Digital Commons Network^™

Formulating A Pharmacy Collection Without A Prescription, Kristin Laughtin-Dunker, Linda Galloway

Library Articles and Research

Librarians without a background in the health sciences were tasked with building a collection to support a new pharmacy school at a traditionally liberal arts institution. Despite little subject expertise, the team assessed current holdings, conducted a review of recommended resources, and collaborated with faculty to prioritize acquisitions to support the developing program as funds became available. The hire of a health sciences librarian provided new opportunities for assessment and for continued collecting. Altogether, this process allowed for the creation of recommended best practices that can be adopted by any librarian procuring resources to support new health science programs.

Secondary Structure Adopted By The Gly-Gly-X Repetitive Regions Of Dragline Spider Silk, Geoffrey M Gray, Arjan Van Der Vaart, Chengchen Guo, Justin Jones, David Onofrei, Brian R Cherry, Randolph V Lewis, Jeffery L Yarger, Gregory P Holland

Chemistry Faculty Publications

Solid-state NMR and molecular dynamics (MD) simulations are presented to help elucidate the molecular secondary structure of poly(Gly-Gly-X), which is one of the most common structural repetitive motifs found in orb-weaving dragline spider silk proteins. The combination of NMR and computational experiments provides insight into the molecular secondary structure of poly(Gly-Gly-X) segments and provides further support that these regions are disordered and primarily non-β-sheet. Furthermore, the combination of NMR and MD simulations illustrate the possibility for several secondary structural elements in the poly(Gly-Gly-X) regions of dragline silks, including β-turns, 3

Investigating The Effects Of Environmental Treatment On Social Stress, Depression And Anxiety, Blessy Johnson

Honors Capstones

In the proposed study we will be investigating how age affects the responsiveness to EE, willingness to exercise, and depression- and anxiety-like behaviors in prairie voles that are subjected to social isolation. Previous research findings show that EE helps in the prevention and remediation of social isolation induced depressive and anxiety related behaviors (Van Praag, Kempermann & Gage, 2000).Therefore, in this study we are hypothesizing that the older prairie voles will be less responsive to EE when compared to younger animals because of less adaptability and flexibility. In addition, older voles will show less remediation of social isolation induced depressive …

Faculty Senate Meeting Minutes Dec 2, 2016, A-State Faculty Senate

Faculty Senate Minutes

Meeting minutes for the Faculty Senate held on December 2, 2016.

Research Express News, Georgia Southern University

Research & Economic Development

• GS Members Receive Research Funding

Weight Management Delivered Through An App, May Help Resolve Body Image Dissatisfaction In Women Enrolled In Wic, Alexis Ariel O’Connell

Honors Capstones

No abstract provided.

In The News: Gbcc's Analytics Program Could Tie To Unh Manchester's, Kimberly Haas

UNH Today Archive

No abstract provided.

Synthesis And Biological Evaluation Of Fluorescein-Tagged Carborane For Boron Neutron Capture Therapy (Bnct), Lucas A. Kuzmanic

Honors Capstones

Boron Neutron Capture Therapy (BNCT) is a bimodal cancer treatment that involves killing cancer cells through a nuclear reaction of two nontoxic species, boron-10 (10B) and thermal neutrons. There are currently only two FDA-approved drugs for this promising area of cancer therapy, so present research focuses on the synthesis of novel compounds with high boron content as well as methods for their delivery into the tumor cell. A fluorescent tag can allow the observation of the delivery vehicle’s uptake during biodistribution studies. Accordingly, fluorescein was conjugated with iodinated 1-methyl-o-carborane and characterized using Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy …

Holistic Psychiatric Care Of Gender Dysphoric Children And Adolescents, Leah Good

Nursing Capstones

No abstract provided.

Copper Oxide Nanoparticles Impact Several Toxicological Endpoints And Cause Neurodegeneration In Caenorhabditis Elegans, Michael Joseph Mashock, Tyler Zanon, Anthony D. Kappell, Lisa N. Petrella, Erik C. Andersen, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Engineered nanoparticles are becoming increasingly incorporated into technology and consumer products. In 2014, over 300 tons of copper oxide nanoparticles were manufactured in the United States. The increased production of nanoparticles raises concerns regarding the potential introduction into the environment or human exposure. Copper oxide nanoparticles commonly release copper ions into solutions, which contribute to their toxicity. We quantified the inhibitory effects of both copper oxide nanoparticles and copper sulfate on C. elegans toxicological endpoints to elucidate their biological effects. Several toxicological endpoints were analyzed in C. elegans, including nematode reproduction, feeding behavior, and average body length. We examined three …

Co-Developing Drugs With Indigenous Communities: Lessons From Peruvian Law And The Ayahuasca Patent Dispute, Daniel S. Sem

Richmond Journal of Law & Technology

This paper will examine the issues surrounding the codevelopment of drugs derived from traditional medicines used by indigenous peoples in Amazonia, with a focus on Peru. In particular, this paper will explore what national, regional and international legal structures are in place to protect the interests of indigenous peoples, while at the same time providing medical benefit to the world. This issue is explored in the context of Peruvian, U.S., and international treaties – especially the TRIPS agreement, the Andean Community, sui generis protections, and the US-Peru Trade Promotion Agreement.

A Grand Unified Model For Liganded Gold Clusters, Wen Wu Xu, Beien Zhu, Xiao Cheng Zeng, Yi Gao

Xiao Cheng Zeng Publications

A grand unified model (GUM) is developed to achieve fundamental understanding of rich structures of all 71 liganded gold clusters reported to date. Inspired by the quark model by which composite particles (for example, protons and neutrons) are formed by combining three quarks (or flavours), here gold atoms are assigned three ‘flavours’ (namely, bottom, middle and top) to represent three possible valence states. The ‘composite particles’ in GUM are categorized into two groups: variants of triangular elementary block Au₃(2e) and tetrahedral elementary block Au₄(2e), all satisfying the duet rule (2e) of the valence shell, akin to …

Focusing On Men And Fathers: A Challenge For Social Work Research And Practice, Kevin Shafer, Jennifer L. Bellamy

Faculty Publications

In introducing this special issue of Social Work Research, we feel it is important to discuss why social work practice and research with men and fathers is of critical importance and deserving of specific attention. Social work researchers and practitioners need to focus on men and fathers, both as a special population and as subpopulations of other groups. A focus on men and fathers is critical because (a) it is a social justice issue for men, women, and children; (b) men are underserved by helping professionals, including social workers, particularly in certain contexts and programs; (c) social workers are uniquely …

Where's The Fire?, Burt Neuborne

Journal of Law and Policy

Freedom of speech is priceless, but distressingly fragile. Life, and law, would be much simpler if we could react to free speech's importance and fragility by granting it absolute legal protection. Since, however, absolute protection of speech is not—and should not be—a serious option, we face the legal realist challenge of erecting a First Amendment legal structure capable of providing real-world protection to highly controversial speech, often by weak speakers, without closing the door to government regulation. Given the uncertainty inherent in applying fact-dependent complex rules in protean factual settings, many potential speakers would avoid being drawn into unpredictable and …

A Novel Tree Structure For Pattern Matching In Biological Sequences, Anas Al-Okaily

Doctoral Dissertations

This dissertation proposes a novel tree structure, Error Tree (ET), to more efficiently solve the Approximate Pattern Matching problem, a fundamental problem in bioinformatics and information retrieval. The problem involves different matching measures such as the Hamming distance, edit distance, and wildcard matching. The input is usually a text of length n over a fixed alphabet of size Σ, a pattern P of length m, and an integer k. The output is those subsequences in the text that are at a distance ≤ k from P by Hamming distance, edit distance, or wildcard matching.

An immediate application …

The Yersinia Pestis Effector Yopm Inhibits Pyrin Inflammasome Activation., Dmitry Ratner, M Pontus A Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, Egil Lien

Department of Biochemistry and Molecular Biology Faculty Papers

Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS components to initiate anti-bacterial mechanisms. The Yersinia pestis T3SS is particularly effective and sophisticated in manipulating the production of pro-inflammatory cytokines IL-1β and IL-18, which are typically processed into their mature forms by active caspase-1 following inflammasome formation. Some effectors, like Y. pestis YopM, may block inflammasome activation. Here we show that YopM prevents Y. pestis induced activation of the Pyrin inflammasome induced …

Research Challenges And Conservation Implications For Urban Cat Management In New Zealand, Kh Kikillus, Gk Chambers, Mj Farnworth, Km Hare

School of Biological and Marine Sciences

Over the past 20 years, conservation efforts in New Zealand have moved from being concentrated in rural and isolated island locations, where exotic mammalian predators are often controlled, to begin to bring native fauna back to major cities. However, human–wildlife conflicts arise when conservation occurs in close proximity to cities. These are particularly intense when companion animals are involved either as potential predators or prey of high-value conservation animals. Within New Zealand, this conflict is particularly fraught around domestic cats (Felis catus) in the urban environment. Cats in New Zealand are recognised as major introduced predators of native fauna, but …

Engineering Design For Engineering Design: Benefits, Models, And Examples From Practice, Ken L. Turner Jr., Melissa Kirby, Sue Bober

i.e.: inquiry in education

Engineering design, a framework for studying and solving societal problems, is a key component of STEM education. It is also the area of greatest challenge within the Next Generation Science Standards, NGSS. Many teachers feel underprepared to teach or create activities that feature engineering design, and integrating a lesson plan of core content with an engineering design perspective can be a daunting task. Nevertheless, engineering design can be a useful tool in building students’ confidence in science, engaging students in science classes, building relationships with the community, and empowering under-represented groups.

The problem-solving approach of engineering design can become a …

The Impact Of Mindfulness-Based Interventions On Stress Eating, Emotional Eating, And Binge Eating: A Literature Review, Kira L. Minot

Food Science and Nutrition

This literature review examines the impact of various mindfulness-based interventions (MBIs) on the obesity-related eating behaviors of stress eating, emotional eating, and binge eating. With the inconsistency of the weight loss industry to provide long-term weight loss results, the United States is in need of alternative methods of weight loss and weight maintenance to combat the current overweight and obesity epidemic. MBIs are thought to be beneficial when targeted at behaviors of weight gain because mindfulness promotes an individual’s awareness of present physical and emotional sensations within the body, including hunger and satiety cues. Self-acceptance and stress reduction are also …

Case Study: Double J Dairy, Jay Tevelde, Chris Reeves, Holden Smith, Bradley Braun

Case Studies in Agribusiness

The case presents the history and current operations of the Double J Dairy, a large scale (milking about 4,300 cows) dairy farm in the Central Valley of California. The case discusses continuing issues with water, labor and environmental regulations.

Rivalry In Toyer: The Impact Of The Male Gaze And The Final Girl On Theatrical Conflict, Sento Ashby

Liberal Arts Capstones

Although much progress has been made in recent years, traditional gender roles still permeate society. This project investigated gender constructs in relation to choreographed violence and found that females are often victims unless they adopt masculine survival styles, while males are usually aggressors – particularly towards females. Analysis of the characters in the play Toyer by Gardner McKay supported this conclusion.

Leadership In Building Communities: Belmont, Eastmont And Hearthstone Neighborhoods, Fitz Center For Leadership In Community, University Of Dayton

Dayton Neighborhood Studies

No abstract provided.

Siu Alumni, Siu Alumni Association

SIU Alumni Magazine

No abstract provided.

Stem Cell And Tissue Engineering Research, Feng Zhao

TechTalks

My research focuses on stem cell and tissue engineering. By combining stem cell biology and engineering tools, the Zhao Lab seeks strategies to biofabricate completely biological tissues to regenerate or repair damaged tissues or organs. The function of engineered tissues is being strengthened by recapitulating the in vivo environment of natural tissues. The underlying mechanism is being explored through investigating the interaction of cells with environmental factors such as topographical cues, biophysical forces, and oxygen tensions. We also prompt stem cell research at Michigan Tech to meet the progress and advance of the outside scientific society. Training opportunities are consistently …

Trapping Redox Partnerships In Oxidant-Sensitive Proteins With A Small, Thiol-Reactive Cross-Linker, Kristin M. Allan, Matthew A. Loberg, Juliet Chepngeno, Jennifer Hurtig, Susmit Tripathi, Min Goo Kang, Jonathan K. Allotey, Afton H. Widdershins, Jennifer M. Pilat, Herbert Sizek, Wesley J. Murphy, Matthew Naticchia, Joseph B. David, Kevin A. Morano, James D. West

All Faculty Articles

A broad range of redox-regulated proteins undergo reversible disulfide bond formation on oxidation-prone cysteine residues. Heightened reactivity of the thiol groups in these cysteines also increases susceptibility to modification by organic electrophiles, a property that can be exploited in the study of redox networks. Here, we explored whether divinyl sulfone (DVSF), a thiol-reactive bifunctional electrophile, cross-links oxidant-sensitive proteins to their putative redox partners in cells. To test this idea, previously identified oxidant targets involved in oxidant defense (namely, peroxiredoxins, methionine sulfoxide reductases, sulfiredoxin, and glutathione peroxidases), metabolism, and proteostasis were monitored for cross-link formation following treatment of Saccharomyces cerevisiae with …

Bossy Beats, December, 2016, Minnesota State University Moorhead, Registrar's Office

Registrar's Office Newsletters

No abstract provided.

Wofford Today Winter 2016, Wofford College. Office Of Marketing And Communications

Wofford Today

No abstract provided.

Daily Announcements December 2016, Wofford College. Office Of Marketing And Communications

Communications Office Daily Announcements

No abstract provided.

Honorable Mentions: A Publication Of Psu Honors College - Public Relations Committee, Honors College

Honorable Mentions

No abstract provided.

Novel Integration Of Conductive-Ink Circuitry With A Paper-Based Microfluidic Battery As An All-Printed Sensing Platform, Rishi A. Kripalani

Master's Theses

The addition of powered components for active assays into paper-based analytical devices opens new opportunities for medical and environmental analysis in resource-limited applications. Current battery designs within such devices have yet to adopt a ubiquitous circuitry material, necessitating investigation into printed circuitry for scalable platforms. In this study, a microfluidic battery was mated with silver-nanoparticle conductive ink to prototype an all-printed sensing platform. A multi-layer, two-cell device was fabricated, generating 200 μA of direct electrical current at 2.5 V sustained for 16 minutes with a power loss of less than 0.1% through the printed circuitry. Printed circuitry traces exhibited resistivity …