Digital Commons Network^™

Sports Cardiology: Core Curriculum For Providing Cardiovascular Care To Competitive Athletes And Highly Active People., Aaron L. Baggish Md, Robert W. Battle Md, James G. Beckerman Md, Alfred A. Bove Md, Phd, Rachel J. Lampert Md, Benjamin D. Levine Md, Mark S. Link Md, Matthew W. Martinez Md, Silvana M. Molossi Md, Phd, Jack Salerno Md, Meagan M. Wasfy Md, Rory B. Weiner Md, Michael S. Emery Md

Department of Medicine

The last few decades have seen substantial growth in the populations of competitive athletes and highly active people (CAHAP). Although vigorous physical exercise is an effective way to reduce the risk of cardiovascular (CV) disease, CAHAP remain susceptible to inherited and acquired CV disease, and may be most at risk for adverse CV outcomes during intense physical activity. Traditionally, multidisciplinary teams comprising athletic trainers, physical therapists, primary care sports medicine physicians, and orthopedic surgeons have provided clinical care for CAHAP. However, there is increasing recognition that a care team including qualified CV specialists optimizes care delivery for CAHAP. In recognition …

Effects Of Fertilizer And Shade Management On Nitrogen Mineralization, Nitrifying Microbial Abundance And Nitrogen-Fixing Capacity Of Erythrina Poeppigiana In Coffee (Coffea Arabica) Agroforestry Systems In Costa Rica, Stuart E. Barker Iii

College of Graduate Studies: Theses & Dissertations

Worldwide chemical fertilizer use has increased by four times during the last 50 years. Conventional agricultural systems have a high nitrifying nature, resulting in a loss of nearly 70% of overall nitrogen (N) fertilizer inputs, an estimated economic loss of $81 billion. Over application of fertilizer is rampant in tropical developing nations in Central America, where coffee is major crop. Agroforestry offers ecologically sustainable land management strategies that promote the provision of ecosystem services such as, protection of biodiversity, climate change mitigation, and water and soil regulation. When legume trees are incorporated as the shade tree in coffee production, direct …

Connecting The Dots: A Food Web Of The Lower Ogeechee River, Allison K. Lutz

College of Graduate Studies: Theses & Dissertations

The Ogeechee is a fifth order river that originates in the Georgia Piedmont region and flows through the Coastal Plain region in the Southeastern portion of the state. The Ogeechee is one of the last unregulated rivers in Georgia; allowing for studies to occur under a natural flow regime. To my knowledge, studies that incorporate fish into ecological networks (e.g., food webs) are yet to be developed for the Ogeechee River, thus, one of the main objectives of this research was to address this knowledge gap. Five fish species were collected from June 2016 to October 2016 in order to …

Antibiotics And Antibiotic-Resistant Bacteria In Coastal Plain Streams, Jason Duff

College of Graduate Studies: Theses & Dissertations

Streams across the United States and globally are influenced by environmental contamination, including antibiotics, which enter streams due to widespread use and multiple pathways into the environment. Antibiotics are also likely to enter streams in mixture with other contaminants that alter the effects on aquatic organisms. Furthermore, antibiotic-resistant bacteria enter streams through similar pathways as antibiotics with implications for natural microbial communities. Therefore, understanding the presence and effects of antibiotic-contaminant mixtures and antibiotic-resistant bacteria in streams is important for resource management.

Chapter one describes an experiment that tested the hypothesis that the antibiotic tetracycline (TC) alone influences phytoplankton communities differently …

Cultivating Ecological Literacy And Rethinking Our Connections To Nature, Sean Fretwell

College of Graduate Studies: Theses & Dissertations

In this dissertation I explore the complex, often contested, relationships between humankind and nature. I consider the changing state of these relationships as they are influenced by factors rooted in science, technology, and economics. I also examine these relationships as they relate to human activities with agriculture. Considering the present state of environmental crisis and the abundance of evidence indicating the deleterious activities of humankind as primary causes for the many global calamities, I argue for revising industrially-driven ideologies; particularly those driven by the economic paradigm of capitalism and self-interest. Additionally, I submit that a return to kinship with nature …

Mass Deworming To Improve Developmental Health And Wellbeing Of Children In Low-Income And Middle-Income Countries: A Systematic Review And Network Meta-Analysis, Vivian A. Welch, Elizabeth Ghogomu, Alomgir Hossain,, Shally Awasthi, Zulfiqar Ahmed Bhutta, Chisa Cumberbatch, Robert Fletcher, Jessie Mcgowan, Shari Krishnaratne, Elizabeth Kristjansson

Department of Paediatrics and Child Health

Background: Soil-transmitted helminthiasis and schistosomiasis, considered among the neglected tropical diseases by WHO, affect more than a third of the world’s population, with varying intensity of infection. We aimed to evaluate the eff ects of mass deworming for soil-transmitted helminths (with or without deworming for schistosomiasis or cointerventions) on growth, educational achievement, cognition, school attendance, quality of life, and adverse effects in children in endemic helminth areas.

Methods: We searched 11 databases up to Jan 14, 2016, websites and trial registers, contacted authors, and reviewed reference lists. We included studies published in any language of children aged 6 months to …

The Effects Of Skin And Seed Removal Of Tomato Fruits For The Home Canning Process On Texture And Nutritional Value, Emilie Sjostrom Burgess

Graduate Theses, Dissertations, and Problem Reports (ETD)

Tomatoes are consumed all over the world, but mainly after the tomatoes have undergone processing. Approximately three quarters of tomatoes consumed within the US are processed. A review of the scientific literature was conducted to investigate nutrient losses caused by the current tomato canning process. The bulk of tomatoes nutrients and health benefits are within the skin and seed components, and currently both are removed for home and commercial canning process. Studies showed that the current tomato canning protocol used by home canners and industries resulted in substantial nutrient loss due to removing the skin and the seeds before placing …

Improving Osmo-Convective Dehydration As A Processing Technique To Food Preservation, Quality Enhancement, And New Product Development, Felix Umaizimede Akharume

Graduate Theses, Dissertations, and Problem Reports (ETD)

Improving Osmo-convective Dehydration as a Processing Technique to Food Preservation, Quality Enhancement, and New Product Development Felix Umaizimede Akharume This thesis is organized into five chapters. Chapter 1 contains a contains background information review of literature on osmo-convective drying of fruits, as well and nutrition, microbiology, and sensory attributes, Chapters 2 through 4 are three journal articles presented in the manuscript style. While chapter 2 is already published chapters 3 and 4 are prepared for submission to scientific journals. The chapter 2 addresses the use of apple juice concentrate as an alternative to the conventionally use of sugar solution in …

Comprehensive Analyses Of Mirna And Dna Methylation In 17beta-Estradiol Exposed Juvenile Rainbow Trout Skeletal Muscle, Prasanthi P. Koganti

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reproductive development in female teleosts like rainbow trout starts with release of the sex steroid estrogen, necessary for synthesis of the egg yolk protein vitellogenin. Increase in estrogen secretion during these reproductive phases results in increased energy demands. Skeletal muscle serves as an immediate endogenous source to address energy demands during vitellogenesis and spawning due to which it undergoes rapid degradation resulting in water accumulation, poor fillet and low egg quality. An imbalance in protein turnover is observed not only because of rapid increase in degradative pathways but also due to decreased protein synthesis. These changes in protein metabolism in …

Evaluation Of Major And Minor Lower Extremity Amputation In Diabetic Foot Patients, Firat Ozan, Kaan Gürbüz, İlhami̇ Çeli̇k, Zehra Beştepe Dursun, Erdal Uzun

Turkish Journal of Medical Sciences

Background/aim: We evaluated the existing risk factors with clinical results in patients who underwent major and minor amputation of the lower extremity as a result of diabetic foot ulcers (DFUs). Materials and methods: We retrospectively studied 107 patients who had undergone lower extremity amputation. The patients were divided into minor (Group 1, n = 75) and major (Group 2, n = 32) amputation groups. On clinical evaluation, the type of surgery performed, smoking history, comorbidities, duration of diabetes mellitus (DM) diagnosis, duration of DFU presence, peripheral neuropathy, peripheral arterial disease, results of deep tissue culture, length of hospitalization, and blood …

Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z

Turkish Journal of Medical Sciences

Background/aim: This study included patients who had digestive system complaints between August 2015 and October 2015. The research was designed to compare conventional microscopy with an antigen detection ELISA kit and the TaqMan-based real-time PCR (RT-PCR) technique for detection of Giardia intestinalis in human stool specimens. Materials and methods: Samples were concentrated by formalin-ether sedimentation technique and microscopic examinations were carried out on wet mount slides. A commercially available ELISA kit (Giardia CELISA, Cellabs, Brookvale, Australia) was used for immunoassay. DNA was extracted from fecal samples of about 200 mg using the QIAamp Fast DNA Stool Mini Kit (QIAGEN, Hilden, …

Subdelegating Powers, Jennifer Nou

Public Law and Legal Theory Working Papers

The traditional portrait of the administrative state often features the politically-appointed agency head at its center: the Administrator of the Environmental Protection Agency, for instance, or the Secretary of the Department of Labor. This picture of bureaucratic power, however, is incomplete. For much of that power is, in fact, subdelegated within the agency. The implication is that decision rights are often exercised not by statutory delegates, but rather by lower-level officials and tenure-protected career staff. The purpose of this work is to bring these background actors—like the Securities and Exchange Commission’s Director of Enforcement—squarely to the foreground.

In doing so, …

Higher Daptomycin Dose Associated With Improved Survival In Methicillin-Resistant Staphylococcus Aureus Bacteremia, Timothy T. Timbrook, R. Caffrey, Megan K. Luther, Vrishali Lopes, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Study Objective: Current guidelines recommend higher daptomycin doses than the daptomycin label dose of 6 mg/kg for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, the evidence supporting this recommendation is from in vitro and case series studies. This study evaluated the comparative effectiveness of the daptomycin label dose versus higher daptomycin doses in patients with MRSA bacteremia.

Design: Retrospective national cohort study.

Setting: Veterans Affairs medical centers.

Patients: A total of 371 adults with MRSA bacteremia who were admitted between 2002 and 2015 and treated initially with vancomycin within 24 hours of initial culture collection and then …

Effects Of Dietary Intake Of Antioxidants And Omega-3 Fatty Acids On Free Radical Production In Children At Various Stages Of Chronic Kidney Disease, Linda Marie Sawyer

Wayne State University Dissertations

The purpose of this study was to understand the relationship between dietary intake of antioxidants and omega-3 fatty acids on free radical injury and free radical scavenging in children with chronic kidney disease (CKD) so that complications of kidney failure, especially cardiovascular disease, may be avoided or delayed. Children with CKD on dialysis and post-renal transplantation are at an extremely high risk for cardiovascular morbidity and mortality. We hypothesized that children with CKD who have higher dietary intake of antioxidants and omega-3 FAs, would have lower free radical injury, as measured by 8-Isoprostanes (8-ISOP) and Thiobarbituric Acid Reactive Substances (TBARS) …

An Enhanced Nerve Conduit Combined With Exercise To Improve Functional Recovery After Peripheral Nerve Injury, Tonya Jo Whitehead

Wayne State University Dissertations

Peripheral nerve injuries affect millions of people each year around the world. Current treatments include an autograft, the gold standard, and commercially available nerve growth conduits (NGC). Autografts have several drawbacks including donor site morbidity and nerve size mismatch, which leads to incomplete recovery. Commercial NGCs can help with recovery but do not contain any specific cues to guide nerve regeneration. This thesis first evaluated mechanical, topographical and chemical cues that can be included in a NGC to promote and direct nerve regeneration. To incorporate all of the cues, a compliant substrate methacrylated hyaluronic acid (MeHA, mechanical cue) is electrospun …

Optimization Of Growth Conditions And Characterization Of Properties On Christensenella Minuta, Qing Ai

Wayne State University Theses

Currently, increasing numbers of people are suffering from obesity. The gut microbiome becomes a useful approach to control the mechanisms associated with obesity. A novel bacterium, Christensenella minuta, which was discovered in 2012, triggers body weight loss. Our purpose in this study is to further realize characteristics of C. Minuta as a potential probiotic supplement for future obesity studies. This study determines the following characteristics of C. Minuta: DNA identification, turbidity verification, generation time, as well as optimization of pH and temperature. To test the tolerance of C. Minuta as a gastrointestinal treatment, the pH and bile salts concentration in …

Patholigical And Prognostic Role Of Mdig In Pancreatic Cancer, Srinivas Ashok Kumar

Wayne State University Theses

Pancreatic cancer is a highly aggressive malignant disease having very limited therapeutic options that ultimately results in its poor prognosis. It is still elusive on the etiology and tumorigenic mechanisms of pancreatic cancer. In the present report, we provide evidence showing involvement of the mineral dust-induced gene (mdig) in the pathogenesis and prognosis of the pancreatic cancer. Using immunohistochemistry approach on human pancreatic cancer tissue microarray, we found differential expression of mdig in pancreatic adenocarcinoma and normal pancreas. Based on the staining intensities of mdig in these tissue samples, we found that 12% of the cancer tissues were strongly positive …

The Relationship Of Assimilation On The Health Behaviors, Health Beliefs, And Use Of Health Care Services Of The Samoan Immigrants In The United States, Miliama Bracken

Wayne State University Theses

This study accepts the null hypothesis that there is no relationship between assimilation and the health behaviors, health beliefs, and use of health care services of the Samoan immigrants in the United States. The target population included Samoans who immigrated from Samoa or American Samoa and were 18 or more years of age. A total of 150 questionnaires were distributed and 126 respondents were included in the study. The respondents were asked how often they visited the doctor during the year. Would they seek the help of a medical doctor if they were sick, or a Samoan healer? They were …

Investigation Into Roseburia Intesinalis For Optimal Growth And Survivability Conditions For Potential Probiotic Use, Lisa Rana Felczak

Wayne State University Theses

Obesity and diabetes is an epidemic of increasing concern. Certain novel bacteria have been found to be an aid in reversing some of the mechanisms associated. This study focused on investigating the optimal stability conditions for R.intestinalis that can associate with an increase in growth. First, environmental conditions were tested to find the optimal conditions associated with each. Once growth conditions were found, generation time was calculated and various prebiotics were used to investigate a potential for additional growth. Next, common antibiotics were tested to see if the R.intestinalis could still show growth when exposed. Large batches of R.intestinalis were …

Development Of Gi Sustainable Probiotic Beads Using Microencapsulation, Jiarun Cui

Wayne State University Theses

Scientists tend to pay a lot attention to probiotics in recent years, due to its health related benefits for humans. Encapsulation is a necessary way to protect probiotics from being killed by harsh conditions of the gastrointestinal tract, and to help probiotics to release in the intestinal environment. This study is mainly focusing on the encapsulation technique of Christensenella minuta, and the food product development of C. minuta beads. The extrusion technique was applied as the encapsulation method, with alginate as the encapsulation material. The effect of single encapsulation and double encapsulation of C. minuta was compared to determine the …

The Potential Stimulation Of C. Minuta Growth By Various Prebiotics, And Its Sensitivity To Various Antibiotics, Maria Elena Hakim

Wayne State University Theses

Gut microbiota play a crucial role in maintaining intestinal health and integrity; a feature that is both heritable, as well as affected by the environment and lifestyle. Probiotics are supplements containing live microorganisms that act in a similar manner to gut microflora, and maintain a balance in the latter. C. minuta is a novel bacterium in the gut that was found to be associated with reduction in body weight and adiposity. The aim of this study was to determine the possible effects of different prebiotics on C. minuta growth, and the survival of C. minuta in response to different antibiotics. …

Effects Of Palm Oil Tocotrienols Rich Fraction On Cholesterol Efflux, Erandi Jayamini Jayawardana Arachchige

Wayne State University Theses

Tocotrienols are naturally occurring bioactive compounds which possess beneficial effects on multiple chronic diseases including atherosclerosis and cancer. It is believed to exert atheroprotective effects via promoting reverse cholesterol transport, a process that removes excess cholesterol from the body. Cholesterol efflux is an early step in reverse cholesterol transport and impaired cholesterol efflux is known to trigger foam cell formation, a hallmark of atherosclerosis. An increase in cholesterol efflux and decrease in cholesterol influx in macrophages has been suggested to reduce atherosclerosis risk by reducing foam cell formation. In addition, tocotrienols have shown anti-cancer effects on Non-small cell lung cancer …

The Effect Of Oil Palm Phenolics (Opp) And Curcumin On Plasma Metabolomic Profile In Atherogenic Diet Induced Rat Model Of Alzheimer’S Disease (Ad), Soniya Katekar

Wayne State University Theses

Alzheimer's disease (AD) is the most widely recognized reason for dementia in the aging population. It is described by intellectual decay and deposition of ß-amyloid plaques in the hippocampus. It has been demonstrated that hypercholesterolemia incited by elevated cholesterol abstain from food is related with AD advancement. Expanded level of oxidative stress has additionally been seen in AD patients. An essential methodology to treat or postpone the disability depends on dietary change, utilizing nourishment supplements. OPP, a water-soluble fraction from oil palm fruit, rich in phenolics has been found to possess significant antioxidant activities. Curcumin, a polyphenol extricated from the …

National Franchise Members’ Perceptions Of The Exercise Psychosocial Environment, Ownership, & Satisfaction, E. Whitney G. Moore, Mary D. Fry

Kinesiology, Health and Sport Studies

The purpose of this study was to examine the relationship between: a) the motivational climate developed by a national exercise franchise and b) members’ sense of ownership in and enjoyment of exercise. Members of a national exercise franchise (N=5,329) were surveyed to learn their views on the motivational climate (autonomy supportive, caring, task- and ego-involving), exercise class ownership, and class enjoyment. Mean scale scores revealed this national exercise franchise succeeded in developing a high caring (M = 4.60 ± .68), task-involving (M = 4.04 ± .62), and autonomy supportive (M = 5.98 ± 1.00) climate, and low ego-involving (M = …

The Ethical Right To Healthcare In The Affordable Care Act, Stella Morden

Electronic Theses and Dissertations

Since the passage of the Affordable Care Act, It has been questioned whether the right to healthcare in it can be ethically justified. The objection to a right to healthcare in general has been prominent over many decades in the U.S. The concern over higher personal taxes, quality care, and national debt steered the opposition. Responding to these concerns has a direct effect on each individual in society. In particular, the lack of healthcare is very significant.

The idea of a comprehensive national healthcare in the United States caught the attention of the public in the 1970s. It was inspired …

The Experiences Of Registered Nurses Injured By Interpersonal Violence While On Duty In An Emergency Department, Salena Wright-Brown

Electronic Theses and Dissertations

Numerous studies and reports identify the concerning incidence of work place violence directed toward healthcare workers (Centers for Disease Control, 2013; Gerberich et al., 2004; Government Accountability Office, 2016; U.S. Department of Labor, 2016). Despite efforts over the past few years to reduce workplace violence in healthcare facilities and specifically in emergency departments, the incidence of violence has not substantially lessened (Government Accountability Office, 2016). In March, 2016, the Government Accountability Office (GAO) released a report that was prepared by congressional request. The GAO found that workers in in-patient healthcare facilities experienced work-place violence that resulted in lost time from …

Examining The Role Of Ethnic Identity In The Relationship Between Characteristics Of Autism Spectrum Disorders And Eating Disorders, Ashley Bojorquez

Electronic Theses and Dissertations

The present work provides a synthetic literature review investigating the potential role of ethnic identity in the relationship between Autism Spectrum Disorders (ASD) and eating disorders (EDs). To date, there is no literature that directly examines the role that ethnic identity may play in the relationship between these two disorders. However, there is reason to believe it may; previous literature has shown that race/ethnicity plays a role in both of these disorders, and the role of ethnic identity has been more fully explored in the ED population. Notably, there is little research that examines the role of ethnic identity on …

Measuring Community And University Impacts Of Critical Civic Geography: Insights From Chicago, Daniel R. Block, Euan Hague, Winifred Curran, Howard Rosing

Faculty Publications - Geography Department

No abstract provided.

The Role Of The 5-Hydroxytrptamine 1f Receptor In Mitochondrial Biogenesis And Acute Kidney Injury, Whitney Sharee Gibbs

MUSC Theses and Dissertations

Mitochondrial dysfunction exacerbates cellular injury, impairs energy-dependent repair, and leads to kidney damage and failure following acute kidney injury (AKI). Mitochondrial dysfunction and impaired mitochondrial biogenesis correlate with decreased in peroxisome proliferator-activated receptor coactivator 1-α (PGC-1α), the reported master regulator of mitochondrial biogenesis, and its downstream targets following I/R-induced AKI. Furthermore, recovery of renal function and tubular injury is accelerated following pharmacological induction of mitochondrial biogenesis following I/R-induced AKI. These results suggest that recovery of mitochondrial number and function may be an effective therapeutic strategy in restoring renal function following AKI. We recently made the novel observation that agonists of …

A Quantitative Review Of Costs: Heart Failure Patients Before And After Implementation Of An Integrated Practice Unit Model At University Of Utah Health, Dayle E. Benson

MUSC Theses and Dissertations

Knowing the cost of delivering patient care is a mandatory first step as health care leaders are tasked with reducing the cost of US health care. The Integrated Practice Unit (IPU) model espoused by Michal Porter is a patient centered organizational framework whose tenets support value driven care. University of Utah Health has developed a proprietary costing model that gives them the ability to measure both costs and outcomes at the patient, provider, or in this research case, IPU program level. An interrupted time series (ITS) study design methodology is used to evaluate whether there has been an immediate effect …