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2016

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Predicting The Duration Of Antibacterial Treatment With Cell Wall Synthesis Inhibitors By Using Mathematical Models, Panit Suavansri Jan 2016

Predicting The Duration Of Antibacterial Treatment With Cell Wall Synthesis Inhibitors By Using Mathematical Models, Panit Suavansri

The Thai Journal of Pharmaceutical Sciences

This paper proposed a new mathematical model of within-host population dynamics of bacteria after cell wall synthesis inhibitors administration for practically predicting treatment duration and drug dosage. Our model deployed various concepts from differ...

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Developing A Signal Triage Algorithm For Thai National Adverse Drug Reaction Database, Suntharee T. Chaisumritchoke Jan 2016

Developing A Signal Triage Algorithm For Thai National Adverse Drug Reaction Database, Suntharee T. Chaisumritchoke

The Thai Journal of Pharmaceutical Sciences

There was increasing adverse drug reaction (ADR) reports submitted to the Health Product Vigilance Center under the Thai FDA. In order to find some signals, the Thai Signal Detection Program was developed to identify and filter the potential signals, cal...

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Factors Affecting Community Pharmacists’ Intention To Provide Medication Management Program And Disease Screening In Bangkok, Payungjit Kangwol, Puree Anantachoti Jan 2016

Factors Affecting Community Pharmacists’ Intention To Provide Medication Management Program And Disease Screening In Bangkok, Payungjit Kangwol, Puree Anantachoti

The Thai Journal of Pharmaceutical Sciences

Objectives: To determine factors affecting community pharmacists’ intention to provide medication management program (MMP) and disease screening (DS) based on diffusion of innovations theory. Methods: A cross-sectional study using self-administered ma...

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Docking And Molecular Dynamic Simulations: Study Of 1, 3, 4-Oxadiazole- Chalcone Hybrid Derivatives To Search New Active Anticancer Agents, Adel Zamri, Neni Frimayanti, Hilwan Yuda Teruna Jan 2016

Docking And Molecular Dynamic Simulations: Study Of 1, 3, 4-Oxadiazole- Chalcone Hybrid Derivatives To Search New Active Anticancer Agents, Adel Zamri, Neni Frimayanti, Hilwan Yuda Teruna

The Thai Journal of Pharmaceutical Sciences

Chalcone hybrid derivatives are one of the anti cancer promising agents. Computational approach (i.e. molecular docking) was applied in this study to search chalcone hybrids derivatives as new anti cancer agents. Blind docking of 81 chalcone derivatives ...

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One Pot Synthesis And Docking Study Of Some Tetrahydrobenzo[B]Pyran Derivatives As Extended Spectrum Class Lactamase Inhibitors For Urinary Tract Infection, Prafulla Balkrishna Choudhari Jan 2016

One Pot Synthesis And Docking Study Of Some Tetrahydrobenzo[B]Pyran Derivatives As Extended Spectrum Class Lactamase Inhibitors For Urinary Tract Infection, Prafulla Balkrishna Choudhari

The Thai Journal of Pharmaceutical Sciences

A series of tetrahydrobenzo[b] pyran derivatives were synthesized and screened for the antimicrobial activity against Proteus vulgaris. Structures of newly synthesized compounds were confirmed by physicochemical, spectral and elemental analysis. The dock...

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Comparison Of Validated Hplc Methods Using Two Derivatizing Agents For Gamma-Aminobutyric Acid Quantification, Kritchapol Panrod, Anyarporn Tansirikongkol, Vipaporn Panapisal Jan 2016

Comparison Of Validated Hplc Methods Using Two Derivatizing Agents For Gamma-Aminobutyric Acid Quantification, Kritchapol Panrod, Anyarporn Tansirikongkol, Vipaporn Panapisal

The Thai Journal of Pharmaceutical Sciences

Gamma-aminobutyric acid (GABA) has many advantages in physiological functions and skin benefits. Therefore, a feasible and simple method is needed for its determination. The purpose of this study was to validate and compare two HPLC analyses of GABA afte...

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Fp-16-10 Over 25 Years Of Change In Men's Entry Into Fatherhood, 1987-2013, Kasey J. Eickmeyer Jan 2016

Fp-16-10 Over 25 Years Of Change In Men's Entry Into Fatherhood, 1987-2013, Kasey J. Eickmeyer

National Center for Family and Marriage Research Family Profiles

No abstract provided.

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Fp-16-18 First Marriage Rate In The U.S., 2014, Lydia R. Anderson Jan 2016

Fp-16-18 First Marriage Rate In The U.S., 2014, Lydia R. Anderson

National Center for Family and Marriage Research Family Profiles

No abstract provided.

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Hate Speech And Double Standards, Thomas M. Keck Jan 2016

Hate Speech And Double Standards, Thomas M. Keck

Political Science - All Scholarship

Many European states ban the public expression of hateful speech directed at racial and religious minorities, and an increasing number do so for anti-gay speech as well. These laws have been subjected to a wide range of legal, philosophical, and empirical investigation, but this paper explores one potential cost that has not received much attention in the literature. Statutory bans on hate speech leave democratic societies with a Hobson’s choice. If those societies ban incitements of hatred against some vulnerable groups, they will inevitably face parallel demands for protection of other such groups. If they accede to those demands, they …

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Modeling Regional Freight Truck Movements Using Tour-Based Approach, Ehsan Doustmohammadi Jan 2016

Modeling Regional Freight Truck Movements Using Tour-Based Approach, Ehsan Doustmohammadi

All ETDs from UAB

In the recent years, the number of freight truck trips has been growing at a staggering pace all over the world. Traditional travel demand forecasting models do not model truck trips separately, but rather include them implicitly in the non-home-based (NHB) trip category. Little attention is, thus, paid to truck types, trip patterns, trip lengths, or actual truck counts. With a growing realization of the importance of truck traffic both to the overall economy and on urban congestion and pollution levels, there is a new interest in modeling truck movements with greater accuracy and detail. The purpose of this research …

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Targeting Voltage Gated Sodium Channels For Prevention Of Breast Cancer Metastasis, Shilpa Dutta Jan 2016

Targeting Voltage Gated Sodium Channels For Prevention Of Breast Cancer Metastasis, Shilpa Dutta

All ETDs from UAB

Voltage gated sodium channels (VGSC) are a recently identified drug target involved in the breast cancer invasion mechanism. VGSCs participate in the acidification of the perimembrane, activating the cysteine proteases, cathepsin B and S, thereby triggering the proteolysis of the extracellular matrix and the basement membrane, thereby promoting cell invasion. Highly aggressive, invasive breast cancer cells dramatically overexpress one subtype of VGSC, nNav1.5. Described here are the design, synthesis and in vitro evaluation of drug-like, small molecule blockers of nNav1.5 that are potential therapeutic agents for the prevention of breast cancer metastasis. Initially, five compounds were designed and synthesized based …

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Discrimination Of Various Rock Units In Abu Zenima Area, South Western Sinai, Egypt, With Emphases To The Radioactive Areas Using The Hyperspectral Remote Sensing And Gis Techniques, Reda El Arafy Jan 2016

Discrimination Of Various Rock Units In Abu Zenima Area, South Western Sinai, Egypt, With Emphases To The Radioactive Areas Using The Hyperspectral Remote Sensing And Gis Techniques, Reda El Arafy

All ETDs from UAB

This research study investigates the potential value of spectral information extraction of Hyperion hyperspectral, The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) and, Landsat 8 OLI remote sensing data for geological mapping and mineral exploration in a semi-arid region in the Southwestern Sinai, Egypt. Previous investigations of known uranium deposits reflect its economic importance and justifies exploration for additional prospects. The study area is subject to low average precipitation associated with sparse to nonexistent vegetation cover, making it quite an ideal location for this remote sensing study. This study tested a diversity of advanced hyperspectral analytical image processing techniques …

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Managing Multiple Roles As A School Leader: A Phenomenological Study Of Female Alabama High School Principals, Amanda Webb Esslinger Jan 2016

Managing Multiple Roles As A School Leader: A Phenomenological Study Of Female Alabama High School Principals, Amanda Webb Esslinger

All ETDs from UAB

The United States Department of Labor (2012) provided that women’s participation in the workforce has grown over the past 50 years. With increased responsibilities outside of the home, many women are experiencing work-family conflict (Shakeshaft, 1989). With a focus on educational leadership, this study examined how female high school principals navigated multiple roles and the strategies they implemented to minimize conflict. The participants acknowledged that as high school principals they occupy multiple professional roles which require a great deal of their time and energy. The demands and emotional nature of their principalships created conflict with their family roles. The participants …

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Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia Jan 2016

Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia

All ETDs from UAB

program pilot study randomly assigned 100 women, aged 19 to 25 to two groups. One

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Serum Vitamin D And C-Reactive Protein: Predictors Of Glucose Control In African-Americans With Type 2 Diabetes?, Mary Luree Garvin-Surpris Jan 2016

Serum Vitamin D And C-Reactive Protein: Predictors Of Glucose Control In African-Americans With Type 2 Diabetes?, Mary Luree Garvin-Surpris

All ETDs from UAB

Introduction African-Americans experience more years of life lost as a result of complications from type 2 diabetes mellitus (T2DM) than any other racial or ethnic group. Evidence suggests that serum 25(OH)D (serum vitamin D), generally low in African-Americans, may play a role in glucose control. In addition, elevated levels of chronic low-grade inflammation, measured by C-reactive protein (CRP), may also relate to glucose control. The purposes of this study were to determine whether serum 25(OH)D and CRP are independent predictors of glucose control in adult African-Americans with T2DM, after controlling for other factors associated with glucose control, and to examine …

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Neurobiological Consequences Of Perinatal Ssri Exposure, Matthew Edward Glover Jan 2016

Neurobiological Consequences Of Perinatal Ssri Exposure, Matthew Edward Glover

All ETDs from UAB

Selective serotonin reuptake inhibitors (SSRIs) have been a mainstay pharmacological treatment for women experiencing depression during pregnancy and postpartum for nearly three decades. Recently, though, growing evidence indicates that early-life SSRI exposure triggers long-lasting behavioral abnormalities. Clinically, children exposed to SSRIs in early life exhibit increased internalizing behavior, reduced social behavior, and increased risk for depression in adolescence. Similarly, in rodents, perinatal SSRI exposure leads to increased traits of anxiety- and depression-like behavior. Interestingly, certain individuals are more susceptible to early-life SSRI exposure than others, suggesting that perinatal SSRI exposure poses greater risks for negative outcome within certain populations; however, …

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The (Non)Tragic Passing Of Rena Walden: Black Female Agency In Charles Chesnutt's The House Behind The Cedars, Sarah Emily Goggans Jan 2016

The (Non)Tragic Passing Of Rena Walden: Black Female Agency In Charles Chesnutt's The House Behind The Cedars, Sarah Emily Goggans

All ETDs from UAB

This project analyzes Charles W. Chesnutt’s The House Behind the Cedars in an attempt to accredit Chesnutt as a forerunner of Critical Race Theory (CRT). Secondly, this project argues that Rena gains agency solely through her black ancestry in her ability to read and write both cultural and written texts. I will also argue in that creating a metanarrative form for his novel, Chesnutt is able to provide a radically feminist text through his representation of the power of Rena’s literacy, and furthermore, that Chesnutt is able to critique the laws and customs of normative white society. Lastly, this project …

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Cultural And Gender Differences In Child Abuse Risk In African American And White Expectant Mothers And Fathers, Anjali Gowda Jan 2016

Cultural And Gender Differences In Child Abuse Risk In African American And White Expectant Mothers And Fathers, Anjali Gowda

All ETDs from UAB

Previous maltreatment literature examining child physical abuse risk has not effectively examined cultural nuances in risk and protective factors. Further, research has relied heavily upon maternal only samples, limiting our understanding of paternal risk factors. The current study examined macro-level variables (i.e., racial identification and gender role ideologies) in conjunction with individual-level factors (i.e., attribution of child intent and acceptability of abuse) as they relate to parental abuse risk. The study employed explicit and implicit measures administered to 142 African American and White first-time expectant mother and father dyads. Study hypotheses were partially supported, identifying both consistencies and inconsistencies across …

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Clustering Phish Using The Simple Set Comparison Tool, Jason Robert Britt Jan 2016

Clustering Phish Using The Simple Set Comparison Tool, Jason Robert Britt

All ETDs from UAB

Phishing has been a problem since before the early 2000s and has only become more prevalent and diverse since. Phishing countermeasures have been developed and used to prevent or mitigate phishing attacks. However, each countermeasure has pros and cons and not every countermeasure is effective in every situation. Choosing the best suited phishing countermeasure or combination of phishing countermeasures to use and track their effectiveness requires grouping phish based upon common characteristics and tactics used by phish or phish grouping. To be effective phish grouping needs to produce dependable groupings, quickly produce groups, and analyze large volumes of phish. This …

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Cardiovascular Risk Factors In Ambulatory Blood Pressure Monitoring Phenotypes, Samantha G. Bromfield Jan 2016

Cardiovascular Risk Factors In Ambulatory Blood Pressure Monitoring Phenotypes, Samantha G. Bromfield

All ETDs from UAB

Hypertension and diabetes are common and are known risk factors for cardiovascular disease (CVD). Several blood pressure (BP) phenotypes, identified by ambulatory BP monitoring (ABPM), have been reported to be associated with an increased risk for CVD. However, there are few data on ABPM phenotypes among individuals with diabetes. Identifying modifiable factors that improve cardiovascular health may reduce CVD events and the prevalence of ABPM phenotypes, such as masked hypertension. Given the ability of ABPM to identify unconventional BP phenotypes that provide prognostic information beyond clinic BP, it is important to understand the optimal number of 24-hour ABPM readings necessary …

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Igniting The Path To Reading Success: Torchbearer Principals' Perceptions Of Reading Instruction, Vilveca Bryant Jan 2016

Igniting The Path To Reading Success: Torchbearer Principals' Perceptions Of Reading Instruction, Vilveca Bryant

All ETDs from UAB

The purpose of this phenomenological study was to explore principal perceptions of how reading scores improved in high-poverty, high-performing schools in Alabama that had achieved Torchbearer School status. In 2005, the Alabama State Department of Education began bestowing the honor of Torchbearer schools to schools in high poverty areas throughout the state that have achieved high academic performance in Reading and Math. The goal of this qualitative study was to understand principal experiences and the essence of what it meant to be a principal of a successful high poverty school, to hear the voices of the participants. Participant descriptions revealed …

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Conceptualizations Of Health And Health Communication By Clergy In Jefferson County, Alabama: A Qualitative Exploration, Anthony David Campbell Jan 2016

Conceptualizations Of Health And Health Communication By Clergy In Jefferson County, Alabama: A Qualitative Exploration, Anthony David Campbell

All ETDs from UAB

The purpose of this dissertation is to examine how clergy define health and how they communicate health messages to their congregations and communities. Clergy are influential figures who fulfill a variety of roles outside of their unique pastoral responsibilities, including serving as a source of health-related information and resources. Little is known about how clergy perceive the role of churches and their own role in health and health ministry. In-depth qualitative interviews were conducted with 32 African American and white clergy members from a variety of religious denominations in Jefferson County, Alabama between January 2015 and February 2016. Data were …

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Design Of Layer-By-Layer Shaped Microparticles For Controlled Drug Delivery, Jun Chen Jan 2016

Design Of Layer-By-Layer Shaped Microparticles For Controlled Drug Delivery, Jun Chen

All ETDs from UAB

Free drug administration is always associated with several problems, such as poor drug solubility, rapid drug breakdown, fast drug clearance, lack of targeting viability, and inappropriate biodistribution. These problems significantly prevent the accumulation of drugs, specifically to the cancer sites, to achieve high therapy efficacy. The unrestricted diffusion of drugs throughout the whole body also results in severe side effects, such as cytotoxicity and immune responses, to healthy cells which limit the accomplishment of the necessary drug dose to produce efficacious therapy. Therefore, to address these prob-lems, it is urgent to design and develop drug delivery carriers that can protect …

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Use Of Medicare Inpatient Claims Data For The Identification Of Myocardial Infarction, Lisandro Damian Colantonio Jan 2016

Use Of Medicare Inpatient Claims Data For The Identification Of Myocardial Infarction, Lisandro Damian Colantonio

All ETDs from UAB

Claims are being used for the identification of myocardial infarctions (MI) in research studies, either as a complement of primary data collection or as the sole data source. However, few data are available to support these approaches. The current dissertation analyzes the use of claims for the identification of MIs in a large population-based cohort linked to Medicare data, the REasons for Geographic and Racial Differences in Stroke study. Analyses included 9,951 study participants ≥65 years of age with Medicare Part A (inpatient) fee-for-service coverage at baseline in 2003-2007. Participant self-report and Medicare inpatient claims with a diagnosis code for …

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Parental Acculturation And Adolescent Depression, Serra Sevde Aydogan Jan 2016

Parental Acculturation And Adolescent Depression, Serra Sevde Aydogan

All ETDs from UAB

This study investigates whether or not parental acculturation is associated with depression levels among youth in US-based immigrant families. Previous research has shown that even though individual acculturation is negatively correlated with adolescents’ good mental health, parental acculturation is associated with higher levels of mental health among youth. This study elaborates on these prior findings by using a large national sample of immigrant children ages 13-14 and considering the mediating role of social ties and social support. Data for the study are derived from the Children of Immigrant Longitudinal Study to examine the relationship between parental acculturation and youth depression. …

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Exploring Bacteriophage P22 As A Selective Molecular Scaffold And Molecular Sensor, Gregory Joseph Bedwell Jan 2016

Exploring Bacteriophage P22 As A Selective Molecular Scaffold And Molecular Sensor, Gregory Joseph Bedwell

All ETDs from UAB

The virus capsids of many dsDNA bacteriophage are finely tuned macromolecular machines. Their functionality begins at assembly, when their capsids are built under the guidance of a class of proteins referred to as scaffolding proteins. The scaffolding protein of bacteriophage P22 is a flexible, highly elongated protein that binds to the interior surface of the P22 procapsid via its C-terminal domain. The finding that N-terminus is dispensable for procapsid binding prompted the development of chimeric scaffolding protein molecules, wherein N-terminal residues of scaffold are replaced with a variety of different peptide sequences or functional proteins that are then encapsidated within …

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Methods For Measuring Individually Experienced Temperature And Food Intake In Controlled Thermal Environments, Molly Bernhard Jan 2016

Methods For Measuring Individually Experienced Temperature And Food Intake In Controlled Thermal Environments, Molly Bernhard

All ETDs from UAB

The three studies to be presented assess individual-level heat exposure in free-living urban and rural environments and assess food intake in randomized controlled trials in a 2-hour exposure, and a 7-hour crossover heat exposure. The first interest was broad: examining heat exposure and its relation to potential health outcomes. To examine whether heat exposure could be measured in free-living organisms, a light and temperature monitoring device was repurposed and used in a pilot study of individual-level heat exposure in urban and rural community members. Differences between the current and most commonly accepted way of estimating heat exposure, weather station datasets, …

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A Comparison Of Soft Tissue Topographical Norms For The Local Ethnic People Of Zimbabwe And African American Norms Based On 3dmd Soft Tissue Photography, Elvin Bhaskar Jan 2016

A Comparison Of Soft Tissue Topographical Norms For The Local Ethnic People Of Zimbabwe And African American Norms Based On 3dmd Soft Tissue Photography, Elvin Bhaskar

All ETDs from UAB

Introduction: The purpose of this study is to determine the soft tissue topographical norms for the local ethnic people of Zimbabwe and compare them with the African American norms based on 3dMD soft tissue photography. The rationale for the study is to evaluate how the soft tissue drape over the facial skeleton correlates with the different soft tissue analysis widely available today. This study seeks to establish an average base on which clinicians can treat people according to their cultural esthetic perceptions. Previous reported studies only evaluate small numbers of populations and it is well known that different races and …

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Structure-Function Relationships In The Sec7 Guanine Nucleotide Exchange Factor Gbf1, Jay Manoj Bhatt Jan 2016

Structure-Function Relationships In The Sec7 Guanine Nucleotide Exchange Factor Gbf1, Jay Manoj Bhatt

All ETDs from UAB

All eukaryotic cells contain a secretory pathway composed of membrane-bound compartments connected by vesicles that transport cargo from the endoplasmic reticulum (ER) through the Golgi apparatus to various destination within and outside the cell. The Golgi Brefeldin A-resistant Factor 1 (GBF1) is required for protein traffic between ER and Golgi and within the Golgi. GBF1 belongs to a family of Guanine nucleotide Exchange Factors (GEFs) that stimulate the nucleotide exchange of GDP for GTP on small GTPases called ADP-ribosylation factors (ARFs). Once GTP-bound, ARFs become active and initiate a cascade of events that lead to vesicle formation. Thus, GBF1 is …

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1,1-Diamino-2,2-Dinitroethylene (Fox-7) Under High Pressure-Temperature, Matthew Marc Bishop Jan 2016

1,1-Diamino-2,2-Dinitroethylene (Fox-7) Under High Pressure-Temperature, Matthew Marc Bishop

All ETDs from UAB

The high pressure-temperature (P-T) phase diagram of 1,1-diamino-2,2-dinitroethylene (FOX-7) was determined by in situ synchrotron infrared radiation spectroscopy and resistively heated diamond anvil cell (DAC) techniques. The stability of the high P-T FOX-7 polymorphs is established from ambient pressure up to 10 GPa and temperatures until decomposition. The phase diagram indicates two near isobaric phase boundaries at ~2 GPa (  I) and ~ 5 GPa ( I  ) that persists from 25oC until the onset of decomposition at ~300oC. In addition, the ambient pressure, high-temperature    phase transition (~111oC) lies along a steep boundary (~100oC/GPa) with …

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