Digital Commons Network^™

Intravenous Formulation Of Het0016 Decreased Human Glioblastoma Growth And Iimplicated Survival Benefit In Rat Xenograft Models, M Jain, N Gamage, M Alsulami, A Shankar, B Achyut, Austin Guo, A Arbab, A Arbab

NYMC Faculty Publications

Glioblastoma (GBM) is a hypervascular primary brain tumor with poor prognosis. HET0016 is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth. Therefore, to explore novel treatments, we have generated an improved intravenous (IV) formulation of HET0016 with HPssCD and tested in animal models of human and syngeneic GBM. Administration of a single IV dose resulted in 7-fold higher levels of HET0016 in plasma and 3.6-fold higher levels in tumor at 60 min than that in IP route. IV treatment with HPssCD-HET0016 decreased tumor growth, and altered vascular kinetics in early and late treatment groups …

Cover, Editors And Editorial Board, Sponsors, Table Of Contents

Journal of Hip Hop Studies

No abstract provided.

250th Annual Report Of The Selectmen And Other Town Officers Cornish, New Hampshire Year Ending December 31, 2016., Cornish Town Representatives

Cornish, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Mercury Bioaccumulation In Three Popular Subsistence And Recreational Estuarine Fishes From Southeastern U.S.A., Taylor Cannon

Theses and Dissertations

A rising concern in recent years has occurred over the presence of methylmercury in seafood, particularly fishes, and its impact on human health. However, fish also provide many health benefits, including improved cardiovascular health and neurodevelopment. Because fishes are the main source of methylmercury exposure to humans, and are such an integral part of the human diet, understanding the risks versus the benefits of fish consumption is imperative in allowing the public to make healthy, educated choices. One way that state and federal governments attempt to do this is through issuing fish consumption advisories. Unfortunately, these advisories do not always …

The Addition Of A Concurrent Bimanual Task Influences Postural Sway And Walking Speed Performance And Prioritization Across All Ages, Derek Matthew Liuzzo

Theses and Dissertations

As individuals age, there is an increase in attentional demands, a heavier reliance on vision, reduction in efficiency of both tasks, and longer processing intervals causing greater dual task interference on postural sway and walking speed. While cognitive-motor interference has been investigated, the impact of adding a functional, manual task while balancing or during gait is poorly understood across all ages. The overall purpose was to examine the relationship between age and task automaticity in dual-task conditions with a functional bimanual task, and describe how age influences attentional prioritization strategies. Older adults demonstrated differences in single and dual task performance …

Losing Weight With Five A’S (5 A’S): Assess, Advise, Agree, Assist, Arrange Framework And Motivational Interviewing (Mi) For Health Behavior Change Counseling, Jacqueline Baer

Theses and Dissertations

According to the Centers for Disease Control and Prevention (CDC), obesity has reached epidemic levels and has associated with increased risk of morbidity and mortality rates. The increasing prevalence of obesity is a major public health concern. Researchers calculate that health care costs are 44% higher among moderately and severely obese older persons than for persons at normal weights. Seventy-five percent of African American (AA) women are overweight and obese according to data from the CDC and The State of Obesity: Better Policies for a Healthier America. Compared to any other racial ethnic group, AA women are more likely to …

Blind Change Point Detection And Regime Segmentation Using Gaussian Process Regression, Sourav Das

Theses and Dissertations

Time-series analysis is used heavily in modeling and forecasting weather, economics, medical data as well as in various other fields. Change point detection (CPD) means finding abrupt changes in the time-series when the statistical property of a certain part of it starts to differ. CPD has attracted a lot of attention in the artificial intelligence, machine learning and data mining communities. In this thesis, a novel CPD algorithm is introduced for segmenting multivariate time-series data. The proposed algorithm is a general pipeline to process any high dimensional multivariate time-series data using nonlinear non-parametric dynamic system. It consists of manifold learning …

Prenatal Methylmercury Exposure Through Rice Consumption In Rural China, Chuan Hong

Theses and Dissertations

Background: Methylmercury is one of the most toxic forms of mercury, which severely afflicts the developing fetus. Methylmercury exposure occurs not only through fish consumption but also through rice consumption. However, rice does not contain the same beneficial micronutrients that fish/shellfish has. Therefore, prenatal methylmercury exposure through maternal rice consumption may potentially increase adverse health effects on the developing fetus.

Objectives: The purpose of this dissertation was to investigate the magnitude of prenatal methylmercury exposure through rice consumption and the relationship between maternal mercury biomarkers and birth outcomes.

Methods: A total of 398 pregnant women were recruited at parturition in …

Early Adoption, Early Abandonment: Parallel Problems In Promoting New Technology, Caitlin Bagley

Foley Library Scholarship

No abstract provided.

Regulating Human Germline Modification In Light Of Crispr, Sarah Ashley Barnett

University of Richmond Law Review

No abstract provided.

Finite Element Modeling Of The Plantar Fascia: A Viscohyperelastic Approach, Alexander Knapp

UNF Graduate Theses and Dissertations

The present work details the creation and analysis of a finite element model of the foot, wherein the plantar fascia was modeled as a viscohyperelastic solid. The objective of this work was to develop a fully functional CAD and Finite Element Model of the foot and plantar fascia for analysis by examining the transient stresses on the plantar fascia through the use of a viscohyperelastic material model. The model’s geometry was developed through the use of image processing techniques with anatomical images provided by the National Institutes of Health. The finite element method was used to analyze the transient response …

Ptsd’S True Color; Examining The Effect Of A Short-Term Coloring Intervention On The Stress, Anxiety And Working Memory Of Veterans With Ptsd., Jourdan A. Rodak

UNF Graduate Theses and Dissertations

The aim of this study was to explore the effect a coloring condition had on minimizing anxiety and stress experienced daily by veterans. The effect that coloring had on working memory was also explored.

A sample of 24 armed forces veterans were split into two coloring conditions, a mandala and a free draw condition, and asked to complete the Primary Care PTSD Screen, the Perceived Stress Scale and the Brief State Trait Anxiety Inventory. Working memory scores were established via a Backward Digit Recall task; pre-and posttest scores were evaluated for significant differences.

Our research suggests the act of coloring, …

Attrition From School-Based Behavioral Parent Training Programs A Meta-Analytic Review, Dominique Levert

UNF Graduate Theses and Dissertations

Currently, very little is understood regarding the effectiveness of school-based Behavioral Parent Training (BPT) programs or associated attrition rates. The goal of the current study is to examine the effectiveness of school-based BPT programs, associated attrition rates, and possible moderator variables related to attrition. Searches within the databases EBSCOhost were conducted to find BPT programs located at schools as well as the associated attrition rates for each individual study. Mean associated attrition rates were calculated using the software Comprehensive Meta-Analysis. The mean weighted attrition rate across all trials of school-based studies was 42.2%. Significant moderators were also found to increase …

The Soundscape Of The St. Johns River And Its Potential Impacts On The Habitat Use Patterns Of Bottlenose Dolphins, Carissa Deeann King

UNF Graduate Theses and Dissertations

The development of effective management plans for animal populations relies on an understanding of how the population is utilizing the habitat as well as the identification of any critical habitat areas. The St. Johns River (SJR), an urban estuary with a high level of anthropogenic disturbance, is home to a resident population of bottlenose dolphins (Tursiops truncatus). In chapter one, SJR dolphin habitat use patterns, the factors that influenced these patterns, and the critical habitat areas were identified. Significant associations were found in most pair-wise comparisons between season, behavioral state, group size, water depth, and location, indicating that …

Anomaly Detection In Rfid Networks, Alaa Alkadi

UNF Graduate Theses and Dissertations

Available security standards for RFID networks (e.g. ISO/IEC 29167) are designed to secure individual tag-reader sessions and do not protect against active attacks that could also compromise the system as a whole (e.g. tag cloning or replay attacks). Proper traffic characterization models of the communication within an RFID network can lead to better understanding of operation under “normal” system state conditions and can consequently help identify security breaches not addressed by current standards. This study of RFID traffic characterization considers two piecewise-constant data smoothing techniques, namely Bayesian blocks and Knuth’s algorithms, over time-tagged events and compares them in the context …

Ado News February 2017, Alpha Kappa Alpha Sorority, Inc. Alpha Delta Omega Chapter

Alpha Delta Omega Chapter 2017 Newsletters

No abstract provided.

Collaborative Instruction For Information Retrieval And Appraisal Skills In Evidence-Based Practice Models For Dental Hygiene Students., Irene M. Lubker, Joan M. Pellegrini

VCU Libraries Faculty and Staff Presentations

Objectives:

1. Collaborate with VCU Dental Hygiene Program faculty to develop and evaluate a model of evidence-based practice (EBP) for students in didactic and clinical settings.

2. Describe how a course was modified to emphasize evidence-based practice.

3. Analyze course evaluations and student scholarly output.

Methods/Materials:

Dental educators strive to develop graduates who practice evidence-based practice and whose clinical decisions are based on current scientific research. A medical librarian was invited to assist in integrating EBP into the dentistry curriculum in 2012. To gain a better understanding of EBP in dental settings, the librarian and dental hygiene faculty attended the …

Old Testament Survey, Steelman Library, Gerry White

Syllabus Repository

No abstract provided.

Introduction To Chemistry Lab, Steelman Library, John Tompkins Dr.

Syllabus Repository

No abstract provided.

Understanding The Relationship Of Contextual Support, Peer Risk Trajectories, And School Outcomes For At-Risk Youth, Emily B. Mancil

Theses and Dissertations

High school dropout (HSDO) is associated with poor life outcomes across many domains. As such, it is crucial to understand and identify the factors that contribute to HSDO risk early to increase the chance of positive student outcomes. Because students at-risk are heterogeneous, researchers recommend using pattern-centered approaches to identify subpopulations with similar risk profiles to better understand various typologies of risk. This may be a more comprehensive and accurate way to understand students atrisk for HSDO and may facilitate the development of more effective interventions. To date, seven empirical studies have used a pattern-centered approach to examine HSDO. However, …

Fiber Optic Guided Wave Sensors For Structural Health Monitoring, Erik Frankforter

Theses and Dissertations

Risks and costs associated with aging infrastructure have been mounting, presenting a clear need for innovative damage monitoring solutions. One of the more powerful damage monitoring approaches involves using ultrasonic guided waves which propagate through a structure and carry damage-related information to permanently bonded sensors. Ultrasonic fiber-optic sensors are one of the most promising technologies for this application: they are immune to electromagnetic interference, present no ignition hazard, and transmit their data over tens of kilometers. However, before they can be widely employed, several limitations need to be overcome: poor sensitivity, unidirectional sensing, and loss of ultrasonic functionality due to …

Scribes Impact On Patient And Provider Experience In The Outpatient Setting, Kimberly A. Taylor

Theses and Dissertations

The purpose of this project was to evaluate the effectiveness of using scribes in the outpatient setting on patient and provider experience. A mixed methods approach with a convenience sample of voluntary patient participants scheduled for an outpatient appointment was utilized. Two primary care physicians volunteered to receive scribes. Four hospital corpsmen were selected and trained to serve in the scribe role.

This quality improvement project evaluated two aspects of experience during the implementation of the scribes. These included: 1) patient experience as indicated via a pre and post implementation questionnaire; and 2) provider experience as indicated via a pre …

A Critical Analysis Of The Effects Of Language Policy, Curriculum, And Assessment On Arabic L1 Student Performance In An Esl 1 Classroom, Juliane Bilotta

Theses and Dissertations

This thesis offers a preliminary analysis into looking at the ways in which Arabicspeaking ESL students are inadvertently marginalized by state standardization, curriculum, and dominant forms of classroom interactions in a NJ recovery program. Specifically, this analysis addresses the absence of orthographic training and a reliance on teacher-fronted, textbook based classroom exercises as a problematic structure that limits opportunities for Arabic-speaking students to participate successfully in an ESL 1 classroom. This data was collected during six-weeks of preliminary research during the summer of 2016 in a Jersey City, NJ ESL classroom. Using transcriptions of recorded data from lessons that typify …

Individual Differences In Markers Of Cholinergic Signaling Correlating To Fear And Extinction Learning, Grace C. Jones

Theses and Dissertations

Posttraumatic stress disorder (PTSD) results when individuals are exposed to a life threatening event, assault, serious injury, or other traumatic incident. Individuals with PTSD are impaired in their ability to extinguish fear memories, resulting in intrusive symptoms that impair their ability to live otherwise healthy lives. It remains unclear why some individuals exposed to traumatic events develop PTSD while others do not. Acetylcholine has been shown to play a critical role in fear learning, but its role in fear extinction is not well understood. This study utilized a rat model of fear learning and extinction to determine if individual differences …

Sex And The State: Sexual Politics In South Carolina In The 1970s, Jennifer Holman Gunter

Theses and Dissertations

Sex and the State: Sexual Politics in South Carolina is an investigation of the interactions of feminists and the state from 1966 through 1985. Nationally, women cooperated with officials of state agencies to push their agenda of self-sovereignty. Using South Carolina as a case study highlights the inherent power struggles inherent in these maneuverings. Inspired by the Second Wave of the women’s movement, activists across South Carolina, in both small towns and urban settings, worked with the state and manipulated state reactions to suit their needs. The work focuses on four key aspects of the women’s movement including: the abortion …

The Regulation Of Glycoprotein130 Dependent Inflammatory Cytokines One Basal And Mechanical Stimuli Induced Protein Synthesis In Myotubes And Skeletal Muscles, Song Gao

Theses and Dissertations

Maintaining skeletal muscle mass has a well-documented role in health and quality of life. Two members of IL-6 family of cytokines, IL-6 and LIF, and have a paradoxical role in skeletal muscle mass regulation: short term elevation of IL-6 and LIF plays a key role in mechanical stimuli induced muscle growth and muscle hypertrophy, while the long term elevated IL-6 and LIF regulate muscle wasting during cancer cachexia by disrupting muscle protein turnover regulation. The regulation of muscle protein synthesis is an important determinant of mechanical stimuli induced muscle hypertrophy and muscle wasting during cancer cachexia. IL-6 family of cytokines …

Evaluation Of Goodness-Of-Fit Tests For The Cox Proportional Hazards Model With Time-Varying Covariates, Shanshan Hong

Theses and Dissertations

The proportional hazards (PH) model, proposed by Cox (1972), is one of the most popular survival models for analyzing time-to-event data. To use the PH model properly, one must examine whether the data satisfy the PH assumption. An alternative model should be suggested if the PH assumption is invalid. The main purpose of this thesis is to examine the performance of five existing methods for assessing the PH assumption. Through extensive simulations, the powers of five different existing methods are compared; these methods include the likelihood ratio test, the Schoenfeld residuals test, the scaled Schoenfeld residuals test, Lin et al. …

Embodied Madness: Contextualizing Biological Stress Among 19th And 20th-Century Institutionalized Euro-American Women, Madeline M. Atwell

Theses and Dissertations

The late 19th and early 20th-centuries in the United States were periods in which white women of middle and low socio-economic status were admitted into insane asylums at a higher rate than men for the first time in recorded history. An existent body of literature helps us to comprehend the social and cultural climate in which the institutionalization of women was both acceptable and commonplace; yet few studies have paired this research with the information that can be revealed on the bones of those institutionalized. A sample of 53 institutionalized women from the Robert J. Terry Anatomical Collection were analyzed …

Assessment Of Providers’ Perception And Knowledge Of Overactive Bladder In Women: A Quality Improvement Project, Helen Wambui Ngigi

Theses and Dissertations

Background: OAB is defined by subjective symptoms, rather than objective measure, the patient’s perspective is important in managing OAB (Hung et al., 2013). As such providers need to capture the patient’s perspective of their OAB symptoms and their impact on the quality of life. A patient work up helps providers determine the cause of the symptoms as well as the degree of bother to the patient (Barkin, 2016). The diagnosis of OAB is essentially clinical and can be performed through structured questionnaires (Juliato et al., 2016). When conducting a patient history, it is important to determine the onset and severity …

Children’S Obesogenic Behaviors During Summer Versus School, Keith Brazendale

Theses and Dissertations

Emerging evidence shows children gain 3-5 times the amount of weight and lose cardiorespiratory fitness (CRF) during summer compared to the 9-months of the school year. Notably, this trend is more pronounced in children who are already overweight or obese going into summer and/or from low-income ethnic minority households. There is little evidence to investigating the underlying mechanisms driving the pronounced occurrence of these negative health outcomes during summer.

The purpose of this dissertation as a whole was to investigate children’s obesogenic behaviors (physical activity, sedentary/ screen time, sleep, and diet) during summer versus school, and compare any differences in …