Digital Commons Network^™

Assessment Of R18, Cog1410, And App96-110 In Excitotoxicity And Traumatic Brain Injury, Li Shan Chiu, Ryan S. Anderton, Jane L. Cross, Vince W. Clark, Adam B. Edwards, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

Cationic arginine-rich and poly-arginine peptides (referred to as CARPs) have potent neuroprotective properties in in vitro excitotoxicity and in vivo models of stroke. Traumatic brain injury (TBI) shares many pathophysiological processes as stroke, including excitotoxicity. Therefore, we evaluated our lead peptide, poly-arginine R18, with the COG1410 and APP96-110 peptides, which have neuroprotective actions following TBI. In an in vitro cortical neuronal glutamic acid excitotoxicity injury model, R18 was highly neuroprotective and reduced neuronal calcium influx, while COG1410 and APP96-110 displayed modest neuroprotection and were less effective at reducing calcium influx. In an impact-acceleration closed-head injury model (Marmarou model), R18, COG1410, …

Study Protocol For A Randomised Controlled Trial Evaluating The Effect Of Prenatal Omega-3 Lcpufa Supplementation To Reduce The Incidence Of Preterm Birth: The Orip Trial, Shao J. Zhou, Karen Best, Robert Gibson, Andrew Mcphee, Lisa Yelland, Julie Quinlivan, Maria Makrides

Health Sciences Papers and Journal Articles

Introduction: Preterm birth accounts for more than 85% of all perinatal complications and deaths. Seventy-five per cent of early preterm births (EPTBs) occur spontaneously and without identifiable risk factors. The need for a broadly applicable, effective strategy for primary prevention is paramount. Secondary outcomes from the docosahexaenoic acid (DHA) to Optimise Mother Infant Outcome trial showed that maternal supplementation until delivery with omega-3 (ω-3) long chain polyunsaturated fatty acid (LCPUFA), predominantly as DHA, resulted in a 50% reduction in the incidence of EPTB and an increase in the incidence of post-term induction or post-term prelabour caesarean section due to extended …

Mobile Learning Technology Acceptance Among Saudi Higher Education Students, Talal Mohammed Alasmari

Wayne State University Dissertations

The rapid development of technology has encouraged Saudi universities to establish initiatives to improve learning. Mobile learning technology is one of the technologies targeted by eLearning and distance education deanships among Saudi universities. However, few studies have been done in investigating mobile learning technology acceptance in the Saudi context. This study aims to provide policy and decision makers in the Saudi higher education with reliable data in order to employ mobile learning technology in learning process. Therefore, this study modified Unified Theory of Acceptance and Use of Technology (UTAUT) to investigate students’ acceptance of mobile learning technology. To this end, …

A Narrative Study Of Chaldean Refugees And The Myth Of Return: From Chaldean Babylon To The New World, Joseph James Byle

Wayne State University Dissertations

With the removal of Saddam following the 2003 U.S. invasion of Iraq, life for all Iraqis changed for the worse, especially for minorities such as Christians, including Chaldeans. Considering the powerful push factors that have compelled Chaldean Refugees in the Detroit area to leave Iraq, the idea of returning to the homeland would seem like a remote possibility, however, these Chaldeans present an intriguing case, due to the fact that they are among the indigenous people in Iraq. Do their deep rooted ties to the homeland contribute to a desire to return? This research examines this possibility through an in-depth …

Does Tort Reform Affect The Market For Lawyers? Evidence From The U.S States., Ablaye Camara

Wayne State University Dissertations

This paper investigates the determinants of the market for lawyers with a focus on demand variables including tort reform laws. In this study, I used the Feasible Generalized Least Squared method and a Panel Corrected Standard Error method, with year and State identifiers applied to a panel of U.S states, to estimate the determinants of the Number of Lawyers. I also used the Fixed Effect model with year and state identifiers to evaluate the effects of these determinants on the Earnings of Lawyers.

The findings show that the Lagged Number of Lawyers and the Lagged Alternative Earnings are both significant …

Maternal Employment, Quality Time And Children Outcomes, Ahlam El Yaman

Wayne State University Dissertations

In this paper, I explore two relationships using the three waves of the Child Development Supplement of the Panel Study of Income Dynamics. In the first model, I assess the effect of maternal employment on the quantity and quality of time spent with the child. I use child and family fixed estimation and I also look at whether this relationship varies according to the mother’s educational attainment, the gender and the age of the child. In the second model, I estimate child production functions to examine the effects of quantity and quality of mother-child time on children’s behavioral and cognitive …

P120 Catenin Regulates Inflammation In Macrophage, Xiaoqing Guan

Wayne State University Dissertations

Objective: p120 catenin (p120ctn) has been reported to play a critical role in maintenance of the stability of adherens junctions. It also has potential anti-inflammatory effects in epithelial and endothelial cells. This research was designed to evaluate the effects of p120ctn on inflammatory responses in human macrophages upon LPS stimulation, as well as the possible mechanism by which p120ctn regulates LPS-induced proinflammatory response in macrophages. Methods: THP-1 cells were induced to differentiate into macrophages by PMA. The isoforms of p120ctn were identified via RT-PCR and Western blot. The expression of p120ctn was examined by Western blot in THP-1 derived macrophages …

The Effectivness Of Advisory Pograms With Teachers And Learning Disabled African-American Students In Urban High Schools, Camelia Ramona Gligor

Wayne State University Dissertations

THE EFFECTIVENESS OF ADVISORY PROGRAMS WITH TEACHERS AND LEARNING DISABLED AFRICAN-AMERICAN STUDENTS IN URBAN HIGH SCHOOLS

By

Camelia Ramona Gligor

ABSTRACT

This is a study that investigated the effects of Advisory program on African American high school students with specific learning disabilities. In this qualitative study the advisory program is examined through the lenses of teachers and students from a Mid East Metropolitan Area (MEMA).

Three research questions guided this dissertation: (1) How do secondary school teachers perceive inclusive advisory in urban schools; (2) How do African-American SLD students value their experiences in advisory; (3) What are the secondary teachers’ …

Clinicopathology And Molecular Determinants Underlying Benign Breast And Breast Cancer Lesions, Andreana Holowatyj Holowatyj

Wayne State University Dissertations

Despite converging incidence rates for breast cancers by race, disparities in mortality persist where black women suffer from poorer prognosis compared to white counterparts. To understand the clinical, demographic, and molecular characteristics underlying these disparities, we examined differences among patients with breast cancer to understand the role of human epidermal growth factor receptor 2 (HER2) status, age, and race/ethnicity among women diagnosed with hormone receptor-positive breast cancer, and disparities in surgical therapy among female patients with early stage young-onset breast cancer. Benign breast disease, another known risk factor for breast cancer, includes a histological spectrum of lesions, could contribute to …

Black Male Genocide: Sanctioned Segregation In American Policy, Alton Maxel James

Wayne State University Dissertations

College degree attainment for Black Americans has significantly fallen their majority counterparts. While educational attainment for this minority demographic has been less than average, a secondary trend emerges. Despite the rises in graduation rates, Black males consistently earn a smaller percentage of the degrees garnered by Black students. Furthermore, policies throughout sectors of American society produce segregation that manifests as genocidal realities in the lives of Black men—including college graduation. Thus, the purpose of this research was to determine the effect of neighborhood segregation on Black men and women’s 4 and 6-year graduation probability and determine if Black men reduce …

Understanding The Mechanism Of Oxidative Stress Generation By Oxidized Dopamine Metabolites: Implications In Parkinson's Disease, Nihar Mehta

Wayne State University Dissertations

Oxidation of dopamine to toxic metabolites is considered to be one of the prime factors involved in the death of dopaminergic neurons in Parkinson’s disease. Some dopamine oxidation products have the capability to redox cycle in the presence of molecular oxygen, further contributing to oxidative stress. Therefore, our aim here was to study the redox cycling of dopamine oxidized metabolites and elucidate the underlying mechanism by which they cause oxidative stress.

Redox reactions involve transfer of one or more electrons between two compounds

resulting in either oxidation or reduction. In redox cycling, a compound undergoes

alternate oxidation and reduction, transferring …

The Effects Of Various High School Scheduling Models On Student Achievement In Michigan, Russell Edward Pickell

Wayne State University Dissertations

This study reviews research and data to determine whether student achievement is affected by the high school scheduling model, and whether changes in scheduling models result in statistically significant changes in student achievement, as measured by the ACT Composite, ACT English Language Arts, and ACT Math scores. The high school scheduling models included in this study are: six period semester (SPS), five period trimester (FPT), seven period semester (VPS), standard 4x4 block (SB), and alternate day block (ADB). Supportive and non-supportive research are discussed in regard to the impact of the student scheduling model on student achievement.

Analysis Of The Secondary Neurodegenerative Consequences Of Primary Oligodendrocyte Stress Through The Use Of The Novel Obiden Mouse Model, Daniel Zdzislaw Radecki

Wayne State University Dissertations

The work of this project was to develop, test and characterize a potential novel mouse model of the neurodegenerative disease Multiple Sclerosis (MS). Historically, MS has been identified as a primary autoimmune disease of the central nervous system (CNS). However, treatments based on this view have met with limited success, and in most cases, fail to prevent progression of MS from mild to moderate and severe forms. Original observations regarding axonal and neuronal pathology in the white and gray matter of the CNS were rediscovered in the 1990s. These observations indicated that even in the absence of the immune system, …

Actuation Of Droplets Using Transparent Graphene Electrodes For Tunable Lenses And Biomedical Applications, Ali Shahini

Wayne State University Dissertations

Variable focal length liquid microlenses are the next candidate for a wide variety of applications. Driving mechanism of the liquid lenses can be categorized into mechanical and electrical actuation. Among different actuation mechanisms, EWOD is the most common tool for actuation of the liquid lenses. In this dissertation, we have demonstrated versatile and low-cost miniature liquid lenses with graphene as electrodes. Tunable focal length is achieved by changing both curvature of the droplet using electrowetting on dielectric (EWOD) and applied pressure. Ionic liquid and KCl solution are utilized as lens liquid on the top of a flexible Teflon-coated PDMS/parylene membrane. …

Pathetic Politics: An Analysis Of Emotion And Embodiment In First Lady Rhetoric, Stephanie Lynn Wideman

Wayne State University Dissertations

This dissertation explores the theoretical and practical relationship between our understandings of emotion’s role in political decision-making. In this pursuit I seek a resurrection for pathos’s legitimacy in persuasive studies through the pursuit of the pathetic political realm. This work has three primary concerns: how may pathetic power be accessed, from where does this power originate, and how might political actors enact this power for their own political goals. I draw primarily from theories related to visual rhetoric and the body in order to provide perspective on how the body is politicized through the pathetic realm. Theoretical perspectives are drawn …

Remote Preconditioning: Evaluating The Efficacy Of Cardioprotection In Type-2 Diabetes And Exploring The Mechanistic Role Of Exosomes, Joseph Michael Wider

Wayne State University Dissertations

Remote preconditioning is a promising and robust treatment for myocardial

ischemia/reperfusion injury that evokes cardioprotection through endogenous neural

and/or humoral signaling. A recent study has reported that protective signaling is

mediated by exosomes through the circulation; however this concept is supported by

limited and inconsistent evidence. Despite overwhelming success in preclinical studies,

the efficacy of remote preconditioning in human studies is inconclusive. Importantly, the

majority of remote preconditioning studies use healthy animal models despite growing

evidence that comorbidities, such as type-2 diabetes, may negatively influence

outcomes. Nonetheless, the efficacy of remote preconditioning in the setting of type-2

diabetes has not …

Self-Efficacy: Understanding African American Male Students Pathways To Confidence In Mathematics, Lisa Ann Williams

Wayne State University Dissertations

This dissertation is about the stories of African American male undergraduate students who have experienced success in mathematics. Bandura’s (1997) social cognitive theory and Tillman’s (2000) culturally sensitive research approach which promotes qualitative methods, recognizes ethnicity, and positions culture as central to the research were applied. Student interviews, parent interviews, teacher interviews, and mathematical autobiographies were used to investigate African American men self-efficacy, the sources of their beliefs, and societal factors that impacted their motivation and academic achievement in mathematics.

The descriptive portraits and the interviews revealed five broad themes: (1) college experiences, (2) K-12 experiences, (3) access and equity, …

Transferrin Receptor Targeted Delivery Of Sirna For Gene Therapy, Yuran Xie

Wayne State University Dissertations

Gene therapy is thought to be a solution for various difficult to treat diseases such as cancer. Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence disease related gene have been exploit in different diseases. However, lack of safe and efficient siRNA delivery systems limits the application of siRNA therapy in clinic. Transferrin receptor (TfR) is an essential transmembrane receptor involved in iron uptake. TfR universally express in most cells/ tissues but upregulated in certain cells, for example, many cancer cells and activated T cells (ATCs). To overcome the biological barriers and increase siRNA delivery efficiency, in …

Cascaded Converters For Integration And Management Of Grid Level Energy Storage Systems, Zuhair Muhammed Alaas

Wayne State University Dissertations

ABSTRACT

CASCADED CONVERTERS FOR INTEGRATION AND MANAGEMENT OF GRID-LEVEL ENERGY STORAGE SYSTEMS

by

ZUHAIR ALAAS

December 2017

Advisor: Dr. Caisheng Wang

Major: ELECTRICAL ENGINEERING

Degree: Doctor of Philosophy

This research work proposes two cascaded multilevel inverter structures for BESS. The gating and switching control of switching devices in both inverter typologies are done by using a phase-shifted PWM scheme. The first proposed isolated multilevel inverter is made up of three-phase six-switch inverter blocks with a reduced number of power components compared with traditional isolated CHB. The suggested isolated converter has only one battery string for three-phase system that can be …

Estimating The Variables Of The Nonlinear Dynamical Theory Of Acute Cell Injury, Fika Tri Anggraini

Wayne State University Dissertations

This Dissertation is the first to estimate the variables D and S of the nonlinear theory of acute cell injury in hippocampal regions CA1 and CA3 using a rat model of global brain ischemia and reperfusion (I/R). D was estimated by quantifying protein aggregates using ubiquitin Western blotting. S was estimated by quantifying changes in polysomal mRNAs as measured by microarray chips. D and S time courses were sampled at 0.5, 8, 16, 24, 48, and 72 hrs of reperfusion after 10 min brain ischemia. CA1 dies and CA3 survives. The theory predicts D will be larger in CA1 and …

Effect Of Endoplasmic Reticulum Stress On Vascular Smooth Muscle Cells And Its Regulation Of Sm22Α, Neeraja Priyanka Annam

Wayne State University Dissertations

Background: The vascular smooth muscle cells(VSMC) possess the ability to differentiate into a synthetic phenotype in response to stress. This phenotypic modulation may be accompanied by inflammatory or osteogenic response in chronic stress. The synthetic state is characterized by low levels of contractile markers unlike the differentiated state.

Hypothesis: Endoplasmic reticulum (ER) stress causes phenotypic modulation in VSMCs leading to apoptosis. Many transcription factors induced by ER stress contribute to the downregulation of Sm22α. Perturbation in cytoskeletal dynamics exacerbates the ER stress response.

Methods: Ex-vivo culture was used to establish importance of Sm22 in ER stress. In vitro analysis was …

Pet Imaging Of Early Therapeutic Response In Solid Tumors, Stephanie J. Blocker

Wayne State University Dissertations

An important pillar of precision medicine for oncology is the ability to identify patients who respond to treatment early into their therapy. Positron emission tomography (PET) allows physicians and researchers to measure changes in tumor behavior prior to noticeable differences in morphology.

Objective: Determine the utility of multiple tracers for PET in assessing early changes in tumor activity that result from treatment.

Methods: Two tracers for PET were studied. 64Cu-labeled liposomes were used to assess changes in liposome delivery two solid colon tumors early into treatment with bevacizumab (Bev). 18F-FMAU thymidine analog (1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)thymine), was utilized to detect early response to …

Protein Phosphatase 2a Interactions In Islet And Human Skeletal Muscle In Diabetes, Divyasri Damacharla

Wayne State University Dissertations

Type 2 Diabetes is a metabolic disorder associated with insulin resistance and consequent high blood glucose levels. Under normal conditions, in response to high blood glucose levels, pancreatic beta cells produce insulin. The secreted insulin is dis-tributed to tissues thereby stimulating insulin stimulated glucose uptake. However, maximum glucose disposal takes place in skeletal muscle. Thus, studying beta cells and skeletal muscle in respect to diabetes is crucial. Protein Phosphatase 2A (PP2A) is one of the major serine/threonine phosphatases belonging to PhosphoProteinPhospha-tase (PPP) family. It constitutes about 80% of all serine/threonine phosphatases. It is regulated by numerous regulatory subunits as well …

Parent Interaction In Primetime Family Themed Television Portrayals: A Replication And Extension Of Dail And Way's (1985) Content Analysis, Anna Maria Katherine Flores

Wayne State University Dissertations

This research is a replication and extension of Dail and Way’s (1985) content analysis identifying parent interactions portrayed in family oriented prime time network television programs. Family structure, parent role, child rearing, and child responses were coded from five episodes each of eight different programs from 2014-2015 television season. The programs presented parent roles more often than child rearing, while mothers were found in child rearing more often than fathers. Traditional family structures were most prevalent with fewer single parent households and a new presence of same-sex parents. Mothers and fathers were still portrayed stereotypically, but children’s responses were more …

Nutrient Processes At The Stream-Lake Interface For A Channelized Versus Unmodified Stream Mouth, Richard G. Niswonger, Ramon C. Naranjo, David R. Smith, Jim E. Constantz, Kip K. Allander, Donald O. Rosenberry, Bethany T. Neilson, Michael R. Rosen, David A. Stonestrom

Civil and Environmental Engineering Faculty Publications

Inorganic forms of nitrogen and phosphorous impact freshwater lakes by stimulating primary production and affecting water quality and ecosystem health. Communities around the world are motivated to sustain and restore freshwater resources and are interested in processes controlling nutrient inputs. We studied the environment where streams flow into lakes, referred to as the stream-lake interface (SLI), for a channelized and unmodified stream outlet. Channelization is done to protect infrastructure or recreational beach areas. We collected hydraulic and nutrient data for surface water and shallow groundwater in two SLIs to develop conceptual models that describe characteristics that are representative of these …

Developing A General Methodology For Evaluating Composite Action In Insulated Wall Panels, Jaiden Olsen, Salam Al-Rubaye, Taylor J. Sorensen, Marc Maguire

Civil and Environmental Engineering Faculty Publications

Precast concrete sandwich wall panels(PCSWPs) have been in use for over 60 years. They provide a very efficient building envelope for many buildings. Characteristic PCSWPs comprise an outer and inner layer (or wythe) of concrete separated by an insulating material. To use all of the material as efficiently as possible, the layers are attached by connectors which penetrate through the insulating layer and are embedded in either concrete wythe. These connectors make it possible for both layers of the wall to work together when resisting loads. The connectors are made out of plastic, or FRP, to prevent heat transfer from …

Restoring And Sustaining Smallholder Kappaphycus Alvarezii Farming Post-Typhoon Haiyan/Yolanda In Molocaboc, Central Philippines, David C. Fenlon

Dissertations, Master's Theses and Master's Reports

The farming of marine seaweed has the potential to provide both nutritional and financial resources to developing communities such as the Molocaboc Islands in the Philippines. To foster this mariculture development approximately $1,000 USD in grant funds received from the US-Philippines Society was used to purchase materials needed to replace seaweed production infrastructure lost to Typhoon Haiyan (known as Super Typhoon Yolanda in the Philippines). The goal was to restore and expand smallholder farming of the seaweed Kappaphycus alvarezii (locally known as ‘guso’ in the Visayan dialect) in the Molocaboc Islands, thereby increasing harvest yields as compared to those …

Federal Trade Commission V. Roca Labs, Middle District Of Florida

Historical and Topical Legal Documents

DEFENDANTS’ MEMORANDUM IN OPPOSITION TO PLAINTIFF’S MOTION FOR SUMMARY JUDGMENT

Mse Annual Report 2017, Department Of Materials Science And Engineering, Michigan Technological University

Department of Materials Science and Engineering Annual Reports

Table of Contents

• Faculty and Staff News
• Faculty Research
• Student News
• Senior Design Teams
• Graduate Student News
• Outreach
• Alumni News
• By the Numbers
• Scholarships

Technical Solar Photovoltaic Potential Of Scaled Parking Lot Canopies: A Case Study Of Walmart U.S.A., Ram Krishnan, Amberlee S. Haselhuhn, Joshua M. Pearce

Department of Materials Science and Engineering Publications

Solar photovoltaic (PV) technology can provide sustainable power for the growing global population in cities, but it demands considerable land area. This is a challenge for densely populated cities. However, the stranded assets of non-productive parking lots areas can be converted to solar farms with PV canopies, enabling sustainable electricity generation while preserving their function to park automobiles. This study provides a method for determining the technical and economic potential for converting a national scale retail company’s parking lot area to a solar farm. First, the parking lot area for the company is determined and divided into zones based upon …