Digital Commons Network^™

Successful Reversal Of Furosemide-Induced Secondary Hyperparathyroidism With Cinacalcet., Tarak Srivastava, Shahryar Jafri, William E. Truog, Judith Sebestyen Vansickle, Winston M. Manimtim, Uri S. Alon

Manuscripts, Articles, Book Chapters and Other Papers

Secondary hyperparathyroidism (SHPT) is a rare complication of furosemide therapy that can occur in patients treated with the loop diuretic for a long period of time. We report a 6-month-old 28-weeks premature infant treated chronically with furosemide for his bronchopulmonary dysplasia, who developed hypocalcemia and severe SHPT, adversely affecting his bones. Discontinuation of the loop diuretic and the addition of supplemental calcium and calcitriol only partially reversed the SHPT, bringing serum parathyroid hormone level down from 553 to 238 pg/mL. After introduction of the calcimimetic Cinacalcet, we observed a sustained normalization of parathyroid hormone concentration at 27 to 63 pg/mL …

Automated Ecological Assessment Of Physical Activity: Advancing Direct Observation., Jordan A. Carlson, Bo Liu, James F. Sallis, Jacqueline Kerr, J Aaron Hipp, Vincent S. Staggs, Amy Papa, Kelsey Dean, Nuno M. Vasconcelos

Manuscripts, Articles, Book Chapters and Other Papers

Technological advances provide opportunities for automating direct observations of physical activity, which allow for continuous monitoring and feedback. This pilot study evaluated the initial validity of computer vision algorithms for ecological assessment of physical activity. The sample comprised 6630 seconds per camera (three cameras in total) of video capturing up to nine participants engaged in sitting, standing, walking, and jogging in an open outdoor space while wearing accelerometers. Computer vision algorithms were developed to assess the number and proportion of people in sedentary, light, moderate, and vigorous activity, and group-based metabolic equivalents of tasks (MET)-minutes. Means and standard deviations (SD) …

Modulation Of Immunological Pathways In Autistic And Neurotypical Lymphoblastoid Cell Lines By The Enteric Microbiome Metabolite Propionic Acid, R Frye, Bistra Nankova, S Bhattacharyya, S Rose, S Bennuri, D Macfabe

NYMC Faculty Publications

Propionic acid (PPA) is a ubiquitous short-chain fatty acid which is a fermentation product of the enteric microbiome and present or added to many foods. While PPA has beneficial effects, it is also associated with human disorders, including autism spectrum disorders (ASDs). We previously demonstrated that PPA modulates mitochondrial dysfunction differentially in subsets of lymphoblastoid cell lines (LCLs) derived from patients with ASD. Specifically, PPA significantly increases mitochondrial function in LCLs that have mitochondrial dysfunction at baseline [individuals with autistic disorder with atypical mitochondrial function (AD-A) LCLs] as compared to ASD LCLs with normal mitochondrial function [individuals with autistic disorder …

Evaluating The Therapeutic Efficacy Of Restoring Wild-Type P53 Activity In P53-Mutant Tumors, Connie A. Larsson

Dissertations and Theses (Open Access)

The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, TP53 mutations have been shown to be remarkably predictive of refractoriness to treatment, resulting in poor outcome. Consequently, the development of p53 pathway activating agents is rapidly evolving and gaining more attention in cancer therapeutics research, with several small molecule compounds currently in preclinical and clinical trials. However, it remains largely unknown what types or proportions of p53-mutant tumors will respond to p53 restoration-based therapies.

Using a mouse model of Li Fraumeni syndrome, we genetically restored wild-type …

The Crucifixion In Matthew And The Theology Of The Cross In Canada Today, Allen Jorgenson

Consensus

No abstract provided.

O'Erwhelmed By Noise: Soundhouses And Sonic Experiments In Ben Jonson's Epicene, Bs Frost

School of Law, Humanities and Social Sciences

No abstract provided.

Identifying Genetic Factors Influencing Sperm Mobility Phenotype In Chicken Using Genome Wide Association Studies, Primordial Germ Cell Transplantation, And Rnaseq., Sohita Ojha

Graduate Theses and Dissertations

Sperm mobility is a major determinant of male fertility in chicken. In spite of low heritability of reproductive traits, sperm mobility has high heritability index which suggests presence of quantitative trait loci (QTLs) governing the trait. Our research focused on three objectives: i) to identify the QTLs affecting low mobility phenotype in chicken, ii) to understand the impact of Sertoli-cells and germ cells interactions in influencing the mobility phenotype and iii) to identify the genes and gene networks differentially expressed in male and female PGCs. To detect the QTLs, genome wide association studies (GWAS) was conducted which revealed the presence …

Determination Of The Effects Of Different Maillard Reaction Products On The Taxonomic Composition Of The Gut Microbiota, Nesreen Hamdan Aljahdali

Graduate Theses and Dissertations

The Maillard Reaction (MR) is a non-enzymatic chemical reaction which results in linkage between the amino group of amino acids and the carbonyl group of reduced sugars. This reaction generates Maillard reaction products (MRPs) which are not present naturally in foods, and are responsible for a range of colors, odors, flavors, and other sensory properties. Conflicting reports of MRPs impacts on human health are probably due to the fact that bioconversion of these digestible molecules by the gut microbiota has been marginally taken into account. This study aimed to determine the effects of different MRPs on rodent’s gut microbiota through16S …

Cellular Mechanisms Of Ionoregulation In The Gill Of Japanese Medaka And Rainbow Trout, Rebecca Jo Bollinger

Graduate Theses and Dissertations

Euryhaline fishes are capable of adapting to a wide range of salinities such as freshwater, brackish water or seawater. Through the combined effort of the gill, kidney and intestine, they are able to osmoregulate to maintain a constant internal hydromineral balance. As the gill is in direct contact with the external environment, it is continuously working to maintain ion and acid/base balance, gas exchange and eliminate nitrogenous waste. Fish in freshwater are subjected to osmotic water gain and diffusional ion loss across the gill and experience the opposite in seawater. Therefore, the gill exhibits extreme plasticity when experiencing a change …

Piglet Gut Microbiota Responses To Exposure To Outdoor Simulated Environment And Formula Feeding, Nguyen Vo

Graduate Theses and Dissertations

Several lines of evidence suggest that early-life gut microbiota composition is a crucial determinant of the susceptibility to diseases later in life. Understanding the evolution of early-life gut microbiota and critical factors that can modify this microbial community will espouse the prevention or reversion of health risk originating from dysbiosis of the gut microbiota in the early stage. In this research, we hypothesized that alterations in the environment (simulation of rural conditions by soil exposure) and feeding mode (breastmilk versus formula milk) will have significant impacts on the establishment of the gut microbiota in early life. At first, in literature …

Class Notes, Georgia Southern University

Arts & Humanities: News & Publications (2009-2023)

No abstract provided.

Magically Empathetic: An Investigation Of Theory Of Mind And Empathy In The Harry Potter Series, Lindsey M. Layman

Honors Theses

Research suggests that reading fiction can increase empathy, and a number of studies have found the Harry Potter series to promote pro-social values. One prosocial value that has not been explored directly in relation to the series, however, is empathy. Defined as “the experience of understanding another person’s condition from their perspective,” empathy is the motivation behind many prosocial behaviors and values, making it an important focus of investigation. In this study, I conduct a textual analysis of the Harry Potter series using the perspective of theory of mind and simulation theory as a guide. After analyzing a range of …

A Biotic Survey Of Outcroppings And Pinctada Longisquamosa In Oyster Pond, San Salvador Island, Bahamas, One Year After Hurricane Joaquin, Ashton Selah Mitchell

Honors Theses

Oyster Pond is one of the marine inland ponds located on San Salvador Island, Bahamas. Oyster Pond has connections to the ocean through a series of conduits in the pond, which cause the salinity of the pond to be marine pond, except after a hurricane and during a drought. Oyster Pond has a variety of marine life such as algae, small fish, and invertebrates occurring in mangroves, flocculent, conduits, and biotic outcroppings. The focus of this research was to evaluate the impact of the 2015 Hurricane Joaquin (17 months later) on water chemistry and the marine life of the biotic …

Effectiveness Of Conservation Education At The Chattanooga Zoo, Luke Allen Black

Honors Theses

Conservation is the central focus of many modern zoos and aquariums. These zoos incorporate guest education to facilitate a connection between zoo guests and animal conservation. I conducted a study at the Chattanooga Zoo and the University of Tennessee at Chattanooga which examined two modern zoo education approaches. The two approaches utilized in the study are currently used in keeper chats at the Chattanooga Zoo. The first approach is an emotional appeal (an appeal to the personalities of the chimps at the zoo) and the second approach is a utilization of a take-action initiative (recycling cell phones to reduce mining …

Droning On: The State And Federal Legal Response To The Deregulation Of U.S. Airspace For Small Unmanned Aircraft Systems, Lisa K. Decker

Journal of Criminal Justice and Law

With the 2012 congressional mandate that the Federal Aviation Administration promulgate rules allowing the use of small unmanned aircraft systems (commonly called drones) in U.S. airspace, many have expressed concerns about potential invasions of privacy by both private citizens and law enforcement agencies. This article provides a survey of the state and federal case law and legislative responses to such concerns through August of 2016, with a detailed focus on legislative enactments creating crimes related to civilian drone use and regulating the law enforcement use of drones to collect evidence in criminal investigations. The article also analyzes and attempts to …

Giving Technology The Place It Deserves In Creative Problem Solving, Yves De Smet

Creativity and Change Leadership Graduate Student Master's Projects

This project explores the potential for using artificial intelligence (AI) in Creative Problem Solving (CPS) to facilitate a creative process. It invites members from the technology and CPS communities to see the opportunities for AI-augmented creative problem solving, and to join forces to turn those opportunities into reality. To this end the author looks at creativity through a knowledge-centered lens. He proposes a model based on how the human brain makes connections, to enable AI developments that help transform the knowledge residing in a team and/or from external resources into creative solutions. A vision of how AI could be leveraged …

Age-Related Host Factors Regulate Lung Cancer Progression., John Caleb Greenwell

Electronic Theses and Dissertations

Cancer is largely a disease of the elderly. In the United States alone, 87% of all cancers in 2017 will be diagnosed in individuals aged 50 years or older. Among them, lung cancer is the deadliest, accounting for 1 in 4 cancer deaths. The 5-year survival rate is below 20%, a number which has not changed substantially over the past several decades. This underscores a desperate need for new strategies in prevention, early detection and treatment of this deadly disease. While tobacco use is unquestionably the number one risk factor for the development of lung cancer, the majority of diagnoses …

Distribution Based Nearest Neighbor Imputation For Truncated High Dimensional Data With Applications To Pre-Clinical And Clinical Metabolomics Studies, Jasmit Shah, Shesh N. Rai, Andrew P. Defilippis, Bradford G. Hill, Aruni Bhatnagar, Guy N. Brock

Brain and Mind Institute

Background: High throughput metabolomics makes it possible to measure the relative abundances of numerous metabolites in biological samples, which is useful to many areas of biomedical research. However, missing values (MVs) in metabolomics datasets are common and can arise due to both technical and biological reasons. Typically, such MVs are substituted by a minimum value, which may lead to different results in downstream analyses.

Results: Here we present a modified version of the K-nearest neighbor (KNN) approach which accounts for truncation at the minimum value, i.e., KNN truncation (KNN-TN). We compare imputation results based on KNN-TN with results …

Behavioral Ecology And Associated Virology Of Mosquito-Host Interactions In Southern California, Oliver Eshun

Loma Linda University Electronic Theses, Dissertations & Projects

Elucidating characteristics of mosquito-host interactions are critical for understanding the ecology and epidemiology of mosquito-borne diseases. In this dissertation, I conducted three studies to explore potential mosquito-host interactions and associated virus infection rates. I first demonstrated that mosquito captures at CO2-baited traps decreased most markedly with height above ground, and also decreased with distance from water at a riparian area but not at an open water source lacking a vegetated border. Birds might therefore prefer elevated nests or roosts to avoid mosquitoes. The second study examined the anti-mosquito behaviors of budgerigars (Melopsittacus undulatus) in a laboratory study. The birds defended …

Endothelin-1 And Hypoxic Vascular Remodeling In Ovine Fetal Cerebral Arteries, Jinjutha Silpanisong

Loma Linda University Electronic Theses, Dissertations & Projects

Intrauterine hypoxia resulting from decreased maternal oxygen uptake, insufficient oxygen carrying capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases Hypoxia Inducible Factor-1α (HIF- 1α), which complexes with HIF-1β to form the active HIF-1 dimer that can affect transcription. This temporary rise in HIF-1 can promote gene transcription of ligands such as Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1), which rises and falls with HIF levels. The absence of chronic elevation of these ligands prompted the question of how long-term effects of hypoxia is …

Mechanism Of Candida Albicans Biofilm And Virulence Inhibition By A Bacterial Secreted Factor, Carrie Graham

Dissertations and Theses (Open Access)

The human microbiome is a diverse polymicrobial population comprised of both fungi and bacteria. Perturbations of the normal microbiome can have a profound impact on health, including the development of infections. Exploitation of these polymicrobial interactions has the potential to provide novel treatment and prevention strategies for infectious diseases. Enterococcus faecalis, a Gram-positive bacterium, and Candida albicans, a polymorphic fungus, occupy overlapping niches as ubiquitous constituents of the gastrointestinal and oral microbiome. Both species are also amongst the most important and problematic, opportunistic nosocomial pathogens and are often co-isolated during infection. Surprisingly, these two species antagonize each other’s …

First Kiss, Lacrosse Star, Zachary Grant Bess

USU Student Folklore Fieldwork

[Had explained to us that both Lacrosse team’s, male and female shared the same practice space and crossed over on practice times] Sierra: “A lot of us, the girls, would come early, and run and warm up, and the guys would like stay after their practice and there was like a thirty minute window when we all play together, and we just mess around, shoot on the goal, and it was like fun, it was a good way to make friends, like between the teams, and we were all pretty close. Like when the girls’ choice dances, like MORP [Prom …

Futurama Fry/Not Sure If”, Melissa Herrera

USU Student Folklore Fieldwork

No abstract provided.

"T-Shirt Quilt", Alexis Robb

USU Student Folklore Fieldwork

My mom made me this blanket about 10 years ago. She made it from shirts that I had obviously out grown. It is special to me because it reminds me of all the sports and activities I did as a kid, and it shows my sense of humor on some of the shirts.

"Christmas Sleepover Tradition", Alexis Robb

USU Student Folklore Fieldwork

I think it was funner as a child because your all sleeping under the tree but than as I got older its like oh my back [ Grabs her back and laughs] but I like it though its fun just to get together and sleep together, especially when we were younger. I remember all the tantrums of you and Brandon not getting to sleep where you wanted to. Good times.

Cookie Day, Carrigan Price

USU Student Folklore Fieldwork

Cookie Day is a day that we- my current family- we spend a Saturday, one of the Saturdays in December, and um we get up early in the morning and we make cookies. We make all different kinds of cookies. We make chocolate chip cookies, we make sugar cookies, sometimes we make shortbread, cookies that are shaped like candy canes, we make fudge, we make sometimes, some years we make different things, we made cream puffs one year, we make star-shaped Rice Krispy treats, we make muffins, one of the things we’ve added recently is we do chocolate-dipped pretzels, and …

Thanksgiving Monopoly Night, Carrigan Price

USU Student Folklore Fieldwork

We go to my Grandma Judy’s house and we eat stuffing and more pie and then everybody goes home except for the cousins that are 12 to 18, well 12 to 20 and we play a game of Monopoly that sometimes goes until 5 in the morning! And we just go until somebody wins the game. We play the board game and play house rules. We do it individually so like there’s no teams and one person is the banker and one person gives out the properties and everybody else just takes care of their piece. After we finish, we …

4th Of July Parade, Carrigan Price

USU Student Folklore Fieldwork

The night before [the 4^th of July] we go and put down blankets for the rest of our family and then we go and usually arrive at 8 o’clock and the parade starts at like 10- oh we put the blankets on the sidewalk on the parade route- and we usually put down a lot because all of our extended family comes, and my dad usually goes and gets McDonalds breakfast sandwiches and that’s what we eat while we wait for the parade to start- or get to us. Sometimes we have siblings or cousins in the parade. It’s …

Hallucinations Are Real To Patients With Dementia, R. C. Hamdy, Amber E. Kinser, J. V. Lewis, Rebecca Copeland

ETSU Faculty Works

In this case study, we present a patient with preexistent posttraumatic stress disorder and psychosis who has been recently diagnosed with Dementia with Lewy Bodies. He is experiencing vivid hallucinations. What went wrong between him and his wife as a result of these hallucinations is presented. Alternative actions that could have been used are suggested.

Human Dispersal From Siberia To Beringia: Assessing A Beringian Standstill In Light Of The Archaeological Evidence, Kelly E. Graf, Ian Buvit

All Faculty Scholarship for the College of the Sciences

With genetic studies showing unquestionable Asian origins of the first Americans, the Siberian and Beringian archaeological records are absolutely critical for understanding the initial dispersal of modern humans in the Western Hemisphere. The genetics-based Beringian Standstill Model posits a three-stage dispersal process and necessitates several expectations of the archaeological record of northeastern Asia. Here we present an overview of the Siberian and Beringian Upper Paleolithic records and discuss them in the context of a Beringian Standstill. We report that not every expectation of the model is met with archaeological data at hand.