Digital Commons Network^™

Hmgcs2 Is A Key Ketogenic Enzyme Potentially Involved In Type 1 Diabetes With High Cardiovascular Risk., Sanket Kumar Shukla, Weijing Liu, Kunal Sikder, Sankar Addya, Amrita Sarkar, Yidong Wei, Khadija Rafiq

Center for Translational Medicine Faculty Papers

Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined. To learn more about biological pathways that are potentially involved in T1D with cardiac dysfunction, we sought to identify differentially expressed genes in the T1D heart. Our study used T1D mice with severe hyperglycemia along with significant deficits in echocardiographic measurements. Microarray analysis of heart tissue RNA revealed that the T1D mice differentially expressed 10 genes compared to …

Welfare And Federalism's Peril, Andrew Hammond

Washington Law Review

Recent scholarship on American federalism lacks case studies to inform that scholarship’s trans-substantive insights and claims. This Article examines the last two decades of devolution brought about by the 1996 Welfare Reform Act (PRWORA). It details the history of PRWORA and how the funding mechanism built into Temporary Assistance for Needy Families (TANF)—the TANF block grant—guaranteed the program’s deterioration. The Article documents the program’s failure to respond to increased need among poor families after Hurricane Katrina and in the Great Recession, showing how the federal government’s use of TANF in both crises teach us the limits of fiscally devolved programs. …

El Leñador, December 2017, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Safeguarding Washington's Trade Secrets: Protecting Businesses From Public Records Requests, John Delaney

Washington Law Review

Lawmakers constantly balance competing interests. They decide where to draw lines so that societal goals are accomplished without ignoring the needs of those who will be affected by their choices. The Washington State Legislature is now in the process of addressing the line between government transparency and the protection of private companies’ trade secrets. Companies who provide technology to the federal government are susceptible to losing their trade secrets through a public records request. The Washington State Legislature is currently reviewing the trade secret exception to the Public Records Act to ensure it is continuing to protect companies from losing …

Biological Condition Of Money Pont Benthic Communities, Southern Branch Of The Elizabeth River (2010, 2013, 2016), Daniel M. Dauer

Elizabeth River Reports

Executive Summary

This report summarizes the ecological condition of the subtidal macrobenthic communities off Money Point in the Southern Branch of the Elizabeth River based upon quantitative sampling in summer 2016. The designated Money Point study area was part of a sediment contaminant remediation effort. The primary objectives were to: (1) characterize the biological health of the benthos of Money Point comparing pre-remediation condition (2010) to post-remediation condition in 2013 and again in 2016, and (2) assess the effectiveness of the sediment contamination remediation efforts with respect to the ecological condition of the Money Point benthos.

Prior to sediment contaminant …

Dance For Special Needs Students: Building Confidence And Motor Skills, Jennifer Monique Dabalsa

Master's Theses

Participating in a dance class is influential in the development of young people’s creative, imaginative, individual, and communicative skills. The use of dance within a classroom increases physical fitness, enriches motor skills, coordination, and enhances social skills. Dance also increases muscular endurance, builds balance, as well as encourages teamwork and group skills. Most, if not all individuals crave to be socially accepted on some level. Many individuals with special needs are limited in verbal communication, or they are completely non-verbal. Connecting to individuals with these types of limitations proves to be challenging in comparison with a typical abled bodied individual. …

Guidelines For The Diagnosis, Evaluation, And Management Of Sports-Related Concussions In Adolescent Athletes: Translating Evidenced-Based Recommendations Into Primary Care Practice, Julie Greenwood

Doctoral Scholarly Projects & Capstones

Sports-related concussions in adolescent athletes are a significant health concern. Evidence demonstrates that despite increased published literature on concussions, many providers are still practicing with outdated information that is not evidenced-based. This puts adolescent athletes at risk for potentially detrimental consequences such as second impact syndrome. This syndrome can result in devastating results such as collapse, death, permanent neurological damage, respiratory failure, and loss of consciousness. Since second-impact syndrome can result from a second injury before complete symptom resolution from the initial concussion, it is imperative for providers to ensure adequate recovery and prevent the athlete from returning to play …

Letting The Electrics Slide: A Constitutional Challenge To State Dealer-Franchise Laws Prohibiting Direct-To-Consumer Car Sales, Thomas Sperber

Fordham Law Review

Tesla Motors has a business model for its U.S. sales unlike that of all other car manufacturers: Tesla sells cars directly to consumers rather than through a system of independently owned dealers. Most car manufacturers choose not to sell cars this way because most states have dealer laws that ban direct-to-consumer sales. To use this business model, Tesla has had to win narrow exceptions to these dealer franchise laws. It has mostly succeeded with this method and can now sell cars, albeit from a limited number of company stores, in all but six states. Tesla is now suing the state …

Ophthalmology Snapshot, Nalinee Tuntivanich

The Thai Journal of Veterinary Medicine

A twelve-year-old, female Miniature pinscher had presented to the Ophthalmology Clinic, Animal Teaching Hospital, Faculty of Veterinary Science, Chulalongkorn University with sudden ocular pain on the right eye. It was disclosed from history taking that the dog always jumped onto furniture. It was three days that she began to show blepharospasm and squinting on the right eye, in particular. Ophthalmic examination revealed mild to moderate eyelid swelling. Blepharospasm was apparent. The dog was not relaxed during examination. Menace response and dazzle reflex were negative. Pupil was fully dilated. Fundus was unclear from retro-illumination.

Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed In The Oral Cavity, Yeshwant B. Rawal, Kenneth M. Anderson, Thomas B. Dodson

School of Dentistry Faculty Research and Publications

The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation. The lesion consisted …

Orpheus, Fall 2017: Hive/Swarm, University Of Dayton

Orpheus: UD's Literary and Artistic Magazine

No abstract provided.

Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated And Defective In Neuroinvasion, Arun S. Annamalai, Aryamav Pattnaik, Bikash R. Sahoo, Ezhumalai Muthukrishnan, Sathish Kumar Natarajan, David Steffen, Hiep Vu, Gustavo Delho, Fernando Osorio, Thomas M. Petro, Shi-Hua Xiang, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

Zika virus (ZIKV), a mosquito-transmitted flavivirus responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, reemerged in the last decade causing serious human diseases, including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have led to the enhanced virulence of ZIKV, experimental evidence supporting the role of specific genetic changes in virulence is currently lacking. One sequence motif, VNDT, containing an N-linked glycosylation site in the envelope (E) protein, is polymorphic; it is absent in many of the African isolates but present in all isolates from the recent …

A Deafness Mechanism Of Digenic Cx26 (Gjb2) And Cx30 (Gjb6) Mutations: Reduction Of Endocochlear Potential By Impairment Of Heterogeneous Gap Junctional Function In The Cochlear Lateral Wall, Ling Mei, Jin Chen, Liang Zong, Yan Zhu, Chun Liang, Raleigh O. Jones, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Digenic Connexin26 (Cx26, GJB2) and Cx30 (GJB6) heterozygous mutations are the second most frequent cause of recessive deafness in humans. However, the underlying deafness mechanism remains unclear. In this study, we created different double Cx26 and Cx30 heterozygous (Cx26^+/−/Cx30^+/−) mouse models to investigate the underlying pathological changes and deafness mechanism. We found that double Cx26^+/−/Cx30^+/− heterozygous mice had hearing loss. Endocochlear potential (EP), which is a driving force for hair cells producing auditory receptor current, was reduced. However, unlike Cx26 homozygous knockout (Cx26^−/−) mice, the cochlea in Cx26 …

Association Mapping For Traits Related To Nitrogen Use Efficiency In Tropical Maize Lines Under Field Conditions, Júlia Silva Morosini, Leandro De Freitas Mendonça, Danilo Hottis Lyra, Giovanni Galli, Miriam Suzane Vidotti, Roberto Fritsche-Neto

Faculty Publications

Aims: Nitrogen deficiency is one of the most critical abiotic stresses for maize (Zea mays) cultivation worldwide. For a productive and sustainable scenario, developing genotypes more efficient in nitrogen use is essential. This study aimed to identify single nucleotide polymorphism (SNP) markers associated with nitrogen use efficiency (NUE) traits under field conditions and candidate genes related to these markers by genome-wide association study (GWAS). Methods: Sixty-four tropical maize inbred lines were evaluated in ideal and low nitrogen conditions for total root length (TRL) and low nitrogen tolerance index (LNTI). GWAS was performed using a fixed and random model circulating probability …

An Analysis Of Prevalence Of Chytrid Fungus In An Amphibian Assemblage In Middle Tennessee, Cameron Brocco

Honors Theses

Chytridiomycosis is an infectious, fungal disease largely seen in amphibians, which is caused by the highly virulent, zoosporic, pathogenic, single-celled fungus Batrachochytrium dendrobatidis (Bd). It is known to cause epidermal hyperplasia, hyperkeratosis, skin ulcerations, and fatalities by asystolic cardiac arrest either from shifts in electrolytes or increased acidity in the blood plasma. Previous research has demonstrated that urban water bodies have a higher prevalence of chytrid fungus than rural water bodies. Researchers have also found that chytrid is more prevalent in open canopy habitats than closed canopy habitats. Furthermore, it is implicated in global population declines and local extinctions in …

Role Of Membrane Gm1 On Early Neuronal Membrane Actions Of Aβ During Onset Of Alzheimer's Disease, E. J. Fernandez-Perez, Fernando Sepulveda, Robert W. Peoples, Luis G. Aguayo

Biomedical Sciences Faculty Research and Publications

The ability of beta-amyloid peptide (Aβ) to disrupt the plasma membrane through formation of pores and membrane breakage has been previously described. However, the molecular determinants for these effects are largely unknown. In this study, we examined if the association and subsequent membrane perforation induced by Aβ was dependent on GM1levels. Pretreatment of hippocampal neurons with D-PDMP decreased GM1 and Aβ clustering at the membrane (Aβ fluorescent-punctas/20 μm, control = 16.2 ± 1.1 vs. D-PDMP = 6.4 ± 0.4, p < 0.001). Interestingly, membrane perforation with Aβ occurred with a slower time course when the GM1 content was diminished (time to establish perforated configuration (TEPC) (min): control = 7.8 ± 2 vs. low GM1 = 12.1 ± 0.5, p < 0.01), suggesting that the presence of GM1 in the membrane can modulate the distribution and the membrane perforation by Aβ. On the other hand, increasing GM1 facilitated the membrane perforation (TEPC: control = 7.8 ± 2 vs. GM1 = 6.2 ± 1 min, p < 0.05). Additionally, using Cholera Toxin Subunit-B (CTB) to block the interaction of Aβ with GM1 attenuated membrane perforation significantly. Furthermore, …

Justin Martyr, Irenaeus Of Lyons, And Cyprian Of Carthage On Suffering: A Comparative And Critical Study Of Their Works That Concern The Apologetic Uses Of Suffering In Early Christianity, Aaron Kilbourn

Doctoral Dissertations and Projects

Suffering in Early Christianity has often been highlighted in martyrdom and the stories surrounding the persecution of the Early Church. The biblical idea of redemptive suffering was not an afterthought to the Christian community or part of what Joyce Salisbury calls, “the unintended consequences of ancient violence,” but it appears to be part and parcel of the Early Christian community as they sought to live faithfully to Christ’s teachings. As the Early Church lived out redemptive suffering, it became apparent to the surrounding culture and critics of Christianity that their suffering was different and it pointed to something else. Through …

The Effectiveness Of High Frequency Word List Instruction On Star Reading Test Scores, Michael Foster

Doctoral Dissertations and Projects

The purpose of this quantitative, quasi-experimental study was to test the theory of using high frequency word list (HFWL)-based instruction when teaching beginning reading instruction. This study compared the reading fluency changes of eight classes across three different grades containing 115 students over 5 months as measured by the Standardized Test for the Assessment in Reading (STAR) when intervention students are given identical instruction using different popular HFWLs. One control group received no such intervention. The Fry HFWL was used. The resulting scores were analyzed using an independent-samples t test. The comparisons determined the effectiveness of teaching beginning reading using …

Hypertension Associated With Atrial Fibrillation, Wilbert S. Aronow

NYMC Faculty Publications

No abstract provided.

Torts, Christopher R. Breault, Christopher B. Newbern, Brian C. Mickelsen

Mercer Law Review

This Article surveys recent developments in Georgia tort law between June 1, 2016 and May 31, 2017.

Learning To Pray The Lord’S Prayer For Spiritual Transformation At Tachikawa Church Of Christ, Naoyoshi Fukushima

Doctor of Ministry Theses and Dissertations

ABSTRACT

This thesis describes a project to lead the members of Tachikawa Church of Christ to learn and experience the power and blessings of praying the Lord’s Prayer for spiritual edification and maturity. The program consisted of eight weeks of learning the meaning of the Lord’s Prayer and doing spiritual exercises. To provide a theological foundation for this project, I delivered eight sermons on the Lord’s Prayer with strong emphasis on the relational nature of the prayer.

Those who engaged in the spiritual exercises were given opportunities to experience joy, peace, and correction as they tried to live in harmony …

Horticulture For Pollinator Conservation, Carter M. Westerhold

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Pollinators worldwide are declining. Consequently, the agricultural and ecological services these insects provide are in danger of being lost. Land use intensification, via urbanization, has greatly influenced this decline in pollinators. Luckily, through targeted horticultural practices, stable populations of pollinators can be sustained within urban areas. The horticultural practices of planting diverse floral resources and managing pollinator habitat in urban areas can sustain these populations. Two studies were conducted with the intent to identify horticultural knowledge gaps that could be reduced to aid in pollinator conservation efforts. First, a study to compare Nebraska native and non-native ornamental plants was conducted. …

Plenary Power In The Modern Administrative State, Catherine Y. Kim

North Carolina Law Review

For the past quarter century, the “plenary power” doctrine of immigration law—under which courts suspended ordinary standards of judicial review to defer to the political branches on questions relating to the exclusion, detention, and deportation of noncitizens—has been in decline. The conventional account attributes this development to the expansion of constitutionally protected individual rights across public law cases. This Article assesses changes in immigration law from a different perspective, one having less to do with individual rights than with constitutional structure. It focuses on the role that delegation concerns have played, contextualizing the judiciary’s willingness to review immigration decisions within …

Datasets On Abundance Of Common Blossom Thrips And Weather Variables In Small-Scale Avocado Orchards At Taita Hills And Mount Kilimanjaro, James J. Odanga, Samira Mohamed, Florence Olubayo, Richard Nyankanga, Sizah Mwalusepo, Sevgan Subramanian, Tino Johansson, Sunday Ekesi

All Peer-Reviewed Publications

Avocado, Persea americana Miller (Lauraceae), is an important fruit crop cultivated by small-holder farmers along Afrotropical highlands of Taita Hills in South-eastern Kenya and Mount Kilimanjaro in Northern Tanzania. The small-holder farmers in these East African regions generate substantial food and cash from avocado fruits. However, the avocado crop is faced with challenges of infestation by insect pests such as the common blossom thrips (Frankliniella schultzei Trybom) which feeds on pollen and floral tissue thereby reducing productivity of the trees. Moreover, there is no information describing distribution patterns of Frankliniella schultzei and associated weather in East African avocado orchards despite …

The Audacity Of Protecting Racist Speech Under The National Labor Relations Act, Michael Z. Green

Faculty Scholarship

This Article, written for a symposium hosted by the University of Chicago Legal Forum on the Disruptive Workplace, analyzes the most recent failures of the National Labor Relations Board (NLRB) to determine a thoughtful and balanced approach in addressing racist speech. Imagine two employees in the private sector workplace are discussing the possibility of selecting a union to represent their interests regarding wages and working conditions. During this conversation, a black employee notes the importance of using their collective voices to improve working conditions and compares the activity of selecting a union with the Black Lives Matter protests aimed at …

Accounting For Soil Inorganic Carbon In The Ecosystem Services Framework For United Nations Sustainable Development Goals, Garth Raymond Groshans

All Theses

Soil inorganic carbon (SIC) is currently not included in the list of key soil properties related to ecosystem services (e.g., provisioning, regulating, cultural, and supporting services). Soil inorganic carbon is a dynamic key soil property used in soil classification, taxonomy and fertility, therefore its inclusion in the framework of ecosystem services is important. With soils rapidly changing due to human use and climate change, the soil ecosystem services framework should not include only soil organic carbon (SOC), but SIC as well since it is of global importance to soil fertility and the long-term carbon cycle, especially in semiarid and arid …

Effects Of Rider Experience Level On Horse Kinematics And Behavior, Rebekah Strunk

All Theses

Large riding lesson programs are an essential part of the horse industry. To meet demand and remain profitable, lesson barns sometimes require horses to work multiple times a day with different rider levels. There is little guidance as to the behavioral and physical effects of such protocols, so lesson program managers have limited scientific evidence upon which to base horse management and welfare decisions. The current data regarding horse and rider interactions includes motion pattern variability, trunk and spine kinematics and force plate analyses. While these data are helpful to explain scenarios that can affect the horse with an accomplished …

Neonatal Growth Measurements, Umbilical Concentrations, And Differential Gene Expression In The Placenta Of Swine In Relation To Placental Efficiency, Shanice Katelin Krombeen

All Theses

Placental efficiency (PE) describes the relationship between placental and fetal weights and is defined as fetal weight divided by placental weight. Within pig litters, PE can vary drastically, resulting in similarly sized pigs associated with very different placenta, up to a 50% weight difference. However, the means enabling the smaller placenta to grow a similarly sized littermate is unknown. The main objectives of this study were to (1) determine the concentration of glucose and cortisol in venous umbilical blood of pigs at birth and evaluate if a relationship existed between concentration and PE, and (2) determine the expression level of …

The Effect Of Hydrostatic Pressure On Neuronal Cell Morphology In Vitro, Kallie Etten

All Theses

Traumatic brain injury (TBI) and subsequent rises in intracranial pressure (ICP) are associated with high mortality and has a number of physical and behavorial consequences to which the specific causes are unknown. We hypothesized that exposure of neuronal cells to elevated pressure can cause neurite retraction and / or apoptosis. Loss of communication between neurons due to these cellular-level events may play a part in complications seen in TBI patients, such as neurodegenerative diseases, increased anxiety, fear, depression, cognitive problems, as well as motor and visual deficits. In the present study, the effect of elevated hydrostatic pressure was evaluated at …

In The Kitchen, Amber Eckersley

All Theses

This series of work explores the fragmented nature of memory, investigates the dynamism of my grandma's kitchen, and subverts nostalgia typically associated with the South. Each image in the series represents a particular memory, set of memories, or fragment of memories from my childhood of planting, growing, and picking food with my grandma as well as preserving it and cooking it with her. The ordering and decision making of what fragments go in which image is imprecise. The imprecision is a reflection of how memory operates - fragmented, mutable, and fleeting. The markings on the pots, remnants of food processes, …