Edo period in Japan, the seventeenth to the mid-nineteenth centuries, which reflected different choices.

In …

Everyday Aesthetics And Everyday Behavior, Ossi Naukkarinen

Contemporary Aesthetics (Journal Archive)

This article addresses everyday aesthetics from the point of view of everyday behavior. I suggest that the ordinary daily interaction of people with each other is one of the most important areas of everyday aesthetics. I present an interpretation of the concepts of both the everyday and aesthetics, and argue that in the context of everyday social relationships, it is wise to understand everyday aesthetics in a way that emphasizes the very everydayness of aesthetics, not its opposite, namely non-everyday or extraordinary aesthetics. This does not mean that extraordinary aesthetics would not have its place in other contexts, but it …

Performer, Persona, And The Evaluation Of Musical Performance, Theodore Gracyk

Contemporary Aesthetics (Journal Archive)

Engaging with recent ideas about the moral evaluation of art, I argue that facts about the lifestyle, attitudes, and moral character of music performers are relevant to evaluating a musical performance. When it contributes to a better understanding of the performance, this knowledge contributes to a more accurate estimation of its aesthetic merits and flaws. I explain how my view departs from those of Berys Gaut and Jeanette Bicknell.

The Role Of Imperfection In Everyday Aesthetics, Yuriko Saito

Contemporary Aesthetics (Journal Archive)

The notions of perfection and imperfection do not have the same prominent presence they once occupied in earlier aesthetics discourse. However, they still play an important role as criteria for aesthetic judgments today in our everyday life. The wide-spread and easily accepted aesthetic appeal of objects with perfection tends to overshadow the potential aesthetic value of imperfect objects that are considered to be defective or deficient. This not only impoverishes our aesthetic lives but also leads to some serious environmental and social consequences. I first argue for the need to cultivate an aesthetic sensibility to appreciate imperfection in our everyday …

A Conceptual Framework For The Aesthetics Of Everyday Object Appreciation, Russell Quacchia

Contemporary Aesthetics (Journal Archive)

This essay takes up the topic of the aesthetics of everyday object experience. In doing so, it strings together a series of fairly complex topics as a conceptual framework. Its focus is upon the nature of certain core features that appear to be at work in giving rise to this kind of experience. It especially considers the role of such features as the aura property of phenomenal objects and the self-activation of aesthetic-interested attention. It gives a level of explanation to the crucial topic of why we tend to ignore taking an active interest in the aesthetic dimension of everyday …

The Aesthetics Of Conversation: Dewey And Davidson, Kalle Puolakka

Contemporary Aesthetics (Journal Archive)

Conversation is one of the most mundane events of human life, yet the conversations we have can vary a lot. Some proceed only with great effort, while others engage us thoroughly. Drawing on Dewey’s aesthetics, this paper argues that the movement and rhythm of conversations can make them into genuine candidates for an aesthetic status. The key term of the paper is interaction. For Dewey, all experience, aesthetic experience included, is constituted by an interaction between humans and their environment. In his later philosophy of language, which is critical of conventionalist explanations of language, Davidson, in turn, offers a very …

Autonomania: Music And Music Education From Mars, Thomas A. Regelski

Contemporary Aesthetics (Journal Archive)

Traditional aesthetic theory has posited an account of music, and the other arts, as autonomous of social meanings, relevance, and conditions. In the case of music, “absolute music” is sequestered from social and other roots that bring music into being in the first place. The typical claim, thus, is that classical music is music for its own sake, divorced from the many and highly evident social dimensions that it serves. It ignores all other genres of music, most of which are more appreciated than can be accounted for by the theory of autonomania. This aesthetic theory of music, one of …

Sublime And Anti-Sublime: Reconsidering The Relation Of The Sublime To Technology, Konstantinos Vassiliou

Contemporary Aesthetics (Journal Archive)

The aesthetic notion of the sublime has been traced in different fields in the growing spheres of technology, capitalism, and digitality. The variable character of the sublime is partly due to the fact that it is identified with specific objects or sources. It can emerge whenever there is an antithesis between the infinite extensions of reason and the limits of the representative faculty. Taking into account this variance, this article seeks to reexamine the relationship of the sublime to technology, especially in view of current digital capabilities. In doing so, I argue that the notion of the sublime involves its …

Bio-Aesthetics: The Evolution Of Sensibility Through Nature, Katya Mandoki

Contemporary Aesthetics (Journal Archive)

[1] This paper gathers a few points developed in my recent book, The Indispensable Excess of the Aesthetic: Evolution of Sensibility in Nature, where I explore the processes that involve aisthesis from their most primal manifestations to their more complex. I propose the concept of bio-aesthetics as the study of all forms of sensibility in living beings, and that, given the fact that it is a function of our corporeal condition, the required starting point is the evolutionary paradigm. Another crucial tool for understanding how different types of creatures value, understand, react, and relate to their environment is provided by …

Master Narratives And The Pictorial Construction Of Otherness: Anti-Semitic Images In The Third Reich And Beyond, Michael Ranta

Contemporary Aesthetics (Journal Archive)

Collective identities of the Self (or Ego) vs. the Other are not only conveyed in and between cultures through verbal discourse but also through pictures. Such cultural constructions are often established and consolidated by storytelling, where, briefly put, events or situations are temporally ordered. Pictures and visual artworks may be powerful narrative resources for establishing and consolidating cultural stances and framing actions. In this paper, I shall focus upon demarcation efforts of Jews as the Other from the Middle Ages onwards, in the Third Reich’s iconography, and in modern, radicalized forms of anti-Semitic picturing in Arab media. Within overarching master …