Digital Commons Network^™

Enterprise Architecture In Poland – The State Of Present And Main Directions Of Evolution, Andrzej Sobczak

European Management Studies

The article aims to present the current implementation of corporate architecture in Polish organizations and to outline possible scenarios for further evolution of this concept. It is based on the analysis of results of the research conducted by its author among companies and public administration units in 2010–2016. The findings provide grounds for concluding that the architectural approach has stagnated after years of dynamic growth in its popularity (ensuing from a considerable increase in awareness of this idea). Many organizations have spotted that the classical mechanisms of corporate architecture management are becoming insufficient in the world of ever faster business …

How To Live In This World, Kim Bongiorno

Erma Bombeck Writers' Workshop Blog

Terrible, gut-wrenching, brain-crashing things happen in life. They don't just throw those who are living through it off balance. We are a web of humanity, one door front, one neighborhood, one phone call, one click away. We know one another's business, and it rocks us all.

Guns And Sorcery: Raiding, Trading, And Kanaima Among The Makushi, James Andrew Whitaker

Tipití: Journal of the Society for the Anthropology of Lowland South America

Raiding, trading, and sorcery are historically-interrelated phenomena among the Makushi Amerindians in Guyana. Colonial documents reveal that the Makushi were heavily targeted during the eighteenth and early nineteenth centuries by Luso-Brazilian and Amerindian slavers. The form of such slaving frequently fluctuated between raiding and trading and formed a nexus around which practices of sorcery came to be centred. A connexion between the historical positions of the Makushi as victims of slaving and practitioners of kanaima sorcery has been identified by Neil Whitehead, who hypothesized that kanaima practices gained socially-sanctioned applications as the introduction of guns led to transformations in traditional …

Persuasive Kinship: Human–Plant Relations In Southwest Amazonia, Fabiana Maizza

Tipití: Journal of the Society for the Anthropology of Lowland South America

Based on my ethnographic research with the Jarawara people, an indigenous society in the Southwest Amazonia, the article explores the idea of thinking kinship as persuasion. Among the Jarawara, children can have more than one father, which is well known in Americanist literature, but there would exist as well an original practice what we could call "multi-maternity". I also observe that the Jarawara can have diverse parental relations - some of their children are human, while others are plants. This occurs in a system of raising (nayana) in which children and plants are raised by a father and/or a mother …

The Role Of Yes-Associated Protein 1 In Ovarian Physiology And Pathology, Xiangmin Lv

Theses & Dissertations

Ovarian granulosa cells are the major somatic components of the ovarian follicle. Proper proliferation and differentiation of ovarian granulosa cells are essential for successful follicle development. Accumulating evidence indicates that the Hippo-YAP signaling pathway plays critical roles in both development and tumorigenesis of several organs. The present study aims to investigate the role of Yes-associated protein 1 (YAP) in ovarian granulosa cell proliferation, differentiation, and malignant transformation. At first, we found that nuclear YAP (active) was highly expressed in proliferative granulosa cells, whereas cytoplasmic YAP (inactive) was detected mainly in terminally-differentiated luteal cells. Further studies suggested that endogenous YAP activity …

Effective Training Modalities To Teach The Use Of Naloxone Nasal Spray, Dominick V. Zurlo

Individual, Family, and Community Education ETDs

This paper examines the use of four different modalities to teach the correct assembly and administration method to use a naloxone nasal device. Naloxone is a medication which can reverse an opioid overdose when administered correctly. This specific device has been used for over a decade, and has been instrumental in opioid prevention educational programs to bystanders and individuals who use substances (NMDOH, 2017). Prior research studies utilizing naloxone nasal devices, have included outcome data collected from programs which train individuals who use opioids, and distribute the naloxone nasal device (Kerr, 2008). Others have included examination of curriculum content with …

Board Of Trustees Meeting Minutes, December 15, 2017

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 15, 2017.

“The Price Of Their Blood And Of Your Independency”: The Social And Economic Disparities Within The Connecticut Line, Ernest Lucian Andreoli Iii

History & Classics Undergraduate Theses

For decades, historians have debated the extent of the social and economic divisions within the Continental Army. Middling, as well as poverty-stricken farmers and mechanics were at the heart of the American Revolution, and were the daring laborers that eventually comprised the majority of the Continental Army. Although no scholar has undertaken a comprehensive analysis on the social and wealth distribution of the Connecticut Line, I did so by constructing a set of case studies on Connecticut soldiers, unveiling the impact of rationing techniques on low-to-middle income soldiers, incorporating why market forces effected the financial security of Connecticut Continentals, as …

Can Addressing Language Skills For Fifth Grade Ells In A Multiplication Curriculum Help Address The Achievement Gap In Math? A Multiplication Workbook For Big Kids, Michelle Douglas

Master's Projects and Capstones

Currently, the state of California has 1,332,405 students from grades k-12 who speak a language other than English at home (Caledfacts, 2016). When I started my first year teaching fifth grade with 95% of my students being English language learners (ELLs), I was surprised to see an achievement gap of two to three years in my student’s reading and math skills. I found that my student’s developmental language and math skills contributed to a lack of engagement during math time. Upon further research, I found that these three factors play a role in the wide achievement gaps between ELLs and …

Discharge By 11:00 Am And The Effects On Throughput, Gena Bravo

Master's Projects and Capstones

This Clinical Nurse Leader project aims to improve the discharge process to increase the percentage of patients discharged before 11:00 AM on the Progressive Care Unit (PCU). One evidence-based approach to help alleviate capacity constraints in the hospital is to create an effective and timely discharge process. The goal of this project is to educate the front line staff, care coordinators, and providers to a standardized discharge process. The PCU is a cardiac telemetry unit with 30 private rooms. The patients on the PCU are post-cardiac surgery with some overflow medical patients throughout the unit. Kotter’s theoretical framework was chosen …

Lessons Learned From Cuba: Using Healthcare Systems And Stillbirth Rate Example, Ravi Patel

Master's Projects and Capstones

Cuba and the U.S. have different health care systems but similar health outcomes. In 2015 U.S. and Cuba had the same stillbirth rate. Cuba is a prevention-based system that is free for all, while the U.S. is a treatment-based system that uses a fee for service system. Cuba has ratified international laws that hold it accountable for improving health outcomes especially for women and children. The U.S. can learn from Cuba when it comes to improving health outcomes. The U.S. can improve their health outcomes by including more preventative based interventions and ratifying international law that will hold the U.S. …

Preserving The Health & Well-Being Of Elderly Adults: Encouraging Standards Of Care Within Residential Care Facilities, Katie Schollander

Master's Projects and Capstones

Hospitalizations are expensive to our healthcare system, and too often can be prevented. A large portion of preventable hospital stays are elderly individuals. In this case, these hospitalizations can also be detrimental to the health of the individual, as they may begin to decline while not going through their daily routines. The Institute on Aging (IOA) is an agency that seeks to keep elderly and disabled adults out of institutionalization. The Community Care Settings Pilot Program (CCSP) is a subset of IOA as a whole, which works with the San Mateo Health Plan patients. Residential care facilities for the elderly …

Health Starts In The Home: An Assessment Of Efforts To Improve Occupant Health Through Healthy Building Materials In San Francisco’S Affordable Housing, Staci Hoell

Master's Projects and Capstones

Americans spend 90% of their lives indoors, and much of this time is spent at home, surrounded by building materials that typically have added chemicals like flame retardants, highly fluorinated compounds, and antimicrobials. Recent research has linked these chemicals to adverse health outcomes such as asthma, endocrine disruption, cancer, neurodevelopmental issues, and reproductive problems (Bayer et al., n.d.; Green Science Policy Institute). Furthermore, these chronic health conditions disproportionately affect low-income populations. Fortunately, substantial efforts in research, practice, and policy are working to reduce the use of these potentially harmful chemicals in building materials, particularly in San Francisco’s affordable housing sector. …

Dancing At My Desk: Examining The Foundations Of A Nonprofit Dance Education Organization, Caeli Koizumi

Honors Thesis

With the implementation of the Common Core State Standards, the demand for further development in arts education has grown. In California, the Visual and Performing Arts have been mandated components of education since 2001; yet, students often experience limited and inconsistent access to the arts due to budget cuts. Thus, the need for a specialized approach to synthesizing the arts and education is imminent. Arts Integration, a pedagogical method that refers to the combination of a visual or performing art with a core content area to provide equal understanding of a topic from both selected fields, is sprinkled throughout primary …

Horizontal Cybersurveillance Through Sentiment Analysis, Margaret Hu

William & Mary Bill of Rights Journal

This Essay describes emerging big data technologies that facilitate horizontal cybersurveillance. Horizontal cybersurveillance makes possible what has been termed as “sentiment analysis.” Sentiment analysis can be described as opinion mining and social movement forecasting. Through sentiment analysis, mass cybersurveillance technologies can be deployed to detect potential terrorism and state conflict, predict protest and civil unrest, and gauge the mood of populations and subpopulations. Horizontal cybersurveillance through sentiment analysis has the likely result of chilling expressive and associational freedoms, while at the same time risking mass data seizures and searches. These programs, therefore, must be assessed as adversely impacting a combination …

Habitat Selection, Survival, And Movement Ecology Of The American Woodcock (Scolopax Minor) In Louisiana Usa, Elisa Constancia Elizondo

LSU Master's Theses

The American Woodcock (Scolopax minor) is a migratory upland game species occurring across much of eastern North America. Across its breeding range in the northern U.S. and southern Canada, this species has experienced significant, pervasive declines over the last half century. As woodcock populations continue to decline, active habitat management for this species has become increasingly important.

The state of Louisiana has substantial amounts of woodcock habitat and receives wintering birds from across the woodcock range. However, few data exist regarding survival rates, habitat utilization, and movement patterns across the state.

In order to better manage for woodcock …

Cpap-Mad Combination Therapy For Cpap Intolerant Patients With Moderate To Severe Osa, Jacob Stadiem

Theses & Dissertations

The treatment of obstructive sleep apnea (OSA) allows for a multidisciplinary approach between dentistry and medicine. Continuous positive airway pressure (CPAP) is the gold standard for OSA treatment, but the non-adherence rates are high. The mandibular advancement device (MAD) has a higher acceptance rate than the CPAP, however the efficacy is much lower in cases of moderate to severe OSA. This thesis attempted to evaluate if there was a change in compliance when a MAD was added as a combination therapy to moderate to severe OSA subjects that were currently non-compliant with their CPAP. In addition, the change in air …

Pictures Of You, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Data Snapshot: Poorer Working Families With Young Children And No Out-Of-Pocket Child Care Struggle Financially, Robert Paul Hartley, Beth Mattingly, Christopher Wimer

Carsey Publications

Low-income families with working parents face significant burdens paying for child care, which can function as a barrier to work and often means parents must rely on child care arrangements that are less formal and less stable.

Food Deserts: What Are The Decisions To Achieving A Healthy Life And Well-Being In Low Income €“ Low Access Neighborhoods?, Roxanne Jimenez

Student Scholarship

There has been a great deal of academic material and public policy published on food deserts, however, there still are significant gaps of understanding in regard to the lived experience of those individuals residing within those geographical locations. This study employed a qualitative methodology to elicit the lived experiences of 20 people who are living within a food desert. The findings from this research suggest those residing in food deserts, do not plan their purchases and travel to markets outside of their immediate neighborhoods in search of food products that have quality, variety and lower price points. It was also …

Self-Efficacy For Symptom Management In Adult Hematopoietic Stem Cell Transplant Patients, Lynn White

Theses & Dissertations

Hematopoietic stem cell transplant (HSCT) is a treatment for hematologic cancers and other hematologic conditions that causes severe treatment-related symptoms. The first 30 days after HSCT, or the acute phase, is when symptoms are most intense. During this time, the ability of patients to manage their symptoms, in collaboration with their health care providers, is crucial to reduce the distress caused by the symptoms. Self-efficacy is the person’s confidence in their ability to perform a behavior, such as symptom management. This body of work describes the concept of self-efficacy for symptom management (SESM), presents an integrated literature review on self-efficacy …

Novel Therapeutic Strategies For Treatment Of Castration-Resistant Prostate Cancer, Matthew A. Ingersoll

Theses & Dissertations

Prostate cancer (PCa) remains the most commonly diagnosed solid tumor and is the third leading cause of cancer-related death in United States men. While androgen deprivation therapy is the current standard-of-care treatment for metastatic PCa, most patients eventually relapse and develop castration-resistant (CR) tumors, for which there is currently no effective treatment. Therefore, synthesis of novel therapeutic agents and identification of alternative target proteins are necessary to improve treatment. Herein, I investigate the efficacy of novel imidazopyridine and statin derivatives as alternative therapeutic compounds. These molecules not only inhibit androgen receptor signaling, but also block activation of the AKT axis, …

Organizational Effects Of Defeminizing Toxicants: Lessons Learned From An Environmental Sentinel Organism, The Fathead Minnow., Jonathan Ali

Theses & Dissertations

Endocrine disrupting compounds (EDCs) are chemicals that interfere with hormone function and are increasingly detected in aquatic environments, where they elicit adverse effects from exposed organisms. The toxicological effects of EDCs can be described as either activational (reversible) or organizational (irreversible), where the latter are associated with adverse outcomes in reproductive performance of adult fish. However, few studies have investigated the organizational impacts of anti-estrogenic or “defeminizing” EDCs, e.g. agrichemicals or pharmacological agents, in an environmentally-relevant or “sentinel” species. The objective of this study was to investigate the impacts of early-life EDC-initiated changes in estrogenic gene expression on organizational effects …

A Role For Δ-Catenin In Synaptic Regulation, Li Yuan

Theses & Dissertations

The cadherin-catenin complex regulates cell-cell adhesion and signal transduction in epithelial cells. It is becoming increasingly evident that components of the complex regulate various aspects of neuronal architecture and function. δ-catenin is a cytosolic component of the cadherin-catenin complex and is predominantly expressed in the central nervous system. Loss of CTNND2, which encodes δ-catenin, is associated with intellectual disability and mutations in CTNND2 have been identified in autism, suggesting that δ-catenin is a critical component of the molecular machinery underlying neural circuit function. We have previously demonstrated that δ-catenin regulates multiple aspects of synaptic and dendritic development, including dendritic …

Effects Of Gm-Csf On Dendritic Cells And Regulatory T Cells In Parkinson’S Disease Patients And Models Of Parkinson’S Disease, Charles Schutt

Theses & Dissertations

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. Pathologically, loss of nigrostriatal neurons and dopamine released by these neurons are responsible for PD motor symptoms. During PD, activation of resident microglia and infiltrating lymphocytes leads to progressive neuroinflammation and reduction in the number and function of regulatory immune cells. Neuroinflammation contributes to progressive neurodegeneration and declining motor function. Reducing neuroinflammation is the target for novel PD therapeutics. Our goal is to increase the number and function of regulatory T cells (Tregs) in PD patients to decrease neuroinflammation and reduce PD symptoms. One potential therapy is granulocyte-macrophage colony stimulating …

Identifying The Role Of Janus Kinase 1 In Mammary Gland Development And Breast Cancer, Barbara Swenson

Theses & Dissertations

The development of the postnatal mammary gland is tightly controlled by peptide hormones and cytokines. The signaling of these extracellular ligands through their corresponding receptors rely on Janus Kinases (JAKs) that activate downstream Signal Transducers and Activators of Transcription (STATs). The JAK/STAT signaling pathway is crucial for processes such as growth, proliferation, and cell survival of the epithelial tissue, but also for the breakdown and remodeling of the mammary gland via IL-6 class inflammatory cytokines (e.g. LIF and OSM). JAK1 and JAK2, which are expressed in the mammary gland, are thought to have redundant functions. However, our previous studies demonstrated …

In-Vitro And In-Vivo Models Of Bile Acid Metabolism And Transport, Rhishikesh Thakare

Theses & Dissertations

All biomedical research is conducted in animal models first. In addition, the Food and Drug Administration requires extrapolation from animal data to predict human responses. There are ongoing scientific and regulatory challenges translating interspecies comparisons and predictions. Metabolic pathways are a cornerstone to understanding drug metabolism and toxicities and the liver is a key organ in this process. Bile acids (BAs) play a central role in the hepatobiliary toxicities of chemicals, toxins, and biological reagents. BAs have many physiological functions including regulation of genes involved in cholesterol and glucose metabolism and BA homeostasis. However, BAs also have several pathological effects …

Role Of Ezrin In Colorectal Cancer Cell Survival Regulation, Premila Leiphrakpam

Theses & Dissertations

Colorectal cancer (CRC) is the second most common cause of cancer related deaths in the United States, mainly due to metastasis to the distant organ sites. However, the molecular basis of CRC metastasis is poorly understood. Therefore, identification and characterization of novel potential anti-cancer therapeutic targets CRC is of urgent need. Utilizing a 2D-DIGE proteomics approach ezrin was identified as a protein that is differentially expressed between primary colon tumors xenografts, orthotopically implanted in athymic nude mice, and corresponding and liver metastatic deposits. Ezrin, a cytoskeletal protein belonging to the ezrin–radixin–moesin (ERM) family plays important roles in cell motility, invasion …

Focus: A Graph Approach For Data-Mining And Domain-Specific Assembly Of Next Generation Sequencing Data, Julia Sommer

Theses & Dissertations

Next Generation Sequencing (NGS) has emerged as a key technology leading to revolutionary breakthroughs in numerous biomedical research areas. These technologies produce millions to billions of short DNA reads that represent a small fraction of the original target DNA sequence. These short reads contain little information individually but are produced at a high coverage of the original sequence such that many reads overlap. Overlap relationships allow for the reads to be linearly ordered and merged by computational programs called assemblers into long stretches of contiguous sequence called contigs that can be used for research applications. Although the assembly of the …

Exploring Perceptions And Experiences With Resources Among Rural Alzheimer's Dementia Family Caregivers In The Midwest, Rita M. Million

Theses & Dissertations

Exploring PERCEPTIONS AND EXPERIENCES WITH RESOURCES AMONG RURAL Alzheimer’s Dementia Family Caregivers in the Midwest

Rita M. Million

University of Nebraska, 2017

Supervisor: Karen Schumacher, Ph.D., RN

Background. Despite vast amounts of research on informal caregiving in the Alzheimer’s dementia (AD) population, research on the experience and perceptions of rural caregivers is limited. A better understanding of rural caregivers’ knowledge, use, and nonuse of resources is essential to offset the impact of caregiving. Purpose. This study explored Alzheimer’s dementia family caregivers’ experiences and perceptions with resources in rural Midwest communities. Design. A descriptive qualitative approach with one-time semi-structured interviews was …