Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2017

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 54931 - 54960 of 60947

Full-Text Articles in Entire DC Network

Cost-Effectiveness Analysis Of Aripiprazole Compare With Risperidone In Patient With Autism Spectrum Disorders, Kridsadadanudej Wongwejwiwat Jan 2017

Cost-Effectiveness Analysis Of Aripiprazole Compare With Risperidone In Patient With Autism Spectrum Disorders, Kridsadadanudej Wongwejwiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Autism spectrum disorders (ASD) are a group of deficits in social interaction and social communication (American Psychiatric Association, 2013). The result of a study in Thailand found that ASD patients with less self-reliance increased the number of caregivers, indirect costs and total costs (Naruemol Junsamut, 2014). Risperidone and aripiprazole showed the effectiveness for treating irritability/disruptive behavior in ASD (LeClerc & Easley, 2015). The objective of this research was to estimate the cost-effectiveness of aripiprazole compared with risperidone for treating ASD patient. Seven studies were selected to analyze the outcomes of effectiveness utilizing network meta-analysis. The number of improving symptoms that …

Go to article

Factors Associated With Infant And Under-Five Mortality In Myanmar, Lal Hrin Mawi Jan 2017

Factors Associated With Infant And Under-Five Mortality In Myanmar, Lal Hrin Mawi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Myanmar is committed to achieve unfinished agenda for reducing child mortality, fourth indicator of Millennium Development Goals (MDGs) and global target to achieve under-five mortality rate 25 per 1000 live births in 2030. Moreover, under-five mortality varies across states and regions within the country and the study aims to explore determinants of mortality across different health care planning zones. The results showed that infants who were breastfed had lower risk of death by 11.7 percent comparison with children who were not, and twin or multiple births were more likely to die by 8.1%. Moreover, short preceding birth interval, mothers with …

Go to article

Private Stakeholders’ Perception On Leveraging Provider Payment Methods For Both Public And Private Sectors To Help Meet National Health Goals In Myanmar, Nay Nyi Nyi Lwin Jan 2017

Private Stakeholders’ Perception On Leveraging Provider Payment Methods For Both Public And Private Sectors To Help Meet National Health Goals In Myanmar, Nay Nyi Nyi Lwin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Myanmar has committed to achieving universal health coverage (UHC) by 2030. With a poor economy and scarce resource, the government alone cannot achieve UHC without the collaboration of private stakeholders which has an increasing role in the health sector with evolving political and administrative circumstances. To uplift equitable access to essential quality health care services with financial risk protection and efficiency, the country is eager to know a suitable mix of provider payment methods which can be used as key levers to support achieving UHC goals. This study is designed to explore the private stakeholders' perception on leveraging provider payment …

Go to article

Technical Efficiency Of Private Clinics Under Universal Coverage Scheme In Bangkok, Thailand, Pimpitcha Kangyang Jan 2017

Technical Efficiency Of Private Clinics Under Universal Coverage Scheme In Bangkok, Thailand, Pimpitcha Kangyang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to measure technical efficiency of 88 private clinics under Universal Coverage Scheme (UC) in Bangkok in fiscal year 2017 and to identify the factors affecting their technical efficiency. The study was divided to two parts. The first part was measuring of technical efficiency with data envelopment analysis (DEA) and the second part was identifying the factors affecting efficiency with regression analysis using Tobit model. The result of DEA under a variable return to scale assumption showed that 84 private clinics under UC (95.45 percent of the target of study) were operating on pure technical efficiency frontier (VRSTE), …

Go to article

Cost-Effectiveness Analysis Of Laparoscopic Cholecystectomy Compared With Open Cholecystectomy At A Private Hospital In Myanmar, Pye Paing Heing Jan 2017

Cost-Effectiveness Analysis Of Laparoscopic Cholecystectomy Compared With Open Cholecystectomy At A Private Hospital In Myanmar, Pye Paing Heing

Chulalongkorn University Theses and Dissertations (Chula ETD)

Laparoscopic cholecystectomy (LC) has become the main treatment of uncomplicated gallstone diseases in developed countries due to shorter hospital stay, faster recovery time and other benefits. However, it is still controversial for developing countries. This study aims to evaluate whether laparoscopic cholecystectomy is more cost-effective than open cholecystectomy (OC) in the treatment of gallstone diseases in Myanmar. A cost-effectiveness analysis was evaluated from the provider perspective. The required cost and outcome data were obtained from a private hospital which is located in Yangon, Myanmar. Two outcomes are used as effectiveness in this study, namely cases of complications avoided and cases …

Go to article

Factors Influencing Health Care Utilization Among Middle Aged And Elderly People In China, Qilimuge - Jan 2017

Factors Influencing Health Care Utilization Among Middle Aged And Elderly People In China, Qilimuge -

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: China's one-child policy, significant advancement in health care, increase in life expectancy and decrease in birth rate all contribute to rapidly aging society. Proportion of elderly will continue to grow, which will put more burden on an already troubled health care system. This study tries to assess factors influencing health care utilization among middle-aged and elderly people in China. Objective: To analyze factors influencing health care utilization among middle-aged and elderly people in China. Methods: The study used secondary data from the China Health and Retirement Longitudinal Study (CHARLS) 2013 wave survey. The outcomes of interest include outpatient and …

Go to article

Technical Efficiency Of Public District Hospitals In Vietnam, Thi Binh Lam Jan 2017

Technical Efficiency Of Public District Hospitals In Vietnam, Thi Binh Lam

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this study aimed to evaluate the Technical Efficiency of public district hospitals in Vietnam and to determine factors affecting the hospitals' efficiency. Input-Oriented Data Envelopment Analysis (DEA) model was applied to estimate the technical efficiency scores among 52 public district hospitals in 6 provinces of Vietnam in 2014. Then, Tobit regression model was employed to explore the determinant factors. Results of the DEA indicated that there were considerable variations of efficiency scores in terms of return to scale assumptions. The average variable return to scale technical efficiency (VRSTE) and constant return to scale technical efficiency (CRSTE) were …

Go to article

Factors Affecting Health Seeking Behavior Of People In Ejin Horo County, China, Yuan Yuan Jan 2017

Factors Affecting Health Seeking Behavior Of People In Ejin Horo County, China, Yuan Yuan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to explore health seeking behavior in Ejin Horo county, China, specifically it tries to assess how socioeconomic-demographic factors and health literacy affect the decision to use formal outpatient care and conditioning on use the choice among the three-tiered health care facilities visited by people in Ejin Horo county, China during the period of 2016. Our attention is placed on the demand side because Ejin Horo county is the most powerful county in Inner Mongolia and the supply of health services in this county is quite comprehensive. In essence, the study on health seeking behavior will be able …

Go to article

Threshold Of Luminance Contrast And Chromaticity Contrast For Subjects Wearing Simulated Low Vision Glasses, Mintra Manavutt Jan 2017

Threshold Of Luminance Contrast And Chromaticity Contrast For Subjects Wearing Simulated Low Vision Glasses, Mintra Manavutt

Chulalongkorn University Theses and Dissertations (Chula ETD)

As reported by WHO in 2010, there are 246 million people with low vision (total population in the world is 6,737 million). The proper environment is important for doing their daily activities not only to be safe and convenient but also to improve the quality of life. This research investigated the threshold of luminance contrast and chromaticity contrast for subjects wearing simulated low vision glasses. The subjests are color normal vision wearing simulated low vision glasses with visual acuity (VA) ranging between 0.05 and 0.3: narrow vision (NV), blur vision (BL), occlusion vision (OLS) and combination of blur and occlusion …

Go to article

Effect Of Degradation Of Peg 600 On Color Fading And Crosslinking In Soft Gelatin Capsule Shell, Weena Nittayasoot Jan 2017

Effect Of Degradation Of Peg 600 On Color Fading And Crosslinking In Soft Gelatin Capsule Shell, Weena Nittayasoot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Autoxidation of polyethylene glycol (PEG) 600, which is a hydrophilic liquid commonly filled in soft gelatin capsules, results in formaldehyde which is an oxidizing agent. The objectives of the present study were to study the effect of formaldehyde on fading of brilliant blue dye and crosslinking in the soft gelatin capsules; also to investigate possibility of inhibition of PEG 600 autoxidation by a selected antioxidant. Nine PEG 600 based fill formulations were prepared according to a full factorial design with 2 factors and 3 levels of water (0, 5, 10 %w/w) and an antioxidant, i.e. d-α-tocopherol (0, 0.001, 0.05 %w/w). …

Go to article

Application Of Radio Frequency Identification (Rfid) Technology For Tracking The Manufacture Of Narcotic Drugs And Psychotropic Substances: A Case Study Of Phenobarbital Tablets Production, Jesdaporn Rachivong Jan 2017

Application Of Radio Frequency Identification (Rfid) Technology For Tracking The Manufacture Of Narcotic Drugs And Psychotropic Substances: A Case Study Of Phenobarbital Tablets Production, Jesdaporn Rachivong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study applied RFID tracking of the manufacturing process and tracing back of product for preventing API loss with phenobarbital tablets as a case study. GPO has produced narcotic drugs, and psychotropic substances complied with GMP, Narcotics Act, and Psychotropic Substances Act. It included designing RFID implementation, determining user requirement and functional specification, selecting suitable devices, evaluating significant parameters and verifying the designed system. The verified software was continuously tested in stages of site testing and was assessed the risk with FMEA tool, user's satisfaction and the impact on the manufacturing process. The risk priority class of a plant which …

Go to article

Preparation And Stabilization Of X-Ray Amorphous Solid State Structure Of Salbutamol Sulfate Adsorbed On Mesoporous Silica, Treeruk Prasertsri Jan 2017

Preparation And Stabilization Of X-Ray Amorphous Solid State Structure Of Salbutamol Sulfate Adsorbed On Mesoporous Silica, Treeruk Prasertsri

Chulalongkorn University Theses and Dissertations (Chula ETD)

The main objective of this study was to focus on the preparation of X-ray amorphous salbutamol sulfate (SS) with mesoporous silica (S244 silica) carrier by using incipient wetness impregnation approach and further investigated on the utilization of poly (vinylpyrrolidone) (PVP) K12 for the stabilization of amorphous produced. Initially, SS was prepared in solution state and later loaded on S244 silica. The output product showed the non-ordered arrangement of SS with the longer interconversion time to crystalline when comparing with ground amorphous SS. It should be explained that SS was located on the silica surface randomly with no molecular packing according …

Go to article

Treading Water: An Ethnography Of The Plight And Capabilities Of Afghan Refugees In Indonesia, Jennifer Kay Moberg Jan 2017

Treading Water: An Ethnography Of The Plight And Capabilities Of Afghan Refugees In Indonesia, Jennifer Kay Moberg

Chulalongkorn University Theses and Dissertations (Chula ETD)

ACCORDING TO THE 2016 UNHCR STATISTICS, THERE ARE OVER 14,000 REFUGEES TRAPPED IN INDEFINITE TRANSIT IN INDONESIA, WITH FAINT HOPE OF EVER BEING RESETTLED TO ANY THIRD COUNTRY. THE WEST JAVA TOWN OF CISARUA ALONE HOSTS NEARLY 5,000 REFUGEES FROM THE ETHNIC HAZARA MINORITY GROUP FROM AFGHANISTAN. IN THEIR INTRACTABLE LIMBO, A GROUP OF THESE HAZARAS HAVE SET UP A NUMBER OF REFUGEE RUN LEARNING CENTRES AND COMMUNITY INITIATIVES, CREATING FOR THEMSELVES MEANING AND PURPOSE DURING THEIR UNBOUNDED TRANSIT. THIS TOWN AND POPULATION REPRESENT A UNIQUE CASE STUDY IN REFUGEE RESILIENCE, TRANSFORMATION, AND EMPOWERMENT IN LIGHT OF A DEEPENING GLOBAL …

Go to article

Sisters, Boyfriends, And The Big City: Trans Entertainers And Sex Workers In Globalized Thailand, Leo Bernardo Escalante Villar Jan 2017

Sisters, Boyfriends, And The Big City: Trans Entertainers And Sex Workers In Globalized Thailand, Leo Bernardo Escalante Villar

Chulalongkorn University Theses and Dissertations (Chula ETD)

As transgender issues penetrate mainstream human rights dialogue, most of the current understanding and research on this marginalized group revolve around the perspective of HIV/AIDS prevention and awareness. To add to the growing academic discourse on transgender women in the world of work, this research looks into the lives of transgender women sex workers and entertainers in the major cities of Bangkok and Pattaya in Thailand. The research uses a qualitative approach consisting of content analysis of relevant Thai policies and semi-structured interviews with 8 transgender women, a transgender-focused local NGO, and the management team of a prominent transgender cabaret …

Go to article

The Challenges And Livelihood Strategies Of Pakistan's Urban Women Refugees In Bangkok,Thailand, Margaret Mbeyu Nguma Jan 2017

The Challenges And Livelihood Strategies Of Pakistan's Urban Women Refugees In Bangkok,Thailand, Margaret Mbeyu Nguma

Chulalongkorn University Theses and Dissertations (Chula ETD)

Despite the fact that Thailand is a non-signatory of the 1951Refugee Convention relating to the Status of Refugee and its 1967 protocol, it has become a home to many and still provides basic protection for many refugees and those who seek asylum. In principle with lack of some legal framework that recognizes and provides documents for asylum seekers and refugees, these subjects are treated as illegal migrants under the Thai Law article 12 of Immigration act. The focus of the study is to understand and examine the challenges and the livelihood strategies faced by Pakistan urban women refugees on access …

Go to article

Singaporean Malays' Perspectives Of Income Inequality And Its Impact On Their Opportunities In Singapore’S Education System, Ngak Leng Tan Jan 2017

Singaporean Malays' Perspectives Of Income Inequality And Its Impact On Their Opportunities In Singapore’S Education System, Ngak Leng Tan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Studies on the profile of income inequality revealed that Singaporean Malays continuously occupied the lowest income strata and fared relatively poorer in their academic performance compared to other races. In a highly competitive meritocratic education system that rewards relative merit, yet neglects how unequal backgrounds provided unfair starting points for some, such low-income Malay households may appear to be systemically disadvantaged by income inequality and their access to better education. Under these circumstances, income inequality is further perpetuated. Through the use of focus group discussions and in-depth interviews, my proposed research will seek to understand how Singaporean Malays perceive such …

Go to article

Development And Dynamics Of The Informal Workers In Thailand: A Case Study Of Informal Workers Network, Tanachot Assawarotjanamitre Jan 2017

Development And Dynamics Of The Informal Workers In Thailand: A Case Study Of Informal Workers Network, Tanachot Assawarotjanamitre

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis aims to analyze the informal worker movement that is associated with a labor NGO named HomeNet Thailand, which helped mobilize informal workers and strengthen their skills and knowledge. The core analysis of thesis follows Resource Mobilization Theory and Political Process Theory to analyze the informal workers' developments, conditions, and limitations. This thesis explores the Informal workers' situation during Yingluck Shinawatra's civilian government (2011-2014) and Prayut Chan-o-cha's miliatry government (2014-Present). The thesis consists of 5 parts. Firstly, an introduction elaborates the research methodology of Archival Research and Interview methods. Secondly, a literature review and theoretical framework show the limitations …

Go to article

Knowledge Politics In National Nuclear Energy Planning In Thailand (2007-2017) With A Case Study Of Ubon Ratchathani Province, Tipakson Manpati Jan 2017

Knowledge Politics In National Nuclear Energy Planning In Thailand (2007-2017) With A Case Study Of Ubon Ratchathani Province, Tipakson Manpati

Chulalongkorn University Theses and Dissertations (Chula ETD)

Thailand has long aspired to nuclear power for electricity generation, and there are plans for nuclear power projects in the most recent Power Development Plans (2015-2036) - PDP 2015. The reason for incorporating nuclear power relates to anticipation of growing energy demand. Nuclear power is seen as an attractive option for diversifying energy sources, as to date Thailand has largely depended on domestic natural gas reserves and imported fuel resources. On the one hand, nuclear power has been promoted as a 'low carbon' emission option to mitigate greenhouse gas (GHG) emissions. On the other hand, nuclear technology carries significant potential …

Go to article

Microcredit And Women's Empowerment In Dry Zone Area, Myanmar, Zon Phyu Linn Jan 2017

Microcredit And Women's Empowerment In Dry Zone Area, Myanmar, Zon Phyu Linn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Microcredit (microloans) has proved to be an important liberating force in societies where women have to struggle against repressive social and economic conditions. As a tradition in Myanmar society, women often take the back seat and are not active in decision-making despite working hard in all aspects of the economic sphere. The improvement in women's economic empowerment has the potential to lead to positive changes in both social and psychological dimensions. An important institution for promoting microcredits in Myanmar is Pact INGO, which is implementing a savings-led economic empowerment program for women, under the WORTH model. Since its launch, Pact …

Go to article

Strategic Fit For Outsourcing Of Pharmaceutical Manufacturing: A Scenario Study In Thailand, Sompong Apithamsoonthorn Jan 2017

Strategic Fit For Outsourcing Of Pharmaceutical Manufacturing: A Scenario Study In Thailand, Sompong Apithamsoonthorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Outsourcing is recognized as one of the critical factors for efficient execution of pharmaceutical supply chain management, many pharmaceutical companies engage in international outsourcing of services (IOS) to survive in global highly competitive business. Since the key success factors for both domestic & international alliances are partnership characteristics and strategic fit management, but there is no empirical research on this issue in Thai pharmaceutical partnership offshore outsourcing. Therefore, this survey of Thai and foreign companies, both contract providers (CPs) and contract manufacturers (CMs), seeks to indicate significant relationships among both outsourcing strategic fit type and partnership type, including outsourcing performance …

Go to article

Effects Of Food On Growth And Gonadal Development Of Seahorse Hippocampus Sp., Thatpon Kamnurdnin Jan 2017

Effects Of Food On Growth And Gonadal Development Of Seahorse Hippocampus Sp., Thatpon Kamnurdnin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hippocampus sp. has received attention as a source of aquarium and ornamental trade. Seahorses have been threatened from non-target fisheries, habitat loss and traditional Chinese medicine (TCM). In response to concern about a decrease of population in the wild, an aquaculture of this species may provide the seahorse numbers for the commercial demands. However, one of the critical problems in aquaculture is the proper dietary for growth and their development. Therefore, this study was conducted on different types of preys on survival rates, growth rates and gonadal development in Hippocampus sp. during the day of birth until the 31day after …

Go to article

Comparision Of Fly Ash And Metakaolin Based Geopolymer Properties For Heavy Metal Adsorption, Sujitra Onutai Jan 2017

Comparision Of Fly Ash And Metakaolin Based Geopolymer Properties For Heavy Metal Adsorption, Sujitra Onutai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work aims to evaluate the effectiveness of fly ash and metakaolin based geopolymer powder and fly ash and metakaolin based geopolymer composite fiber as an adsorbent for removal of heavy metal ions from aqueous solution. The fly ash and metakaolin used as raw materials in this research was from Thailand. Fly ash based geopolymer (FAG) was synthesized by mix with an alkali solution. After that, the geopolymerization process was occurred and then cured geopolymer samples at 60oC for 24 h and left at 25 oC for 6 days. The fly ash based geopolymer was ground, washed and sieved through …

Go to article

Measurement Of Eye Lens Dose In Interventional Radiologist From Tace Procedures Using Osld, Mananchaya Vimolnoch Jan 2017

Measurement Of Eye Lens Dose In Interventional Radiologist From Tace Procedures Using Osld, Mananchaya Vimolnoch

Chulalongkorn University Theses and Dissertations (Chula ETD)

For routine clinical service at Section of Interventional Radiology, Department of Radiology, King Chulalongkorn Memorial Hospital (KCMH), TACE procedure has been one of the high exposure procedures, which result in increasing eye lens dose in interventional radiologists. Thus, radiation dose should be evaluated in interventional radiology staff who may receive high eye lens dose. Currently, there is insufficient information to comply with the ICRP dose limit on the occupation exposure to the eye lens. One of the factors affecting the eye lens dose is the variation in tube directions in the interventional radiology (IR) laboratories. A preliminary study about tube …

Go to article

Monitor Unit (Mu) Validation Using Various Types Of Dosimeters For Commissioning Small Field In Eclipse™ Treatment Planning System, Sammuel Mamesa Jan 2017

Monitor Unit (Mu) Validation Using Various Types Of Dosimeters For Commissioning Small Field In Eclipse™ Treatment Planning System, Sammuel Mamesa

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this study was to investigate the differences of calculated MU between commissioning using corrected FOF from single detector and commissioning using average uncorrected FOF from three detectors. Measurements were carried out on 6 MV flattened photon beams from 1x1 cm2 to 10x10 cm2. Four detectors were utilized to measure depth doses and beam profiles: IBA CC01, IBA PFD, IBA EFD and Sun Nuclear EDGE. For FOF determination, Sun Nuclear EDGE was not used. The determination of FOF was classified into corrected FOF according to IAEA/AAPM TRS 483 and uncorrected FOF from three detectors. Commissioning was undertaken in …

Go to article

The Determination Of Optimal Protocol For Digital Chest Tomosynthesis, Sarawut Tongkum Jan 2017

The Determination Of Optimal Protocol For Digital Chest Tomosynthesis, Sarawut Tongkum

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recently, digital chest tomosynthesis (DTS) is introduced as alternative technique in digital chest radiography for evaluating pulmonary disease and enhancing the internal structures in different slices. However, the radiation dose is higher compared to general chest radiography. The present study was to determine the optimal protocol for DTS in order to reduce the radiation dose to patients while maintaining the image quality. The multipurpose chest phantom N1 "LUNGMAN'' was scanned by digital radiographic systems model Definium 8000.Such phantom was inserted with simulated nodules with size diameter of 3, 5, 8, 10, 12 mm, and the data were acquired using chest …

Go to article

Ct Number And Electron Density Relationship For Photon Dose Calculation In Head And Neck, Chest, Spine And Pelvic Regions, Siriporn Wong Jan 2017

Ct Number And Electron Density Relationship For Photon Dose Calculation In Head And Neck, Chest, Spine And Pelvic Regions, Siriporn Wong

Chulalongkorn University Theses and Dissertations (Chula ETD)

CT images supply the HU information that relates to electron density (ρe). The ρe is important for tissue inhomogeneity correction for accurate dose calculation. The purpose of this study was to evaluate the dosimetric effect on CT images on different kVp setting using single HU-ρe curve. Anthropomorphic phantom was scanned using Siemens-SOMATOM Definition AS with 120 kVp setting and used as a reference image set. The procedures were repeated with DECT option (80/140 kVp), 80 and 140 kVp. The 120 kVp HU-ρe relationship curve from Gammex 467 tissue characterization phantom was created and applied into Eclipse treatment planning system. The …

Go to article

Radiation Dose And Image Quality In Chest Region Using Single- And Dual-Energy Ct: Phantom Study, Taninchai Jutawiriya Jan 2017

Radiation Dose And Image Quality In Chest Region Using Single- And Dual-Energy Ct: Phantom Study, Taninchai Jutawiriya

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chest CT examinations are routinely performed by using single energy protocol (SE). As CT had been evolved by using dual energy protocol (DE), the patients with underlying lung nodules or pulmonary nodules will be followed up by CT examination several times. The purpose of this study is to study the radiation dose and image quality between single-energy CT (SECT) and dual-energy CT (DECT) protocols in chest phantom at King Chulalongkorn Memorial Hospital. The Lungman Kyoto Kagaku phantom inserted by five simulated lesions of various diameters was scanned by dual-source CT system (Somatom Force, Siemens Healthineers). The acquisition protocols consist of …

Go to article

Involvement Of Notch Signaling In Interleukin-4-Stimulated Human Macrophages, Naunpun Sangphech Jan 2017

Involvement Of Notch Signaling In Interleukin-4-Stimulated Human Macrophages, Naunpun Sangphech

Chulalongkorn University Theses and Dissertations (Chula ETD)

Macrophages respond to various stimuli, resulting in distinct effector phenotypes that range from LPS-stimulated proinflammatory to IL-4-activated pro-healing phenotype. The regulatory mechanism of this polarization is not fully understood. Notch signaling pathway is a conserved signaling pathway involved in polarization of macrophages, especially proinflammatory macrophages. However, the role of Notch signaling in IL-4 stimulated macrophages (M(IL-4)) is not well defined. PPARgamma is a signature nuclear receptor in M(IL-4) that function mainly in regulating lipid metabolism. There are many reports that revealed the interaction of Notch signaling and PPARgamma in various cells but not in macrophages. In this study, the interaction …

Go to article

Ctl-Mediated Immune Evasion In Hiv Viraemic Controllers And Non-Controllers, Prathanporn Kaewpreedee Jan 2017

Ctl-Mediated Immune Evasion In Hiv Viraemic Controllers And Non-Controllers, Prathanporn Kaewpreedee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To compare T cell response and to identify the mechanism of escape in HIV-infected volunteers. Methods: HIV-infected volunteers (CD4>450 cells/µL) were enrolled from the anonymous clinic. Volunteers were classified into two groups based on HIV plasma viral load; viraemic controllers (VC) (VL<2000 cp/mL) and non-controllers (NC) (VL>2000 cp/mL). EDTA-whole blood was collected and determined the response against Gag p24 by IFNγ ELISpot assay. Population sequencing within the Gag p24 region was performed to identify escape mutations. Results: Demographic data [age, gender, sexual preference and the presence of protective alleles (HLA-B27, -B57 and –B58)] between VC (n=23) and NC (n=41) were no statistical …

Go to article

Development Of Gold Nanoparticle-Based Lateral Flow Immunoassay For Detection Of Pathogenic Leptospiral Antigen, Prayoon Lae-Ngee Jan 2017

Development Of Gold Nanoparticle-Based Lateral Flow Immunoassay For Detection Of Pathogenic Leptospiral Antigen, Prayoon Lae-Ngee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leptospirosis, caused by pathogenic Leptospira spp., is a global re-emerging zoonosis and endemic disease in tropical and sub-tropical countries including Thailand. Point-of-care testing (POCT) for rapid diagnosis of leptospirosis is needed for prompt and appropriate treatment particularly in resource-poor settings. Lateral flow immunoassay (LFA)-based POCT devices are rapid, user friendly, cheap, have one-step analysis, and need no sophisticated equipment. LipL32 is a common target for diagnostic tests of leptospirosis because it is the major outer membrane protein (OMP) that is specific and highly conserved among pathogenic Leptospira. This study aimed to develop the gold nanoparticle (AuNP)-based LFA for detection of …

Go to article

First Prev Next Last