Digital Commons Network^™

Developing High-Content Screening To Assay Trans-Epithelial Transport Of Complex Proteins, Reid Allan Martin

Student Theses and Dissertations

Therapeutic proteins are becoming one of the fastest growing classes of drugs on the market. These large biologically-synthesized macromolecules are typically administered intravenously and are dependent upon cellular receptors and other active uptake mechanisms for delivery into tissues and cells. There is significant interest in developing cell-based assays to assess kinetics and mechanisms of endocytosis and transcytosis of large therapeutic proteins across various cell layers. The goal of this research was to develop a transwell “disease tissue on a chip” model to compare rates and efficiencies of different delivery systems for moving bioactive lysosomal enzymes across a human epithelial cell …

Integrated Vectorcardiogram System And Method Of Use, Richard D. Gitlin, Gabriel E. Arrobo, Peter J. Fabri, Thomas P. Ketterl, Calvin Perumalla

USF Patents

An integrated vectorcardiogram (VCG) device having 3 pairs of electrodes placed in three orthogonal directions with the capability to continuously measure the electrical activity of the heart. All of the electrode pairs may be contained within a single miniaturized housing thereby eliminating the need for cumbersome wires required with current 12-lead ECG systems, while providing the same amount and quality of information as the 12-lead ECG system. The integrated VCG device also includes a communications function to allow the data collected by the electrodes to be transmitted wirelessly to a remote device, such as a pacemaker, to control its function …

The Sun Star Vol 36 No 5 (September 27th, 2016), N/A N/A

Sun Star

No abstract provided.

Executive Committee - Agenda 9/27/2016, Academic Senate

Academic Senate Agendas

No abstract provided.

Characterization Of Chemical Profiles Produced By Opuntia Humifusa In Response To Herbivory And Exogenous Methyl Jasmonate In Comparison To Hairy Root Cultures, John Milton Kilmer

Student Theses and Dissertations

The South American Cactus Moth, Cactoblastis cactorum (Berg), an invasive insect herbivore, has similar feeding habits and life history as a native Florida cactus moth, Melitara prodenialis Walker; however, regional Opuntia species only defend against M. prodenialis. Extracts of C. cactorum host plants and M. prodenialis host plants were compared to methyl jasmonate (MeJA)-treated Opuntia humifusa and MeJA-treated O. humifusa hairy root cultures using high performance thin layer chromatography. MeJA and C. cactorum treatments led to a reduction in tissue concentrations of terpenoid or phenolic compounds; however, significant increases in seven putative terpenoid compounds were observed in hairy root culture …

The Bg News September 27, 2016, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 27, 2016. Volume 96-Issue 12.

Mirna-145 Increases Therapeutic Sensibility To Gemcitabine Treatment Of Pancreatic Adenocarcinoma Cells., Yong Lin, Xin Ge, Yiyang Wen, Zhu-Mei Shi, Qiu-Dan Chen, Min Wang, Ling-Zhi Liu, Bing-Hua Jiang, Yuan Lu

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Pancreatic adenocarcinoma is one of the most leading causes of cancer-related deaths worldwide. Although recent advances provide various treatment options, pancreatic adenocarcinoma has poor prognosis due to its late diagnosis and ineffective therapeutic multimodality. Gemcitabine is the effective first-line drug in pancreatic adenocarcinoma treatment. However, gemcitabine chemoresistance of pancreatic adenocarcinoma cells has been a major obstacle for limiting its treatment effect. Our study found that p70S6K1 plays an important role in gemcitabine chemoresistence. MiR-145 is a tumor suppressor which directly targets p70S6K1 for inhibiting its expression in pancreatic adenocarcinoma, providing new therapeutic scheme. Our findings revealed a new mechanism underlying …

Dissection Of Molecular Assembly Dynamics By Tracking Orientation And Position Of Single Molecules In Live Cells, Shalin B. Mehta, Molly Mcquilken, Patrick J. La Riviere, Patricia Occhipinti, Amitabh Verma, Rudolf Oldenbourg, Amy Gladfelter, Tomomi Tani

Dartmouth Scholarship

Regulation of order, such as orientation and conformation, drives the function of most molecular assemblies in living cells but remains difficult to measure accurately through space and time. We built an instantaneous fluorescence polarization microscope, which simultaneously images position and orientation of fluorophores in living cells with single-molecule sensitivity and a time resolution of 100 ms. We developed image acquisition and analysis methods to track single particles that interact with higher-order assemblies of molecules. We tracked the fluctuations in position and orientation of molecules from the level of an ensemble of fluorophores down to single fluorophores. We tested our system …

The Eastern Echo, September 27, 2016, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Book Reviewed By Ezekiel Joubert Iii: Lam, K. D. (2015). Youth Gangs, Racism, And Schooling: Vietnamese American Youth In A Postcolonial Context. New York, Ny: Springer. 179 Pp. $47.45 (Hardcover). Isbn: 978-1-137-47558-9., Ezekiel Joubert Iii

Journal of Southeast Asian American Education and Advancement

Book Reviewed by Ezekiel Joubert III: Lam, K. D. (2015). Youth Gangs, Racism, and Schooling: Vietnamese American Youth in a Postcolonial Context. New York, NY: Springer

Phoenix, 2016-09-26, Student Life

Phoenix

The Phoenix is a student newspaper published at Governors State University since August 2002. The newspaper features student reporting, opinions, news, and photos.

The Statesman, V. 60, I. 05, Stony Brook University

Stony Brook Statesman-Sucolian

v. 60;i. 05

Maurice Didon V. Alicia Castillo

2016 Decisions

USDC for the Middle District of Pennsylvania

Curricular Affairs Committee Minutes September 26, 2016, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

2016 September 26 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Gec Meeting Minutes For Sept, 26, 2016, General Education Committee

General Education Committee Minutes

No abstract provided.

Are Researchers Registering Systematic Reviews In Clinicaltrials.Gov?, Gary E. Kaplan, Ms, Ahip

Academic Commons and Scott Memorial Library Staff Papers and Presentations

BACKGROUND:

ClinicalTrials.gov (CT) is an increasingly important resource for systematic reviewers attempting to identify published and unpublished clinical studies. In addition to clinical studies, however, some searches of the CT database also return systematic reviews (SRs). When I inquired about the SRs appearing in the results, the NLM Help Desk responded that “We do not recommend that systematic reviews be entered in ClinicalTrials.gov, since we only want the results of a clinical trial entered once. However, we will not refuse them if they are entered.” I wanted to find out how many SRs are included, describe their characteristics, and suggest …

Week Of September 26, 2016, New York Medical College

InTouch

• 2015 NYMC Faculty Authors Lauded
• NYMC Lights It Up Gold
• NYMC Student Clubs Reach Record High
• SHSP Student Lands Competitive Summer Internship

Daily Eastern News: September 26, 2016, Eastern Illinois University

September

No abstract provided.

Cerebellar Neuropathology Influences Cerebellar-Prefrontal Cortex Pathways: A Comprehensive Approach As Relevant To Autism Spectrum Disorders, Eric Mckimm

Electronic Theses and Dissertations Archive

The cognitive and social dexterity of humans is attributed to the neocortex, an area of the brain well accepted to elevate us beyond the mental processing of all other species. The cognitive ability of the cerebellum however, remains one of the most misunderstood. Autism spectrum disorders (ASDs), with a prevalence of 1 in 68 children, lack clear empirical explanations for abnormal neuropathology and potential neuronal disconnections influenced by the cerebellum. The current evaluation takes a comprehensive look at how the cerebellum, pre-frontal cortex, and basal ganglia are interconnected and influenced by each other as relevant to ASDs. With a better …

Grand Valley Forum, Volume 041, Number 05, September 26, 2016, Grand Valley State University

2016-2017, Volume 41

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Crow's Nest, September 26, 2016, Crow's Nest Staff

Crow's Nest

The September 26, 2016, issue of the Crow's Nest.

My News

My News (2014-2020)

• Fourth Annual GreenFest Set for Oct. 1
• Nursing Faculty Awarded Grant Through NAPNAP Foundation
• Biology Professor Receives $280,798 NSF Grant
• The Drifters Set to Appear Oct. 2
• Georgia Southern Student­Athletes Support Flood Relief

Faculty In The News: September 26, 2016, University Of Dayton

College of Arts and Sciences Newsroom

Julius Amin discusses America's ignorance about Africa in a contribution to "The Conversation," and other highlights of recent media coverage of College of Arts and Sciences faculty research, scholarship and commentary.

Faculty Senate Meeting Minutes, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

The Free Press Vol. 48, Issue No. 4, 09-26-2016, Krysteana Scribner

Free Press, The

Social media and convoluted social discussions -- New administration brings back four retrenched faculty -- Resident assistants help foster community in dorms -- Students voice concerns over upcoming election

Hyperspectral Reflectance Signature Protocol For Predicting Subsurface Bottom Reflectance In Water: In-Situ And Analytical Methods, Charles R. Bostater, Tyler A. Rotkiske, Taylor Scott Oney

Ocean Engineering and Marine Sciences Faculty Publications

In-situ measurement of bottom reflectance signatures and bottom features in water are used to test an analytical based irradiance model protocol. Comparisons between predicted and measured bottom reflectance signatures are obtained using measured hyperspectral remote sensing reflectance signatures, water depth and water column constituent concentrations. Analytical solutions and algorithms are used to generate synthetic signatures of different bottom types. The analytical methodology used to simulated bottom reflectance contains offset and bias that can be corrected using spectral window based corrections. Example results are demonstrated for application to coral species, submerged aquatic vegetation and a sand bottom type. Spectral windows are …

Platforms For Hyperspectral Imaging, In-Situ Optical And Acoustical Imaging In Urbanized Regions, Charles R. Bostater, Taylor Scott Oney

Ocean Engineering and Marine Sciences Faculty Publications

Hyperspectral measurements of the water surface of urban coastal waters are presented. Oblique bidirectional reflectance factor imagery was acquired made in a turbid coastal sub estuary of the Indian River Lagoon, Florida and along coastal surf zone waters of the nearby Atlantic Ocean. Imagery was also collected using a pushbroom hyperspectral imager mounted on a fixed platform with a calibrated circular mechatronic rotation stage. Oblique imagery of the shoreline and subsurface features clearly shows subsurface bottom features and rip current features within the surf zone water column. In-situ hyperspectral optical signatures were acquired from a vessel as a function of …

Fhf-Independent Conduction Of Action Potentials Along The Leak-Resistant Cerebellar Granule Cell Axon, Katarzyna Dover, Christopher Marra, Sergio Solinas, Marko Popovic, Sathyaa Subramaniyam, Dejan Zecevic, Egidio D'Angelo, Mitchell Goldfarb

Publications and Research

Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell’s unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Nav)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Nav inactivation, distal axonal Navs show little FHF association or FHF requirement for high-frequency transmission, velocity and waveforms of conducting action potentials. In addition, leak conductance density along the distal axon is estimated as o1% that of somatodendritic membrane. The faster …

The Rider (2016-09-26), Jesus Sanchez

The Rider Archives

Vol.2 No.5