Digital Commons Network^™

Does Ivabradine Improve Quality Of Life In Cardiovascular Disease Patients?, Daniel E. Lynch

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this review is to determine whether ivabradine therapy can improve the quality of life in cardiovascular disease patients.

Study Design: The studies included in this review are one randomized control study and two double blind randomized control studies from 2008, 2010, and 2012.

Data Source: The three studies in this review were obtained by performing a PubMed search using the keywords “ivabradine” and random control trial.” All articles were published in English and in peer-reviewed journals.

Outcomes Measured: The three studies ascertained whether there was a decrease in hospitalization events within coronary artery disease and heart …

Is Dance/Movement Therapy An Effective Treatment For Depression In Students?, Jillian R. Ranker

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence-based medicine (EBM) review is to determine whether or not Dance/Movement Therapy (DMT) is an effective treatment for depression in students.

STUDY DESIGN: Systematic review of three published, randomized controlled trials (RCTs) between 2005 and 2013, all English language

DATA SOURCES: Three RCTs analyzing DMT use in depression were found using PudMed

OUTCOMES MEASURED: Decrease in depressive symptoms, measured by the Beck Depression Scale, a self-rated health questionnaire, and Symptom Check List-90-Revision (SCL- 90-R)

RESULTS: DMT resulted in lessened depressive symptoms for students in all three RCTs. Jeong et al. observed a significant decrease …

Actuarial Review Of The Tenncare Program, Development Of State Fiscal Year 2016 Per Member Costs, Tennessee. Division Of Tenncare.

TennCare Actuarial Report

No abstract provided.

Office Of Criminal Justice Programs Annual Report 2014-2015, Tennessee. Department Finance & Administration.

Office of Criminal Justice Programs

No abstract provided.

Corn Stover's Feasibility As A Biomass Feedstock Utilizing The "Reach" Process, Oskar James Kane

Open Access Theses

Kane, Oskar J. S. MS, Purdue University, December 2016. Corn Stover’s Feasibility as a Biomass Feedstock Utilizing the “REACH” Process. Major Professor: Dr. Gozdem Kilaz.

Journal Of Hip Hop Studies

Journal of Hip Hop Studies

No abstract provided.

About Gods, I Don't Believe In None Of That Shit, The Facts Are Backwards: Slaughterhouse's Lyrical Atheism, Marquis Bey

Journal of Hip Hop Studies

Hip Hop group Slaughterhouse's multi-membered, perversely holy quadrinity provides a fertile site for a pseudo-non-theological theological reading-a theology with and without god, that is, with god's titular presence but bereft of any ethos of a mover and shaker god. God, in my reading of Slaughterhouse's lyrics, is impotent. Rather than the Word, Slaughterhouse publishes sacred texts (albums and mixtapes) that speak to Black embodied life; their albums are the scriptural holy ghetto-Word, the Gospels that of Royce, Crooked, Joell, and Joey, rather than Matthew, Mark, Luke, and John. Through the lyrics of Slaughterhouse's songs, they craft a god that is …

Representations And Discourses Of Black Motherhood In Hip Hop And R&B Over Time, Cassandra Chaney, Arielle Brown

Journal of Hip Hop Studies

This study will examine how representations and discourses regarding Black motherhood have changed in the Hip Hop and R&B genres over time. Specifically, this scholarly work will contextualize the lyrics of 79 songs (57 Hip Hop songs; 18 R&B songs; 2 songs represented the Hip Hop and R&B genre; 2 songs represented artists who produce music in 5 or 6 genres) from 1961-2015 to identify the ways that Black male and Black female artists described motherhood. Through the use of Black Feminist Theory, and by placing the production of these songs within a sociohistorical context, we provide an in-depth qualitative …

Development Of The Neuron Assessment For Measuring Biology Students’ Use Of Experimental Design Concepts And Representations, Annwesa P. Dasgupta, Trevor R. Anderson, Nancy J. Pelaez

PIBERG Publications

Researchers, instructors, and funding bodies in biology education are unanimous about the importance of developing students’ competence in experimental design. Despite this, only limited measures are available for assessing such competence development, especially in the areas of molecular and cellular biology. Also, existing assessments do not measure how well students use standard symbolism to visualize biological experiments. We propose an assessment-design process that 1) provides background knowledge and questions for developers of new “experimentation assessments,” 2) elicits practices of representing experiments with conventional symbol systems, 3) determines how well the assessment reveals expert knowledge, and 4) determines how well the …

Accurate Classification Of Rna Structures Using Topological Fingerprints, Jiajie Huang, Kejie Li, Michael Gribskov

Department of Biological Sciences Faculty Publications

While RNAs are well known to possess complex structures, functionally similar RNAs often have little sequence similarity. While the exact size and spacing of base-paired regions vary, functionally similar RNAs have pronounced similarity in the arrangement, or topology, of base-paired stems. Furthermore, predicted RNA structures often lack pseudoknots (a crucial aspect of biological activity), and are only partially correct, or incomplete. A topological approach addresses all of these difficulties. In this work we describe each RNA structure as a graph that can be converted to a topological spectrum (RNA fingerprint). The set of subgraphs in an RNA structure, its RNA …

The Prevalence And Impact Of Chronic Pain In Baccalaureate Nursing Students, Kathleen M. Davis, Julia E. Schwarz

Williams Honors College, Honors Research Projects

Chronic pain is a problem because it can have a large impact on activities of daily life of people, regardless of age. Few researchers have described the prevalence and impact of chronic pain in young adults, while even fewer have done so in the United States. The purpose of this study is to determine the prevalence of chronic pain and the impact it has on daily life for undergraduate nursing students. The theoretical framework is guided on the biopsychosocial model of chronic pain. This cross-sectional, descriptive study uses convenience sampling and data collected through an online Qualtrics survey, which was …

The Effect Of Drying On The Release Of Small Hydrophilic Molecular Drugs From Polyelectrolyte Complex Beads, Dounsavanh Letdara

Williams Honors College, Honors Research Projects

The effects of bead composition and dryness on the release rate of small molecules, like a drug or dye, from polyelectrolyte complex (PEC) beads were studied. Release studies were performed on dried and not dried beads prepared using different PEC to drug ratios. The beads were dried for two hours, which allowed them to reach a constant weight. The beads were loaded with a dye, so their release could be detected through the visible light regime. A plate reader was used to determine the absorbance of a sample, and then the amount of dye released was determined. The data presented …

Microbiologically Influenced Corrosion: Rhamnolipid Effects, Andrea M. Wildroudt

Williams Honors College, Honors Research Projects

The purpose of this experiment was to identify if a rhamnolipid could inhibit the growth of a biofilm on carbon steel coupons and result in less corrosion activity. This type of research impacts various industries (with one of the largest being the oil and gas industry). Multiple systems with varying concentrations of the rhamnolipid were created to determine, if any, the optimum concentration to inhibit biofilm growth. The systems were created and exposed to optimum physio-chemical environments to promote SRB induced corrosion. Coupons were immersed for 28 days. Seven systems were created with varying rhamnolipid concentrations; to ensure accurate results, …

Calcium Alginate Microbead Production Via An Air Assisted Shearing Process, Ryan Loftus

Williams Honors College, Honors Research Projects

The purpose of this project was to model the size of calcium alginate microbeads produced by extruding a solution of 1.5 wt.% alginate from a syringe and needle with air shear generated from a pneumatic line flowing in an annular tube around the extrusion needle. The air shear would create microdroplets that would fall into a solution of 2 wt.% calcium chloride in water, crosslinking the droplets into beads. These microbeads can be used in drug dispersion applications or in encapsulation of cells throughout the body due to their biocompatibility. The goal was to create uniform beads that ranged from …

Protein Sequence-Structure-Function Relationship: Testing Ke-50 Modification On Recombinant Green Fluorescent Protein (Acgfp), Anna E. Burkey

Williams Honors College, Honors Research Projects

Protein modification shows promise for improving the effectiveness of protein therapy, including the use of Interferon-beta-1b for the treatment of multiple sclerosis. The addition of a chain of 50 lysine and glutamic acid residues (also called a KE50 modification) was tested on green fluorescent protein (AcGFP) to determine its effect on the bioactivity of the protein. Standard transformation protocol was used to grow the normal and modified proteins in E.Coli, and the bioactivity of the protein was measured using quantum yield and extinction coefficients to determine the reduction in brightness from the native form to the modified form. The …

Professional Values In Baccalaureate Nursing Students, Hope E. Caldwell, Katie L. Miller

Williams Honors College, Honors Research Projects

Professional nursing values that affect patient safety and outcomes are important to the hospitals and facilities that hire nurses. Therefore, it is reasonable to be concerned with the consistency of professional value development within nursing education. The aim of this study was to determine level differences of professional nursing values in pre-nursing, sophomore, junior, and senior baccalaureate nursing students and examine the relationship between professional values and other demographics in the students. Benner’s novice-to-expert model served as a framework for this study. With this in mind, nursing values were evaluated with the 26-item Nurses Professional Values Scale-Revised. A non-experimental cross-sectional …

Exploring Speech And Language Skills In Gifted Children: A Parent Perspective, Amanda Brewer

Williams Honors College, Honors Research Projects

The purpose of this research study was to examine the speech and language skills of gifted students, and to further look into gifted students who have previously had speech or language therapy. Information pertaining to gifted children, typical speech and language development, and gifted children who have a delay in speech was evaluated. The information was used to develop a survey instrument that asked parents about their gifted child’s speech and language. The overall results of this study confirmed many previously known characteristics of gifted students. It also showed that expressive language skills were less developed than receptive language skills. …

The Synthesis Of Poly(Propylene Fumarate), Brian N. Fitch

Williams Honors College, Honors Research Projects

Poly(propylene fumarate) is a promising material in the field of bone tissue engineering. A recently described chain growth polymerization was developed for the synthesis of poly(propylene fumarate). This pathway uses the ring-opening polymerization of maleic anhydride and propylene oxide with magnesium ethoxide as an initiator to yield poly(propylene maleate). The poly(propylene maleate) was then isomerized to poly(propylene fumarate) using diethyl amine. In order to scale up the reaction to a 20L reactor, several optimizations of the purification schemes was required. The main optimizations were done to the purification of poly(propylene maleate). Several methods were tested including replacing the water washes …

Modulation Of Body Weight By Intestinal Flora In Orphan Nuclear Receptor Shp-/- Mice, Ryan Mifflin

Williams Honors College, Honors Research Projects

The whole-body deletion of small heterodimer partner (SHP) in mice is associated with protection from diet-induced obesity and hepatic steatosis upon feeding of a western diet. This protection was reported to be mediated through decreases in hepatic gene expression for lipogenesis, as well as increases in gene expression for fatty acid oxidation. SHP has been known to regulate the expression of the CYP7A1 gene, encoding the rate-limiting enzyme for bile acid synthesis, thereby altering the bile acid pool. The effects of this altered bile acid profile on the gut microbiome are unknown, as some bacteria in the gut are responsible …

A Comparison Of The Effectiveness Of Two Educational Interventions Developed To Teach Early Infant Hunger Cues To Junior Level Nursing Students., Melissa D. Gainer

Williams Honors College, Honors Research Projects

Due to multiple learning styles, it can be difficult to teach to large groups of students. The purpose of this study is to compare the effectiveness of two different educational interventions designed to teach infant hunger cues to undergraduate nursing students to increase the knowledge and confidence levels needed for the future teaching of infant hunger cues to new parents. Flemings VARK theory was used to guide this quasi-experimental study. A pretest posttest two-group design was used to evaluate both knowledge and confidence levels in the participants (N= 86). Data was analyzed utilizing a paired t-test. The results noted significant …

Cell Viability, Cytoskeleton Organization And Cytokines Secretion Of Raw 264.7 Macrophages Exposed To Gram-Negative Bacterial Components, Ali Awadh Alshehri

Browse all Theses and Dissertations

Macrophages play an important role in innate immunity by controlling cellular responses. In this study, the effects of gram-negative bacterial components (Flagellin, lipoprotein, lipopolysaccharides (LPS), outer membrane proteins-A (OMP-A) and peptidoglycan) were determined on cell viability, morphology, cytoskeletal filament and cytokines secretion of murine RAW 264.7 macrophages at 24 hours. The effect of LPS, flagellin and peptidoglycan from gram negative bacteria on viability murine RAW 264.7 macrophages were evaluated using different concentrations (1, 5 and 10 µg/ml). Cells stimulated with LPS displayed ~ 2-fold decrease (P=0.001) in cell viability compared to control cells at 24 hours whereas cells stimulated with …

De-Anonymization Attack Anatomy And Analysis Of Ohio Nursing Workforce Data Anonymization, Jacob M. Miracle

Browse all Theses and Dissertations

Data generalization (anonymization) is a widely misunderstood technique for preserving individual privacy in non-interactive data publishing. Easily avoidable anonymization failures are still occurring 14 years after the discovery of basic techniques to protect against them. Identities of individuals in anonymized datasets are at risk of being disclosed by cyber attackers who exploit these failures. To demonstrate the importance of proper data anonymization we present three perspectives on data anonymization. First, we examine several de-anonymization attacks to formalize the anatomy used to conduct attacks on anonymous data. Second, we examine the vulnerabilities of an anonymous nursing workforce survey to convey how …

Translocation And Phosphorylation Of Ampa Receptors Following Transcranial Direct Current Stimulation In Vivo, Justin Andrew Stafford

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Transcranial direct current stimulation (tDCS) is the current technique used clinically to attenuate the effects of various neurological related deficits and augment functions such as memory and learning. The cellular and molecular mechanisms behind tDCS remain largely unknown and this study provides some of the first insights into the mechanisms behind tDCS. Direct current stimulation has been used to increase levels of long term potentiation (LTP) ex vivo suggesting that this stimulation has an effect on the LTP mechanisms of action. Subcellular protein extraction and fractionation methods were used to isolate synaptoneurosomes from various brain regions to assess the effects …

The Expression Of Dopamine-Related Genes And Behavioral Performance In Mice, Victoria Lynne Dershem

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While the neurotransmitter dopamine has been well-studied for its role in mood regulation and activation of the intrinsic reward pathway, several psychiatric disorders linked to dopamine are also known to cause memory impairment, a phenomenon which has attracted much less attention. In the current study, whole-transcriptome RNA sequencing was performed, and transcript levels of several dopamine-related genes were compared to results of behavioral assays designed to test spatial and emotional memory, as well as anxiety. The results suggest a positive relationship between expression level of Nurr1, a nuclear receptor known to initiate transcription of genes necessary for dopaminergic signaling, …

The Effect Of Green Structures On Hydrology In Urban Areas Of Akron, Ohio, Brooke Hayes, Brian Long

Williams Honors College, Honors Research Projects

Stormwater runoff is a major environmental concern in dense urban areas. Runoff in these areas contributes to flooding as well as water quality problems in the streams, lakes, and reservoirs downstream. The Cuyahoga River is the receiving waterbody for the City of Akron’s stormwater runoff. Currently, combined sewer overflow (CSO) from the city's outdated sewer system is the overriding reason for poor water quality in the Cuyahoga River.

Implementation of green infrastructure is one way to mitigate problems associated with stormwater runoff from urban areas. In this study, hydrologic modeling of the Little Cuyahoga watershed was conducted to determine how …

Assessing The Effectiveness Of The New Senior Ed Program At Summa Akron City Hospital, Ahmed F. Ozgur

Williams Honors College, Honors Research Projects

Objectives: To compare the outcomes of patients seen during a pilot Senior Emergency Department (ED) program to a historical cohort of geriatric patients receiving usual ED care.

Methods: We performed a retrospective cohort analysis of quality assurance data obtained to evaluate the implementation of a pilot Senior ED program at a 78,000 visit hospital ED. The historical cohort covered 1/23/2012 to 12/31/2012. The pilot Senior ED program was implemented from 1/1/2013 to 12/31/2013. Patients 65 years and older arriving between 8:30 am and 8:30 pm were triaged to a 15 bed Senior ED. Interventions included assessment by a nurse transitional …

Criminogenic Of The Older Adult With Addiction: Case Study, Maria A. Dixon

Williams Honors College, Honors Research Projects

Throughout history of America’s criminal justice system as it relates to drug use has been utilize as a reactive solution to crime and addiction. In current times, this framework has become ineffective in addressing the criminogenic of the older adult with substance abuse. There needs to be alternatives to the incarceration of this population. The implication for social work is advocacy for policy change, and alternative programs.

Investigation Of Exoribonuclease-1 Function In Regulation Of Stem Cells During Planarian Regeneration, Steven Gobinsing Sayson

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Precise regulation of gene expression is crucial for the maintenance of pluripotency and proper differentiation of stem cells. Due to their exceptional capacity for stem cell-driven regeneration, planarians are ideal models to dissect mechanisms regulating gene expression that secure stem cell function in vivo. While mechanisms of transcriptional regulation of gene expression in stem cells have been extensively investigated, less is known about regulation at the post-transcriptional level. Exoribonuclease-1 (XRN-1) is a conserved enzyme in eukaryotes that catalyzes 5' to 3' exonucleolytic degradation of RNA. XRN-1 is known to be required for proper regeneration of Dugesia japonica. Here, I …

Development And Validation Of Virus And Ebola Misconceptions Assessment (Viremia): Ebola Virus Misconceptions In College Students, Michele Miller

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In this study an assessment (VirEMiA) on college students' knowledge and misconceptions of the Ebola virus was created and validated. VirEMiA was then used to determine what misconceptions college students have about Ebola, if there is a difference in misconceptions between students with and without a strong science background, and if Just-in-Time Teaching (JiTT) increases students' knowledge of Ebola and decreases their misconceptions. VirEMiA was shown to be a valid and reliable assessment whether confidence was integrated (seprel=0.97) or not (seprel=0.98), and for measuring misconceptions (seprel=0.97). If psychology and nursing majors were considered to have a strong background in science, …

A Stochastic Petri Net Based Nlu Scheme For Technical Documents Understanding, Adamantia Psarologou

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Natural Language Understanding (NLU) is a very old research field, which deals with machine reading comprehension. Despite the many years of work and the numerous accomplishments by several researchers in the field, there is still place for significant improvements. Here, our goal is to develop a novel NLU methodology for detecting and extracting event/action associations in technical documents. In order to achieve this goal we present a synergy of methods (Kernel extraction, Formal Language Modeling, Stochastic Petri-nets (SPN) mapping and Event Representation via SPN graph synthesis). In particular, the basic meaning of a natural language sentence is given by its …