Digital Commons Network^™

Habitat Patch Size Alters The Importance Of Dispersal For Species Diversity In An Experimental Freshwater Community, Matthew Schuler, Jonathan M. Chase

Department of Biology Faculty Scholarship and Creative Works

Increased dispersal of individuals among discrete habitat patches should increase the average number of species present in each local habitat patch. However, experimental studies have found variable effects of dispersal on local species richness. Priority effects, predators, and habitat heterogeneity have been proposed as mechanisms that limit the effect of dispersal on species richness. However, the size of a habitat patch could affect how dispersal regulates the number of species able to persist. We investigated whether habitat size interacted with dispersal rate to affect the number of species present in local habitats. We hypothesized that increased dispersal rates would positively …

High Crlf2 Expression Associates With Ikzf1 Dysfunction In Adult Acute Lymphoblastic Leukemia Without Crlf2 Rearrangement., Zheng Ge, Yan Gu, Gang Zhao, Jianyong Li, Baoan Chen, Qi Han, Xing Guo, Juan Liu, Hui Li, Michael D. Yu, Justin Olson, Sadie Steffens, Kimberly J. Payne, Chunhua Song, Sinisa Dovat

Student Papers, Posters & Projects

Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to contribute to oncogenesis and unfavorable outcome in ALL. We studied B-ALL and T-ALL patients without CRLF2 rearrangement and observed that CRLF2 is significantly increased in a subset of these patients. Our study shows that high CRLF2expression correlates with high-risk ALL markers, as well as poor survival. We found that the IKZF1-encoded protein, Ikaros, directly binds to the CRLF2 promoter and regulates CRLF2 expression in leukemia cells. CK2 inhibitor, which can increase Ikaros activity, significantly increases Ikaros binding in …

Dasatinib-Loaded Albumin Nanoparticles Possess Diminished Endothelial Cell Barrier Disruption And Retain Potent Anti-Leukemia Cell Activity, Chunling Dong, Bo Li, Zhenyu Li, Sreerama Shetty, Jian Fu

Internal Medicine Faculty Publications

Dasatinib (DAS), a second-generation tyrosine kinase inhibitor, is highly effective in treating chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. However, its clinical use is limited due to serious adverse effects. DAS can disrupt endothelial barrier integrity and increase endothelial permeability which may cause peripheral edema and pleural effusion. Albumin nanoparticles (NPs) as a drug carrier may serve as a useful tool for cell-selective drug delivery to reduce DAS-induced endothelial hyperpermeability and maintain endothelial barrier integrity. In this study, we reported that DAS-loaded NPs exhibited potent anti-leukemia efficacy as DAS alone. Importantly, albumin NPs as a drug carrier markedly …

A Month In Nepal: Life And Medicine In One Of The World's Poorest Countries, Emma Gootee

UNH Today Archive

No abstract provided.

Layered Xerogel Films Incorporating Monolayer Protected Cluster Networks On Platinum Black Modified Electrodes For Enhanced Sensitivity In 1st Generation Uric Acid Biosensing, Mulugeta B. Wayu, Michael J. Pannell, Michael C. Leopold

Chemistry Faculty Publications

Amperometric uric acid (UA) biosensing schemes incorporating networks of alkanethiolate‐protected gold nanoparticles, monolayer protected clusters (MPCs), and platinum black (Pt‐B) electrode modification through the layer‐by‐layer construction of xerogels are investigated. MPC doping and Pt‐B augmentation are implemented within hydroxymethyltriethoxysilane xerogel bilayers at platinum electrodes. The first xerogel adlayer is doped with an MPC network and houses uricase for the enzymatic reaction required for first‐generation schemes. Polyluminol–aniline and polyurethane are used as selective/stabilizing interfacial layers. The sensing performance with and without Pt‐B and/or MPC doping is assessed by amperometry with standardized UA injections. The use of each individual material results in …

Biomarkers Of Orthodontic Tooth Movement With Fixed Appliances And Vibration Device: A Randomized Clinical Trial, Marie-Claude Chouinard

Master's Theses

Biomarkers of orthodontic tooth movement with fixed appliances and vibration device: A randomized clinical trial

Marie-Claude Chouinard D.M.D.

ABSTRACT

Background: On average, comprehensive orthodontic treatments last approximately 21-27 months in non-extraction cases and 25-35 months when teeth elected for extraction. Longer treatment times have been associated with multiple detrimental effects such as white spot lesions, root resorption, gingival inflammation and dental caries. Recently, some evidence has shown that the application of mechanical vibration to the dentition can increase the rate of tooth movement. However, the biological mechanism underlying this effect is not clearly understood. The aims of this study were …

3d Map Of The Human Corneal Endothelial Cell, Zhiguo He, Fabien Forest, Philippe Gain, Damien Rageade, Aurélien Bernard, Sophie Acquart, Michel Peoc'h, Dennis M. Defoe, Gilles Thuret

ETSU Faculty Works

Corneal endothelial cells (CECs) are terminally differentiated cells, specialized in regulating corneal hydration and transparency. They are highly polarized flat cells that separate the cornea from the aqueous humor. Their apical surface, in contact with aqueous humor is hexagonal, whereas their basal surface is irregular. We characterized the structure of human CECs in 3D using confocal microscopy of immunostained whole corneas in which cells and their interrelationships remain intact. Hexagonality of the apical surface was maintained by the interaction between tight junctions and a submembraneous network of actomyosin, braced like a drum. Lateral membranes, which support enzymatic pumps, presented complex …

Conversations With Classic Film Stars: Interviews From Hollywood's Golden Era, Melinda F. Matthews

The Southeastern Librarian

Conversations with Classic Film Stars: Interviews from Hollywood’s Golden Era. James Bawden and Ron Miller. Lexington: University Press of Kentucky, 2016. ISBN: 978-0-8131-6710-7. 428 pages. $26.98.

Bibliography Of Secondary Sources On The History Of Dermatology Ii. Obituaries And Biographies In English Supplemented Through 2015, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21^st century. In short, yes. While Index …

Bibliography Of Secondary Sources On The History Of Dermatology, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21^st century. In short, yes. While Index …

Bibliography Of Secondary Sources On The History Of Dermatology Iii. Books, Monographs, And Chapters In English Supplemented Through 2015, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp (Uk, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21^st century. In short, yes. While Index …

Research Express News, Georgia Southern University

Research & Economic Development

• New GS President talks about new job
• Students from around the country participate in research at Georgia Southern

Biofouling Management In The Pacific Northwest And Predation On Native Versus Non-Native Ascidians, Erin Suzanne Kincaid

Dissertations and Theses

Marine non-native species threaten economic and environmental health, making it crucial to understand factors that make them successful. Research on these species, therefore, allows for greater preparedness and informed management of biological invasions and increases understanding of elements structuring biological communities. Among the marine non-native species, and particularly the fouling community, non-native ascidians are a taxon of particular concern because they can crowd out native benthic species and smother mariculture products. This thesis addresses management for ascidians and other fouling organisms and includes research on the invasiveness of this taxon in addition to the invasibility of recipient fouling communities. On …

From Political Liberalism To Para-Liberalism: Epistemological Pluralism, Cognitive Liberalism & Authentic Choice, Musa Al-Gharbi

Comparative Philosophy

Advocates of political liberalism hold it as a superior alternative to perfectionism on the grounds that it avoids superfluous and/or controversial claims in favor of a maximally-inclusive approach undergirded by a "free-standing" justification for the ideology. These assertions prove difficult to defend: political interpretations of liberalism tend to be implicitly ethnocentric; they often rely upon a number of controversial, and even empirically falsified, assumptions about rationality--and in many ways prove more parochial than their perfectionist cousins. It is possible to reform political liberalism to address these challenges, but generally at the expense of the supposed normative force and universality of …

Changing Attitudes Towards Animals In The Wild And Speciesism, Oscar Horta

Animal Sentience

I argue that despite Ng’s claim that we should postpone the defense of those animals that live in the wild, we do have reasons to start spreading concern for them now. We can do it by (i) changing public attitude by heightening awareness of speciesism, by which we will also challenge animal exploitation; and (ii) by disseminating information about the situation of animals in the wild.

Self-Care And Mobility Disability At Mid-Life In Lucky Few, Early-, And Late-Baby Boom Birth-Cohorts, Carlos Siordia

Journal of Health Disparities Research and Practice

Disability is related in definite ways with makers of social stratum, as it can be influenced by and has the potential to contribute to the production and reproduction of social stratification. Intersectional markers of social stratification processes are ignored determinants of health. The Class, Race, Sex (CRS) hypothesis presented here argues that a low-education, racial-minority, and female disadvantage will compound to affect the prevalence and risks of disability. The evidence presented validates the CRS hypothesis by showing that disability prevalence and risk clusters first by class, race, and then sex. The cross-sectional study of community-dwelling adults in the Unites States, …

Intersecting Positions Of Social Disadvantage And Self-Reported Health Status Disparities, Carla S. Alvarado, Chunhuei Chi

Journal of Health Disparities Research and Practice

Health disparities along the gender, race and class are particularly important to monitor and study given the predicted differential distribution of health along these social identities. Intersectionality is a theoretical framework that allows public health and health disparities researchers to account for the simultaneous, mutually constitutive, reinforcing and multidimensional effects of gender, class, and race with the aim to better understand health disparities. Disparities along gender, race and class have been noted in self-reported health status (SRHS) which has been shown to be a strong predictive factor of mortality, morbidity and mental health independent of other physiologic, behavioral and psychosocial …

Latinos And Cancer Information: Perspectives Of Patients, Health Professionals And Telephone Cancer Information Specialists, Celia P. Kaplan, Anna Nápoles, Sharon Davis, Monica Lopez, Rena J. Pasick, Jennifer Livaudais-Toman, Eliseo J. Pérez-Stable

Journal of Health Disparities Research and Practice

Semi-structured interviews were conducted with 16 Latino cancer patients diagnosed in California; 10 health professionals from the San Francisco Bay Area and Fresno, California; and 10 Cancer Information Services (CIS) information specialists from the regional offices handling calls from Spanish-speakers. Interview guides were designed by the investigators to answer three main research questions: 1) How do Latinos obtain information about cancer and what types of information do they access?; 2) What sources of cancer information do they seek out and find credible?; and 3) What are the barriers and facilitators to Latinos obtaining cancer information? Stakeholders generally viewed health professionals …

Parts Of The Whole: Teaching Quantitative Reasoning In An Exponential Decay Model, Dorothy Wallace

Numeracy

The simple calculus example of exponential decay can be an excellent vehicle for teaching quantitative reasoning in calculus or differential equations. Insect maturation provides a rich context for thinking about the meaning of the rate constant for exponential decay, which is derived in the context of a system at equilibrium but is generally measured using a single cohort of individuals.

Quantitative Literacy At Michigan State University, 3: Designing General Education Mathematics Courses, Samuel L. Tunstall, Vincent Melfi, Jeffrey Craig, Richard Edwards, Andrew Krause, Bronlyn Wassink, Victor Piercey

Numeracy

In this paper, we describe the process at Michigan State University whereby we have created two courses, Math 101 and 102, designed to foster numeracy and alleviate mathematics anxiety. The courses--which are not sequential--provide a means of satisfying the University's general education requirement without taking college algebra or calculus, among other options. They are context-driven and broken into modules such as "The World and Its People" and "Health and Risk." They have been highly successful thus far, with students providing positive feedback on their interest in the material and the utility they see of it in their daily lives. We …

Rethinking The Numerate Citizen: Quantitative Literacy And Public Issues, Ander W. Erickson

Numeracy

Does a citizen need to possess quantitative literacy in order to make responsible decisions on behalf of the public good? If so, how much is enough? This paper presents an analysis of the quantitative claims made on behalf of ballot measures in order to better delineate the role of quantitative literacy for the citizen. I argue that this role is surprisingly limited due to the contextualized nature of quantitative claims that are encountered outside of a school setting. Instead, rational dependence, or the reasoned dependence on the knowledge of others, is proposed as an educational goal that can supplement quantitative …

Grassroots Numeracy, H. L. Vacher

Numeracy

The readers and authors of papers in Numeracy compose a multidisciplinary grassroots interest group that is defining and illustrating the meaning, content, and scope of quantitative literacy (QL) and how it intersects with educational goals and practice. The 161 Numeracy papers that have been produced by this QL community were downloaded 42, 085 times in a total of 178 countries, including all 34 OECD countries, during 2015 and the first quarter of 2016. A scatterplot of normalized downloads per month vs. normalized total downloads for the eight years of Numeracy’s life allows identification of the 24 “most popular” of …

Wise Interns Tasked With Studying Water-Related Problems, Winthrop University

Winthrop News 2016

• Winthrop has received the Robert Noyce Scholarship grant through the National Science Foundation since 2010 and pairs it with additional funding from the Duke Energy Foundation to fund the Winthrop Initiative for STEM Educators (WISE) program.
• Students engaged in three research teams examining various water-related problems.

Ode To Ehrlich And Raven Or How Herbivorous Insects Might Drive Plant Speciation, Robert Marquis, Diego Salazar, Christina Baer, Jason Reinhardt, Galen Priest, Kirk Barnett

Biology Department Faculty Works

Fifty years ago, Ehrlich and Raven proposed that insect herbivores have driven much of plant speciation, particularly at tropical latitudes. There have been no explicit tests of their hypotheses. Indeed there were no proposed mechanisms either at the time or since by which herbivores might generate new plant species. Here we outline two main classes of mechanisms, prezygotic and postzygotic, with a number of scenarios in each by which herbivore‐driven changes in host plant secondary chemistry might lead to new plant lineage production. The former apply mainly to a sympatric model of speciation while the latter apply to a parapatric …

Community Remembers Norman Cohn Distinguished Professor Emeritus, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Distinct And Shared Functions Of Als-Associated Proteins Tdp-43, Fus And Taf15 Revealed By Multisystem Analyses, Katannya Kapeli, Gabriel A. Pratt, Anthony Q. Vu, Kasey R. Hutt, Fernando J. Martinez, Balaji Sundararaman, Ranjan Batra, Peter Freese, Nicole J. Lambert, Stephanie C. Huelga, Seung J. Chun, Tiffany Y. Liang, Jeremy Chang, John P. Donohue, Lily Shiue, Jiayu Zhang, Haining Zhu, Franca Cambi, Edward J. Kasarskis, Shawn Hoon, Manuel Ares Jr., Christopher B. Burge, John Ravits, Frank Rigo, Gene W. Yeo

Molecular and Cellular Biochemistry Faculty Publications

The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, and show that TAF15 binds to ∼4,900 RNAs enriched for GGUA motifs in adult mouse brains. TAF15 and FUS exhibit similar binding patterns in introns, are enriched in 3′ untranslated regions and alter genes distinct from TDP-43. However, unlike FUS and TDP-43, TAF15 has a minimal role in alternative splicing. In human neural progenitors, TAF15 and FUS affect turnover of their RNA targets. In human stem cell-derived motor …

Mechanotransduction Of Matrix Stiffness Regulates Cell Adhesion Strength: An Analysis Using Biomaterial Surfaces With Tunable Mechanical And Chemical Properties, Asma Sharfeddin Sharfeddin

USF Tampa Graduate Theses and Dissertations

Cells have the ability to sense the rigidity of the extracellular matrix which directly affects the control of cellular functions in development, wound healing and malignant transformation. Polydimethylsiloxane elastomers are useful model biomaterials for mechanotransduction studies because they possess several advantages including ease of fabrication, tunable elasticity and modifiable surface chemistry. In this work, we are investigating the influence of matrix stiffness on adhesion strength and the mechanosensory structures that regulate these processes. In addition, the effect of surface modifications to this elastic substrate system on other physical properties such as local stiffness and topography will be analyzed. Based on …

Stationary-Phase Mutagenesis In Stressed Bacillus Subtilis Cells Operates By Mfd-Dependent Mutagenic Pathways, Martha Gómez-Marroquín, Holly A. Martin, Amber Pepper, Mary E. Girard, Amanda Kidman, Carmen Vallin, Ronald E. Yasbin, Mario Pedraza-Reyes, Eduardo Robleto

Life Sciences Faculty Research

In replication-limited cells of Bacillus subtilis, Mfd is mutagenic at highly transcribed regions, even in the absence of bulky DNA lesions. However, the mechanism leading to increased mutagenesis through Mfd remains currently unknown. Here, we report that Mfd may promote mutagenesis in nutritionally stressed B. subtilis cells by coordinating error-prone repair events mediated by UvrA, MutY and PolI. Using a point-mutated gene conferring leucine auxotrophy as a genetic marker, it was found that the absence of UvrA reduced the Leu+ revertants and that a second mutation in mfd reduced mutagenesis further. Moreover, the mfd and polA mutants presented low but …

Genomics-Informed Isolation And Characterization Of A Symbiotic Nanoarchaeota System From A Terrestrial Geothermal Environment, Louie Wurch, Richard J. Giannone, Bernard S. Belisle, Carolyn Swift, Sagar Utturkar, Robert L. Hettich, Anna-Louise Reysenbach, Mircea Podar

Biology Faculty Publications and Presentations

Biological features can be inferred, based on genomic data, for many microbial lineages that remain uncultured. However, cultivation is important for characterizing an organism’s physiology and testing its genome-encoded potential. Here we use single-cell genomics to infer cultivation conditions for the isolation of an ectosymbiotic Nanoarchaeota (‘Nanopusillus acidilobi’) and its host (Acidilobus, a crenarchaeote) from a terrestrial geothermal environment. The cells of ‘Nanopusillus’ are among the smallest known cellular organisms (100–300 nm). They appear to have a complete genetic information processing machinery, but lack almost all primary biosynthetic functions as well as respiration and …

Methylation Of The Leukocyte Glucocorticoid Receptor Gene Promoter In Adults: Associations With Early Adversity And Depressive, Anxiety And Substance-Use Disorders, A. R. Tyrka, S H. Parade, E S. Welch, K. K. Ridout, L Price, C Marsit, L Carpenter

Dartmouth Scholarship

Early adversity increases risk for developing psychopathology. Epigenetic modification of stress reactivity genes is a likely mechanism contributing to this risk. The glucocorticoid receptor (GR) gene is of particular interest because of the regulatory role of the GR in hypothalamic–pituitary–adrenal (HPA) axis function. Mounting evidence suggests that early adversity is associated with GR promoter methylation and gene expression. Few studies have examined links between GR promoter methylation and psychopathology, and findings to date have been mixed. Healthy adult participants (N = 340) who were free of psychotropic medications reported on their childhood experiences of maltreatment and parental death and desertion. …