Digital Commons Network^™

Regulation Of Early Zebrafish Embryogenesis By Calcium Signaling And Dachsous1b Cadherin, Jiakun Chen

Arts & Sciences Graduate Student Theses and Dissertations

Early animal embryogenesis entails a dynamic combination of embryonic cleavages, axial patterning, and gastrulation movements to shape a basic body plan. The underlying molecular signaling responsible for regulating this process remains poorly understood. In this thesis work, I first review recent progress in understanding of gastrulation movements in various model organisms brought by advances in imaging techniques. The externally developing and optically translucent zebrafish embryo is an ideal model organism to study vertebrate embryonic development by in vivo imaging. The objective of my thesis research is to leverage experimental advantages in the zebrafish model to uncover novel regulators and elucidate …

A Generalized Biophysical Model Of Transcription Factor Binding Specificity And Its Application On High-Throughput Selex Data, Shuxiang Ruan

Arts & Sciences Graduate Student Theses and Dissertations

The interaction between transcription factors (TFs) and DNA plays an important role in gene expression regulation. In the past, experiments on protein–DNA interactions could only identify a handful of sequences that a TF binds with high affinities. In recent years, several high-throughput experimental techniques, such as high-throughput SELEX (HT-SELEX), protein-binding microarrays (PBMs) and ChIP-seq, have been developed to estimate the relative binding affinities of large numbers of DNA sequences both in vitro and in vivo. The large volume of data generated by these techniques proved to be a challenge and prompted the development of novel motif discovery algorithms. These algorithms …

Investigation Of Neonatal Pulmonary Structure And Function Via Proton And Hyperpolarized Gas Magnetic Resonance Imaging, Nara Savoye Higano

Arts & Sciences Graduate Student Theses and Dissertations

Magnetic resonance imaging (MRI) is a modality that utilizes the phenomenon of nuclear magnetic resonance (NMR) to yield tomographic images of the body. Proton (1H) MRI has historically been successful in soft tissues but has suffered in the lung due to a variety of technical challenges, such as the low proton-density, rapid T2* relaxation time of the lung parenchymal tissue, and inherent physiological motion in the chest. Recent developments in radial ultrashort echo time (UTE) MRI have in part overcome these issues. In addition, there has been much progress in techniques for hyperpolarization of noble gases (3He and 129Xe) out …

Assessing And Enhancing Nuclear Safety And Security Culture For Small Facilities That Handle Radioactive Material, Solymosi Máté

International Journal of Nuclear Security

The use of radioactive sources is expanding all over the world and abreast the necessity of the enhancement of its safe and secure application is increasing too. In the nuclear industry, the safety and security are top priorities since decades. They share the same goal, to protect humans from the negative affect of the ionizing radiation. The human component of them is a significant factor and technical solutions can protect us so far and thus the culture for safety and security become a major focus. On the other hand, there are still some contradiction between recommendations and international guidance of …

Board Of Trustees Meeting Minutes, December 15, 2017

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 15, 2017.

Can Addressing Language Skills For Fifth Grade Ells In A Multiplication Curriculum Help Address The Achievement Gap In Math? A Multiplication Workbook For Big Kids, Michelle Douglas

Master's Projects and Capstones

Currently, the state of California has 1,332,405 students from grades k-12 who speak a language other than English at home (Caledfacts, 2016). When I started my first year teaching fifth grade with 95% of my students being English language learners (ELLs), I was surprised to see an achievement gap of two to three years in my student’s reading and math skills. I found that my student’s developmental language and math skills contributed to a lack of engagement during math time. Upon further research, I found that these three factors play a role in the wide achievement gaps between ELLs and …

Dancing At My Desk: Examining The Foundations Of A Nonprofit Dance Education Organization, Caeli Koizumi

Honors Thesis

With the implementation of the Common Core State Standards, the demand for further development in arts education has grown. In California, the Visual and Performing Arts have been mandated components of education since 2001; yet, students often experience limited and inconsistent access to the arts due to budget cuts. Thus, the need for a specialized approach to synthesizing the arts and education is imminent. Arts Integration, a pedagogical method that refers to the combination of a visual or performing art with a core content area to provide equal understanding of a topic from both selected fields, is sprinkled throughout primary …

Focus: A Graph Approach For Data-Mining And Domain-Specific Assembly Of Next Generation Sequencing Data, Julia Sommer

Theses & Dissertations

Next Generation Sequencing (NGS) has emerged as a key technology leading to revolutionary breakthroughs in numerous biomedical research areas. These technologies produce millions to billions of short DNA reads that represent a small fraction of the original target DNA sequence. These short reads contain little information individually but are produced at a high coverage of the original sequence such that many reads overlap. Overlap relationships allow for the reads to be linearly ordered and merged by computational programs called assemblers into long stretches of contiguous sequence called contigs that can be used for research applications. Although the assembly of the …

Metabolic Reprogramming Of Pancreatic Ductal Adenocarcinoma Cells In Response To Chronic Low Ph Stress, Jaime Abrego

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of all cancers with a 5-year survival rate of only 8.2%. This is because PDAC is diagnosed in its advanced stages and is characterized by radio and chemotherapy resistance. Aggressiveness of PDAC tumors is attributed to its high metabolic phenotype, which is characterized by increased glycolysis rate and lactate secretion, while oxidative metabolism is reduced. These metabolic features are required to fulfill the biosynthetic demands of proliferating PDAC cells. However, this increase in metabolic activity results in acidification of the extracellular space because the dense fibrotic stroma of PDAC tumors limits …

Dreams: A Unified Theory Approach, Chance Mcdermott

Dissertations, 2014-2019

Henriques (2011) proposed a new unified theory of psychology (UT) which he argued could assimilate and integrate divergent lines of thought into a coherent whole. An implication of this claim is that the system can be applied to phenomena that was not addressed in the original work and the current work tests this proposition. Specifically, the current work utilized the UT and its components to examine the dream literature, especially psychodynamic, physiological and evolutionary approaches. Following a brief introduction, the project reviews the various lines of research and interpretations of why we dream and what they may mean for us. …

Relativistic Three-Dimensional Lippman-Schwinger Cross Sections For Space Radiation Applications, Charles M. Werneth, Xiaojing Xu, Ryan B. Norman, Khin M. Maung

Faculty Publications

Radiation transport codes require accurate nuclear cross sections to compute particle fluences inside shielding materials. The Tripathi semi-empirical reaction cross section, which includes over 60 parameters tuned to nucleon-nucleus (NA) and nucleus-nucleus (AA) data, has been used in many of the world’s best-known transport codes. Although this parameterization fits well to reaction cross section data, the predictive capability of any parameterization is questionable when it is used beyond the range of the data to which it was tuned. Using uncertainty analysis, it is shown that a relativistic three-dimensional Lippmann-Schwinger (LS3D) equation model based on Multiple Scattering Theory (MST) that uses …

Untangling The Mechanics Of Co-Entangled Cytoskeletal Networks, Shea Ricketts

Undergraduate Honors Theses

Active networks of interlinked protein filaments comprising the cytoskeleton largely control cellular mechanics and cell architecture. By forming cytoskeleton networks that combine motile, semiflexible actin with rigid, supportive microtubules, cells maintain structural integrity and shape while being able to flow and move. To elucidate the complex mechanical processes that arise between interacting networks of actin and microtubules within cells, we create a suite of randomly-oriented, well mixed networks of actin and microtubules by co-polymerizing varying ratios of both proteins in situ. We use optical tweezer microrheology in order to characterize the nonlinear mesoscale mechanics of in vitro co-entangled actin-microtubule composites. …

Synthesis, Characterization, And Spectroscopy Of Donor-Acceptor Charge Transfer Complexes, Dominic Kofi Kersi

Chemistry and Chemical Biology ETDs

A series of square-planar metal (diimine)(dichalcogenolene) chromophoric complexes have been synthesized, characterized and studied spectroscopically. Studies conducted on diimineplatinum(II) dichalcogenolene complexes (LPtL’) using time resolved spectroscopic techniques such as transient absorption and emission, reveal a charge-separated excited state of the type dichalcogenolene → diimine charge-transfer (LL’CT) [(dichalcogenolene^•+)Pt(diimine^•-) with an open shell donor-acceptor biradical character. This makes the low-energy ligand-to-ligand charge-transfer (LL’CT), or the mixed-metal ligand-to-ligand charge-transfer (MMLL’CT), transitions of diimineplatinum(II) dichalcogenolene complexes particularly interesting to us in facilitating our knowledge of biradical charge-separated states. Long-live excited state lifetimes were observed for these complexes upon visible photoexcitation …

The Effectiveness Of K-12 Principal’S Digital Leadership In Supporting And Promoting Communication And Collaboration Regarding Ccss Implementation, Lin Zhong

Journal of Educational Technology Development and Exchange (JETDE)

Technology plays an important role in supporting successful College-and Career- State Standards (CCSS) implementation, which requires principals and educators effectively communicate and collaborate at the local, state, and national level. This study aims to investigate the effectiveness of digital leadership in supporting communication and collaboration regarding CCSS implementation in K-12 schools. In this study, 254 public school teachers from five school districts in Mississippi were surveyed. Results showed that principals were most effective in supporting professional development and digital citizenship. In addition, teachers’ age and teaching grades have an impact on the effectiveness of principals’ digital leadership strategies. Implications are …

Comparison Of Complete Bouguer Anomalies From Satellite Marine Gravity Models With Shipborne Gravity Data In East Sea, Korea, Dong Ha Lee, Tri Dev Acharya

Journal of Marine Science and Technology–Taiwan

This paper describes the results of complete bouguer anomalies (B.A) computed from the free-air anomalies (F.A) of Sandwell and DTU13 marine gravity models that derived from satellite altimetry observations in the area of East Sea, South Korea. In order to confirm the usefulness of satellite-derived gravity anomalies to analyze the geophysical, geological and geographical characteristics in East Sea, the results of marine gravity models have been compared with shipborne gravity anomalies obtained from KHOA (Korea Hydrographic and Oceanographic Agency). To calculate the complete B.A, we applied complete bouguer correction which consists of three steps: the bouguer slab correction (Bullard A), …

The Processing And Polarization Reversal Dynamics Of Thin Film Poly(Vinylidene) Fluoride, Noel Mayur Dawson

Nanoscience and Microsystems ETDs

Many ferroelectric devices benefit from the ability to deposit thin ferroelectric layers. Poly(vinylidene) fluoride (PVDF) is the prototypical ferroelectric polymer, but processing of thin film ferroelectric PVDF remains a challenge due to the formation of large voids in the film during traditional thin film processing. The research described in this dissertation starts by investigating the origin of these voids. The cause of these voids is found to be caused by vapor induced phase separation (VIPS). Guided by the thermodynamics of VIPS, a process is then designed to produce void-free ferroelectric PVDF thin films on polar and non-polar substrates. The films …

Digital Resources For Scottish Neo-Latin Literature, Ralph Mclean

Studies in Scottish Literature

Provides an annotated guide to the Scottish neo-Latin texts and translations now available in two major digital projects, the Philological Museum (University of Birmingham) and Bridging the Continental Divide (University of Glasgow), with briefer notes on other related print and digital resources, commenting on the importance of fully-annotated editorial and translation projects now fewer students and researchers can tackle such texts in the original Latin.

Repairing Gaps In Kinari-2 For Large Scale Protein And Flexibility Analysis Applications, Magdalena Metlicka, Mojtaba Nouri Bygi, Ileana Streinu

Computer Science: Faculty Publications

Pebble game rigidity analysis is a combinatorial method, implemented in our free web server KinariWeb, for extracting protein rigidity and flexibility information without performing costly molecular dynamics simulations. Due to the idiosynchrasies of the data in the Protein Data Bank (PDB), Kinari succeeds only on a fraction of the available files. Motivated by large scale applications, aiming at processing almost all the PDB files, we have recently developed a faster and more robust version, the phased pebble game algorithm. It is specifically designed to take advantage of the sequential structure of biopolymers. However, the structural data available in the Protein …

Repairing Gaps In Kinari-2 For Large Scale Protein And Flexibility Analysis Applications, Magdalena Metlicka, Mojtaba Nouri Bygi, Ileana Streinu

Computer Science: Faculty Publications

Pebble game rigidity analysis is a combinatorial method, implemented in our free web server KinariWeb, for extracting protein rigidity and flexibility information without performing costly molecular dynamics simulations. Due to the idiosynchrasies of the data in the Protein Data Bank (PDB), Kinari succeeds only on a fraction of the available files. Motivated by large scale applications, aiming at processing almost all the PDB files, we have recently developed a faster and more robust version, the phased pebble game algorithm. It is specifically designed to take advantage of the sequential structure of biopolymers. However, the structural data available in the Protein …

Probing Consciousness, Samia Bouzid

Capstones

For centuries, the study of consciousness remained the purview of philosophers, spiritualists and religious leaders. But in the 1980s, the co-discoverer of the double-helix, James Crick, initiated a quest for a scientific explanation for consciousness — in a secret club. In the decades that followed, consciousness gained ground as a respectable area of scientific study, in fields such as neuroscience, artificial intelligence and physics. Yet, the more scientists learn about consciousness, the more it calls into question our fundamental assumptions about the way the world works. https://samiabouzid.atavist.com/probing-consciousness

Breadcrumbs: Privacy As A Privilege, Prachi Bhardwaj

Capstones

Breadcrumbs: Privacy as a Privilege Abstract

By: Prachi Bhardwaj

In 2017, the world saw more data breaches than in any year prior. The count was more than the all-time high record in 2016, which was 40 percent more than the year before that.

That’s because consumer data is incredibly valuable today. In the last three decades, data storage has gone from being stored physically to being stored almost entirely digitally, which means consumer data is more accessible and applicable to business strategies. As a result, companies are gathering data in ways previously unknown to the average consumer, and hackers are …

Characterization And Modeling Of Asphalt Concrete For Dynamic Properties And Performances, A S M A. Rahman

Civil Engineering ETDs

The recently developed mechanistic-empirical pavement design guide (MEPDG, also known as Pavement M-E design method) uses the nationally calibrated, binder viscosity-based dynamic modulus predictive model for the design and analysis of asphalt pavements. In this study, this model is assessed for its appropriateness for asphalt-aggregate mixtures typically used in New Mexico. In essence, this study investigates the predictability issue of complex modulus of New Mexico mixes. A total of 54 Superpave mixes with different aggregate gradations, air voids, and binder grades were collected from the mixing plants and from the pavement construction sites. The loose asphalt mixtures were then compacted, …

Development Of Design Equations For Drilled Shafts In Granular Dense Soils Using Dem Simulations, Sadia Faiza

Civil Engineering ETDs

Drilled shafts have proven to be cost-effective, excellent performing, deep foundation systems where large loads and lateral resistance are major factors. The available design methods that are recommended by FHWA (2010) for drilled shafts are mostly empirical and are developed based on generalized data which sometimes can be conservative for a particular soil. The main objective of this study is to develop a design methodology for estimating the side resistance of an axially loaded drilled shaft based on the current and the unique properties of the soil. The objective was met through using the discrete element method (DEM) to investigate …

Modified Pid Controller Design For Active Transverse Anti-Rolling System For Ships With Low Roll Motion, Hsing-Cheng Yu, Jhih-Jyun You

Journal of Marine Science and Technology–Taiwan

Multi-domain physical modeling software with an intuitive simulation methodology using MapleSim was adopted in this study to create a rigid body structure model of an active transverse anti-rolling system (ATARS) of a container ship. At the same time, a ship stability analysis was also conducted to determine the force model, dynamic equilibrium, and motion behavior of the ATARS of the container ship. Once various external transverse force generated by waves impact varied roll angles of the ATARS on the vessel, a modified proportional-integral-derivative (PID) controller designed to improve the capability of the active stabilizer fins used in the ATARS is …

The Nonlinear Dynamics And Anti-Sway Tracking Control For Offshore Container Crane On A Mobile Harbor, You-Gang Sun, Hai-Yan Qiang, Junqi Xu, Da-Shan Dong

Journal of Marine Science and Technology–Taiwan

The offshore container crane (OCC), as a novel maritime container transfer system, can handle container from a large container-ship anchored in open sea to address the congestion and limited water-depth of port. However, for the wave- and wind-induced movements of the ship, the crane's control system should be redesigned to ensure the load transfer on the sea. In this paper, we derive the nonlinear dynamic equations of OCC system subjected to the ship motions based on dynamic analysis. Then a double-layer sliding manifold is constructed to realize the position tracking and sway control simultaneously, irrespective of ship motions and parameters …

Simulation And Motion Analysis Of Deepwater Manifold Lifting, Zhiwei Chen, Tingdi Zhao, Jian Jiao, Dongfeng Mao

Journal of Marine Science and Technology–Taiwan

The development and utilization of oil and gas resources has expanded to deep water. The installation of a subsea manifold is crucial for developing offshore oil-gas fields. In this study, we used the lifting installation method (LIM) to install a subsea manifold. First, the appropriate environmental parameters were selected through the analysis of environmental loads at the Liwan 3-1 Gasfield in the South China Sea. The wind and wave spectra were selected using noise power density and Joint North Sea Wave Project spectra, respectively. The entire lifting and installation system that responds to environmental loads comprised a vessel, cable, and …

Energy Efficient Trajectory Design For The Underwater Vehicle With Bounded Inputs Using The Global Optimal Sliding-Mode Control, Mai The Vu, Hyeung-Sik Choi, Jin-Il Kang, Dae-Hyung Ji, Hyun Joong

Journal of Marine Science and Technology–Taiwan

In this paper, we propose a novel global sliding mode controller (SMC) for an uncertain linear time-varying second order system. The proposed controller was implemented on the underwater vehicle (UV) with uncertainty of bounded parameters and disturbances within limited control input. By applying the proposed controller to the second-order UV system, the arrival time at the reference position and the maximum allowable acceleration are expressed in a closed-form equation if ranges of parametric uncertainties and reference inputs are specified. The closed-form equation can be utilized in designing the capacity of vehicle systems with the condition of the minimum arrival time …

Survey Of Trajectory Tracking Control Of Autonomous Underwater Vehicles, Wen-Yang Gan, Da-Qi Zhu, Wei-Li Xu, Bing Sun

Journal of Marine Science and Technology–Taiwan

Autonomous underwater vehicles (AUVs) are powerful instruments that enable the exploration of the ocean. In recent years, AUVs have been developed considerably. Trajectory tracking control, which has been a major research focus for many decades due to its variety of applications, is one of the key advancements in the AUV technology. This paper presents six trajectory tracking control methods: PID (proportion integration differentiation) control, fuzzy control, adaptive control, sliding mode control, backstepping control, and neural network control. A few novel methods for trajectory tracking control are also introduced. First, the concept of trajectory tracking control for an AUV and the …

A Numerical Model For Pipeline Abandonment In Deep Water, Duanfeng Han, Kuo Huang, Yingfei Zan, Zhaohui Wu

Journal of Marine Science and Technology–Taiwan

In offshore oil and gas engineering, pipeline abandonment is unavoidable and its mechanical analysis is necessary and important. For this problem, a numerical model is developed in this study to evaluate pipeline abandonment for the J-laying method. The whole system considered in this model is divided into two parts: the A&R cable and the pipeline in the water. A catenary model was proposed for the former, and the latter is solved by a numerical iterative method. In addition to the boundary conditions at the two end points, a special set of boundary conditions is required at the junction that connects …

Experimental Study Of Dynamic Stability Of Underwater Vehicle-Manipulator System Using Zero Moment Point, Jin-Il Kang, Hyeung-Sik Choi, Mai The Vu, Nguyen Ngoc Duc, Dae-Hyeong Ji, Joon-Young Kim

Journal of Marine Science and Technology–Taiwan

For manipulative underwater operations, an underwater vehiclemanipulator system (UVMS) has more degrees of freedom than those required to conduct a given mission. To follow the desired end-effector position and velocity accurately, UVMS should be able to generate trajectories of manipulators and the underwater vehicle can maintain dynamic stability of the entire system. In this paper, redundancy resolution is performed to find a solution satisfying the given task among many joint-space solutions. Also, to improve the dynamic stability of the UVMS, zero moment point (ZMP) is adopted such that it requires some constraints. For application of UVMS, a joint limitation is …