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Repair Severed Nerve Connections Through A Multi-Branch Microchannel Scaffold To Control The Direction Of The Regenerated Nerve, Luis Enrique Castanuela Ramon

Theses and Dissertations

Damage to the peripheral nervous system may result in functional abnormalities due to disrupted nerve connections. Existing methods of repairing severed nerve connections in the peripheral nervous system have limitations and disadvantages such as a limited availability of donor nerves and a lack of control of the direction of nerve regeneration within nerve conduits. A handcrafted multi-branch microchannel scaffold improves upon the current methods of nerve repair by incorporating microchannels, which guide and accommodate the nerve regeneration to distal ends, allowing for the treatment of nerve injuries involving multiple branches with fewer surgeries. This scaffold is also made more accessible …

Biocompatible Microchannel Scaffold With Microwires For Recording Regenerative Peripheral Nerve Neural Spikes, Manisankar Chennamsetti

Theses and Dissertations

A new process for the fabrication of a microchannel scaffold with microwires for peripheral nerve applications is presented. This microchannel scaffold implemented between the ends of nerves, the axons of which regenerate through microchannel in scaffold and fixed microelectrodes. This device is entirely handcrafted using commercially available materials such as microwires, PDMS film, liquid PDMS, dental cement, and epoxy glue. This device was implemented in the a Lewis rat sciatic nerve to better analyze the electrical signals of regenerated axons. 64-electrode microchannel scaffolds were developed for both peripheral nerve interfacing and peripheral nerve regeneration. The microwires were used for recording …

A Comparison Of Stride Length And Lower Extremity Kinematics During Barefoot And Shod Running In Well Trained Distance Runners, Peter Francis, James Ledingham, Sarah B. Clarke Phd, Dj Collins, Philip Jakeman

Journal Articles

Stride length, hip, knee and ankle angles were compared during barefoot and shod running on a treadmill at two speeds. Nine well-trained (1500m time: 3min:59.80s ± 14.7 s) male (22 ±3 years; 73 ±9 kg; 1.79 ±0.4 m) middle distance (800 m – 5,000 m) runners performed 2 minutes of running at 3.05 m·s^-1 and 4.72 m·s^-1 on an treadmill. This approach allowed continuous measurement of lower extremity kinematic data and calculation of stride length. Statistical analysis using a 2X2 factorial ANOVA revealed speed to have a main effect on stride length and hip angle and footwear to …

Silver-Polymer Nanocomposites, Anita N. Paul

Electronic Theses and Dissertations

The objective of this research was the development of an efficient method for the preparation of silver-polymer nanocomposites containing finely dispersed silver nanoparticles. The surface of nanosilver was functionalized by thiolation with 2-aminoethanethiol. Amino-modified nanosilver was covalently bonded to polyacrylic acid, biodegradable polymers like acid terminated polylactic acid, ester terminated poly(DL-lactide-co-glycolide) and acid terminated poly(DL lactide-co-glycolide) in the presence of diisopropylcarbodiimide by carbodiimide method. Esterification of the carboxyl groups of Ag-polyacrylic acid by hydrochloric acid in methanol resulted in the formation of a stable colloidal dispersion of Ag nanoparticles in the polymer matrix. It was observed that not just acid …

Exploring The Relationship Between Behaviour And Neurochemistry In The Polyphenic Spider, Anelosimus Studiosus (Araneae: Theridiidae), Jennifer B. Price

Electronic Theses and Dissertations

The importance of social behaviour is evident in human society, but there are both costs and benefits associated with cooperation and sociality throughout the animal kingdom. At what point do the benefits outweigh the costs, and when do selective pressures favour sociality and colonization over solitude and independence? To investigate these questions, we have focused on an anomalous species of spider, Anelosimus studiosus, also known now as the northern social spider. Throughout its broad range, A. studiosus is solitary and aggressive, but recently, colonies of cooperative and social individuals have been observed at northern latitudes. This leads to two …

Endothelial Hspa12b Is A Novel Protein For The Preservation Of Cardiovascular Function In Polymicrobial Sepsis Via Exosome Mir-126, Xia Zhang

Electronic Theses and Dissertations

Sepsis is the most frequent cause of mortality in most intensive care units. Cardiovascular dysfunction is a major complication associated with sepsis, with high mortality rates up to 70%. Currently, there is no effective treatment approach for sepsis.

The integrity of the endothelium is fundamental for the homeostasis of the cardiovascular system. Sepsis induces endothelial cell injury which is the key factor for multiple organ failure. The increased expression of adhesion molecules and chemokines in endothelial cell promotes leukocytes infiltration into the tissue. The loss of tight junction proteins and increased permeability of the endothelial cells will provoke tissue hypoxia …

The Combined Effects Of Leptin And Coenzyme Q10 In Ameliorating Obesity- Induced Infertility In Female Rats, Adekunle Adedeji

Electronic Theses and Dissertations

Infertility is one of the major problems of obesity. Studies have shown that administration of leptin reversed obesity-induced infertility in rats and mice. Coenzyme Q₁₀ (CoQ₁₀) is an antioxidant and also supplies the energy needed for ovulation and embryo development. We hypothesized that leptin when combined with CoQ₁₀ could greatly improve obesity-induced infertility. The results showed a significant decrease in food intake, body weight, and the regular estrous cycle was restored after treatment with leptin+CoQ₁₀. There was a significant increase (p10 significantly (p10 can improve fertility in obese infertile female rats. This study could …

Insights Summer 2016

Insights

Notes from the Dean; Alumna Promotes People as Our Greatest Resource; The Echo of Translation: LAS Faculty Translators Discuss the Challenges and Creativity of Their Work; Plugged-In Pedagogy; Access Art: Under a New DePaul-Art Institute Partnership, Undergraduates Get Unlimited Free Access to the Museum; Faculty Team Up for Innovative Research; Can Our Political System Be Saved?; Supporting Faculty Research: Social Science Research Center; Faculty Publications; New LAS Dean Named; Mowat Mellon Fellowship; In Memoriam: Ellin M. Kelly; Boren and Fulbright Scholars; French Language and Culture Award; DePaul Night at the Art Institute of Chicago; Byzantine Studies Director;

The Lived Experiences Of Women In The Information Technology Field As They Transition From One Leadership Level To The Next: A Phenomenological Study, Marilyn Delmont

UNLV Theses, Dissertations, Professional Papers, and Capstones

There is an increasing disparity of women in the IT field, when compared to men, specifically within IT executive leadership roles. The number of women in IT executive leadership lags drastically behind men IT executives and has gone down by five percent since 2008. Despite significant growth in the IT field women are not growing with it. IT jobs are expected to increase by 1.5 million in the next decade. The purpose and central question of this qualitative phenomenological study was to explore the lived experiences of women and how they develop as IT leaders. Beginning with 19 broad questions, …

Sheltering For Safety In Community Women With Divorce Histories., Ashlee J. Warnecke, Yvette Z. Sabo, Vicki E. Burns, Rafael Fernandez-Botran, James J. Miller, Tamara L. Newton

Faculty and Staff Scholarship

This cross-sectional study compared the prevalence of formal and informal sheltering (i.e., staying in an agency shelter, or with friends/family, respectively), and evaluated associations with abuse severity. Community women (N = 197) with divorce histories reported on lifetime intimate partner abuse, including sheltering for safety. Prevalence of informal sheltering (43%) exceeded that of formal sheltering (11%). Rates/levels of coercive control, severe violence, injury, and police involvement were comparable for women who sheltered formally or informally, and exceeded those of women who never sheltered. Sheltering histories can be identified in community samples of women with divorce histories. Informal sheltering is …

The Effects Of 4-Nonylphenol On The Immune Response Of The Pacific Oyster, Crassostrea Gigas, Following Bacterial Infection (Vibrio Campbellii), Courtney Hart

Master's Theses

Endocrine disrupting chemicals (EDCs) are compounds that can interfere with hormone signaling pathways and are now recognized as pervasive in estuarine and marine waters. One prevalent EDC in California’s coastal waters is the xenoestrogen 4-nonylphenol (4-NP), which has been shown to impair reproduction, development, growth, and in some cases immune function of marine invertebrates. To further investigate effects of 4-NP on marine invertebrate immune function we measured total hemocyte counts (THC), relative transcript abundance of immune-relevant genes, and lysozyme activity in Pacific oysters (Crassostrea gigas) following bacterial infection. To quantify these effects we exposed oysters to dissolved phase …

The Effectiveness Of Periodically-Harvested Closures In Meeting Ecological And Socioeconomic Objectives, Paul G. Carvalho

Master's Theses

Periodically-harvested fisheries closures (PHCs) are a widespread form of community-based marine spatial management used throughout the Indo-Pacific that also is currently being intensively advocated by conservation organizations for supporting productive fisheries and healthy marine ecosystems. However, local implementation of PHCs has historically been designed to support occasional and efficient exploitation of fish stocks, and not necessarily sustainable fisheries yields and stock conservation. The efficacy of PHCs for achieving their historical cultural objectives of periodicity and efficiency of harvest, simultaneously with achieving contemporary fisheries objectives of fisheries productivity and conservation is undetermined. As a result, the utility of PHCs for supporting …

Effects Of Experimental Noise Exposure On Songbird Nesting Behaviors And Nest Success, Tracy I. Mulholland

Master's Theses

Anthropogenic noise is an increasingly prevalent global disturbance. Animals that rely on the acoustical environment, such as songbirds, are especially vulnerable to these sounds. Traffic noise, in particular, overlaps with the frequency range of songbirds, creating masking effects. We investigated the effects of chronic traffic noise on provisioning behaviors and breeding success of nesting western bluebirds (Sialia mexicana) and ash-throated flycatchers (Myiarchus cinerascens). Because anthropogenic noise exposure has the potential to interrupt parent-offspring communication and alter vigilance behaviors, we predicted that traffic noise would lead to changes in provisioning behaviors, such as fewer visits to the …

Family Influences On Ethnic Identity Development Among Transracial Adoptees, Holly Mee Seong Stangle

Master's Theses

This study focused on the experiences of transracial adoptees in the United States, in an effort to examine the roles of cultural socialization and family influences on adoptees’ ethnic identity development. This study explored these issues through in-depth interviews with 11 adult transracial adoptees. Qualitative data analysis indicated various factors influencing participants’ ethnic identity development. Analysis compared levels of parental connection to adoptees’ birth culture, according to participants’ responses to interview questions. Analysis also compared socialization activities perceived by participants as meaningful to those that participants described as superficial or lacking in meaning. Themes included freedom of choice, opportunities for …

Fluid Flow Characterization And In Silico Validation In A Rapid Prototyped Aortic Arch Model, Alexandra Mariel Knauer

Master's Theses

Transcatheter aortic heart valve replacement (TAVR) is a procedure to replace a failing aortic valve and is becoming the new standard of care for patients that are not candidates for open-heart surgery [2]. However, this minimally invasive technique has shown to cause ischemic brain lesions, or “silent infarcts”, in 90% of TAVR patients, which can increase the patient’s risk for stroke by two to four times in future years [3]. Claret Medical Inc., a medical device company, has developed a cerebral protection system that filters and captures embolic debris released during endovascular procedures, such as TAVR. This thesis utilized CT …

The Preservation And Protection Of Native Biodiversity In The Guadalupe Nipomo Dunes Complex, Lindsey M. Whitaker, Matthew Ritter, Scott J. Steinmaus, Jonathan Hall

Master's Theses

The Guadalupe Nipomo Dunes Complex (GNDC) is located within the California Floristic Province, a biodiversity hotspot characterized by high rates of endemism and exceptional loss of habitat. In 1980, the US Fish and Wildlife Service described the GNDC as, “the most unique and fragile ecosystem in the State of California,” and ranked it first on a list of 49 habitat areas needing state protection. It is the largest coastal dune area in California and it is one of the last remaining, relatively intact ecosystems of its type and size in the western United States. The growing recognition of species decline …

An Evaluation Of Pesticide And Disposal Structures Appropriate To The Needs Of The Southern Illinois University Farms: A Review Of The Literature, Theodore B. Ballard

Research Papers

No abstract provided.

Extraction, Purification And Characterization Of An Antibiotic-Like Compound Produced By Rhodococcus Sp. Mtm3w5.2, Pushpavathi Reddyvari Manikindi

Electronic Theses and Dissertations

The bacterium Rhodococcus is a potential source for novel antimicrobial metabolites. Recently, the Rhodococcus strain MTM3W5.2 was isolated from a soil sample collected from Morristown, East Tennessee and was found to produce an inhibitor molecule that is active against similar Rhodococcus species. The aim of this research is to extract, purify, and characterize the active compound. The compound was obtained from both agar and broth cultures of strain MTM3W5.2 and purified by primary fractionation of crude extract on a Sephadex LH-20 column, followed by semi-preparative reversed phase column chromatography. Final purification was achieved using multiple rounds of an analytical C …

Using The Theory Of Planned Behavior To Predict Executives’ Intentions To Hire Psychologists In Federally Qualified Health Centers, Robert M. Tolliver

Electronic Theses and Dissertations

Health psychologists with training in integrated care are ideal candidates to work in Federally Qualified Health Centers (FQHCs). However, despite the large documented need for more behavioral health providers in FQHCs, psychologists are underrepresented in this setting compared to other behavioral health professions. The purpose of this study was to: 1) examine the specific beliefs that are most relevant to executives’ intentions to hire psychologists, 2) determine how executives’ perceived control over hiring psychologists varies by several demographic variables, and 3) examine how well the Theory of Planned Behavior (TPB) predicts executives’ intentions to hire psychologists. Method: Executives (N …

The Phenology And Compatibility Of Hazelnut (Corylus Avellana) Cultivars In Tennessee, Ben Nigel Heard

Honors Theses

The European hazelnut (Corylus avellana L.), is an important temperate zone nut tree species for which there is an expanding demand worldwide. Historically, the Eastern filbert blight disease (EFB), caused by the ascomycete fungus Anisogramma anomala, has prevented commercial hazelnut growing in Tennessee. As part of a UTC hazelnut cultivar trial, EFB resistant hazelnut cultivars and numbered selections from Oregon State University and Burnt Ridge Nursery were planted in 2003 at Smith Farm in Ooltewah, TN. Hazelnut trees are wind-pollinated, dichogamous, and self-incompatible, which means they are not self-fertile, their male and female blossoms may open at different times, and …

The Role The N-Terminal Domain Plays In Spidroin Assembly, Krystal Audrey Cadle

All Dissertations

One of the most interesting biomaterials known to man is spider silk. These fibers, composed primarily of protein, show beneficial mechanical and biological properties that have many uses in medical and industrial fields. Spider silk proteins (spidroins) are composed of three core components that consists of a C-terminal domain (CTD), repeat domain (R), and N-terminal domain (NTD). The NTD and CTD are highly conserved and are believed to form “multimeric strands” that make up spider silk. Although it is known that the NTD undergoes a conformational change that results in stable homodimer formation at acidic pH , the way in …

Development Of A New Multimodal Membrane Adsorber And Its Application In Chromatographic Bioseparations, Juan Wang

All Dissertations

This dissertation presents work on the design and synthesis of a new membrane chromatography material, the description of its protein binding behavior using a thermodynamic adsorption isotherm model, and the application of the new membrane material in biologics downstream recovery and purification processes. As protein titers continue to increase dramatically in upstream biomanufacturing, innovations in downstream purification are not keeping pace, resulting in manufacturing capacity constraints and high production costs. Chromatography is the key unit operation used in several steps of the downstream purification platform. Traditional resin bead chromatography, while effective and reliable for isolation and purification of proteins, limits …

Ruminant Supplementation Of Gluconeogenic Substrates Via Drinking Water, Gabriela Volpi-Lagreca

All Dissertations

Dark cutting or high pH meat is found in all meat species, inducing significant losses to the meat industry. Dark cutting meat is a direct consequence of low muscle glycogen at slaughter, which affects the normal acidification of meat during rigor development, hence, the ultimate pH remains high. The ultimate pH of the meat has a great influence on certain meat quality parameters, such as color, water holding capacity, and tenderness. An animal exposed to stress previous to slaughter may significantly depletes its glycogen reserves. This situation leads to a high ultimate pH if the animal is slaughtered before it …

Numerical Study For Non-Newtonian Fluid-Structure Interaction Problems, Shuhan Xu

All Dissertations

In this work, we consider non-Newtonian fluid structure problems, which have significant applications in biology and industry. Numerical approximation schemes are developed based on the Arbitrary Lagrangian-Eulerian (ALE) formulation of the flow equations. A spatial discretization is accomplished by the finite element method, and the time discretization is carried out by the implicit Euler method. We first consider a fluid-structure interaction problem that consists of a two-dimensional viscoelastic flow and a one-dimensional structure equation. We show how the system can be decoupled and how each subproblem can be solved using interface conditions. Numerical results of different algorithms are presented, showing …

Tackling Adverse Environment—Molecular Mechanism Of Plant Stress Response And Biotechnology Tool Development, Ning Yuan

All Dissertations

Abiotic and biotic stresses such as drought, salt, nutrition starvation, and pathogen infection are major factors threatening our agricultural production. With the rapidly increasing population and limited arable land area, genetic engineering of crops for new products with more stable and higher yield than conventional cultivars under adverse environment provides a powerful new tool for use in developing novel GMOs (Genetically Modified Organisms) to feed the large population in the immediate future. To develop novel GMOs with enhanced performance under adverse conditions, we need first to understand molecular mechanisms underlying plant stress response. To better understand how signaling transduction pathway …

Relationship Between Morphogenesis And Secretion In The Filamentous Fungus Aspergillus Nidulans, Lakshmi Preethi Yerra

School of Biological Sciences: Dissertations, Theses, and Student Research

Filamentous fungi have a long history in biotechnology for the production of food ingredients, pharmaceuticals and enzymes. The advancements made in recent years have earned filamentous fungi such as Aspergillus species a dominant place among microbial cell factories. Although the model fungus A. nidulans has been extensively studied, the genetic and regulatory networks that underlie morphogenesis and development have yet to be fully characterized. The Rho GTPases (Cdc42 and RacA) are one of the most important regulators of the morphogenetic processes among diverse eukaryotic organisms. Although the functions of these GTPases are relatively well-characterized, little is known about their …

Characterization Of The Role Of Host And Dietary Factors In The Establishment Of Bacteria In The Gastrointestinal Tract, Janina A. Krumbeck

School of Biological Sciences: Dissertations, Theses, and Student Research

Probiotic bacteria and synbiotics are used as therapeutic and prophylactic agents. The majority of probiotic and synbiotic applications contain bacterial strains that are allochthonous to the human gastrointestinal (GI) tract. Accordingly, many bacterial strains do not survive digestion, or are not capable of persisting and competing the resident gut microbiota, and are therefore washed out of the GI tract shortly after the treatment is discontinued. This might reduce the health effects of these treatments. Therefore, research is needed to address the ecological challenges that probiotic strains encounter in the GI tract in order to develop probiotic regimens. Determining which ecological …

Antimitotic Activity Of Cayratia Trifolia Ethanol Extract On Zygote Cells Of Tripneustes Gratilla, Eva Feriadi, Wahyuni Wahyuni, Muhammad I. Yusuf

Pharmacology and Clinical Pharmacy Research

Cancer is a devastating disease characterized by abnormal cell growth. Due to several safety issues associated with current cancer treatment, identification of new strategies for cancer therapy is considered necessary. Natural substances in plants m and fruits have the potentials to be developed as anticancer drugs. One of them is Cayratia trifolia (C. trifolia). This study was aimed to determine the cytotoxic activity of stem and leaf ethanol extract of C. trifolia against zygote cells of sea urchin or Tripneustes gratilla (T. gratilla). Extraction of stem and leaf of C. trifolia was conducted using maceration method in ethanol solvent. Thin …

Antibacterial Activity Of Pluchea Indica And Piper Betle Ethanol Extract On Staphylococcus Epidermidis And Pseudomonas Aeruginosa, Nela Simanjuntak, Umi Yuniarni, Diki Prayugo

Pharmacology and Clinical Pharmacy Research

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonas aeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 …

Common Property Redux

UBC Law Review

No abstract provided.