Digital Commons Network^™

Synthetic (P)Ppgpp Analogue Is An Inhibitor Of Stringent Response In Mycobacteria, Kirtimaan Syal, Kelly Flentie, Neerupma Bhardwaj, Krishnagopal Maiti, Narayanaswamy Jayaraman, Christina L. Stallings, Dipankar Chatterji

Open Access Publications

No abstract provided.

Randomized, Open-Label, Phase 1/2a Study To Determine The Maximum Tolerated Dose Of Intraventricular Sustained Release Nimodipine For Subarachnoid Hemorrhage (Newton [Nimodipine Microparticles To Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]), Daniel Hanggi, Nima Etminan, Francois Aldrich, Hans Jakob Steiger, Stephen A. Mayer, Michael N. Diringer, Brian L. Hoh, J Mocco, Herbert J. Faleck, R. Loch Macdonald, Newton Investigators

Open Access Publications

No abstract provided.

A Case Of Apparent Upper-Body Freezing In Parkinsonism While Using A Wheelchair, Samuel T. Nemanich, Marie E. Mcneely, Gammon M. Earhart, Scott A. Norris, Kevin J. Black

Open Access Publications

No abstract provided.

Stat3/Cdc25a-Dependent Cell Proliferation Promotes Embryonic Axis Extension During Zebrafish Gastrulation, Yinzi Liu, Diane S. Sepich, Lilianna Solnica-Krezel

Open Access Publications

No abstract provided.

Antipyretic Therapy In Critically Ill Septic Patients: A Systematic Review And Meta-Analysis, Anne M. Drewry, Enyo A. Ablordeppey, Ellen T. Murray, Carolyn R.T. Stoll, Sonya R. Izadi, Catherine M. Dalton, Angela C. Hardi, Susan A. Fowler, Brian M. Fuller, Graham A. Colditz

Open Access Publications

No abstract provided.

Loss Of Navβ4-Mediated Regulation Of Sodium Currents In Adult Purkinje Neurons Disrupts Firing And Impairs Motor Coordination And Balance, Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, Jeanne M. Nerbonne

Open Access Publications

No abstract provided.

Phase 1 Results Of Zuma-1: A Multicenter Study Of Kte-C19 Anti-Cd19 Car T Cell Therapy In Refractory Aggressive Lymphoma, Nancy L. Bartlett, Armin Ghobadi, Et Al

Open Access Publications

No abstract provided.

The Role Of Retinol Dehydrogenase 10 In The Cone Visual Cycle, Yunlu Xue, Shinya Sato, David Razafsky, Bhubanananda Sahu, Susan Q. Shen, Chloe Potter, Lisa L. Sandell, Joseph C. Corbo, Krzysztof Palczewski, Akiko Maeda, Didier Hodzic, Vladimir J. Kefalov

Open Access Publications

No abstract provided.

Long-Term Kidney Outcomes Among Users Of Proton Pump Inhibitors Without Intervening Acute Kidney Injury, Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Yan Yan, Ziyad Al-Aly

Open Access Publications

No abstract provided.

How Existing Environmental Laws Respond To Climate Change And Its Mitigation, Justin Gundlach

Sabin Center for Climate Change Law

Existing environmental laws interact with public health priorities and with aspects of the changing climate in numerous and varied ways. This chapter does not attempt to catalogue those interactions, but instead focuses on two that are especially important and illustrative of the operation and limitations of existing environmental laws vis-à-vis climate change-driven challenges. The first interaction is between pollution levels boosted by climate change and pollution control laws that employ health-based standards to determine pollution limits. The second is between a wider array of existing laws and the effects of climate change mitigation measures on public health. Examining these interactions …

Critics Float Legal Theories To Challenge Pruitt's Science Advisor Policy, Maria Hegstad

Sabin Center for Climate Change Law

House Democrats and a Columbia University law professor are detailing possible legal arguments that could be used to challenge Administrator Scott Pruitt’s controversial new directive barring scientists who are receiving an EPA research grant from serving on one of its scientific advisory committees.

Transparency And Icao's Aviation Offsetting Scheme: Two Separate Concepts?, Aoife O'Leary

Sabin Center for Climate Change Law

The International Civil Aviation Organisation (ICAO), the UN specialised body for aviation, is developing a scheme to reduce the climate impact of aviation emissions, the Carbon Offsetting and Reduction Scheme for International Aviation (CORSIA). From 2021, participating countries will (voluntarily at first) offset any growth in CO2 aviation emissions above the level those emissions have reached in 2020. This paper does not consider the climate implications of the scheme but rather focuses on whether the governance structure under which the scheme is being developed – especially its transparency and opportunities for public participation – meets an appropriate standard, given the …

Appliance And Equipment Efficiency Standards: A Roadmap For State And Local Action, Peter Ross

Sabin Center for Climate Change Law

For decades, federal energy and water efficiency standards have demonstrably saved consumers money, reduced pollution, and increased grid reliability. The U.S. Department of Energy (“DOE”) periodically reviews standards and test procedures for more than 60 products, representing about 90% of home energy use, 60% of commercial building energy use, and 30% of industrial energy use. Due in part to their incremental nature and proven track record of success, these standards have been relatively uncontroversial, and often have been reached via consensus between manufacturers seeking regulatory certainty and environmental advocates seeking greater efficiency.

Recently, however, the political winds have shifted. Immediately …

To Negotiate A Carbon Tax: A Rough Map Of Policy Interactions, Tradeoffs, And Risks, Justin Gundlach

Sabin Center for Climate Change Law

Sooner or later, the federal government will assign a price to carbon dioxide emissions via legislation. The contents of that legislation will reflect negotiated agreement – built on various political tradeoffs – over a host of policy issues, ranging from taxes to energy efficiency standards. These tradeoffs would implicate not only the scope and price assigned by the carbon pricing policy, but also the policies with which it would interact. This paper anticipates that price will take the form of a carbon tax and describes interactions between that tax and various existing and proposed policies relating to climate change, energy, …

Act Locally, Reflect Globally: A Checklist Of Options For U.S. Cities And States To Engage Internationally In Climate Action, Susan Biniaz

Sabin Center for Climate Change Law

U.S. cities and states are increasingly asking how they can play a more visible and active role in international climate change efforts.

Cities and states have obvious incentives to take action to mitigate and adapt to climate change. But why engage internationally? They may seek to demonstrate leadership or gain appropriate recognition for “doing their part.” They may want to inspire others to follow suit or support them in doing so, such as through exchanging best practices. They may seek to join the global march toward low-emission and resilient societies. Or they may want to show the world that U.S. …

The Energy Improvement Of The Urban Existing Building Stock: A Proposal For Action Arising From Best Practice Examples, Teresa Parejo-Navajas

Sabin Center for Climate Change Law

Improving energy efficiency in existing buildings presents an opportunity for reducing greenhouse gas emissions. Numerous measures meant to increase efficiency and decrease emissions have been implemented in cities across Europe and the United States. Standing out from the rest is New York City, a remarkable example of commitment to the fight against climate change. The city has urged its authorities to take important measures in order to eliminate (or at least diminish) the adverse effects resulting from its special characteristics, great urban density, and large percentage of greenhouse gas emissions coming from an aged building stock. Yet there is always …

Climate Legislation And Litigation In Brazil, Gabriel Wedy

Sabin Center for Climate Change Law

Brazil plays a major role in the global fight against climate change, especially because of its vast forests. However, the amount of deforestation now occurring is in great dispute. Between August 2014 and July 2015, for example, deforestation in the Amazon rainforest increased by 215% according to Imazon Research Institute. Contrarily, according to the Brazil Government, the increase was only 16%.

This paper discusses the role that legislation and litigation are playing, and the roles they may and should play in the future, in combatting deforestation and other factors relevant to climate change in Brazil.

10 Questions To Ask About The Proposed “Global Pact For The Environment”, Susan Biniaz

Sabin Center for Climate Change Law

There is no doubt that more needs to be done, both nationally and internationally, to protect the environment. It is tempting, particularly during the Trump era, to welcome any concerted effort to do so. The issue is whether the proposed “Global Pact” is the right vehicle for enhancing environmental protection.

The Global Pact was launched this past June in Paris, with support from, among others, President Macron of France and former California Governor Arnold Schwarzenegger. At least in its preliminary state, the Pact reflects broad, cross-cutting principles in legally binding form. France intends to seek support at the upcoming UN …

Carbon Pricing In New York Iso Markets: Federal And State Issues, Justin Gundlach, Romany M. Webb

Sabin Center for Climate Change Law

Does the law permit the New York Independent Service Operator (NYISO) to incorporate, directly or indirectly, a carbon price into New York State’s wholesale electricity market? And, if so, what is the appropriate design of a carbon pricing scheme for the NYISO market? For example, at what level should a carbon price be set and when/how should it be adjusted? How should the revenues generated by such a price be used? What impact (if any) will it have on the Regional Greenhouse Gas Initiative (RGGI) and New York’s Clean Energy Standard? This working paper explores answers to those questions with …

How Did Federal Environmental Impact Statements Address Climate Change In 2016?, Saloni Jain, Omri Klagsbald, Giovanna Leigh Crozier-Fitzgerald, Taylor Quinn, Elana Sulakshana

Sabin Center for Climate Change Law

In partnership with the Sabin Center for Climate Change Law, this project surveyed 31 federal environmental impact statements (EISs) published from September through November 2016. The objective was to evaluate how federal agencies were implementing the guidance released in August 2016 by the Council on Environmental Quality (CEQ) on how to account for climate change and greenhouse gas (GHG) emissions in the environmental review process.

The Application Of Open Records Laws To Publicly Funded Science, Lauren Kurtz

Sabin Center for Climate Change Law

The federal Freedom of Information Act (FOIA) and the state law equivalents promote government transparency by allowing citizens to request copies of administrative records. Any citizen can file a request with a government entity for copies of government documents, and the government must either produce the information or explain why it is exempt from production (for example, for national security purposes).

While these laws were originally written with an eye toward policy makers and bureaucrats, in recent years, these open records laws have been used increasingly to request information from publicly funded scientists. Scientists employed by federal agencies, state agencies, …

Downstream And Upstream Greenhouse Gas Emissions: The Proper Scope Of Nepa Review, Michael Burger, Jessica A. Wentz

Sabin Center for Climate Change Law

Recently, legal controversies have arisen regarding the scope of greenhouse gas emissions that should be considered in environmental reviews of fossil fuel extraction and transportation proposals under the National Environmental Policy Act (“NEPA”). The key question is whether and how agencies should account for emissions from activities that occur “downstream” from the proposed action, such as the combustion of fossil fuels, and emissions from activities that occur “upstream” of the proposed action, such as the extraction of fossil fuels. This question is important, because consideration of such emissions can alter the balance of costs and benefits for a proposed project …

The Status Of Climate Change Litigation: A Global Review, Michael Burger, Justin Gundlach

Sabin Center for Climate Change Law

Over the last decade, laws codifying national and international responses to climate change have grown in number, specificity, and importance. As these laws have recognized new rights and created new duties, litigation seeking to challenge either their facial validity or their particular application has followed. So too has litigation aimed at pressing legislators and policymakers to be more ambitious and thorough in their approaches to climate change. In addition, litigation seeking to fill the gaps left by legislative and regulatory inaction has also continued. As a result, courts are adjudicating a growing number of disputes over actions – or inaction …

Planning For The Effects Of Climate Change On Natural Resources, Jessica A. Wentz

Sabin Center for Climate Change Law

Climate change has important implications for the management and conservation of natural resources and public lands. The federal agencies responsible for managing these resources have generally recognized that considerations pertaining to climate change adaptation should be incorporated into existing planning processes, yet this topic is still treated as an afterthought in many planning documents. Only a few federal agencies have published guidance on how managers should consider climate change impacts and their management implications. This Article explains why these agencies are legally required to consider climate- related risks in planning processes, and presents recommendations and a model protocol for conducting …

Saudi Medical Journal 2016: A Year In A Review, Fahdah Alokaily

Saudi Medical Journal

No abstract provided.

Glycogenic Hepatopathy, An Underdiagnosed Cause Of Relapsing Hepatitis In Uncontrolled Type 1 Diabetes Mellitus, Zafar A. Zaidi, Amir M. Babiker

Saudi Medical Journal

Glycogenic hepatopathy is a rare condition that causes significant hepatomegaly and elevated liver enzyme levels in uncontrolled type 1 diabetic patients. It develops due to excessive accumulation of glycogen in the hepatocytes. It is typically reversible with good glycemic control and rarely progresses to mild fibrosis, but not cirrhosis.

Pediatric Spots

Saudi Medical Journal

No abstract provided.

Anesthesia Methods Used By Anesthetic Specialists For Circumcision Cases: National Survey Study For Turkey, Cafer Altaş, Gamze Küçükosman, Bülent S. Yurtlu, Rahşan D. Okyay, Bengü G. Aydın, Özcan Pişkin, Murat Çimencan, Hilal Ayoğlu, Volkan Hancı, Işıl Özkoçak-Turan

Saudi Medical Journal

Objectives: To examine the anesthesiologist’s choice for anesthesia techniques and drugs in circumcision and determine the preoperative examination, intraoperative monitoring techniques, postoperative analgesia methods, and common complications among anesthesiologists working in Turkey. Methods: This cross-sectional study was conducted at Bulent Ecevit University Hospital, Zonguldak, Turkey, between May and July 2012. Survey data were obtained via survey forms through electronic data over the web. The questionnaire consists of 20 questions. These questions included demographic data, methods of anesthesia for circumcision, postoperative analgesia methods, and monitoring methods. Results: The data were obtained from 206 anesthesiologists who agreed to participate in the survey. …

Efficacy Of Carboplatin-Based Preoperative Chemotherapy For Triple-Negative Breast Cancer: A Meta-Analysis Of Randomized Controlled Trials, Li-Yang Wang, Hua Xie, Hang Zhou, Wen-Xiu Yao, Xin Zhao, Yi Wang

Saudi Medical Journal

Objectives: To evaluate the efficacy and safety of carboplatin-based preoperative chemotherapy in triple-negative breast cancer patients (TNBC). Methods: PubMed, EMBASE, the Web of Science, the Cochrane Library, major clinical trial registries, and abstract collections from major international meetings were systematically searched for relevant randomized controlled trials. Endpoints included rates of pathologic complete response (pCR), overall response (ORR), breast-conserving surgery (BCS) and toxicity. Pooled relative risk (RR) was calculated for each endpoint using a fixed- or random-effect model depending on the heterogeneity among included studies. Results: A total of 5 randomized controlled trials involving 1007 patients were included in the meta-analysis. …

Diagnostic Performance Of Bone Metabolic Indexes For The Detection Of Stroke, Li-Ming Tan, Lu Wang, Juan-Juan Chen, Hua Li, Wen-Bo Luo

Saudi Medical Journal

Objectives: To explore the diagnostic performance of 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), bone alkaline phosphatase (BALP), and osteocalcin (OC) in predicting stroke. Methods: This retrospective survey was conducted in The Second Affiliated Hospital to Nanchang University, Nanchang, Jiangxi Province, China. involved 121 cerebral infarction patients and 103 cerebral hemorrhage patients as the experimental groups, 100 volunteers as the healthy control group and 80 brain trauma patients as the disease control group. The 25(OH)D, PTH, BALP, and OC levels of all participants were measured by electrochemiluminescence immunoassay. Results: The serum concentration of 25(OH)D in stroke patients was appreciably lower than …