Digital Commons Network^™

Simultaneous Uplc–Ms/Ms Analysis Of Two Stable Isotope Labeled Versions Of Sucrose In Mouse Plasma And Brain Samples As Markers Of Blood-Brain Barrier Permeability And Brain Vascular Space, Ekram Ahmed Chowdhury, Saad Alqahtani, Raktima Bhattacharya, Reza Mehvar, Ulrich Bickel

Pharmacy Faculty Articles and Research

Blood Brain Barrier (BBB) permeability is frequently compromised in the course of diseases affecting the central nervous system (CNS). Sucrose is a low molecular weight, hydrophilic marker with low permeability at the naive BBB and therefore one of the widely used indicators of barrier integrity. Our laboratory recently developed a highly sensitive UPLC-MS/MS method for stable isotope labelled [13C12]sucrose in biological matrices. Correction of total brain concentration for contribution of intravascular space is required in such experiments in order to accurately measure BBB permeability, and it is often accomplished by vascular perfusion with buffer solutions prior to brain sampling. The …

An Iconographic Analysis Of Mississippian Kneeling Effigy Figures From The Central Mississippi Valley, Amanda Pesce

Electronic Theses and Dissertations Archive

No abstract provided.

Scaling Up With Radically Embodied Cognition, Benjamin Aguda

Electronic Theses and Dissertations Archive

Radically embodied cognitive science (REC) is typically concerned with basic cognition such as perception and action. However, complex cognition or higher-order cognition is difficult to explain for REC, as these theories eschew traditional representational explanations. This leaves REC with a scaling-up problem. In this dissertation I will explore options for REC to fix its scaling-up problem. I am specifically interested in autonoetic cognition, which is the ability to remember and imagine objects and events in the way they would be experienced if they were immediately present to be perceived. I contend that a simulationist account provides many of th necessary …

Establishing Cognitive Predictor Thresholds For Proficiency In Reading And Mathematics: Analysis Of The Woodcock-Johnson Iv Developmental-Age Norming Sample, Philip A. Norfolk

Electronic Theses and Dissertations Archive

Assessment of specific learning disabilities (SLD) in educational settings is one important function of a school psychologist. The federal definition of SLD describes"underlying cognitive processing deficits" as part of the assessment criteria, that is also incorporated into several states' SLD eligibility criteria, that is difficult to directly evaluate using traditional assessment methods. Traditionally, use of norm-referenced scores have been used to compare an examinee's relative performance on assessment tests. Such a method does not provide direct evidence of underlying cognitive processing deficits associated with poor academic achievement. In an effort to directly inform this cognitive processing ability and academic proficiency …

From Here I Saw What Happened And I Cried: Carrie Mae Weems And Critiquing Institutional Histories, Katherine Layne Kizer

Electronic Theses and Dissertations Archive

While scholarship on Carrie Mae Weems's series titled From Here I Saw What Happened and I Cried often reflects the significance of the work as it relates to the African American experience and the African diaspora, critical discussion downplays the relationship the installation has to institutional critique and social practice. Through the course of this paper, I present extensive research on Weems's series. In order to conduct my investigation, I look to the genesis of the series in 1995 as a response piece to Hidden Witness. I then consider Weems's methodology and the way in which she appropriates historic photographs …

Rodion Shchedrin's Five Concertos For Orchestra: Expressing Ensemble Virtuosity, Nadezda Potemkina

Electronic Theses and Dissertations Archive

This dissertation introduces the work of Russian composer Rodion Shchedrin (b. 1932), and examines his approach to the genre of concerto for orchestra. Chapter one provides a brief survey of the current state of research on concertos for orchestra, as well as the composer's biography, and an overview of his compositional style. Chapter two focuses on the 1960s, the period when the first two concertos were written. It begins with an outline of the cultural and political climate that might have influenced the two pieces, and proceeds with the analysis of the Concerto for Orcehstra no. 1, the most popular …

Fiberblender: A Realistic Computer Model Of Nerve Bundles For Simulating And Validating The Acquisition Of Diffusion Tensor Imaging, Teddy Salan

Electronic Theses and Dissertations Archive

Diffusion Tensor Imaging (DTI) is a powerful medical imaging technique that provides a unique method to investigate the structure and connectivity of neural pathways. DTI is a special magnetic resonance imaging (MRI) modality that combines the principles of magnetic resonance with molecular diffusion to trace the motion of water molecules. In the central nervous system, where nerve fibers are packed in highly-directional bundles, these molecules diffuse along the orientation of the fibers. Hence, characterizing the motion of water with DTI delivers a non-invasive in vivo technique to capture the connectivity of nerves themselves. Despite its promises and successful clinical applications …

Enhancing Federal-Tribal Coordination Of Invasive Species, Blaine Parker, Chuck Bargeron, Sean Southey, Lori Buchanan, Miles Falck, Chris Fisher, Joe Maroney, Mervin Wright, Gintas Zavadkas

National Invasive Species Council

Invasive species are defined by the United States government to mean “with regard to a particular ecosystem, a non-native organism whose introduction causes or is likely to cause economic or environmental harm, or harm to human, animal, or plant health” (Executive Order [EO] 13751). The ecosystems to which invasive species are introduced or spread are not delimited by jurisdictional boundaries; they intersect with lands managed by federal, tribal, state, territorial, and county governments, as well as properties under private ownership. For this reason, effective coordination and cooperation across jurisdictions is of paramount importance in the prevention, eradication, and control of …

Sudden Infant Death Syndrome And Nursing Implications, Alesha M. Gauntt

Honors Capstones

Sudden Infant Death Syndrome (SIDS) continues to be an ongoing health problem as it caused the death of approximately 1,600 infants in 2015. The aim of this thesis and research study was to examine at-risk populations, the factors that increase and decrease the risk of SIDS, educational needs, and the associated nursing implications. The thesis consists of a literature review focusing on literature within the past five years, as well as a research study conducted to investigate areas where further education on SIDS prevention is needed. The research study was a self-reported survey examining practices that parents and caregivers of …

Strategic Leadership Newsletter: Volume 3, Number 4, Larry M. Starr Phd

Leadership Doctorates Newsletter (Formerly Strategic Leadership Newsletter)

Jefferson Strategic Leadership Newsletter reports information relevant to the Jefferson (Philadelphia University + Thomas Jefferson University) Doctor of Management Program in Strategic Leadership (DSL) and its community including personal and professional events and accomplishments, new practices, research, opportunities, and suggestions. You are encouraged to forward the Newsletter to friends and colleagues to expand awareness and to brand yourself as a community member. You are also invited to recommend people or organizations to be added to the mailing list. Contact Jefferson Strategic Leadership Newsletter by emailing [email protected].

The Free-Play Sandbox: A Methodology For The Evaluation Of Social Robotics And A Dataset Of Social Interactions, S Lemaignan, C Edmunds, E Senft, T Belpaeme

School of Engineering, Computing and Mathematics

Evaluating human-robot social interactions in a rigorous manner is notoriously difficult: studies are either conducted in labs with constrained protocols to allow for robust measurements and a degree of replicability, but at the cost of ecological validity; or in the wild, which leads to superior experimental realism, but often with limited replicability and at the expense of rigorous interaction metrics. We introduce a novel interaction paradigm, designed to elicit rich and varied social interactions while having desirable scientific properties (replicability, clear metrics, possibility of either autonomous or Wizard-of-Oz robot behaviours). This paradigm focuses on child-robot interactions, and builds on a …

The Free-Play Sandbox: A Methodology For The Evaluation Of Social Robotics And A Dataset Of Social Interactions, S Lemaignan, C Edmunds, E Senft, T Belpaeme

School of Engineering, Computing and Mathematics

Evaluating human-robot social interactions in a rigorous manner is notoriously difficult: studies are either conducted in labs with constrained protocols to allow for robust measurements and a degree of replicability, but at the cost of ecological validity; or in the wild, which leads to superior experimental realism, but often with limited replicability and at the expense of rigorous interaction metrics. We introduce a novel interaction paradigm, designed to elicit rich and varied social interactions while having desirable scientific properties (replicability, clear metrics, possibility of either autonomous or Wizard-of-Oz robot behaviours). This paradigm focuses on child-robot interactions, and builds on a …

Walton Kromer: Narratives, Walton Kromer

Professional Practices (ART 399)

11/1/17

Walton Kromer

Mid Degree Review

. I’ve always been driven by good stories with the hope to create my own someday. Whether it be from a movie, book, or video game, if it has the ability to captivate me, and my creativity, I’ll try to incorporate it in my work. My main focus is Illustration, mostly in either an ink or graphite medium, with the aim to create a narrative image with some semblance of storytelling. I have more than a soft spot for the realm of science fiction. Practically everything from the entire genre has inspired me one …

Comparative Analysis Of Double-Stranded Rna Degradation And Processing In Insects, Indrakant K. Singh, Satnam Singh, Kanakachari Mogilicherla, Jayendra Nath Shukla, Subba R. Palli

Entomology Faculty Publications

RNA interference (RNAi) based methods are being developed for pest management. A few products for control of coleopteran pests are expected to be commercialized soon. However, variability in RNAi efficiency among insects is preventing the widespread use of this technology. In this study, we conducted research to identify reasons for variability in RNAi efficiency among thirty-seven (37) insects belonging to five orders. Studies on double-stranded RNA (dsRNA) degradation by dsRNases and processing of labeled dsRNA to siRNA showed that both dsRNA degradation and processing are variable among insects belonging to different orders as well as among different insect species within …

The Timecourse Of Phonological Competition In Spoken Word Recognition: A Comparison Of Adults And Very Young Children, Elizabeth Schoen Simmons

Master's Theses

Spoken word recognition (SWR) is the mapping of speech sounds to words from many potential candidates in one’s lexicon. In adults, words that are phonetically similar, of high frequency, or semantically related compete for recognition. An ongoing debate in the literature is whether or not very young children encode spoken words with fine-grained temporal and phonetic detail. Specifically, whether they represent words wholistically or as smaller phonetic units similar to that of adults. The adult literature demonstrates that words that are phonetically similar at onset (cohorts) and offset (rhymes) compete for recognition. As it happens, rhymes have the potential to …

Best Way To Hunt Deer, Thomas Lee

USU Student Folklore Fieldwork

Text: You know what they say, if you wanna be a great dear hunter, just slow the bullet down to 55 mph

Loss Of Sympathetic Nerves In Spleens From Patients With End Stage Sepsis, Donald B. Hoover, Thomas Christopher Brown, Madeleine K. Miller, John B. Schweitzer, David L. Williams

ETSU Faculty Works

The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans. Experimental studies using animal models have established that sympathetic innervation of the spleen is essential for cholinergic anti-inflammatory responses evoked by vagal nerve stimulation, and clinical studies are evaluating this approach for treating inflammatory diseases. Most data on sympathetic nerves in spleen derive from rodent studies, and this work has established that remodeling of sympathetic innervation can occur during inflammation. However, little is known about the effects of sepsis on spleen …

The Diamond, December 6, 2017, Dordt College

Dordt Diamond

• Front Page: Dordt South Koreans Express Opinions on $8 Million Humanitarian Aid Package for North Koreans; Updated Network Brings Changes; Opioid Crisis Has Far-Reaching Effects
• News: One Dictator for Another: The Situation in Zimbabwe; Professor Profile: Deb Bomgaars; Lane Proposal for Highway 75; Pool Expansion Plan in Place
• Opinion: Jenna, Just Married: Take One Down... ; Travel Blog: Worshiping with the Saints; League is Better Than You Think; Women: Don't Be Passive Victims
• Feature: FACT Club Continues Annual Operation Christmas Child; Genetic Modification: Would You Like Your Chicken Grilled or CRISP[R]?; Study Tips for Finals Crunchtime; Cosmology Course Set to …

Assault On Peer Review A New Threat, Aldemaro Romero Jr.

Publications and Research

On October 17, Sen. Rand Paul (R-KY) introduced to the Senate U.S. Committee of Homeland Security and Governmental Affairs a bill titled “BASIC Research Act.” This apparent innocent title covers the real intention of this legislation – an attempt to defund basic research and make it subject to partisan politics. This legislation would change the way grant proposals are evaluated by all federal agencies, from the National Science Foundation (NSF) and the National Institutes of Health (NIH) to the National Endowment for the Humanities (NEH). These and other federal agencies are the main funders of scholarly work in higher education …

Methylglyoxal Requires Ac1 And Trpa1 To Produce Pain And Spinal Neuron Activation, Ryan B. Griggs, Don E. Laird, Renee R. Donahue, Weisi Fu, Bradley K. Taylor

Physiology Faculty Publications

Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and produces behavioral nociception via the cation channel transient receptor potential ankyrin 1 (TRPA1). However, rigorous characterization of an animal model of methylglyoxal-evoked pain is needed, including testing whether methylglyoxal promotes negative pain affect. Furthermore, it remains unknown whether methylglyoxal is sufficient to activate neurons in the spinal cord dorsal horn, whether this requires TRPA1, and if the calcium-sensitive adenylyl cyclase 1 isoform (AC1) contributes to MG-evoked pain. We administered intraplantar methylglyoxal and then evaluated …

The Pul37 Tegument Protein Guides Alphaherpesvirus Retrograde Axonal Transport To Promote Neuroinvasion, Alexsia L. Richards, Patricia J. Sollars, Jared D. Pitts, Austin M. Stults, Ekaterina E. Heldwein, Gary E. Pickard, Gregory A. Smith

School of Veterinary and Biomedical Sciences: Faculty Publications

A hallmark property of the neurotropic alpha-herpesvirinae is the dissemination of infection to sensory and autonomic ganglia of the peripheral nervous system following an initial exposure at mucosal surfaces. The peripheral ganglia serve as the latent virus reservoir and the source of recurrent infections such as cold sores (herpes simplex virus type I) and shingles (varicella zoster virus). However, the means by which these viruses routinely invade the nervous system is not fully understood. We report that an internal virion component, the pUL37 tegument protein, has a surface region that is an essential neuroinvasion effector. Mutation of this region rendered …

Prenatal Opioid Exposure And Intermittent Hypoxemia In Preterm Infants: A Retrospective Assessment, Elie G. Abu Jawdeh, Philip M. Westgate, Amrita Pant, Audra L. Stacy, Divya Mamilla, Aayush Gabrani, Abhijit R. Patwardhan, Henrietta S. Bada, Peter J. Giannone

Pediatrics Faculty Publications

Introduction: Intermittent hypoxemia (IH) is defined as episodic drops in oxygen saturation (SpO₂). Preterm infants are at increased risk for IH due to their immature respiratory control/apnea of prematurity. The clinical relevance of IH is a relatively new observation with rising evidence linking IH to neonatal morbidities and long-term impairment. Hence, assessing factors that influence IH in preterm infants is imperative. Given the epidemic of opioid misuse in the USA, there is an urgent need to understand the impact of prenatal opioid exposure on neonatal outcomes. Hence, we wanted to assess the relationship between isolated prenatal opioid exposure …

The Artistic And Anthropological Influence Of Lighting Design On Guests At The Disneyland Resort, Jennifer Pershon

Student Scholar Symposium Abstracts and Posters

Lighting design, while popularized by theatre, has emerged beyond the stage into real world environments and settings. Its advancement has led to an evolution of light, allowing for light to appear as a work of art independent from objects and productions despite lacking a tangible existence. As themed entertainment has grown into an entire industry of spectacle and performance, the concept of theme parks developed from one man’s dream to bring his animated films to life in a constructed environment for the promotion of imagination. Lighting design within the Disneyland Resort facilitates the ideologies of Walt Disney, utilizing its foundation …

Oct4 Is Crucial For Transdifferentiation Of Hepatocytes To Biliary Epithelial Cells In An In Vitro Organoid Culture Model, Mboya Doffou, George Adams, William C Bowen, Shirish Paranjpe, Harish S Parihar, Huy Nguyen, George K Michalopoulos, Vishakha Bhave

PCOM Scholarly Works

BACKGROUND: Hepatocyte to biliary transdifferentiation has been documented in various models of bile duct injury. In this process, mature hepatocytes transform into mature biliary epithelial cells by acquiring biliary phenotypic markers. Several signaling pathways including PI3 kinase, Notch, Hes1, Sox9, and Hippo are shown to be involved in the process. However, if Oct4 is involved in hepatocyte to biliary transdifferentiation is unknown.

METHODS: We investigated the role of Oct4 in hepatocyte to biliary transdifferentiation utilizing an in vitro organoid culture system as a model of transdifferentiation. Oct4 was inhibited using adenovirus containing Oct4 shRNA. Hepatocyte specific HNF-4α and biliary specific …

Vincent De Paul And The Empowerment Of Women, Louise Sullivan

Journal of Vincentian Social Action

The year 2017, marking the 400th Anniversary of the birth of the Vincentian Charism, has proven to be one of celebration for the entire Vincentian Family. While thousands of women are taking part in these celebrations around the world, the role women played in the birth and development of the charism is often overlooked. To do so however, is to miss a singularly significant aspect of Vincent de Paul’s genius, namely, the mission of charity he confided to the laity and particularly to women. Vincent de Paul’s life and his works would become what they were and what they continue …

Vincentian Social Justice: A Work In Progress, John E. Rybolt

Journal of Vincentian Social Action

St. Vincent de Paul has become a “universal” figure, a polymorph or shape-shifter, if you will. As a classic figure, somewhat like Jesus in certain circles, he is represented in various guises: founder, saint, simultaneously traditional and modern, even a revolutionary. Just like Vincent de Paul, the somewhat universal figure, his sons have attempted to follow Christ the evangelizer of the poor. Some have been more successful than others. But I am proud to be among their number: rich or poor in virtue, rich or poor in commitment, rich or poor in initiative or inventiveness.

Journal Of Vincentian Social Action, November 2017, John T. Maher

Journal of Vincentian Social Action

This special edition of the Journal of Vincentian Social Action is a welcome addition to this unique, ground-breaking journal. It comes at a special time for the Congregation of the Mission, the community of priests and brothers who founded St. John’s University 147 years ago. Commonly called “Vincentians,” this religious community animates the mission of St. Vincent de Paul to benefit all members of this outstanding community of scholars, students, and staff. Vincent’s vision and mission came from a profound spiritual experience that guided his life and work; and the Vincentian charism is a living, organic reality in today’s world. …

Effects Of Migration On Wing Morphology In Rock Wrens, Nickolas Godlove

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

This study examined how Rock Wren (Salpinctes obsoletus) wing shape varies with latitude and relates to the presence or absence of migration. Existing research on other species has demonstrated that long, narrow wings are ideal for longer distance travels such as migration trips, while short, rounder wings are best suited for quick take-offs and maneuverability. Currently, there is no data on how wing morphology relates to migration in the Rock Wren populations of North America. Rock Wrens provide a great opportunity for studying this topic because their migratory and sedentary populations are separated; northern Rock Wrens migrate and southern ones …

Thermal Effects During Incubation On Corn Snake (Pantherophis Guttatus) Pigment And Pattern Formation, Hawken Carlton

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Coloration and patterning can be as critical to an animal’s survival and fitness as its physiology and behavior, and how appearance develops is key in determining likelihood of survival. In reptiles, the environmental factor of higher vs. lower mean temperatures during egg incubation can influence physical and physiological traits and incubation length to hatching, important in temperate regions or habitats with seasonal food supplies; fluctuating temperatures may have additive effects. Pattern or color may also influence fitness via aposematism, crypsis, and other survival strategies; however, thermal effects on pattern development have not been fully studied. This experimental study used the …

Kids Make Sense... And They Vote: The Importance Of Child Study In Learning To Teach Responsively, Frederick Erickson

Occasional Paper Series

A lecture that discusses the "developmental-interaction" perspective and practice that has become the hallmark of Bank Street. Erickson builds upon the relations of mutual influence among students, teachers, and learning environments, and taking account of the relations between local practice within the small-scale "here and now" interactional ecosystems of immediate learning environments and the workings of culture, language, and society across more distal connections in social space and time.