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2016

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Evaluation Of Genexpert Mtb/Rif For Detection Of Mycobacterium Tuberculosis Complex And Rpo B Gene In Respiratory And Non-Respiratory Clinical Specimens At A Tertiary Care Teaching Hospital In Saudi Arabia, Ali M. Somily, Mazin A. Barry, Hanan A. Habib, Fawzia E. Alotaibi, Fahad A. Al-Zamil, Mohammed A. Khan, Mohammed S. Sarwar, Nawab D. Bakhash, Abdulkarim A. Alrabiaah, Zahid A. Shakoor, Abiola C. Senok Dec 2016

Evaluation Of Genexpert Mtb/Rif For Detection Of Mycobacterium Tuberculosis Complex And Rpo B Gene In Respiratory And Non-Respiratory Clinical Specimens At A Tertiary Care Teaching Hospital In Saudi Arabia, Ali M. Somily, Mazin A. Barry, Hanan A. Habib, Fawzia E. Alotaibi, Fahad A. Al-Zamil, Mohammed A. Khan, Mohammed S. Sarwar, Nawab D. Bakhash, Abdulkarim A. Alrabiaah, Zahid A. Shakoor, Abiola C. Senok

Saudi Medical Journal

Objectives To assess the performance of Xpert MTB/RIF, an automated molecular test for Mycobacterium tuberculosis (MTB) and resistance to rifampin (RIF), against smear microscopy and culture method for diagnosis of MTB infection. Methods This is a retrospective analysis of 103 respiratory and 137 non-respiratory patient specimens suspected of tuberculosis at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia performed between April 2014 and March 2015. Each sample underwent smear microscopy, mycobacterial culture, and GeneXpert MTB/RIF test. Results Fifteen out of 103 respiratory samples were smear and culture positive, whereas 9 out of 137 non-respiratory samples were smear positive. Out …


Barriers Related To Prenatal Care Utilization Among Women, Nasibeh Roozbeh, Fatemeh Nahidi, Sepideh Hajiyan Dec 2016

Barriers Related To Prenatal Care Utilization Among Women, Nasibeh Roozbeh, Fatemeh Nahidi, Sepideh Hajiyan

Saudi Medical Journal

Objectives To investigate barriers related to prenatal care utilization among women. Methods Data was collected in both English and Persian databases. English databases included: the International Medical Sciences, Medline, Web of Science, Scopus, Google Scholar. The Persian databases included: the Iranmedex, the State Inpatient Databases (SID) with the use of related keywords, and on the basis of inclusion-exclusion criteria. The keywords included are barrier, prenatal care, women, access, and preventive factors. OR and AND were Boolean operators. After the study, articles were summarized, unrelated articles were rejected, and related articles were identified. Inclusion criteria were all published articles from 1990 …


Moorfields Manual Of Ophthalmology, Ahmed Al Salem Dec 2016

Moorfields Manual Of Ophthalmology, Ahmed Al Salem

Saudi Medical Journal

No abstract provided.


Over 1 Million Treated With Highly Effective Hepatitis C Medicines Dec 2016

Over 1 Million Treated With Highly Effective Hepatitis C Medicines

Saudi Medical Journal

No abstract provided.


Who Recommends 29 Ways To Stop Surgical Infections And Avoid Superbugs Dec 2016

Who Recommends 29 Ways To Stop Surgical Infections And Avoid Superbugs

Saudi Medical Journal

No abstract provided.


Roles Of Nucleolin: Focus On Cancer And Anti-Cancer Therapy, Zhuo Chen, Xinhua Xu Dec 2016

Roles Of Nucleolin: Focus On Cancer And Anti-Cancer Therapy, Zhuo Chen, Xinhua Xu

Saudi Medical Journal

Nucleolin, a multifunctional protein distributed in the nucleolus, participates in many modulations including rDNA transcription, RNA metabolism, and ribosome assembly. Nucleolin is also found in the cytoplasm and on the cell membrane, and surface nucleolin can bind to various ligands to affect many physiological functions. The expression and localization of nucleolin is often abnormal in cancers, as the differential distribution of nucleolin in cancer can influence the carcinogenesis, proliferation, survival, and metastasis of cancer cells, leading to the cancer progression. Thus, nucleolin may be a novel and promising target for anti-cancer treatment. Here, we describe how nucleolin act functions in …


Personalized Medicine: Is It Time For Infectious Diseases?, Maha A. Al-Mozaini, Michael K. Mansour Dec 2016

Personalized Medicine: Is It Time For Infectious Diseases?, Maha A. Al-Mozaini, Michael K. Mansour

Saudi Medical Journal

No abstract provided.


Healthcare Professionals’ Awareness And Knowledge Of Adverse Drug Reactions And Pharmacovigilance, Noor B. Almandil Dec 2016

Healthcare Professionals’ Awareness And Knowledge Of Adverse Drug Reactions And Pharmacovigilance, Noor B. Almandil

Saudi Medical Journal

Objectives To document the knowledge of, attitudes toward, and practices of adverse drug reaction (ADR) reporting and pharmacovigilance systems among healthcare professionals. Methods This descriptive cross-sectional study was conducted using a questionnaire. This study took place at King Fahd Hospital of the University (KFHU), Khobar, Kingdom of Saudi Arabia, between April 2015 and April 2016. Healthcare professionals, including physicians, pharmacists, pharmacy technicians, and nurses, were considered eligible and invited to take part in the study. A link to the online questionnaire was sent to each participant via E-mail, and a hard copy was circulated at the hospital after the objectives …


Effects Of Personality Traits On Collaborative Performance In Problem-Based Learning Tutorials, Hye Won Jang, Seung Won Park Dec 2016

Effects Of Personality Traits On Collaborative Performance In Problem-Based Learning Tutorials, Hye Won Jang, Seung Won Park

Saudi Medical Journal

Objectives To examine the relationship between students’ collaborative performance in a problem-based learning (PBL) environment and their personality traits. Methods This retrospective, cross-sectional study was conducted using student data of a PBL program between 2013 and 2014 at Sungkyunkwan University School of Medicine, Seoul, South Korea. Eighty students were included in the study. Student data from the Temperament and Character Inventory were used as a measure of their personality traits. Peer evaluation scores during PBL were used as a measure of students’ collaborative performance. Results Simple regression analyses indicated that participation was negatively related to harm avoidance and positively related …


Phase Down Of Amalgam: Awareness Of Minamata Convention Among Jordanian Dentists, Mohammad A. Al-Rabab’Ah, Mohammad A. Bustani, Ameen S. Khraisat, Faleh A. Sawair Dec 2016

Phase Down Of Amalgam: Awareness Of Minamata Convention Among Jordanian Dentists, Mohammad A. Al-Rabab’Ah, Mohammad A. Bustani, Ameen S. Khraisat, Faleh A. Sawair

Saudi Medical Journal

Objectives To assess the knowledge of Jordanian dentists toward phase down of dental amalgam as recommended by the Minamata Convention, and their training and competency in placing posterior composites. Methods This study was conducted through structured questionnaire interviews with randomly selected cohort of dentists in Jordan between March 2015 and June 2015. Out of 230 dentists who were invited, 196 (85.2%) agreed to participate. Dentists were asked if they know about the Minamata Convention. They were also asked about their training in placement of posterior composite. Results Out of the 196 interviewed, only 13.8% know about Minamata Convention and 17% …


Prevalence Of Obesity In Elementary School Children And Its Association With Dental Caries, Deema J. Farsi, Heba M. Elkhodary, Leena A. Merdad, Najat M.A. Farsi, Sumer M. Alaki, Najlaa M. Alamoudi, Haneen A. Bakhaidar, Mohammed A. Alolayyan Dec 2016

Prevalence Of Obesity In Elementary School Children And Its Association With Dental Caries, Deema J. Farsi, Heba M. Elkhodary, Leena A. Merdad, Najat M.A. Farsi, Sumer M. Alaki, Najlaa M. Alamoudi, Haneen A. Bakhaidar, Mohammed A. Alolayyan

Saudi Medical Journal

Objectives To investigate the prevalence of obesity among elementary school children and to examine the association between obesity and caries activity in the mixed dentition stage. Methods This cross-sectional study was conducted in King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia between September 2014 and June 2015 using a multi-stage stratified sample of 915 elementary school children (482 boys, 433 girls) in Jeddah, Saudi Arabia. Anthropometric measurements, consisting of height, weight, body mass index (BMI), and waist circumference (WC), were obtained. Children were classified as underweight/healthy, overweight, or obese and as non-obese or obese according to their BMI and WC, …


Excision Of Oral Pyogenic Granuloma In A Diabetic Patient With 940nm Diode Laser, Maha A. Al-Mohaya, Abdulaziz M. Al-Malik Dec 2016

Excision Of Oral Pyogenic Granuloma In A Diabetic Patient With 940nm Diode Laser, Maha A. Al-Mohaya, Abdulaziz M. Al-Malik

Saudi Medical Journal

Pyogenic granuloma (PG) is a common, acquired, benign vascular reactive proliferation that typically develops as a small erythematous papule on the skin or oral mucosal surface. Oral PG is often caused by constant low-grade infection, minor trauma, poor oral hygiene, and due to hormonal disturbances. It shows a striking predilection for the gingiva. Lesions can be excised surgically with removal of the underlying causes. However, this modality may be associated with unnecessary complications. Recently, different laser wavelengths have been used for removal of oral PG. Herein, we present a case of gingival PG in a 51-year-old uncontrolled diabetic woman. The …


The Potential Collapse Of The Tpp: Implications For Asean, Henry S. Gao Dec 2016

The Potential Collapse Of The Tpp: Implications For Asean, Henry S. Gao

Research Collection Yong Pung How School Of Law

Asia has the most to lose in the event of a collapse of the Trans-Pacific Partnership (TPP) given the importance of trade to growth performance for the region’s economies, and that a third of the TPP members are also part of the Association of Southeast Asian Nations (ASEAN).


Nucleic Acid Amplification Techniques In The Diagnosis Of Infectious Diseases: The Way Forward, K N Brahmadathan Dec 2016

Nucleic Acid Amplification Techniques In The Diagnosis Of Infectious Diseases: The Way Forward, K N Brahmadathan

Manipal Journal of Medical Sciences

Nucleic acid amplification-based tests as laboratory diagnostic tools have attracted a lot of attention in the past several years. From the discovery of polymerase chain reaction in 1983 to the human genome sequencing in 2001, these tests have come into prominence as major tools for rapid diagnosis of infectious diseases, identification of microbes directly from clinical samples, and their genotyping for epidemiological studies. Identification of fastidious or uncultivable microbes, hitherto unrecognized microorganisms, and rapid identification of multidrug resistance have been made possible by refining many of these techniques. Several modifications are now available, which make them more accessible to a …


Methylxanthine Induced Cardiotoxicity And Its Mechanisms: An Experimental Study, Md Shamsuzzaman, Gulati Kavita, Ray Arunabha Dec 2016

Methylxanthine Induced Cardiotoxicity And Its Mechanisms: An Experimental Study, Md Shamsuzzaman, Gulati Kavita, Ray Arunabha

Manipal Journal of Medical Sciences

Background: Methylxanthines like theophylline are re-emerging as effective adjuncts in the treatment of obstructive airway disease and several newer mechanisms have been proposed. In view of its effectiveness, pharmacoeconomic viability, and easy availability, it could rationalize the drug treatment in bronchial asthma and chronic obstructive pulmonary disorders (COPD) – but its narrow therapeutic index and resultant safety concerns need to be aggressively addressed, particularly in developing countries. Cardiotoxicity and neurotoxicity are amongst the most noted adverse effects associated with its clinical use. The present study evaluated the possible mechanisms involved in aminophylline (water-soluble ethylene diamine salt of theophylline) on potential …


A Prospective Observational Study Ofthe Disease Profile Ofthe Muslim Patients Attending The Outpatient Department Of Internal Medicine During The Ramadan Fasting Season, Sadananda B. Naik, Krishna Mohan Prabhu, Harish P. Nayak Dec 2016

A Prospective Observational Study Ofthe Disease Profile Ofthe Muslim Patients Attending The Outpatient Department Of Internal Medicine During The Ramadan Fasting Season, Sadananda B. Naik, Krishna Mohan Prabhu, Harish P. Nayak

Manipal Journal of Medical Sciences

Background: Ramadan is the fasting month of the Muslim calendar. There is a paucity of data on the prevalence of morbidity among those who visit the outpatient department of the hospital while observing the Ramadan fasting. Materials and Methods: The clinical profile of 61 Muslim patients who visited the outpatient department of the internal medicine of the specialty hospital during the holy Ramadan fasting season at Moodabidri, South India was collected. The diagnosis of all the medical conditions were classified according to the International Classification of Disease (ICD-10) coding system and the demographic profile and clinical data were analyzed. Analysis …


Evaluation Of The Effects Of The Antiretroviral Drug Regimen (Stavudine +Lamivudine + Nevirapine) On Cd4 Count, Body Weight And Hb% Of The Hiv Patients – A Retrospective Study, Reshma S R, Navin A P, Narendranath S, Dinakar K R, Keerthi Sagar J, Somashekar H S, Vaneet Aggarwal Dec 2016

Evaluation Of The Effects Of The Antiretroviral Drug Regimen (Stavudine +Lamivudine + Nevirapine) On Cd4 Count, Body Weight And Hb% Of The Hiv Patients – A Retrospective Study, Reshma S R, Navin A P, Narendranath S, Dinakar K R, Keerthi Sagar J, Somashekar H S, Vaneet Aggarwal

Manipal Journal of Medical Sciences

Human immunodeficiency virus infection (HIV) has become a manageable disease due to antiretroviral therapy. Although many treatment schedules are effective in controlling the viral load, maintaining it for a long period is difficult due to many factors such as adverse effects, long-term toxicity, and dosing schedules, all of them may result in poor patient compliance, treatment failure and drug resistance. The evaluation of these treatment schedules in terms of their efficacy, duration, and acceptance is an important aspect for treating doctors, patients, and policy makers. Therefore, our objective is to evaluate stavudine, lamivudine, and nevirapine regimen in the management of …


Standardized Viva-Voce Examination: Year 1 Medical Degree Programme In An Integrated Undergraduate Medical Curriculum In A Malaysian University, Urban John Arnold D’Souza, Ahmad Faris Abdullah, Zainal Arifin Mustapha Dec 2016

Standardized Viva-Voce Examination: Year 1 Medical Degree Programme In An Integrated Undergraduate Medical Curriculum In A Malaysian University, Urban John Arnold D’Souza, Ahmad Faris Abdullah, Zainal Arifin Mustapha

Manipal Journal of Medical Sciences

Background: Viva voce examinations play an important evaluation process in the medical degree course in most of the Universities around the World. They mainly assess the cognitive domain and if well structured, become an important process of evaluation. Traditionally, a conventional non-structured oral examination was a practice and still remains as an evaluation process in a few countries. Over the years, different medical schools have evolved on such examinations and have come out with structured, standardized viva voce examinations. The research studies on such examinations have positive impact. Among the faculty of Medicine, an integrated curriculum is in practice and …


Promethazine Induced Acute Dystonia: A Case Report, Jyothi C H, Rudraiah H. Gm, Vidya H K, Shashikala G Dec 2016

Promethazine Induced Acute Dystonia: A Case Report, Jyothi C H, Rudraiah H. Gm, Vidya H K, Shashikala G

Manipal Journal of Medical Sciences

Promethazine is a first generation antihistaminic belonging to phenothiazine family. Because of its strong anticholinergic property, it is used for the treatment of drug-induced dystonia, which is characterized by sustained or repetitive involuntary muscle contractions associated with twisting or repetitive movements with abnormal postures. Promethazine, which is used to treat dystonia, can itself rarely cause dystonia as an adverse effect. Here, we present a rare case of promethazine induced acute dystonia


Characterization Of Wy 14,643 And Its Complex With Aldose Reductase, Michael Sawaya, Malkhey Verma, Vaishnavi Balendiran, Nigam Rath, Duilio Cascio, Ganesaratnam Balendiran Dec 2016

Characterization Of Wy 14,643 And Its Complex With Aldose Reductase, Michael Sawaya, Malkhey Verma, Vaishnavi Balendiran, Nigam Rath, Duilio Cascio, Ganesaratnam Balendiran

Chemistry & Biochemistry Faculty Works

The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements of the equilibrium dissociation constants, Kd, of oxidized (hAR•NADP+) and reduced (hAR•NADPH) holoenzyme complexes display a 2-fold difference between them. Kd values for the dissociation of WY 14,643 from the oxidized (hAR•NADP+•WY 14,643) and reduced (hAR•NADPH•WY 14,643) ternary complexes are comparable to each other. The ternary complex structure of hAR•NADP+•WY 14,643 reveals the first structural evidence of a fibrate class drug binding to hAR. These observations demonstrate how fibrate molecules such as …


Resource-Efficient Technology To Produce 4-Aminodiphenylamine, V.V. Bochkarev, L.S. Soroka, J.K. Bashkin Dec 2016

Resource-Efficient Technology To Produce 4-Aminodiphenylamine, V.V. Bochkarev, L.S. Soroka, J.K. Bashkin

Chemistry & Biochemistry Faculty Works

No abstract provided.


Peering Below The Diffraction Limit: Robust And Specific Sorting Of Viruses With Flow Cytometry, Shea T. Lance, David J. Sukovich, Kenneth M. Stedman, Adam R. Abate Dec 2016

Peering Below The Diffraction Limit: Robust And Specific Sorting Of Viruses With Flow Cytometry, Shea T. Lance, David J. Sukovich, Kenneth M. Stedman, Adam R. Abate

Biology Faculty Publications and Presentations

Background: Viruses are incredibly diverse organisms and impact all forms of life on Earth; however, individual virions are challenging to study due to their small size and mass, precluding almost all direct imaging or molecular analysis. Moreover, like microbes, the overwhelming majority of viruses cannot be cultured, impeding isolation, replication, and study of interesting new species. Here, we introduce PCR-activated virus sorting, a method to isolate specific viruses from a heterogeneous population. Specific sorting opens new avenues in the study of uncultivable viruses, including recovering the full genomes of viruses based on genetic fragments in metagenomes, or identifying the …


Simple Soil Quality Tests And Organic Management Practices For Orchards In The Intermountain West, Esther Oline Thomsen Dec 2016

Simple Soil Quality Tests And Organic Management Practices For Orchards In The Intermountain West, Esther Oline Thomsen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Soil health is often overlooked as a long-term management strategy as growers face an increasing number of short-term management challenges in the Intermountain West. The costs of inputs are rising and water resources are becoming more limited. Soil with poor health typically requires more amendments and fertlizers to meet crop needs. Soil health tests can help reveal management practices that reduce soil health, as well as those that improve soil health. Practices known to improve soil health are reduced to no tillage, cover crop use- especially legumes, and addition of mulch and other organic materials. Soil health testing is not …


Religiosity Among Muslims: A Scale Development And Validation Study, Nor Diana Mohd Mahudin, Noraini Mohd Noor, Mariam Adawiah Dzulkifli, Nazariah Shari’E Janon Dec 2016

Religiosity Among Muslims: A Scale Development And Validation Study, Nor Diana Mohd Mahudin, Noraini Mohd Noor, Mariam Adawiah Dzulkifli, Nazariah Shari’E Janon

Makara Human Behavior Studies in Asia

While religiosity as a field of inquiry has been gaining research interest in recent years, a central issue about its conceptualisation, measurement, and relationships with work outcomes remains unresolved. The aims of this paper are: (1) to introduce a new scale designed to measure religiosity among Muslims, based on an Islamic perspective that centres on the bodily action or human activity (Islam), the mind or understanding of God (iman), and the spirit or actualisation of virtue and goodness (ihsan); and (2) to demonstrate how religiosity relates to various work outcomes. We followed a rigorous multi-steps scale development procedure using four …


Book Review: Contemporary Issues In Mediation (Volume 1), Dorcas Quek Anderson Dec 2016

Book Review: Contemporary Issues In Mediation (Volume 1), Dorcas Quek Anderson

Research Collection Yong Pung How School Of Law

This is a review of a publication by Singapore International Mediation Institute (SIMI) featuring the top ten entries of its inaugural essay writing competition. The author comments on the essays covering a range of topics in the mediation field including the impact of Singapore culture on the practice of mediation; mediation theories and techniques; and the interface between mediation and the law.


From Context To Text In Contractual Interpretation: Is There Really A Problem With The Plain Meaning Rule?, Yihan Goh Dec 2016

From Context To Text In Contractual Interpretation: Is There Really A Problem With The Plain Meaning Rule?, Yihan Goh

Research Collection Yong Pung How School Of Law

Much of the contemporary scholarship on contractual interpretation is staunchly against a textual analysis, by which a court can only depart from the plain meaning of a contract exceptionally. It is therefore no surprise that scholars have reacted negatively to the spate of recent cases where the English courts have re-emphasized the plain meaning of the text in contractual interpretation. Yet one cannot help but wonder whether a textual analysis is really so problematic when courts across the common law world have re-embraced it. Drawing from both theoretical and comparative perspectives, this paper suggests that a focus on the text …


The Use Of Scenarios In Legal Education To Develop Futures Thinking And Sustainability Competencies, Michelle Mei Ling Lim, Andrew Allan Dec 2016

The Use Of Scenarios In Legal Education To Develop Futures Thinking And Sustainability Competencies, Michelle Mei Ling Lim, Andrew Allan

Research Collection Yong Pung How School Of Law

Achieving sustainability requires a populace equipped to deal with complex, interacting and ever-changing realities as well as uncertain futures. There is however a significant lack of focus on developing sustainability competencies within legal and governance education. Legal education plays a key role in shaping sustainable futures. Long-term sustainability relies on lawyers, judges and policy-makers being able to make optimal decisions in the present when faced with significant uncertainty about the future. This paper discusses how the combination of problem-based learning (PBL) and scenario-based pedagogical approaches can provide an authentic contextualised learning environment to empower law students to deal with the …


Guest Lecture By Professor Michael Jacobs, “The Durability Of The Chicago School In Antitrust: What Accounts For It?”, Anna Tworkowska-Baraniuk Dec 2016

Guest Lecture By Professor Michael Jacobs, “The Durability Of The Chicago School In Antitrust: What Accounts For It?”, Anna Tworkowska-Baraniuk

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Guest seminar


From The Editor (Maciej Bernatt), Maciej Bernatt Dec 2016

From The Editor (Maciej Bernatt), Maciej Bernatt

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

From the Editor


A Renewed Consideration Of Consideration: Mwb Business Exchange Centres Ltd V Rock Advertising Ltd [2016] Ewca Civ 553, Kenny Chng, Yihan Goh Dec 2016

A Renewed Consideration Of Consideration: Mwb Business Exchange Centres Ltd V Rock Advertising Ltd [2016] Ewca Civ 553, Kenny Chng, Yihan Goh

Research Collection Yong Pung How School Of Law

This note argues thatthe English Court of Appeal decision of MWBBusiness Exchange Centres Ltd v Rock Advertising Ltd is a significantmodification of the present understanding of consideration with respect toagreements to accept part-payments of a debt and to perform pre-existing duties,and that the preferred way forward for the development of the law should be judicialintervention by the Supreme Court to reconcile the logical inconsistenciesbetween Foakes v Beer and Williams v Roffey Bros & Nicholls(Contractors) Ltd.