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2016

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Fastnumerics: Compiling Matlab To C++, Sujan Khadka Jan 2016

Fastnumerics: Compiling Matlab To C++, Sujan Khadka

All ETDs from UAB

and bone strength feedback. Participants, through computer surveys, rated perceived

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Perturbation Formulas For Gross-Pitaevskii Equation With Periodic Potential, Seonguk Kim Jan 2016

Perturbation Formulas For Gross-Pitaevskii Equation With Periodic Potential, Seonguk Kim

All ETDs from UAB

Gross-Pitaevskii equation (GPE), which was introduced in early 1960s, is widely used in several areas, such as condensed matter physics, and nonlinear optics. The purpose of this thesis is to carry out mathematical studies for GPE. We concentrate on extended solutions of GPE. This thesis mainly contains three parts. The first part is to investigate explicit perturbation formulas for stationary solutions close to a plane wave and their corresponding energies for the nonlinear polyharmonic equation when 2l > n, where n is dimension and l is a power of the Laplacian. The main idea is to consider a non-linear term as …

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The Lived Experiences Of African American Male School Leaders In Suburban School Districts, Dexter Clayton Leblanc Jan 2016

The Lived Experiences Of African American Male School Leaders In Suburban School Districts, Dexter Clayton Leblanc

All ETDs from UAB

The purpose of this qualitative study was to explore the personal, professional, and social experiences of African American male school leaders in suburban school districts. Suburban school districts were defined as residential areas on the outskirts of metropolitan areas that often have higher standardized test scores and successful programs with higher rates of college attendance. The area also has higher family incomes and few African American residents. Using a phenomenological design allowed the researcher to inquire and gather data through open-ended, face-to-face, interviews with study participants. Critical Race Theory was used to frame this study. The researcher identified 10African American …

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The Effect Of The Combination Of Low Income And Low Education, Access To Care, And Social Isolation On Chd Outcomes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Cohort Study, Marquita Lewis Jan 2016

The Effect Of The Combination Of Low Income And Low Education, Access To Care, And Social Isolation On Chd Outcomes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Cohort Study, Marquita Lewis

All ETDs from UAB

Coronary heart disease (CHD) disparities persist for low socioeconomic populations, in spite of declines globally. In order to reduce these disparities, it is critical that investigators better understand determinants of health that exacerbate these disparities. This study investigated the association between the combination of low income and low education on CHD incidence, and the mediating effects of access to care and social isolation on this association. Data was used from participants recruited between 2003-2007 free of CHD at baseline from the national biracial prospective Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study of participants aged >45 years. …

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Regulation Of Breast Cancer Metastasis By Sin3 Chromatin Remodeling Complexes, Monica Jeanene Lewis Jan 2016

Regulation Of Breast Cancer Metastasis By Sin3 Chromatin Remodeling Complexes, Monica Jeanene Lewis

All ETDs from UAB

Metastasis continues to be the most difficult clinical challenge for breast cancer. Survival rates for patients with metastatic breast cancer have not significantly changed in the past 20 years. Therefore, we need a better understanding of the molecular mechanisms that regulate breast cancer metastasis to develop effective therapies. SIN3 chromatin remodeling complexes have been implicated in breast cancer progression. Mammalian cells have two paralogs of SIN3 (SIN3A and SIN3B) that are encoded by distinct genes and have unique functions during development. However, specific roles for SIN3A and SIN3B in breast cancer progression have not been characterized. To better understand how …

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Non-Violent Resistance Vs. Passivity: A Look Into Percy Shelley's Politics In Prometheus Unbound, The Mask, And The Cenci, Kayla Lashae Light Jan 2016

Non-Violent Resistance Vs. Passivity: A Look Into Percy Shelley's Politics In Prometheus Unbound, The Mask, And The Cenci, Kayla Lashae Light

All ETDs from UAB

This thesis explores the differences between passiveness in Percy Shelley and Martin Luther King Jr.’s works by sectioning it off into types of passiveness: positive and negative passivity. Positive passivity is equated with a non-violent resistance, and negative passivity is the refusal or fear of acknowledging evil. Shelley and King agree that this type of evil is the most prominent among common people. In Shelley’s, Cenci, Mask of Anarchy, and Prometheus Unbound, readers can see how he is using minor characters and some major characters to illustrate oppression. King’s works, however, use personal examples and a more direct narrative. Even …

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Development Of A Split Luciferase Complementation Assay To Investigate Growth Hormone Receptor/ Prolactin Receptor Homo-/ Hetero-Association, Ying Liu Jan 2016

Development Of A Split Luciferase Complementation Assay To Investigate Growth Hormone Receptor/ Prolactin Receptor Homo-/ Hetero-Association, Ying Liu

All ETDs from UAB

Growth hormone receptor (GHR) and prolactin receptor (PRLR) are transmembrane glycoproteins cytokine receptors that are structurally homologous. Each can pre-homodimerize and ligand binding of each activates JAK2-STAT signaling pathways by inducing conformational change within the receptor homodimer. Human GHR can be activated by growth hormone (GH) while human PRLR can be activated by both GH and prolactin (PRL). We devised a split luciferase complementation assay, in which one receptor is fused to the N-terminal fragment of luciferase and the other receptor is fused to the C-terminal fragment of luciferase. When the two receptors approximate, luciferase activity (complementation) results. Using this …

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Histopathology And Image Validation Of Outer Retinal Tubulations In Age-Related Macular Degeneration, Katie M. Litts Jan 2016

Histopathology And Image Validation Of Outer Retinal Tubulations In Age-Related Macular Degeneration, Katie M. Litts

All ETDs from UAB

High-resolution imaging of the retina using spectral domain optical coherence tomography (SD-OCT) and adaptive optics scanning laser ophthalmoscopy (AOSLO) is revealing new information about photoreceptor degeneration in age-related macular degeneration (AMD) and other diseases impacting rod and cone photoreceptors. By SD-OCT, the hyperreflective outer retinal bands are visible due to the precise vertical compartmentalization and horizontal alignment of outer retinal cells and tissues (Müller cells, photoreceptors, RPE, and Bruch’s membrane). Validating these bands with normal eyes is difficult because the outer retina is very delicate making accurate histology requiring attached retina and vertically aligned photoreceptors challenging. Conversely, the bands are …

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Understanding Protein-Protein Interactions In Plantae In Network Biology Utilizing A Novel Y2h Liquid Assay Approach, Jessica Lopez Lopez Jan 2016

Understanding Protein-Protein Interactions In Plantae In Network Biology Utilizing A Novel Y2h Liquid Assay Approach, Jessica Lopez Lopez

All ETDs from UAB

The Yeast-2-Hybrid (Y2H) assay is a heterologous system that is expanding network biology knowledge via in vivo investigations of binary protein-protein interactions. Traditionally, the Y2H protocol entails the mating or co-transformation of yeast in solid agar media followed by visual analysis for diploid selection. Having played a key role in identifying protein-protein interactions for nearly three decades, the Y2H system includes the interaction between two proteins of interest which result in a reconstituted transcription factor allowing a reporter gene to be transcribed. In this thesis, two primary objectives were pursued to expand the knowledge of protein-protein interactions. The primary objective …

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A Wavelet Representation For A Fractional Brownian Motion, Robert Mann Jan 2016

A Wavelet Representation For A Fractional Brownian Motion, Robert Mann

All ETDs from UAB

like adequate calcium and vitamin D intake, to prevent osteoporosis and osteoporosisrelated

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Changes In Intrinsic Local Functional Connectivity In Children With Autism Followed By A Visualizing/Verbalizing Reading Intervention, Jose Omar Maximo Jan 2016

Changes In Intrinsic Local Functional Connectivity In Children With Autism Followed By A Visualizing/Verbalizing Reading Intervention, Jose Omar Maximo

All ETDs from UAB

Deficits in language are a major clinical feature of autism spectrum disorders (ASD). Previous studies suggest that individuals with ASD may rely on visuospatial skills to compensate for these deficits. Existing intervention programs in autism have not been tested at the neural level, thus falling short of quantifiable neurobiological changes underlying behavioral improvement. The current study takes a translational neuroimaging approach to test the impact of a structured visual imagery-based reading intervention on improving reading comprehension and its underlying neural circuitry. Changes in connectivity of a set of brain regions commonly known as the “reading network” were examined in children …

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Rural Hos[Ital Closure In Alabama - Post Aca, Dennis Otto Mccay Jan 2016

Rural Hos[Ital Closure In Alabama - Post Aca, Dennis Otto Mccay

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RURAL HOSPITAL CLOSURES IN ALABAMA: POST ACA DENNIS O. MCCAY HEALTH SERVICES ADMINISTRATION ABSTRACT Rural hospitals differ from their urban counterparts with regard to two main areas. First, rural hospital patients are usually older, of lower income, and less healthy than those in urban areas. Second, their facilities tend to be smaller, older, and more prone to staff shortages than those in an urban environment. Rural hospitals have been closing at higher rates than their urban counterparts for a number of years, but more so since the implementation of the Affordable Care Act in 2010. The objective of this research …

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Cell-Specific Pgc-1Α-Dependent Transcription: Implications For Cognitive And Motor Dysfunction, Laura Mcmeekin Jan 2016

Cell-Specific Pgc-1Α-Dependent Transcription: Implications For Cognitive And Motor Dysfunction, Laura Mcmeekin

All ETDs from UAB

health beliefs in young women. The Prevention of Osteoporosis in Women (POW)

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Improving The Scalability Of Directed Model Checking Of Concurrent Java Code Through Hybrid And Distributed Analysis, Reed Morgan Milewicz Jan 2016

Improving The Scalability Of Directed Model Checking Of Concurrent Java Code Through Hybrid And Distributed Analysis, Reed Morgan Milewicz

All ETDs from UAB

Since the widespread adoption of multi-core architectures at the turn of the millennium, parallel and concurrent programming paradigms, such as multi-threaded programming, have been advanced to enable programmers to take advantage of this abundance of computational resources. However, the need for speed has also given new life to ancient evils, namely concurrency bugs. The term concurrency bug, broadly speaking, refers to any bug that arises due to improper or inadequate synchronization of threads in their use of shared resources. These include deadlocks, race conditions, and atomicity violations. Model checking has proven to be a powerful and versatile approach to the …

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A Comprehensive Investigation Of Hp1b, A Chromatin Protein, And Its Role In Aging, Benjamin Mills Mills Jan 2016

A Comprehensive Investigation Of Hp1b, A Chromatin Protein, And Its Role In Aging, Benjamin Mills Mills

All ETDs from UAB

Genetic regulation determines which genes are expressed, in which tissues, at which time, and to which level. This regulation is necessary for proper organismal development, and loss of gene regulation can result in phenotypic consequences. As organisms grow older, gene regulation often begins to fail, resulting in negative phenotypic outcomes associated with aging. The exact reason for this failure of gene regulation remains unknown, but current models suggest that chromatin, and its associated proteins, plays a large role. The structure of chromatin impacts gene expression, directly affecting several phenotypes including aging. In this study, we investigate HP1B, a chromatin protein, …

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Molecular Analysis Of Streptococcus Mutans Genetic Diversity For The Epidemiological Study Of Oral Disease, Stephanie Stahlbuhk Momeni Jan 2016

Molecular Analysis Of Streptococcus Mutans Genetic Diversity For The Epidemiological Study Of Oral Disease, Stephanie Stahlbuhk Momeni

All ETDs from UAB

Dental caries is chronic global infectious disease. Streptococcus mutans are most frequently associated with dental caries. The goal of this work is to use molecular genotyping methods to investigate the genetic diversity and evidence for transmission of S. mutans for the epidemiological study of dental caries. It was first necessary to validate methods proposed in this study including choice of selective media, choice of multilocus sequence typing (MLST) scheme, and the frequency of clonality. Analysis included 13,906 S. mutans isolates obtained from oral samples collected from children and their household members in an 8-year longitudinal epidemiological study. Two genotyping methods …

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Fabrication And Characterization Of Buckypapers For Use In Air Sampling, Jonghwa Oh Jan 2016

Fabrication And Characterization Of Buckypapers For Use In Air Sampling, Jonghwa Oh

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FABRICATION AND CHARACTERIZATION OF BUCKYPAPERS FOR USE IN AIR SAMPLING JONGHWA OH ENVIRONMENTAL HEALTH SCIENCES ABSTRACT Occupational exposure to volatile organic compounds (VOCs) is a concern from a public health perspective. In many industrial activities, workers’ exposure to VOCs can be sufficiently high to induce adverse health effects, so their monitoring is necessary. In exposure assessment, post sampling extraction and quantification are the typical analytical procedures. Recently, our group developed the photothermal desorption (PTD) technique in which a pulse of light thermally desorbs an analyte directly from a sorbent. Advantages of this technique are; it is solvent free, repeated analysis …

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Fmic Annual Report 2016 | English, French Medical Institute For Mothers And Children Jan 2016

Fmic Annual Report 2016 | English, French Medical Institute For Mothers And Children

French Medical Institute for Mothers and Children (FMIC) Archives

No abstract provided.

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Cancer Care, Aga Khan University Hospital Jan 2016

Cancer Care, Aga Khan University Hospital

The Aga Khan University Hospital, Nairobi Archives

This brochure outlines the comprehensive cancer services provided by the Aga Khan University Hospital, Nairobi. It highlights the hospital’s multidisciplinary approach to cancer care, including screening, diagnostics, radiology, radiotherapy, chemotherapy, inpatient care, and support services. The document also details specialist clinics, research initiatives, and patient support programs aimed at delivering individualized, high-quality care across the cancer treatment continuum.

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Department Of Community Health Sciences Medical College (Report 2009 - 2016), Department Of Community Health Sciences, Medical College Jan 2016

Department Of Community Health Sciences Medical College (Report 2009 - 2016), Department Of Community Health Sciences, Medical College

Department of Community Health Sciences Archives

This report comprehensively documents the academic, research, and service accomplishments of the Department of Community Health Sciences (CHS) at the Aga Khan University from 2009 to 2016. It highlights the department’s mission to strengthen public health education and systems through innovative programs, strategic partnerships, and impactful research. Topics covered include CHS faculty profiles, educational programs, strategic initiatives, community outreach, grant-funded projects, and the vision for establishing a School of Public Health.

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Dietary Patterns, Insulin Resistance, And Cognitive Outcomes In A Cohort Of Black And White Americans, Keith Pearson Jan 2016

Dietary Patterns, Insulin Resistance, And Cognitive Outcomes In A Cohort Of Black And White Americans, Keith Pearson

All ETDs from UAB

As life expectancy continues to increase and the number of elderly Americans rises, public health initiatives are seeking to identify modifiable risk factors to preserve cognitive function and increase quality of life in advanced ages. The primary objective of this dissertation was to investigate dietary patterns, carbohydrate consumption, and insulin resistance as modifiable risk factors that may contribute to the development of cognitive impairment and cognitive decline. Three separate studies were performed in the REasons for Geographic And Racial Differences in Stroke study, a prospective cohort containing 30,239 black and white participants. Cognitive impairment was defined using the Six-Item Screener. …

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Study Of Cobalt, Cobalt-Iron, And Chromium Doped Ii-Vi Media For Laser Applications, Jeremy M. Peppers Jan 2016

Study Of Cobalt, Cobalt-Iron, And Chromium Doped Ii-Vi Media For Laser Applications, Jeremy M. Peppers

All ETDs from UAB

The middle infrared (mid-IR) spectral range of 2-15 μm possesses characteristics that make it interesting for a number of applications such as spectroscopy, free-space communication, remote detection of organic compounds, materials processing and medical diagnosis. Many organic molecules exhibit strong absorption in this spectral range, rendering their detection and identification possible. There also exist bands of atmospheric transmission which can allow free-space propagation of mid-IR light over considerable distances within the atmosphere. Because of these, there is an increasing demand for broadly tunable laser sources operating in this spectral range. II-VI wide bandgap semiconductor hosts doped with transition metal (TM) …

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Evaluation Of Merge Control Strategies For Interstate Work Zones And Their Impacts On Construction Planning And Scheduling Decisions, Ossama Elsayed Mahmoud Ramadan Jan 2016

Evaluation Of Merge Control Strategies For Interstate Work Zones And Their Impacts On Construction Planning And Scheduling Decisions, Ossama Elsayed Mahmoud Ramadan

All ETDs from UAB

Maintenance and rehabilitation projects of interstate facilities typically mandate lane closures which often result in bottlenecks. Merging maneuvers at these bottlenecks have adverse impacts on traffic operations. Conventionally, transportation management plans are developed to address such impacts; however, such plans rely on conventional bottleneck merge control as stipulated in the Manual on Uniform Traffic Control Devices and overlook the relevant impacts on construction plans and schedules. Accordingly, agencies opt to schedule work zones during off-peak (nighttime) periods, which adversely impacts safety and productivity of workers. The issue persists because little is known about the performance of alternative bottleneck merge control …

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Early-Life Programming Of Emotional Behaviors And Cardiovascular Function, Samir Rana Jan 2016

Early-Life Programming Of Emotional Behaviors And Cardiovascular Function, Samir Rana

All ETDs from UAB

Extensive evidence implicates bi-directional relationship between mood disorders and cardiovascular disorders. Early-life experience can have strong effects both on emotional development and cardiovascular function throughout life. Studies in humans are limited to correlational analyses, which are necessarily limited in terms of revealing mechanistic underpinnings of these associations. Thus, various pre-clinical models are utilized to investigate the effects of early-life experience in various domains, such as behavior and cardiovascular function, which are likely mediated by epigenetic mechanisms. Previous studies have used maternal separation and neonatal handling in developing rodents as a way to model differences in early-life experience. The effect of …

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Optimal Harmonic Filter Topology Applied In Hv And Ehv Networks Using Particle Swarm Optimization, Reynaldo Ramos Jan 2016

Optimal Harmonic Filter Topology Applied In Hv And Ehv Networks Using Particle Swarm Optimization, Reynaldo Ramos

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Passive shunt harmonic filter banks have proven to be an effective method for reducing harmonic distortion in high-voltage and extra high-voltage networks, while providing the necessary volt-ampere-reactive power support and voltage support. Previous work in this area has provided information regarding the design and application of harmonic filters as well as discussion of the different harmonic filter topologies that are typically employed. However, there is a lack of information in the area of optimal harmonic filter topology selection and sizing when the power system is networked. The core contribution of this work is the development of an optimization method for …

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Correlating High Reliability Organization Practices With Preventable Harms Across Children’S Hospitals Participating In The Children’S Hospitals’ Solutions For Patient Safety Collaborative, Kelly H. Randall Jan 2016

Correlating High Reliability Organization Practices With Preventable Harms Across Children’S Hospitals Participating In The Children’S Hospitals’ Solutions For Patient Safety Collaborative, Kelly H. Randall

All ETDs from UAB

Background: Despite significant effort, focus, and resources dedicated to reducing patient safety risk, the healthcare system continues to have high error rates. Approaches and strategies implemented to decrease human error have been marginally successful in achieving sustainable reduction in patient harm. Purpose: The purpose of this study was to examine the association between high reliability and patient safety outcomes by testing the following hypotheses: Organizations exhibiting more advanced high reliability practice will have fewer hospital acquired conditions (as defined by the Serious Harm Event Index (SHE) than organizations exhibiting less advanced high reliability practices; and organizations exhibiting more advanced high …

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Reorganization Of The Golgi Apparatus During Human Cytomegalovirus Infection, George Michael Rebmann Jan 2016

Reorganization Of The Golgi Apparatus During Human Cytomegalovirus Infection, George Michael Rebmann

All ETDs from UAB

Human cytomegalovirus (HCMV) is the largest and most structurally complex of all the herpesviruses. HCMV is an important human pathogen that results in significant morbidity and disease in immunocompromised individuals. The assembly of herpesviruses is complex and involves a nuclear and cytoplasmic phase. The nuclear events of capsid assembly and genome incorporation as well as nuclear egress are believed to be similar in all herpesviruses and as such, are more clearly defined then the cytoplasmic phase; including the process of tegument and envelope acquisition. Human Cytomegalovirus induces the reorganization of the cellular secretory pathway including the Golgi apparatus and membranes …

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Examining Hiv-Associated Symptom Burden And Microbial Translocation In The Veterans Aging Cohort Study: A Secondary Data Analysis, Natalie Lynn Wilson Jan 2016

Examining Hiv-Associated Symptom Burden And Microbial Translocation In The Veterans Aging Cohort Study: A Secondary Data Analysis, Natalie Lynn Wilson

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group of 50 women (group 1) received computer-tailored feedback with brief counseling.

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The Impact Of Rrna And Trna Synthesis On Chromatin Structure And Cell Fate, Jessica Makofske Woolnough Jan 2016

The Impact Of Rrna And Trna Synthesis On Chromatin Structure And Cell Fate, Jessica Makofske Woolnough

All ETDs from UAB

The Central Dogma of molecular biology describes the process by which genetic material is faithfully converted into functional molecules across all domains of life. Originally, RNA was solely understood as an intermediate in this process. However, mounting evidence over the past 50 years has made clear that RNA have diverse functional roles as a class of molecule termed non-coding RNA. Two of the first described non-coding RNA have essential roles within the Central Dogma, itself: ribosomal RNA (rRNA) and transfer RNA (tRNA). These two non-coding RNA are highly abundant, collectively accounting for up to 90% of the total transcript in …

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Retention Of Cad/Cam Crowns Luted With A Novel Biomimetic Cement, Nan Xiang Jan 2016

Retention Of Cad/Cam Crowns Luted With A Novel Biomimetic Cement, Nan Xiang

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Objectives: To measure the tensile strength of e.max copings cemented with resin, calcium silicate and calcium phosphate cements following thermocycling. Methods: 40 extracted non-carious mandibular premolar teeth were examined and selected using Keyence microscope for no carious cracks etc.were mounted in acrylic. The teeth were placed in a lathe and prepared to uniform dimensions (22° total taper) using a flat-end tapered diamond bur (846.11.025HP, Brasseler) and a 3mm preparation height. The surface area of the prepared surface was calculated with digital microscopy. The teeth were scanned with a Cerec 3 (Sirona) digital scanner. E.max crowns were milled using Cerec 3 …

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