Digital Commons Network^™

Finite Element And Probabilistic Analysis Of Soft Tissue Structures Of The Human Lumbar Spine, Dana Joseph Coombs

Electronic Theses and Dissertations

Human lumbar spine mechanics are influenced by soft tissue structures. Understanding and properly modeling these structures can help determine pathology, treatment, and implant design and performance. Finite element models of the L4-L5 level of the lumbar spine are often used, which include a representation of the intervertebral disc and spinal ligaments. Validation of these models are typically based on torque rotation data from a single subject or the models use average properties reported in literature. However, experimental testing reports variation up to 40% in ligament stiffness and even greater variability for annulus fibrosis properties. Probabilistic approaches enable consideration of the …

Anatomy, Implant Selection And Placement Influence Spine Mechanics Associated With Total Disc Replacement, Justin F.M. Hollenbeck

Electronic Theses and Dissertations

Through aging and injury, the intervertebral disc of the lumbar spine can undergo degeneration, leading to collapse of the vertebrae and low back pain, a symptom that affects half the adult population in any given year. In an effort to reduce low back pain, total disc replacement treatment removes the degenerated disc, restores natural height and lordosis of the segment, and preserves motion at the joint. Patient anatomy, implant selection, and implant placement play significant roles in a patient's outcomes after total disc replacement surgery. Thus, the objective of the work presented in this thesis was to develop a suite …

Neoclassical Pioneers: Neoclassicism Before Stravinsky, Breanna Corah

Electronic Theses and Dissertations

For a century and a half composers have been inspired by the classic works of composers from the Baroque and Classical periods. Composers who returned to the sounds and structures of the classics and used them as a model were called neoclassicists and created a new genre of music often identified as neoclassicism. It is commonly understood that the composer Igor Stravinsky and his contemporaries created this genre of music in the 1920s. However, Stravinsky would not have been able to promote this genre of music without the initial efforts of pioneer composers. In fact, composers were experimenting with neoclassicism …

Methods And Implementation Of Fluid-Structure Interaction Modeling Into An Industry-Accepted Design Tool, Donn R. Sederstrom

Electronic Theses and Dissertations

Fluid-structure interaction (FSI) modeling is a method by which fluid and solid domains are coupled together to produce a single result that cannot be produced if each physical domain was evaluated individually. The work presented in this dissertation is a demonstration of the methods and implementation of FSI modeling into an industry-appropriate design tool. Through utilizing computationally inexpensive equipment and commercially available software, the studies presented in this work demonstrate the ability for FSI modeling to become a tool used broadly in industry.

To demonstrate this capability, the cases studied purposely include substantial complexity to demonstrate the stability techniques required …

Multiscale Musculoskeletal Modeling Of The Lower Limb To Perform Personalized Simulations Of Movement, Alessandro Navacchia

Electronic Theses and Dissertations

Computational modeling has been used for many decades to inform design and decision-making in several fields of engineering, such as aerospace, automotive, petroleum, and others. However, it still struggles to have a similar impact in fields of medicine, such as orthopaedics. Three of the challenges that have limited the use of computational modeling in the clinical practice and in product development are model validation, personalization, and realism. Validation is a challenge because several internal parameters of the human body, such as muscle forces, are not safely measurable in vivo and, consequently, a thorough comparison between model outputs …

X-Ray Absorption Study Of Ceria Nanorods Promoting The Disproportionation Of Hydrogen Peroxide, Tai-Sing Wu, Yunyun Zhou, Renat F. Sabirianov, Wai-Ning Mei, Yun-Liang Soo, Barry Chin Li Cheung

Barry Chin Li Cheung Publications

A quasi in situ X-ray absorption study demonstrated that the disproportionation of hydrogen peroxide (H₂O₂) promoted by ceria nanorods was associated with a reversible Ce³⁺/Ce⁴⁺ reaction and structural transformations in ceria. The direction of this reversible reaction was postulated to depend on the H2O2 concentration and the fraction of Ce³⁺ species in ceria nanorods.

A Nocsae Drop Test/ 3d-Fem Study On The Relationship Between Kinematic Response Of The Head, Head Impact Contact Pressure (Hicp) And Kinetic Response Of The Brain To Delineate The Risk Of Traumatic Brain Injuries (Tbi)., Raghavendra Krishna Tej Bhamidipati

Dissertations, Master's Theses and Master's Reports

How many times have you seen a person slip and fall down and had a good laugh about it? How many times we slip and fall down on the floor and got up and walked away thinking everything is normal? Probably we might wonder “Are drops which occur at a small height dangerous?” Yes, they can be. Brain injuries are main reason for the fatality in youth [1], and low level falls are one of the most neglected and understated injuries.

The main objective of this study is to study the response of the brain for low level falls from …

Risk-Based Assessment And Strengthening Of Electric Power Systems Subjected To Natural Hazards, Abdullahi Salman

Dissertations, Master's Theses and Master's Reports

Modern economic and social activities are dependent on a complex network of infrastructure systems that are highly interdependent. Electric power systems form the backbone of such complex network as most civil infrastructure systems cannot function properly without reliable power supply. Electric power systems are vulnerable to extensive damage due to natural hazards, as evident in recent hazard events. Hurricanes, earthquakes, floods, tornados and other natural hazards have caused billions of dollars in direct losses due to damage to power systems and indirect losses due to power outages, as well as social disruption. There is, therefore, a need for a comprehensive …

The Effect Of Community Connectivity On Water And Sanitation Systems In Rural Panama, M.C. Moritz

Dissertations, Master's Theses and Master's Reports

The world has yet to realize universal access to water and sanitation. Various academic and professional fields provide frameworks for understanding water and sanitation access, but none directly consider the impact of community connectivity. Community connectivity refers to the infrastructures linking rural communities with urban centers. These infrastructures fall under the broad categories of transportation, energy, and telecommunication. This paper examines 23 rural Panamanian communities and compares connectivity measures with the functionality of the communities’ rural water and sanitation systems (RWSS). Community connectivity was evaluated with the Community Connectivity Analysis Tool (CCAT), while the water and sanitation systems were evaluated …

Design And Simulation Of A Residential Pv-Battery System, Sevket Burak Ovali

Dissertations, Master's Theses and Master's Reports

This thesis provides the design and simulation of a stand-alone photovoltaic (PV) system to ensure the load demands for a single residential in Houghton (MI) and Tucson (AZ). The fundamental activities of this study aim to model for particular stand-alone photovoltaic of components. Entire stand-alone design stages for used load data sets are carried out. Daily irradiance and load data are taken into consideration throughout the design stages. The Simulink program is developed to obtain simulation results to observe PV system and battery behaviors regarding various months which have most various irradiances throughout 30 days. Sizing of PV systems is …

The Complicated Economics Of Prison Reform, John F. Pfaff

Faculty Scholarship

No abstract provided.

The Myths Of Macpherson, Benjamin C. Zipursky, John C.P. Goldberg

Faculty Scholarship

For a symposium marking the centenary of MacPherson v. Buick, we identify three common characterizations of Cardozo’s famous opinion that purport to explain its importance. Unfortunately, each of these characterizations turns out to be a myth. MacPherson is worthy of celebration, but not because it recognizes that negligence law’s duty of care is owed to the world, nor because it displays the promise of an instrumental, policy-oriented approach to adjudication, nor because it embraces a nascent form of strict products liability. These myths of MacPherson reflect deep misunderstandings of tort law, and of Cardozo’s distinctively pragmatic approach to adjudication. Ironically, …

Contributing Factors For Drought In United States Forest Ecosystems Under Projected Future Climates And Their Uncertainty, Charles H. Luce, James M. Vose, Neil Pederson, John Campbell, Connie Millar, Patrick Kormos, Ross Woods

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Observations of increasing global forest die-off related to drought are leading to more questions about potential increases in drought occurrence, severity, and ecological consequence in the future. Dry soils and warm temperatures interact to affect trees during drought; so understanding shifting risks requires some understanding of changes in both temperature and precipitation. Unfortunately, strong precipitation uncertainties in climate models yield substantial uncertainty in projections of drought occurrence. We argue that disambiguation of drought effects into temperature and precipitation-mediated processes can alleviate some of the implied uncertainty. In particular, the disambiguation can clarify geographic diversity in forest sensitivity to multifarious drivers …

Ecosystem Services Of Woody Crop Production Systems, Ronald S. Zalesny Jr., John A. Stanturf, Emile S. Gardiner, James H. Perdue, Timothy M. Young, David R. Coyle, William L. Headlee, Gary S. Bañuelos, Amir Hass

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Short-rotation woody crops are an integral component of regional and national energy portfolios, as well as providing essential ecosystem services such as biomass supplies, carbon sinks, clean water, and healthy soils. We review recent USDA Forest Service Research and Development efforts from the USDA Biomass Research Centers on the provisioning of these ecosystem services from woody crop production systems. For biomass, we highlight productivity and yield potential, pest susceptibility, and bioenergy siting applications. We describe carbon storage in aboveground woody biomass and studies assessing the provision of clean and plentiful water. Soil protection and wildlife habitat are also mentioned, in …

Institutionalizing Faculty Mentoring Within A Community Of Practice Model, Emily R. Smith, Patricia E. Calderwood, Stephanie Burrell Storms, Paula Gill Lopez, Ryan P. Colwell

To Improve the Academy: A Journal of Educational Development

In higher education, faculty work is typically enacted—and rewarded—on an individual basis. Efforts to promote collaboration run counter to the individual and competitive reward systems that characterize higher education. Mentoring initiatives that promote faculty collaboration and support also defy the structural and cultural norms of higher education. Collaborative mentoring initiatives, however, support all faculty to be lifelong learners. We analyze a reciprocal model of mentoring—a community of practice for mentoring—that integrates collaborative mentoring into faculty’s daily work. Additionally, we examine the dilemmas, benefits, and costs of institutionalizing a community of practice model for mentoring in higher education. Our analyses indicate …

Entomology 101: Introduction To Entomology, Brian Kelly

Department of Entomology: Distance Master of Science Projects

The goal of this particular project is to create an entry-level curriculum for Entomology to present to the local university / community college. My Bachelor’s Degree was obtained from the University of Colorado at Colorado Springs (UCCS). The higher institutions of learning in the city of Colorado Springs (to include Pikes Peak Community College, or PPCC, as well) lack any courses relating to Entomology. UCCS has a strong presence in the city and is growing by leaps and bounds, currently enrolling about 13,000 students and expanding its degree programs. PPCC has several campuses around town, and offers many elective courses …

Analysis Of Mycobacterium Avium Subsp. Paratuberculosis Mutant Libraries Reveals Loci-Dependent Transposition Biases And Strategies For Novel Mutant Discovery, Govardhan Rathnaiah, John Bannantine, Darrell O. Bayles, Denise K. Zinniel, Judith R. Stabel, Yrjö T. Gröhn, Raúl G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Mycobacterium avium subsp. paratuberculosis (MAP), the aetiological agent of Johne’s disease, is one of the most important bacterial pathogens in ruminants. A thorough understanding of MAP pathogenesis is needed to develop new vaccines and diagnostic tests. The generation of comprehensive random transposon mutant libraries is a fundamental genetic technology to determine the role of genes in physiology and pathogenesis. In this study, whole MAP genome analysis compared the insertion sites for the mycobacterial transposon Tn5367 derived from the Mycobacterium smegmatis insertion sequence IS1096 and the mariner transposon MycoMarT7 carrying the Himar1 transposase. We determined that only MycoMarT7 provides …

Mapping Marginal Croplands Suitable For Cellulosic Feedstock Crops In The Great Plains, United States, Yingxin Gu, Bruce K. Wylie

United States Geological Survey: Staff Publications

Growing cellulosic feedstock crops (e.g., switchgrass) for biofuel is more environmentally sustainable than cornbased ethanol. Specifically, this practice can reduce soil erosion and water quality impairment from pesticides and fertilizer, improve ecosystem services and sustainability (e.g., serve as carbon sinks), and minimize impacts on global food supplies. The main goal of this study was to identify high-risk marginal croplands that are potentially suitable for growing cellulosic feedstock crops (e.g., switchgrass) in the US Great Plains (GP). Satellitederived growing season Normalized Difference Vegetation Index, a switchgrass biomass productivity map obtained from a previous study, US Geological Survey (USGS) irrigation and crop …

A Personal Perspective On Searching For The Ivory-Billed Woodpecker: A 41-Year Quest, Paul W. Sykes Jr.

United States Geological Survey: Staff Publications

I first learned about the Patuxent Wildlife Research Center (Patuxent) in Laurel, MD, while attending high school in the mid-1950s. Patuxent wildlife biologists Brooke Meanley, Chandler (Chan) S. Robbins, and Robert (Bob) E. Stewart, Sr., visited me at my parents’ home in Norfolk, VA. I was the compiler of the Norfolk County Christmas Bird Count (which included the eastern portion of the Virginia sector of the Dismal Swamp). As part of that count, we had for several years been estimating populations of red-winged blackbirds (Agelaius phoeniceus) and common grackles (Quiscalus quiscula) in the millions. Patuxent was …

Patuxent’S Role In The Development Of The North American Breeding Bird Survey, John R. Sauer

United States Geological Survey: Staff Publications

The North American Breeding Bird Survey (BBS) is a roadside survey of the breeding birds of North America. The BBS provides data from the contiguous United States, Alaska, southern and central Canada, and northern Mexico. Begun in 1966 by Chandler (Chan) S. Robbins at the U.S. Geological Survey (USGS) Patuxent Wildlife Research Center (Patuxent), and now jointly managed by Patuxent, the Canadian Wildlife Service, and the Mexican Commission for the Knowledge and Use of Biodiversity, the survey is conducted primarily in June along more than 5,000 roadside survey routes that are surveyed once each year. Volunteer observers drive the 39.4-kilometer …

A Synthetic Porcine Reproductive And Respiratory Syndrome Unprecedented Levels Of Heterologous Protection, Hiep Vu, Fangrui Ma, William W. Laegreid, Asit K. Pattnaik, David Steffen, Alan R. Doster, Fernando A. Osorio

School of Veterinary and Biomedical Sciences: Faculty Publications

Current vaccines do not provide sufficient levels of protection against divergent porcine reproductive and respiratory syndrome virus (PRRSV) strains circulating in the field, mainly due to the substantial variation of the viral genome. We describe here a novel approach to generate a PRRSV vaccine candidate that could confer unprecedented levels of heterologous protection against divergent PRRSV isolates. Using a set of 59 non-redundant, full genome sequences of type-2 PRRSV, a consensus genome (designated as PRRSV-CON) was these 59 PRRSV full genome sequences, followed by selecting the most common nucleotide found at each position of the alignment. Next, the synthetic PRRSV-CON …

The Mechanistic Basis Of Hemoglobin Adaptation In The High-Flying Barheaded Goose: Insights From Ancestral Protein Resurrection, Chandrasekhar Natarajan, Amit Kumar, Hideaki Moriyama, Roy E. Weber, Angela Fago, Jay F. Storz

School of Veterinary and Biomedical Sciences: Faculty Publications

The bar-headed goose (‘BHG’, Anser indicus) is renowned for its trans-Himalayan migratory flights, and the elevated hemoglobin (Hb)-O2 affinity of this species is thought to make a key contribution to its capacity for powered flight at elevations of ~9000 m. Here we revisit the molecular basis of this text-book example of biochemical adaptation. Previous hypotheses about the molecular basis of the evolved increase in Hb-O2 affinity were tested by engineering BHGspecific mutations into recombinant human Hb. This approach can provide important insights, but one problem with such ‘horizontal’ comparisons – swapping residues between proteins of contemporary species – is that …

Localization Of Cd8 T Cell Epitope Within Cardiac Myosin Heavy Chain-Α334-352 That Induces Autoimmune Myocarditis In A/J Mice, Chandirasegara Massilamany, Arunakumar Gangaplara, Rakesh H. Basavalingappa, Rajkumar A. Rajasekaran, Vahid Khalilzad-Sharghi, Zhongji Han, Shadi F. Othman, David Steffen, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Background—Cardiac myosin heavy chain-α (Myhc), an intracellular protein expressed in the cardiomyocytes, has been identified as a major autoantigen in cardiac autoimmunity. In our studies with Myhc_334-352-induced experimental autoimmune myocarditis in A/J mice (H-2a), we discovered that Myhc_334-352, supposedly a CD4 T cell epitope, also induced antigen-specific CD8 T cells that transfer disease to naïve animals.

Methods and Results—In our efforts to identify the CD8 T cell determinants, we localized Myhc_338-348 within the full length-Myhc_334-352, leading to four key findings. (1) By acting as a dual epitope, Myhc_338-348 induces both …

Domain I Of The 5′ Non-Translated Genomic Region In Coxsackievirus B3 Rna Is Not Required For Productive Replication, L. Jaramillo, S. Smithee, S. Tracy, N. M. Chapman

Nebraska Center for Virology: Faculty Publications

Domain I is a cloverleaf-like secondary structure at the 5′ termini of all enterovirus genomes, comprising part of a cis-acting replication element essential for efficient enteroviral replication. 5′ genomic terminal deletions up to as much as 55% of domain I can occur without lethality following coxsackie B virus infections. We report here that the entire CVB structural domain I can be deleted without lethality.

Reversion To Wildtype Of A Mutated And Nonfunctional Coxsackievirus B3cre(2c), Shane Smithee, Steven Tracy, Nora M. Chapman

Nebraska Center for Virology: Faculty Publications

The cis-acting replication element (CRE) in the 2C protein coding region [CRE(2C)] of enteroviruses (EV) facilitates the addition of two uridine residues (uridylylation) onto the virus-encoded protein VPg inorder for it to serve as the RNA replication primer. We demonstrated that coxsackievirus B3 (CVB3) is replication competent in the absence of a native (uridylylating) CRE(2C) and also demonstrated that lackof a functional CRE(2C) led to generation of 5’ terminal genomic deletions in the CVB3 CRE-knock-out (CVB3-CKO) population. We asked whether reversion of the mutated CRE(2C) occurred, thus permitting sustained replication, and when were 5’ terminal deletions generated during replication. Virions …

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with ade- novirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we de- veloped “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than …

Annual Report Of The Chancellor Of The University Of Mississippi, 2015-2016 V. I-Ii, University Of Mississippi. Chancellor

Annual Report of the Chancellor to the Board of Trustees of IHL

Chancellor, 2015: Daniel W. Jones

Chancellor, 2016: Jeffrey S. Vitter

Improving The Precision Of Dynamic Forest Parameter Estimates Using Landsat, Evan B. Brooks, John W. Coulston, Randolph H. Wynne, Valerie A. Thomas

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The use of satellite-derived classification maps to improve post-stratified forest parameter estimates is well established.When reducing the variance of post-stratification estimates for forest change parameters such as forest growth, it is logical to use a change-related strata map. At the stand level, a time series of Landsat images is ideally suited for producing such a map. In this study, we generate strata maps based on trajectories of Landsat Thematic Mapper-based normalized difference vegetation index values, with a focus on post-disturbance recovery and recent measurements. These trajectories, from1985 to 2010, are converted to harmonic regression coefficient estimates and classified according to …

Expression Of Streptococcus Pneumoniae Bacteriocins Is Induced By Antibiotics Via Regulatory Interplay With The Competence System, Morten Kjos, Eric L. Miller, Jelle Slager, Frank B. Lake, Oliver Gericke

Biology Faculty Scholarship

No abstract provided.

Cryptography With Right-Angled Artin Groups, Ramon Flores, Delaram Kahrobaei

Publications and Research

In this paper we propose right-angled Artin groups as a platform for secret sharing schemes based on the efficiency (linear time) of the word problem. Inspired by previous work of Grigoriev-Shpilrain in the context of graphs, we define two new problems: Subgroup Isomorphism Problem and Group Homomorphism Problem. Based on them, we also propose two new authentication schemes. For right-angled Artin groups, the Group Homomorphism and Graph Homomorphism problems are equivalent, and the later is known to be NP-complete. In the case of the Subgroup Isomorphism problem, we bring some results due to Bridson who shows there are right-angled Artin …