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The Role Of Mapk And Scf In The Destruction Of Med13 In Cyclin C Mediated Cell Death, David C Stieg, Stephen D Willis, Joseph Scuorzo, Mia Song, Vidyaramanan Ganesan, Randy Strich, Katrina F Cooper

Rowan-Virtua School of Osteopathic Medicine Departmental Research

In response to stress, the yeast¹ and mammalian² cyclin C translocate from the nucleus to the cytoplasm, where it associates with the GTPase Drp1/Dnm1 to drive mitochondrial fragmentation and apoptosis. Therefore, the decision to release cyclin C represents a key life or death decision. In unstressed cells, the cyclin C‐Cdk8 kinase regulates transcription by associating with the Mediator of RNA polymerase II. We previously reported that the Mediator component Med13 anchors cyclin C in the nucleus³. Loss of Med13 function leads to constitutive cytoplasmic localization of cyclin C, resulting in fragmented mitochondria, hypersensitivity to stress and …

Snf1 Dependent Destruction Of Med13 Is Required For Programmed Cell Death Following Oxidative Stress In Yeast, Stephen D Willis, David C Stieg, R. Shah, Randy Strich, Katrina F Cooper

Rowan-Virtua School of Osteopathic Medicine Departmental Research

All eukaryotic cells, when faced with unfavorable environmental conditions, have to decide whether to mount a survival or cell death response. The conserved cyclin C and its kinase partner Cdk8 play a key role in this decision. Both are members of the Cdk8 kinase module that, along with Med12 and Med13, associate with the core mediator complex of RNA polymerase II. In S. cerevisiae, oxidative stress triggers Med13 destruction¹, which thereafter releases cyclin Ci nto the cytoplasm. Cytoplasmic cyclin C associates with mitochondria where it induces hyper-fragmentation and programmed cell death². This suggests a model in …

The Impact Of Student Leadership Engagement On Meaning In Life And Work During College, Heather Janel Strine-Patterson

Dissertations, 2014-2019

The rising need, cost, and debt for postsecondary education has increased attention and scrutiny on its value, and colleges and universities must underscore outcomes beyond employment of graduates. Psychological well-being is a promising area to expand the value of postsecondary education. Using correlations, multiple regression, and multivariate analysis of variance (MANOVA), this study seeks to contribute to an emergent body of empirical knowledge about the impact of postsecondary education on students’ well-being by specifically examining the relationship between participation in cocurricular and extracurricular experiences and students’ well-being defined by their sense of meaning in life and work. To this end, …

Authentic Leadership—Is It More Than Emotional Intelligence?, Phyllis Duncan, Mark Green, Esther Gergen, Wenonah Ecung

Administrative Issues Journal

One of the newest theories to gain widespread interest is authentic leadership. Part of the rationale for developing a model and subsequent instrument to measure authentic leadership was a concern that the more popular theory, the full range model of leadership and its instrument, the Multifactor Leadership Questionnaire (MLQ) (Bass & Avolio, 1985), did not sufficiently emphasize aspects of leader emotional intelligence (EI), such as self-awareness (Avolio & Gardner, 2005).

In its current configuration, the Authentic Leadership Questionnaire (ALQ) (Walumba, Avolio, Gardner, Wernsing & Peterson, 2008) measures four dimensions of leadership: relational transparency, internal moral perspective, balanced processing, and self-awareness. …

Translocation Of Cyclin C During Oxidative Stress Is Regulated By Interactions With Multiple Trafficking Proteins, Daniel G J Smethurst, Katrina F Cooper, Randy Strich

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Eukaryotic cells take cues from their environment and interpret them to enact a response. External stresses can produce a decision between adjusting to behaviors which promote surviving the stress, or enacting a cell death program. The decision to undergo programmed cell death (PCD) is controlled by a complex interaction between nuclear and mitochondrial signals. The mitochondria are highly dynamic organelles that constantly undergo fission and fusion. However, a dramatic shift in mitochondrial morphology toward fission occurs early in the PCD process. We have identified the transcription factor cyclin C as the biochemical trigger for stress‐induced mitochondrial hyper‐fragmentation in yeast (Cooper …

Mechanistic Insights Into The Regulation Of Mitochondrial Fission By Cyclin C, Vidyaramanan Ganesan, Katrina F Cooper, Randy Strich

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Cyclin C is a component of the mediator complex of RNA polymerase II that localizes to the nucleus under normal conditions. In response to stress, cyclin C translocates to the cytosol and mitochondria and mediates stress‐induced mitochondrial fission and apoptosis. The molecular mechanisms by which cyclin C induces mitochondrial fission are unknown. Using in vitro experimental approaches, we sought to investigate the mechanistic basis of cyclin C mediated mitochondrial fission.

Lvhn Weekly-Pocono, Lehigh Valley Health Network

LVHN Weekly-Pocono

No abstract provided.

Lvhn Weekly, Lehigh Valley Health Network

LVHN Weekly

No abstract provided.

Assessing Morphological Deformities In Cetaceans: Definition Of Patterns And Quantification With A Case Study (Madeira Island, Ne Atlantic), Erich Dietterle

Masters Theses, 2010-2019

Documenting deformities in cetaceans can lead to understandings in the health of the populations, but also the state of ocean and human health in an area. Deformities like skin lesions can lead to information about local pollution levels or possible diseases, while physical impacts can give insight into vessel traffic or fishing gear entanglement information. Cetaceans encounter threats like vessel strikes and fishing gear entanglements worldwide, but less obvious activities like whale watching or pollution can also have impacts. Studies have been conducted worldwide and around the Madeira Archipelago to document deformities, but there are various descriptions for what is …

2017 Audit Report, Southwestern Oklahoma State University

Independent Audit Reports

This is an Independent Audit Report produced by the SWOSU Office of Business Services

Medical Sciences 4300: London-Middlesex Suicide Prevention Council, Harshith Bhaskar, Adnan Husein, Ramin Javaheri-Poya, Sabrina Jetly, Christopher Nguyen, Serena Tejpar

Community Engaged Learning Final Projects

Suicide is an issue that affects people of all backgrounds, and takes the lives of many individuals every year. The London-Middlesex Suicide Prevention Council (LMSPC), an organization established in 1990, seeks to provide suicide prevention training to members of the community. They seek to engage community members in prevention and intervention by recognizing warning signs that may exist among the London-Middlesex region. The three main programs that strive to deliver these skills are ASIST, ASK, and safeTALK, each with a slightly different focus. LMSPC’s current goal is to increase access to these services through external grants and potential partnerships. Our …

Increases Student Aid Funding At California Public Colleges And Universities By Enacting A Dedicated Tax On Some Estates. Initiative Constitutional Amendment And Statute.

Initiatives

Increases student aid funding for undergraduate students at University of California, California State University, and California Community Colleges, by enacting a dedicated tax (ranging from 12-22%, depending on value) on estate property in California valued at $3.5 million or more and transferred upon death. Exempts revenue from constitutionally required: annual state spending limit, minimum-funding guarantee for schools, and state budget reserve deposits. Requires that revenue would supplement, and not replace, existing financial aid programs for college students. Summary of estimate by Legislative Analyst and Director of Finance of fiscal impact on state and local government: Increased state revenues of a …

Thomas Rink V. Northeastern Educational

2017 Decisions

USDC for the Middle District of Pennsylvania

Root Cause Analysis: A Tool To Promote Officer Safety And Reduce Officer Involved Shootings Over Time, John Hollway, Calvin Lee, Sean Smoot

Villanova Law Review (1956 - )

No abstract provided.

A Qualitative Exploration Into Larry Wilson's Transformational Leadership, Peter D. Engstrom

Theses and Graduate Projects

Larry Wilson was considered by many to be a transformational leader.

This paper explores the intersection of how people associated with Larry experienced him relative to the current research on transformational leadership through an interpretive method of gathering data from former employees, customers, and family. Data was gathered through a series of personal interviews, published text, and a questionnaire. The interviews and questionnaire yielded five main themes. The evidence suggests Larry’s style of leadership is consistent with the Full Range of Transformational Leadership, as posited by Bernard Bass and Bruce Avolio (1994).

An Examination Of The Teaching Of Missional Concepts Of Christian Discipleship And Their Potential For Creating An Attitudinal Change At Berea Lutheran Church, Richfield, Minnesota, Kevin Tiaden

Doctor of Ministry Major Applied Project

Tiaden, Kevin N. “An Examination of the Teachings of Missional Concepts of Christian Discipleship and their Potential for Creating Attitudinal Change at Berea Lutheran Church, Richfield, Minnesota.” Doctor of Ministry. Major Applied Project, Concordia Seminary, 2017. 132 pp.

The purpose of this study is to examine the teaching of missional principles of discipleship at Berea Lutheran Church. I examine the attitudinal changes that take place as a result of this class. The first step in this process is looking at what those missional and Biblical principles are and then creating a method of teaching them in a large group setting …

The Indigenous Sovereign Body: Gender, Sexuality And Performance, Michelle S. A. Mcgeough

Art & Art History ETDs

Gender variance and artist production are not topics that are often discussed within the discipline of art history. In fact gender variance and in particular its relationship to sexual orientation was not a topic studied, much less discussed outside of the medical community until the mid-twentieth century. It was generally thought that sexuality and gender were “biologically determined” and deviation from the heterosexual norm was considered pathological. In contrast, Indigenous nations in Canada and the United States had a very different understanding regarding the relationship between gender, biology, and sexual object of choice. One area that provides us with a …

Seasonal Resource Selection And Habitat Treatment Use By A Fringe Population Of Greater Sage-Grouse, Rhett Boswell

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Movement and habitat selection by Greater Sage-grouse (Centrocercus uropasianus) is of great interest to wildlife managers tasked with applying conservation measures for this iconic western species. Current technology has created small and lightweight GPS (Global Positioning Systems) transmitters that can be attached to sage-grouse. Using GIS software and statistical programs such as Program R, land managers can analyze GPS location data to assess how sage-grouse are geospatially interacting with their habitats. Within the Panguitch Sage-Grouse Management Area (SGMA) thousands of acres of land have been restored or manipulated to enhance sage-grouse habitat; this usually involves removal of pinyon pine …

Inpatient Hospice Home: A Needs Assessment And Business Plan, Stacey Middleton

Doctor of Nursing Practice Scholarly Project

An Abstract of the Scholarly Project by

Stacey Middleton

There are two constants that every person can count on in life, being born and dying. No amount of research is required, and there is no need to challenge the inevitable. When a child is born, people celebrate and congratulate the new parents and their family. When a person dies, people are saddened by the loss of a friend and loved one. Death comes to all and is either, fast and unexpected or a slow drawn out process. Every dying patient deserves to die with dignity, be free from pain, and …

Residential Life Curriculum: Wyoming Seminary, Allie Maxwell

Capstone Collection

This course linked capstone will focus on creating a residential life curriculum that is student centered, increases cultural competencies, and strengthens the community of the Wyoming Seminary Upper School. Many boarding schools have accepted international students into their schools to respond to a growing revenue need while simultaneously adding to a school’s diversity. The shift in student demographics has created a secondary level international education sector without many people specializing in this arena. Additionally, there has been a push to increase residential life resources in schools to help increase student support. With the drive for additional support and a growing …

Um Researchers Working On Acoustic Detection For Undersea Oil Leaks, Shea Stewart

University of Mississippi News

Team gets $591,000 grant for work to make crude production safer for the environment

Board Of Trustees Agenda, Dec. 15 2017, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

The Right To Work And The Right To Strike, Laura Weinrib

Articles

No abstract provided.

Effects Of Aquatic And Land Plyometrics On Athletic Performance: A Systematic Review, Alissa Rhode, David C. Berry

International Journal of Aquatic Research and Education

The purpose of this study was to systematically review literature to determine whether aquatic plyometric training (APT) increases athletic performance compared to land-based plyometric training (LPT). We identified 6 articles from PubMed, CINAHL, MEDLINE, and single-citation matching from January, 1995 through January, 2017 using search words “aquatic plyometric training OR aquatic plyometric OR aquatic plyometrics.” After screening (title, abstract), 6 articles were reviewed for inclusion criteria: (1) full-report/abstract, (2) peer-reviewed RCTs/clinical trials, (3) English language, (4) focused on healthy individuals (free of current, lower-extremity, musculoskeletal injuries) ages 16-30 years, and (6) included strength, power, and/or vertical jump [VJ] dependent …

The Effect Of Z-Binding Yarns On The Electrical Properties Of 3d Woven Composites, Mohamed Nasr Saleh, Arief Yudhanto, Gilles Lubineau, Constantinos Soutis

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Electrical resistance monitoring (ERM) has been used to study the effect of the z-binding yarns on the initial electrical resistance (ER) and its change of three architectures of 3D woven carbon fiber composites namely (orthogonal "ORT", layer-to-layer "LTL" and angle interlock "AI") when tested in tension. Specimens are loaded in on-axis "warp" and off-axis "45°" directions. In situ ERM is achieved using the four-probe technique. Monotonic and cyclic "load/unload" tests are performed to investigate the effect of piezo-resistivity and residual plasticity on resistance variation. The resistance increases for the off-axis loaded specimens (∼90%) is found to be higher than that …

Uab School Of Nursing Launches Joint Initiative With Birmingham-Southern College, Staff

Browse All News

No abstract provided.

Master Of Nuclear Medicine Technology Program Graduates Inaugural Class, Staff

Browse All News

No abstract provided.

Uab's Ferniany Listed Among Nation's Leading Nonprofit Health System Ceos, Staff

Browse All News

No abstract provided.

The Future Of Nuclear Security: A Medical Physicist’S Perspective, Katharine E. Thomson

International Journal of Nuclear Security

Planning for the future of nuclear security is a vital and complex task, requiring cooperation and contribution from many disciplines and industries. This diversity of expertise should include the medical sector, which faces many of the same challenges as the nuclear industry: controlling access to dangerous material, creating a strong security culture, cooperating with the wider world and engaging the public.

Medical physicists, of which the author is one, oversee all aspects of small-scale radiation use. This paper discusses three key areas increasingly important to both medical and nuclear uses of radioactive materials: public engagement, prevention of nuclear and radiological …

The Future Of Nuclear Security In Moroccan Territory After The Creation Of The New Moroccan Agency Of Nuclear And Radiological Safety And Security: Opportunities And Challenges, Amal Touarsi, Amina Kharchaf

International Journal of Nuclear Security

Nowadays, a security regime for protecting nuclear and radiological material—providing an intelligent national regulatory institution and establishing national security laws—is necessary in order for a state to ensure security of nuclear and radiological materials used within its borders.

This paper focuses on discussing the opportunities and challenges facing the future of nuclear security after the creation of the new Moroccan Agency of Nuclear and Radiological Safety and Security.