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2016

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The Free Press Vol. 48, Issue No. 1, 09-05-2016, Krysteana Scribner Sep 2016

The Free Press Vol. 48, Issue No. 1, 09-05-2016, Krysteana Scribner

Free Press, The

Goodbye, Bedford Street: Master Plan reveals the future of USM -- Tired of buying textbooks? New options to rent for free -- Sodexo opens amid student critiques -- “We have more things in common than we do in differences” David McKenzie, Interim Dean of Students, shares his life story and offers insight on diversity at USM


The Rider (2016-09-05), Jesus Sanchez Sep 2016

The Rider (2016-09-05), Jesus Sanchez

The Rider Archives

Vol.2 No.2


Medical School Watercooler Newsletter - September 4, 2016, Lindsey Lyle Sep 2016

Medical School Watercooler Newsletter - September 4, 2016, Lindsey Lyle

Watercooler Newsletter

This is the September 4, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

  • USA Health to Host Welcome Reception for New Physicians
  • Harvey Ikner Honored with Retirement Reception
  • Neurology Grand Rounds: 'Differential Diagnosis of MS'
  • Sept. 8 DSS to Feature Dr. Ratna K. Vadlamudi


Survey Of Keratinophilic Fungi In The Tigris River In Baghdad, Teeba Hashim Mohammad, Khalid Abdulrazak Habeb Sep 2016

Survey Of Keratinophilic Fungi In The Tigris River In Baghdad, Teeba Hashim Mohammad, Khalid Abdulrazak Habeb

Baghdad Science Journal

The present study includs the isolation and identification of Keratinophilic fungi in fresh water samples collected from Tigris river in Baghdad, Iraq. Samples were collected from different districts of Baghdad (Al-Rustumia, Madina Al-Teb, Al-Azamia, Al-Kadimia, Al-Dorha and Al-Kanah). The water samples were examined for keratinophilic fungi by the plating method culturing and Hair Baiting Technique. A total number of 18 genera are recorded, in which the Tigris water indicates an impressive diversity of fungi. A variety of fungal strains were isolated from river water, out of 814 fungal colonies, Aspergillus terrus (5.5%) was the most frequent species, followed by Aspergillus …


Degradation Of Brilliant Green By Using A Bentonite Clay- Based Fe Nano Composite Film As A Heterogeneous Photo- Fenton Catalyst., Khulood Abid Saleh Al-Saade, Shatha Fadel Al- Saidi, Hamdia Hateem Juad Sep 2016

Degradation Of Brilliant Green By Using A Bentonite Clay- Based Fe Nano Composite Film As A Heterogeneous Photo- Fenton Catalyst., Khulood Abid Saleh Al-Saade, Shatha Fadel Al- Saidi, Hamdia Hateem Juad

Baghdad Science Journal

This paper aims to study the chemical degradation of Brilliant Green in water via photo-Fenton (H2O2/Fe2+/UV) and Fenton (H2O2/Fe2+) reaction. Fe- B nano particles are applied as incrustation in the inner wall surface of reactor. The data form X- Ray diffraction (XRD) analysis that Fe- B nanocomposite catalyst consist mainly of SiO2 (quartz) and Fe2O3 (hematite) crystallites. B.G dye degradation is estimated to discover the catalytic action of Fe- B synthesized surface in the presence of UVC light and hydrogen peroxide. B.G dye solution with 10 ppm primary concentration is reduced by 99.9% under the later parameter 2ml H2O2, pH= …


Spectroscopic Studies And Thermal Analysis Of New Azo Dyes Ligands And Their Complexes With Some Transition Of Metal Ions, Abbas Ali Salih Al-Hamdani, Zainab Abd Al-Hadi Hasan Sep 2016

Spectroscopic Studies And Thermal Analysis Of New Azo Dyes Ligands And Their Complexes With Some Transition Of Metal Ions, Abbas Ali Salih Al-Hamdani, Zainab Abd Al-Hadi Hasan

Baghdad Science Journal

New Azo ligands HL1 [2-Hydroxy-3-((5-mercapto-1,3,4-thiadiazol-2-yl)diazenyl)-1-naphth aldehyde] and HL2 [3-((1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)diazenyl)-2-hydroxy-1-naphthaldehyde] have been synthesized from reaction (2-hydroxy-1-naphthaldehyde) and (5-amino-1,3,4-thiadiazole-2-thiol) for HL1 and (4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one) for HL2. Then, its metal ions complexes are synthesized with the general formula; [CrHL1Cl3(H2O)], [VOHL1(SO4)] [ML1Cl(H2O)] where M = Mn(II), Co(II), Ni(II) and Cu(II), and general formula; [Cr(L2)2 ]Cl and [M(L2)2] where M = VO(II), Mn(II), Co(II), Ni(II) and Cu(II) are reported. The ligands and their metal complexes are characterized by phisco- chemical spectroscopic techniques (FT.IR, Mass, UV-Vis, 1H and 13C-NMR, TGA, (C.H.N.), molar conductivity, Atomic Absorbance, Chloride containing magnetic susceptibility). The spectral data suggest that the (HL1) behaves …


Bio-Based Renewable Additives For Anti-Icing Applications (Phase I), Mehdi Honarvar Nazari, Eden Adele Havens, Xianming Shi, Anburaj Muthumani Sep 2016

Bio-Based Renewable Additives For Anti-Icing Applications (Phase I), Mehdi Honarvar Nazari, Eden Adele Havens, Xianming Shi, Anburaj Muthumani

CESTiCC Project Reports

The performance and impacts of several bio-based anti-icers along with a traditional chloride-based anti-icer (salt brine) were evaluated. A statistical design of experiments (uniform design) was employed for developing anti-icing liquids consisting of cost-competitive chemicals such as bio-based compounds (e.g., sugar beet extract and dandelion extract), rock salt, sodium metasilicate, and sodium formate. The following experimentally obtained parameters were examined as a function of the formulation design: ice-melting capacity and ice penetration at 25°F (−3.9°C) and 15°F (−9.4°C), compressive strength of Portland cement mortar samples after 10 freezethaw/deicer cycles, corrosion rate of C1010 carbon steel after 24-hour immersion, and impact …


A Study The Effect Of Tio2 Nanoparticles Combination With Antibiotics And Plant Extracts Against Some Gram Negative Bacteria, Rana Mujahid Abdullah Sep 2016

A Study The Effect Of Tio2 Nanoparticles Combination With Antibiotics And Plant Extracts Against Some Gram Negative Bacteria, Rana Mujahid Abdullah

Baghdad Science Journal

Titanium dioxide TiO2 has been widely utilized in cleaning and sterilizing material for many clinical tools sanitary ware, food tableware and cooking and items for use in hospitals. Titanium dioxide TiO2 non toxicity and long term physical and chemical stability. It has been widely used decomposition of organic compounds and microbial organisms such as cancer cell, viruses and bacteria as well as its potential application in sterilization of medical devices. The aim of the study the effect of titanium dioxide TiO2 on some Gram negative bacteria and study their effects on some virulence factors and chromosomal DNA.In this study, we …


Study Of The Immunological Status Of Iraqi Vitiligo Patients, Shatha F. Tariq, Talib A. Hussein Sep 2016

Study Of The Immunological Status Of Iraqi Vitiligo Patients, Shatha F. Tariq, Talib A. Hussein

Baghdad Science Journal

Vitiligo is an acquired idiopathic skin disorder characterized by depigmented macules due to the loss of cutaneous melanocytes. Immune dysfunction may play a role in vitiligo, prompting the investigation of certain cytokines (IL-17A and TNF-α) and immunoglobulins (IgM, IgG, IgA, and total IgE). The study involved 60 patients (age 6-55 years), including 30 untreated and 30 treated with Narrow Band Ultraviolet-B (NB-UVB), plus 30 healthy controls. Serum cytokine and immunoglobulin levels were measured using ELISA and SRID methods. Results showed significantly increased serum IL-17A and TNF-α in both untreated and NB-UVB treated vitiligo patients (p ≤ 0.05). Serum IgG and …


Association Of Cestoda Raillietina Echinobothrida In Rock Pigeon Columba Livia From Baghdad City Of Iraq, Wasan Addai Al-Marsomy, Hani Sabaar Al-Hamadaani Sep 2016

Association Of Cestoda Raillietina Echinobothrida In Rock Pigeon Columba Livia From Baghdad City Of Iraq, Wasan Addai Al-Marsomy, Hani Sabaar Al-Hamadaani

Baghdad Science Journal

The tapeworm parasite Raillietina echinobothrida, belonging to the class Cestoda, causes nodular tapeworm disease in poultry. This study aimed to determine tapeworm infections in Columba livia from two markets in Baghdad between May and December 2014. Thirty-five Columba livia samples were randomly selected, and their elementary canals were examined. The study found that 6 out of 35 pigeons (17.14%) were infected with Raillietina echinobothrida. Statistical analysis revealed significant differences in all characteristics of the cestode, except for the length of the rostellum hooks.


Synthesis And Study Of Biological Activity Of Some New Imidazole Derivatives, Abdul Jabar Kh. Atia, Mohammed Fraj Al-Marjani, Muayad Abbood Qaban Sep 2016

Synthesis And Study Of Biological Activity Of Some New Imidazole Derivatives, Abdul Jabar Kh. Atia, Mohammed Fraj Al-Marjani, Muayad Abbood Qaban

Baghdad Science Journal

In this work ester derivatives were synthesized by the reaction of imidazole derivatives (C1) with ethylchloroacetate in ethanol and NaOH to give the corresponding (C2) .While compound (C3) acetohydrazide was synthesized by the reaction of ester derivatives (C2) with hydrazine hydrat in ethanol. Compound (C3) from the reaction with different aromatic aldehydes in absolute ethanol gave the Schiff′s bases (C4,C5). The product compounds were characterized by FT-IR, U.V and 1HNMR spectra and the biological activities were studied as antibacterial.


Evaluate The Effectiveness Of Agaricus Bisporus (Spawn) On Control Damping – Off Caused By Pythium Aphanidermatum On Cucumber, Tareq Abdulsada Kareem, Dareen Safwat Ismael, Bushra Subair Abdulsada Al-Maliky Sep 2016

Evaluate The Effectiveness Of Agaricus Bisporus (Spawn) On Control Damping – Off Caused By Pythium Aphanidermatum On Cucumber, Tareq Abdulsada Kareem, Dareen Safwat Ismael, Bushra Subair Abdulsada Al-Maliky

Baghdad Science Journal

This study was conducted to test the effectiveness of *Agaricus bisporus* inoculums (spawn) in the ratios of 0.25%, 0.5%, and 1% v/v to control *Pythium aphanidermatum*, the causal agent of damping-off disease in cucumber plants. Results showed the ability of *A. bisporus* fungus to protect seedlings from infection by *P. aphanidermatum*. All treatments with edible fungus inoculums were significantly different from the pathogen-only treatment after 15 days of planting, with no significant difference from the control treatment (without pathogen). The success of *A. bisporus* continued to protect seedlings even after 30 and 45 days of planting. Seedling numbers for the …


Synthesizing, Characterizing And Studying The Biological Activity Of Some New Schiff-Bases Derivatives Containing The Monosaccharide Moiety, Amina. A. Fayad Sep 2016

Synthesizing, Characterizing And Studying The Biological Activity Of Some New Schiff-Bases Derivatives Containing The Monosaccharide Moiety, Amina. A. Fayad

Baghdad Science Journal

A new series of α-D-glucose Schiff base derivatives was synthesized and characterized for bioactivity. Hydroxyl groups at C(1,2 & 5,6) of the sugar moiety were converted into acetal form using dry acetone with phosphoric acid and anhydrous zinc chloride as catalysts, producing 1,2:5,6-di-O-isopropylidene α-D-glucofuranose (I). The five-membered acetal at C(5,6) was hydrolyzed with acetic acid (65%), and a reaction with sodium periodate produced an aldehyde group, which was used to synthesize Schiff bases by reacting with various amino compounds like 4-aminoantipyrine. The chemical structures of the prepared compounds were confirmed using UV, FT-IR, and 1H-NMR spectra. Most of the compounds …


The Synbiotic Effect Of Volaticle Oil Extracted From Leaves Rosmarinus Officinolis And Nigellai Sativa On Microbial And Sensory Characteristics Of Minced Poultry Meat During Cold Storage, Bushra S. R . Zangana Sep 2016

The Synbiotic Effect Of Volaticle Oil Extracted From Leaves Rosmarinus Officinolis And Nigellai Sativa On Microbial And Sensory Characteristics Of Minced Poultry Meat During Cold Storage, Bushra S. R . Zangana

Baghdad Science Journal

The objective of the present study was to investigate the effect of using duplex volatile oil of *Rosmarinus officinalis* and *Nigella sativa* on microbial quality, sensory properties, and extending the storage time of minced cold poultry meat. Duplex volatile oil was added at 25, 50, and 75 mg/kg to minced poultry meat. These treatments were stored individually for 0, 4, and 7 days at 4-7°C. After conducting several microbial and sensory tests, the following results were obtained: The addition of duplex volatile oil from *Rosmarinus officinalis* and *Nigella sativa* led to a significant reduction (P<0.01) in total aerobic count, psychrophilic count, and coliform bacteria during refrigerated storage periods. The results also showed a significant improvement in sensory evaluation (P<0.01) for the organoleptic characteristics of minced poultry meat (flavor, juiciness, tenderness, overall palatability). It can be concluded that adding duplex volatile oil positively influenced the sensory and microbial safety of minced poultry meat when stored under refrigeration (4-7°C) for up to 7 days.


Effect Of Soaking Seeds Citrusaurantium And Citrus Limonumat Different Concentrations Of Licorice Extract On The Percentage Of Germination And Growth Of Seedlings, Fatima M. K. Al-Wailli Sep 2016

Effect Of Soaking Seeds Citrusaurantium And Citrus Limonumat Different Concentrations Of Licorice Extract On The Percentage Of Germination And Growth Of Seedlings, Fatima M. K. Al-Wailli

Baghdad Science Journal

This research was conducted under the Lath house canopy at Baghdad University in 2013 to study the effect of soaking lemon seeds (sour orange) in different concentrations of licorice extract (0, 0.5, 2.5, and 4.5 g/l) for 24 hours, on the percentage of germination and vegetative growth of seedlings. The results showed that the bitter orange seedlings soaked in licorice extract at 4.5 g/l exhibited significant superiority in most traits, including plant height (31.077 cm), leaf number (14.46 leaves/plant), root length (25.35 cm), and stem diameter (0.52 mm). These results were significantly higher compared to the control treatment, which showed …


Bioadsorption Of Heavy Metals From Industrial Wastewater Using Some Species Of Bacteria, Fikrat M. Hassan, Adnan N. A. R. Al-Baidhani, Sahira H. H. Al-Khalidi Sep 2016

Bioadsorption Of Heavy Metals From Industrial Wastewater Using Some Species Of Bacteria, Fikrat M. Hassan, Adnan N. A. R. Al-Baidhani, Sahira H. H. Al-Khalidi

Baghdad Science Journal

Three isolated bacteria were examined to remove heavy metals from the industrial wastewater of the Diala State Company of Electrical Industries, Diyala-Iraq. The isolated bacteria were identified as Pseudomonas aeruginosa, Escherichia coli and Sulfate Reducing Bacteria (SRB). The three isolates were used as an adsorption factor for different concentrations of Lead and Copper (100, 150, and 200 ppm.), in order to examine the adsorption efficiency of these isolates. In addition, the effect of three factors on heavy metals adsorption were examined; temperature (25, 30, and 37 °C), pH (3 and 4.5) and contact time (2 and 24 hrs). The results …


Extraction Conditions Of Polyphenol Oxidase From Banana Peel, Ghazi M. Aziz, Ali J. R. Al-Sa'ady Sep 2016

Extraction Conditions Of Polyphenol Oxidase From Banana Peel, Ghazi M. Aziz, Ali J. R. Al-Sa'ady

Baghdad Science Journal

Polyphenol oxidase (PPO) is an enzyme containing copper, presents in various fruits and vegetables. It is responsible for the browning reactions when the cells are damaged during handling. The best conditions for extraction of polyphenol oxidase from banana peel was by using an extraction buffer containing phosphate buffer (0.05 M, pH 7), 0.01 M ascorbic acid and 0.5% polyethylene glycol, with extraction ratio 1:4 (w:v) for one minute by using blender. The enzyme activity was measured spectrophotometrically at 425 nm. PPO was studied to prevent the browning of banana peel which results in the loss of their marketability. The aim …


The Removal Of Zinc From Aqueous Solutions Using Malvaparviflora, Ahlam Mohammed Farhan, Rasha Abed Jassim, Nafeesa J. Kadhim Sep 2016

The Removal Of Zinc From Aqueous Solutions Using Malvaparviflora, Ahlam Mohammed Farhan, Rasha Abed Jassim, Nafeesa J. Kadhim

Baghdad Science Journal

In this study, the adsorption of Zn (NO3)2 is carried out by using surfaces of malvaparviflora. The validity of the adsorption is evaluated by using atomic absorption Spectrophotometry through determination the amount of adsorbed Zn (NO3)2. Various parameters such as PH, adsorbent weight and contact time are studied in terms of their effect on the reaction progress. Furthermore, Lagergren’s equation is used to determine adsorption kinetics. It is observed that high removal of Zn (NO3)2 is obtained at PH=2. High removal of Zn (NO3)2 is at the time equivalent of 60 min and reaches equilibrium,where 0.25gm is the best weight …


Synthesis Of Some New Nucleoside Analogues Containing Seven Membered Ring And Studying Their Biological Activity, Thanaa Mahdi Al-Mouamin, Surorabdulrahman Mahdi, Omar Abdulateef Mohammed, Yasmeen H. Muhamad Sep 2016

Synthesis Of Some New Nucleoside Analogues Containing Seven Membered Ring And Studying Their Biological Activity, Thanaa Mahdi Al-Mouamin, Surorabdulrahman Mahdi, Omar Abdulateef Mohammed, Yasmeen H. Muhamad

Baghdad Science Journal

In this work, a series of new Nucleoside analogues (D-galactopyranose linked to oxepanebenzimidazole moiety) was synthesized via multisteps synthesis. The first step involved preparation of two benzimidazoles 2-styrylbenzimidazole and 2-(phenyl ethynyl) benzimidazole via reaction of phenylenediamine with cinnamic acid or β-phenyl propiolic acid. Electrophilic addition of the prepared benzimidazoles by three anhydrides in the second step afforded (4-6) and (14-16) which in turn were treated with 1,2,3,4-di-O-isopropylidene galactopyranose in the third step to afford a series of the desirable protected nucleoside analogues (7-9) ,(17-19)which after hydrolysis in methanolic sodium methoxidein the fourth step afforded the free nucleoside analogues (10-12) and …


Synthesis And Characterization Of Some New Pyrazoline And Isoxazoline Derivatives As Antibacterial Agents, Ali K. Alywee Al-Naseeri Sep 2016

Synthesis And Characterization Of Some New Pyrazoline And Isoxazoline Derivatives As Antibacterial Agents, Ali K. Alywee Al-Naseeri

Baghdad Science Journal

In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria. Several derivatives …


Quinton Holloway Sep 2016

Quinton Holloway

African American Funeral Programs

Services were held at Metter Community Center.


The Role Of Na/K-Atpase Signaling In Oxidative Stress Related To Obesity And Cardiovascular Disease, Krithika Srikanthan, Joseph I. Shapiro Md, Komal Sodhi Sep 2016

The Role Of Na/K-Atpase Signaling In Oxidative Stress Related To Obesity And Cardiovascular Disease, Krithika Srikanthan, Joseph I. Shapiro Md, Komal Sodhi

Biochemistry and Microbiology

Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic


September 3, 2016 (Pages 5717-5804), Pennsylvania Legislative Reference Bureau Sep 2016

September 3, 2016 (Pages 5717-5804), Pennsylvania Legislative Reference Bureau

Volume 46 (2016)

No abstract provided.


The Murray Ledger And Times, September 3-5, 2016, The Murray Ledger And Times Sep 2016

The Murray Ledger And Times, September 3-5, 2016, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.


Exposures To The Environmental Toxicants Pentachlorophenol (Pcp) And Dichlorodiphenyltrichloroethane (Ddt) Modify Secretion Of Interleukin 1-Beta (Il-1Β) From Human Immune Cells, Tamara J. Martin, Margaret M. Whalen Sep 2016

Exposures To The Environmental Toxicants Pentachlorophenol (Pcp) And Dichlorodiphenyltrichloroethane (Ddt) Modify Secretion Of Interleukin 1-Beta (Il-1Β) From Human Immune Cells, Tamara J. Martin, Margaret M. Whalen

Chemistry Faculty Research

Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) are environmental contaminants found in human blood. Previous studies have shown that PCP and DDT inhibit the lytic function of highly purified human natural killer (NK) lymphocytes and decrease the expression of several surface proteins on NK cells. Interleukin-1 βeta (IL-1β) is a cytokine produced by lymphocytes and monocytes, and anything that elevates its levels inappropriately can lead to chronic inflammation, which among other consequences can increase tumor development and invasiveness. Here, PCP and DDT were examined for their ability to alter secretion of IL-1β from immune cell preparations of various complexity: NK cells; monocyte-depleted …


Self-Perceived Competence And Social Acceptance Of Young Children Who Stutter: Initial Findings, Naomi H. Rodgers, Patricia Zebrowski Ph.D Sep 2016

Self-Perceived Competence And Social Acceptance Of Young Children Who Stutter: Initial Findings, Naomi H. Rodgers, Patricia Zebrowski Ph.D

Department of Special Education and Communication Disorders: Faculty Publications

Purpose: The goals of this study were to determine whether young children who stutter (CWS) perceive their own competence and social acceptance differently than young children who do not stutter (CWNS), and to identify the predictors of perceived competence and social acceptance in young speakers.

Method: We administered the Pictorial Scale of Perceived Competence and Social Acceptance for Young Children (PSPCSA; Harter & Pike, 1984) to 13 CWS and 14 CWNS and examined group differences. We also collected information on the children’s genders, temperaments, stuttering frequencies, language abilities, and phonological skills to identify which of these factors predicted PSPCSA scores. …


09-02-2016 Seventeen Freshmen Selected For Swosu Honors Program, Southwestern Oklahoma State University Sep 2016

09-02-2016 Seventeen Freshmen Selected For Swosu Honors Program, Southwestern Oklahoma State University

THE BARK ARCHIVE 2016

Seventeen freshmen have been selected to be in Southwestern Oklahoma State University’s honors program.


The Neu1-Selective Sialidase Inhibitor, C9- Butyl-Amide-Dana, Blocks Sialidase Activity And Neu1-Mediated Bioactivities In Human Lung In Vitro And Murine Lung In Vivo, Sang W. Hyun, Anguo Liu, Zhenguo Liu, Alan S. Cross, Avelino C. Verceles, Sadagopan Magesh, Yadagiri Kommagalla, Chandrababunaidu Kona, Hiromune Ando, Irina G. Luzina, Sergei P. Atamas, Kurt H. Piepenbrink, Eric J. Sundberg, Wei Guang, Hideharu Ishida, Erik P. Lillehoj, Simeon E. Goldblum Sep 2016

The Neu1-Selective Sialidase Inhibitor, C9- Butyl-Amide-Dana, Blocks Sialidase Activity And Neu1-Mediated Bioactivities In Human Lung In Vitro And Murine Lung In Vivo, Sang W. Hyun, Anguo Liu, Zhenguo Liu, Alan S. Cross, Avelino C. Verceles, Sadagopan Magesh, Yadagiri Kommagalla, Chandrababunaidu Kona, Hiromune Ando, Irina G. Luzina, Sergei P. Atamas, Kurt H. Piepenbrink, Eric J. Sundberg, Wei Guang, Hideharu Ishida, Erik P. Lillehoj, Simeon E. Goldblum

Food for Health: Publications

Neuraminidase-1 (NEU1) is the predominant sialidase expressed in human airway epithelia and lung microvascular endothelia where it mediates multiple biological processes. We tested whether the NEU1-selective sialidase inhibitor, C9-butyl-amide-2-deoxy-2,3-dehydro-Nacetylneuraminic acid (C9-BA-DANA), inhibits one or more established NEU1-mediated bioactivities in human lung cells. We established the IC50 values of C9-BA-DANA for total sialidase activity in human airway epithelia, lung microvascular endothelia and lung fibroblasts to be 3.74 µM, 13.0 µM and 4.82 µM, respectively. In human airway epithelia, C9-BA-DANA dose-dependently inhibited flagellin-induced, NEU1-mediated mucin-1 ectodomain desialylation, adhesiveness for Pseudomonas aeruginosa and shedding. In lung microvascular endothelia, C9-BA-DANA reversed NEU1-driven restraint of …


Quantifying The Toxicity Of 1-Methylnaphthalene To The Shallow-Water Coral, Porites Divaricata, For Use In The Target Lipid Model, Nicholas Turner Sep 2016

Quantifying The Toxicity Of 1-Methylnaphthalene To The Shallow-Water Coral, Porites Divaricata, For Use In The Target Lipid Model, Nicholas Turner

HCNSO Student Theses and Dissertations

The proximity of coral reefs to coastal urban areas and shipping lanes predisposes corals to petroleum pollution from multiple sources. Previous research has evaluated petroleum toxicity to coral using a variety of methodologies, including monitoring effects of acute and chronic spills, in situ exposures, and ex situ exposures with both adult and larval stage corals. Variability in toxicant, bioassay conditions, species and other methodological disparities among studies prevents comprehensive conclusions regarding the toxicity of hydrocarbons to corals. This research evaluated the 48-hour toxicity of 1-methylnaphthalene to Porites divaricata using a continuous-flow passive dosing system. The range-finding exposure evaluated the dosing …


2016-September-02-Blue Weekend, University Marketing And Communications, East Tennessee State University Sep 2016

2016-September-02-Blue Weekend, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.