Digital Commons Network^™

Cycle Training Modulates Satellite Cell And Transcriptional Responses To A Bout Of Resistance Exercise, Kevin A. Murach, R. Grace Walton, Christopher S. Fry, Sami L. Michaelis, Jason S. Groshong, Brian S. Finlin, Philip A. Kern, Charlotte A. Peterson

Clinical and Translational Science Faculty Publications

This investigation evaluated whether moderate-intensity cycle ergometer training affects satellite cell and molecular responses to acute maximal concentric/eccentric resistance exercise in middle-aged women. Baseline and 72 h postresistance exercise vastus lateralis biopsies were obtained from seven healthy middle-aged women (56 ± 5 years, BMI 26 ± 1, VO_2max 27 ± 4) before and after 12 weeks of cycle training. Myosin heavy chain (MyHC) I- and II-associated satellite cell density and cross-sectional area was determined via immunohistochemistry. Expression of 93 genes representative of the muscle-remodeling environment was also measured via NanoString. Overall fiber size increased ~20% with cycle training ( …

Use Of Parthenolide Derivatives As Antileukemic And Cytotoxic Agents, Peter A. Crooks, Craig T. Jordan, Xiaochen Wei

Pharmaceutical Sciences Faculty Patents

To read this abstract, please download this patent.

Semi-Synthetic Mithramycin Derivatives With Anti-Cancer Activity, Jürgen Rohr, Daniel Scott, Markos Leggas, Jhong-Min Chen, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Patents

Mithramycin derivatives and their pharmaceutically acceptable salts are disclosed. The mithramycin derivatives can be used in the treatment of Ewing sarcoma or other cancer or neuro-disease associated with an aberrant erythroblast transformation- specific transcription factor.

Undergraduate Research Scholars Program Features Work Of Seven Stellar Students, Office Of University Communications

Gardner-Webb NewsCenter Archive

The Gardner-Webb University Undergraduate Research Scholars program funded a total of seven students during the summer 2016 term, which represents the greatest number of scholars in the program’s history. As part of their research project, each scholar spends five weeks of a summer term on campus working on his/her topic for 40 hours a week. At the same time, students are mentored by a dedicated faculty member, who provides information and guidance to ensure a successful research experience for the scholar.

WGWG: GWU Undergraduate Research Scholar Chris Beguhl

WGWG: GWU Undergraduate Research Scholar Mariah Case

WGWG: GWU Undergraduate Research Scholar …

Empirical Comparative Analysis Of 1-Of-K Coding And K-Prototypes In Categorical Clustering, Fei Wang, Hector Franco, John Pugh, Robert J. Ross

Conference papers

Clustering is a fundamental machine learning application, which partitions data into homogeneous groups. K-means and its variants are the most widely used class of clustering algorithms today. However, the original k-means algorithm can only be applied to numeric data. For categorical data, the data has to be converted into numeric data through 1-of-K coding which itself causes many problems. K-prototypes, another clustering algorithm that originates from the k-means algorithm, can handle categorical data by adopting a different notion of distance. In this paper, we systematically compare these two methods through an experimental analysis. Our analysis shows that K-prototypes is more …

Cell Culture Investigation Of The Effects Of Aerogel Surface Topography And Dc Electric Field Stimulation On Pc12 Cell Neurite Growth, Kyle Jeremiah Lynch

Electronic Theses and Dissertations Archive

Polyurea crosslinked silica aerogel (PCSA) is an open pore light-weight and topographically rich material with tunable physical and chemical properties. Because of the unique properties of this material, and the ability to tailor the properties to specific needs and applications, PCSA has attracted significant interest from the biophysical and biomedical fields in recent years. Recent advances in cell biology and biophysics have demonstrated that cells respond to their micro- and nanoscale environmental cues in the presence and/or absence of electrical cues and stimuli. Aerogels offer a unique platform for studying the effects of topography, substrate stiffness, and porosity on cellular …

September 20, 2016, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Sun Star Vol 36 No 4 (September 20th, 2016), N/A N/A

Sun Star

No abstract provided.

Hspa12b Attenuated Acute Myocardial Ischemia/Reperfusion Injury Via Maintaining Endothelial Integrity In A Pi3k/Akt/Mtor-Dependent Mechanism, Qiuyue Kong, Leyang Dai, Yana Wang, Xiaojin Zhang, Chuanfu Li, Surong Jiang, Yuehua Li, Zhengnian Ding, Li Liu

ETSU Faculty Works

Endothelial damage is a critical mediator of myocardial ischemia/reperfusion (I/R) injury. HSPA12B is an endothelial-cell-specifically expressed heat shock protein. However, the roles of HSPA12B in acute myocardial I/R injury is unknown. Here we reported that myocardial I/R upregulated HSPA12B expression in ventricular tissues, and endothelial overexpression of HSPA12B in transgenic mice (Tg) limited infarct size, attenuated cardiac dysfunction and improved cardiomyocyte survival compared with their wild type littermates. These improvements were accompanied with the diminished myocardial no-reflow phenomenon, decreased microvascular leakage, and better maintained endothelial tight junctions. The I/R-evoked neutrophil infiltration was also suppressed in Tg hearts compared with its …

Myelinating Glia Differentiation Is Regulated By Extracellular Matrix Elasticity, Mateusz M. Urbanski, Lyle Kingsbury, Daniel Moussouros, Imran Kassim, Saraf Mehjabeen, Navid Paknejad, Alicia Meléndez

Publications and Research

The mechanical properties of living tissues have a significant impact on cell differentiation, but remain unexplored in the context of myelin formation and repair. In the PNS, the extracellular matrix (ECM) incorporates a basal lamina significantly denser than the loosely organized CNS matrix. Inhibition of non-muscle myosin II (NMII) enhances central but impairs peripheral myelination and NMII has been implicated in cellular responses to changes in the elasticity of the ECM. To directly evaluate whether mechanotransduction plays a role in glial cell differentiation, we cultured Schwann cells (SC) and oligodendrocytes (OL) on matrices of variable elastic modulus, mimicking either their …

Using Geographic Information Systems To Identify Habitat For The Golden-Winged Warbler (Vermivora Chrysoptera) In Western New York, Jesse Michael Rubenstein

Theses

The Golden-winged Warbler (Vermivora chrysoptera) is a passerine species whose populations have decreased internationally by approximately 66 percent since the 1960s, and by approximately 50 percent in New York. Major causes for declines are from loss of shrubland habitat and through hybridization with the Blue-winged Warbler (Vermivora cyanoptera). This study utilized published data and expert opinion on Golden-winged Warbler (GWWA) habitat requirements to create habitat suitability models within the Western Finger Lakes Region of NY (NYSDEC Region 8) using a geographic information system. This region is an important area for migratory birds and is previously unstudied for GWWA. The concentration …

Mlkl And Fadd Are Critical For Suppressing Progressive Lymphoproliferative Disease And Activating The Nlrp3 Inflammasome., Xixi Zhang, Cunxian Fan, Haiwei Zhang, Qun Zhao, Yongbo Liu, Chengxian Xu, Qun Xie, Xiaoxia Wu, Xianjun Yu, Jianke Zhang, Haibing Zhang

Department of Microbiology and Immunology Faculty Papers

MLKL, a key component downstream of RIPK3, is suggested to be a terminal executor of necroptosis. Genetic studies have revealed that Ripk3 ablation rescues embryonic lethality in Fadd- or Caspase-8-deficient mice. Given that RIPK3 has also been implicated in non-necroptotic pathways including apoptosis and inflammatory signaling, it remains unclear whether the lethality in Fadd(-/-) mice is indeed caused by necropotosis. Here, we show that genetic deletion of Mlkl rescues the developmental defect in Fadd-deficient mice and that Fadd(-/-)Mlkl(-/-) mice are viable and fertile. Mlkl(-/-)Fadd(-/-) mice display significantly accelerated lymphoproliferative disease characterized by lymphadenopathy and splenomegaly when compared to Ripk3(-/-)Fadd(-/-) mice. …

Decreasing Patient Cost And Travel Time Through Pediatric Rheumatology Telemedicine Visits., Elizabeth A. Kessler, Ashley K. Sherman, Mara L. Becker

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: There is a critical shortage of pediatric rheumatologists in the US. Substantial travel to clinics can impose time and monetary burdens on families. The aim of this study was to evaluate the cost of in-person pediatric rheumatology visits for families and determine if telemedicine clinics resulted in time and cost savings. Factors associated with interest in telemedicine were also explored.

METHODS: Surveys were offered to parents and guardians of patients in Pediatric Rheumatology follow-up clinics in Kansas City, Missouri, the primary site of in-person care, and at a telemedicine outreach site 160 miles away, in Joplin, Missouri. Survey questions …

Volume 114, Number 3 - Tuesday, September 20, 2016, Saint Mary's College Of California

The Collegian

No abstract provided.

Heterogeneity Among Isolates Reveals That Fitness In Low Oxygen Correlates With Aspergillus Fumigatus Virulence, Caitlin H. Kowalski, Sarah R. Beattie, Kevin K. Fuller, Elizabeth A. Mcgurk, Yi-Wei Tang, Tobias Hohl, Joshua Obar, Robert Cramer Jr.

Dartmouth Scholarship

Previous work has shown that environmental and clinical isolates of Aspergillus fumigatus represent a diverse population that occupies a variety of niches, has extensive genetic diversity, and exhibits virulence heterogeneity in a number of animal models of invasive pulmonary aspergillosis (IPA). However, mechanisms explaining differences in virulence among A. fumigatus isolates remain enigmatic. Here, we report a significant difference in virulence of two common lab strains, CEA10 and AF293, in the murine triamcinolone immunosuppression model of IPA, in which we previously identified severe low oxygen microenvironments surrounding fungal lesions. Therefore, we hypothesize that the ability to thrive within these lesions …

Theme Invites Discussion Of Women's Power, Women's Justice, University Communications

News and Events (Discontinued Series)

No abstract provided.

Determination Of Pathotypes From Indonesian Xanthomonas Oryzae Pv. Oryzae Population Causing Bacterial Leaf Blight And Their Reactions On Differential Rice, Yadi Suryadi, I Made Samudra, Tri Puji Priyatno, Dwi Ningsih Susilowati, Puji Lestari, Fatimah, Trini Suryani Kadir

Makara Journal of Science

The objective of this work was to study the virulence of 15 Xanthomonas oryzae pv. oryzae (Xoo) isolates collected in three provinces in Indonesia (North Sumatra, South Sumatra, and South Sulawesi) based on five Indonesian differential rice genotypes and 10 near isogenic lines (NILs) that have been known to differ in their resistance to bacterial leaf blight (BLB), in a greenhouse assessment. In addition, this study also aims to monitor the responses of 31 rice genotypes (21 NILs, five differentials, five improved cultivars) to BLB disease in a field experiment. The 15 isolates showed different virulence patterns on the NILs’genotypes …

Atomic Ensemble Effects And Non-Covalent Interactions At The Electrode–Electrolyte Interface, Angel Cuesta

Makara Journal of Science

Cyanide-modified Pt(111) electrodes have been recently employed to study atomic ensemble effects in electrocatalysis. This work, which will be briefly reviewed, reveals that the smallest site required for methanol dehydrogenation and formic acid dehydration is composed of three contiguous Pt atoms. By blocking these trigonal sites, the specific adsorption of anions, such as sulfate and phosphate, can be inhibited, thus increasing the rate of oxygen reduction reaction by one order of magnitude or more. Moreover, alkali metal cations affect hydrogen adsorption on cyanide-modified Pt(111). This effect is attributed to the non-covalent interactions at the electrical double layer between specifically adsorbed …

Sister Justina Segale And The New Woman: Tradition And Change In The Progressive Era, M. Christine Anderson Ph.D.

Vincentian Studies

M. Christine Anderson discusses the usefulness of Justina Segale’s journal as a tool to teach undergraduates about women’s changing roles in the early twentieth century. Examples from the journal are cited. Similarities and differences between Segale and the “new woman” are discussed. While women’s entrance into the professions of teaching, nursing, and social work is often held up as a new development of the Progressive era, Catholic women religious had long been trained for these occupations. In her social service and educational capacities, Segale illustrates the complexity of women’s roles in this era. Anderson contrasts Segale’s experience and perspective working …

Ifn-G Induces Histone 3 Lysine 27 Trimethylation In A Small Subset Of Promoters To Stably Silence Gene Expression In Human Macrophages, Yu Qiao, Kyuho Kang, Eugenia Giannopoulou, Celeste Fang, Lionel B. Ivashkiv

Publications and Research

The mechanisms by which IFN-g activates expression of interferon-stimulated genes that have inflammatory and host defense functions are well understood. In contrast, little is known about how IFN-g represses gene expression. By using transcriptomic and epigenomic analysis, we found that stable repression of a small group of genes by IFN-g is associated with recruitment of the histone methyltransferase EZH2 and deposition of the negative mark histone 3 lysine 27 trimethylation (H3K27me3) at their promoters. Repressed genes included MERTK, PPARG, and RANK, which have anti-inflammatory functions and promote osteoclast differentiation. Gene repression and H3K27me3 persisted after IFN-g signaling was terminated, and …

Tackling The Crisis In Phd Supervision Through Group Active-Learning, Carly J. Stevens, Beth F.T. Brockett, Catherine Baxendale, Ali J. Birkett, Caley Brown, Andrew J. Cole, Iain Gould, Hannah Griffiths, Richard Nicholson, Helen Quirk, Isabel Rogers, Tom N. Walker, Susan E. Ward

Teaching and Learning Together in Higher Education

No abstract provided.

Control System Research And Development To Support Virtual Prototyping Of Pump And Motors, Rajith Weerasinghe, Monika Ivantysynova, Paul Kalbfleisch

The Summer Undergraduate Research Fellowship (SURF) Symposium

Virtual prototyping of positive pumps and motors is incredibly useful, increasing speed of development and lowering cost. The calculations of fluids discharge pressure, displaced by a swashplate-type-axial piston pump/motor is dependent on the load impedance driven by the unit. The load impedance is estimated by a variable orifice found downstream of the unit. Similarly, the suction line impedance is also estimated with an orifice. The current project aims to evaluate the various loading architectures in their ability to quickly and accurately create the desired impedance. The robustness of the loading architectures was tested on a wide range of pump sizes, …

Receptor-Type Guanylyl Cyclase At 76c (Gyc76c) Regulates De Novo Lumen Formation During Drosophila Tracheal Development, Monn Monn Myat, Unisha Patel

Publications and Research

Lumen formation and maintenance are important for the development and function of essential organs such as the lung, kidney and vasculature. In the Drosophila embryonic trachea, lumena formde novo to connect the different tracheal branches into an interconnected network of tubes. Here, we identify a novel role for the receptor type guanylyl cyclase at 76C (Gyc76C) in de novo lumen formation in the Drosophila trachea.We show that in embryosmutant for gyc76C or its downsteam effector protein kinase G (PKG) 1, tracheal lumena are disconnected. Dorsal trunk (DT) cells of gyc76C mutant embryos migrate to contact each other and complete the …

Cseas Weekly Bulletin (September 19, 2016), Center For Southeast Asian Studies

CSEAS Bulletin

No abstract provided.

Grand Valley Forum, Volume 041, Number 04, September 19, 2016, Grand Valley State University

2016-2017, Volume 41

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Urban Agriculture As Embedded In The Social And Solidarity Economy Basel: Developing Sustainable Communities, Isidor Wallimann

Program for the Advancement of Research on Conflict and Collaboration

The Social and Solidarity Economy (SSE) is a viable strategy in dealing with some contemporary problems known both in industrial and developing countries. Addressed is how local populations could reach certain objectives and satisfy certain needs using techniques characteristic of SSE and, thus, carve out a social and economic space of their own vis-à-vis anonymous markets, global actors, local and national elites. Illustrated further is this strategy on the example of Urban Agriculture Basel, a unit of the Social Economy Basel. Within this self governed space, it is suggested, a path can be laid for the necessary transition towards local, …

Goldwater Scholarship Winner, Cassidy Colarik

College of Arts and Sciences Newsroom

University of Dayton senior Raphael Crum has been named a 2016 Barry Goldwater Scholar, marking the second year in a row that a University student was awarded a scholarship from the federally endowed Barry Goldwater Scholarship and Excellence in Education Foundation.

Hyperplanes That Intersect Each Ray Of A Cone Once And A Banach Space Counterexample, Chris Mccarthy

Publications and Research

Suppose � is a cone contained in real vector space �. When does � contain a hyperplane � that intersects each of the 0-rays in �\{0} exactly once? We build on results found in Aliprantis, Tourky, and Klee Jr.’s work to give a partial answer to this question.We also present an example of a salient, closed Banach space cone � for which there does not exist a hyperplane that intersects each 0-ray in � \ {0} exactly once.

The Statesman, V. 60, I. 04, Stony Brook University

Stony Brook Statesman-Sucolian

v. 60;i. 04

Collecting Quality Infrared Spectra From Microscopic Samples Of Suspicious Powders In A Sealed Cell, Brooke Weinger Kammrath, Pauline E. Leary, John A. Reffner

Forensic Science Publications

The infrared (IR) microspectroscopical analysis of samples within a sealed-cell containing barium fluoride is a critical need when identifying toxic agents or suspicious powders of unidentified composition. The dispersive nature of barium fluoride is well understood and experimental conditions can be easily adjusted during reflection–absorption measurements to account for differences in focus between the visible and IR regions of the spectrum. In most instances, the ability to collect a viable spectrum is possible when using the sealed cell regardless of whether visible or IR focus is optimized. However, when IR focus is optimized, it is possible to collect useful data …