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Tumor-Specific Cell Death Induction By Noxa Overexpression For Head And Neck Squamous Cell Carcinoma (Hnscc) Treatment, Nicolas T. Maxim Mr.

Theses and Dissertations

The primary focus of this research is the mechanisms of cell death in head and neck squamous cell carcinoma (HNSCC) treatment. These cancers typically originate in squamous cells that line the moist mucosal surfaces of head and neck. HNSCC is commonly treated with a platinum based agent, cisplatin. While the drug does offer strong antitumor effects, its prolonged use often results in tumor-acquired resistance, which limits treatment effectiveness. We have shown that cisplatin treatment induces the expression of a pro-apoptotic BCL-2 family member Noxa, which then initiates caspase- dependent apoptosis through its binding and sequestration of pro-survival protein MCL-1 for …

If She Isn’T Working Miracles, What Is She Doing On The Battlefield?, Alex Matzke

Theses and Dissertations

The images included in my thesis work reflect my experience growing up with military propaganda—pictures of cheerful white women in pearls as part of my rural middle American landscape. I do not name the oppressor because I am not here to pick at the thorns, but to get to the root of the oppression. These are some of the servicewomen I’ve met. Their stories parallel but cannot encompass the private experiences of all service women. I am grateful for their generosity; without them there would be no pictures.

The battle for equality is much older than Rosie the Riveter but …

Roles Of Planar Cell Polarity Proteins In Copa Axon Pathfinding, Ashley Morgan Purdy

Theses and Dissertations

In zebrafish, CoPA (Commissural Primary Ascending) is the first among ascending commissural axons to pathfind anteriorly and form the spinal commissure. One pathway that guides their anterior growth is the planar cell polarity (PCP) signaling pathway, but it is not fully known how PCP signaling regulates anterior guidance. We examined CoPA pathfinding in various PCP mutants to determine if anterior-posterior (A-P) guidance of CoPAs is dependent on PCP signaling. We found that certain PCP mutants exhibited anterior pathfinding defects, with approximately half of all affected CoPAs migrating incorrectly posteriorly. By using a translation-blocking DCC (Deleted in …

Pharmacological Inhibition Of Cyclophilin Ameliorates Experimental Allergic Encephalomyelitis, Zi L. Huang

Theses and Dissertations

A subset of cyclophilins have been implicated in mechanisms of neuroinflammation and neurodegeneration that contributes to the pathogenesis of Multiple Sclerosis. Mitochondrial dysfunction leading to mitochondrial permeability transition plays a pivotal role in axonal damage and disease progression in Multiple Sclerosis. Cyclophilin D (CypD) is a crucial regulatory component of the mitochondrial permeability transition pore and it was demonstrated that the cyclophilin D knockout animals showed reduced experimental allergic encephalomyelitis (EAE) clinical disease severity and axonal injury. We investigated the effect of N-methyl-4-isoleucine-cyclosporin (NIM811), a non-immunosuppressive and non-selective cyclophilin inhibitor, on the course and severity of EAE. EAE mice treated …

Reciprocity As A Species Of Fairness: Completing Malinowski’S Theory Of Law, James M. Donovan

Law Faculty Books and Chapters

The present essay seeks to recast Malinowski’s arguments grounding law in the social phenomena of reciprocity in light of current information. Reciprocity is argued to be a higher order construct built out of more basic influences, the most relevant of which are the inherent fairness evaluations humans perform in contexts of distributive justice. Deconstructing Malinowski’s claims into these elemental components preserves the original insight that explains the civil law in terms of social reciprocity. More importantly, this analysis generates a description for the criminal law in these same terms, something Malinowski himself was unable to achieve. The outcome realizes his …

When It Comes To Parents, Three's No Longer A Crowd: California's Answer To In Re M.C., Jason De Jesus

Loyola of Los Angeles Law Review

The California Legislature recently amended the California Family Code by granting courts the authority and discretion to find that a child can have more than two parents. This Article addresses the issues raised by this amendment, focusing on the rare instances in which rejecting a third parent's claim for custody would be detrimental to the child. By exploring public perceptions of multiple parentage and assessing recent cases highlighting the discretion courts use to find that a child has more than two parents, this Article concludes that recognizing that a child has more than two parents can protect not only the …

Is Textualism Required By Constitutional Separation Of Powers?, Ofer Raban

Loyola of Los Angeles Law Review

This article examines the often-heard claim that textualism in statutory interpretation is mandated by constitutional separation of powers. The claim is examined using both the formalist and the functionalist approaches to separation of powers doctrine under the Federal Constitution. As we shall see, these doctrinal inquiries quickly devolve into examinations of the purposes and justification of textualism, and of separating the three branches of government. The article concludes not only that standing constitutional doctrine fails to support the textualist claim, but also that, as a matter of fact, textualism is a judicial philosophy that runs counter to the most basic …

Real World Superpowers: How Super Athletes Come To Be, Tara Santora

The Synapse: Intercollegiate science magazine

No abstract provided.

Copley Library Annual Report 2015-2016, Helen K. And James S. Copley Library, University Of San Diego

Copley Library Annual Reports

2015-2016: A Year of Collaborations, Partnerships, and Services; Holleman Foundation Grant to Support Collections; Copley Library 2016-2020 Strategic Plan; Library Open Education Resources Initiative; Inaugural Roy and Marian Holleman Copley Library Student Assistant Scholarship; Reference Services Update; Satelite Libraries at the University of San Diego; Bayside Community Center; Barrio Logan/Logan Heights Connection; Exhibit Spaces at Copley Library; Patrons’ Voices; Third Annual Digital Initiatives Symposium; Copley Website Redesign; Digital@USanDiego; Campus Engagement — Copley Library Spring 2016 Salon Celebrates Library Resources; Library Committee; Student Assistants 2015-2016; Celebrating Faculty and Staff; 2015-2016 Faculty Presentations and Publications; Copley Library Stats and Expenditures; Giving to …

Nsu College Of Optometry The Visionary - Fall 2016, Nova Southeastern University

Visionary

No abstract provided.

The Myths Of Data Exclusivity, Erika Lietzan

Faculty Publications

This article contributes to an ongoing academic and public policy dialogue over whether and on what terms U.S. law should provide “data exclusivity” for new medicines. Five years after a new drug has been approved on the basis of an extensive application that may have cost more than one billion dollars to generate, federal law permits submission of a much smaller application to market a duplicate version of the drug. This second application is a different type of application, and it may cost no more than a few million dollars to prepare. A similar sequence is true for biological medicines: …

Unm Hsc Annual Education Day Agenda 2016, Office For Medical Educator Development

HSC Education Days

No abstract provided.

Seasonal Differences In Density But Similar Competitive Impact Of Aedes Albopictus (Skuse) On Aedes Aegypti (L.) In Rio De Janeiro, Brazil, Daniel Cardoso Portela Camara, Claudia Torres Codeço, Steven A. Juliano, Philip Lounibos, Thais Irene Souza Riback, Glaucio Rocha Pereira, Nildimar Alves Honorio

Faculty Publications – Biological Sciences

Previous studies have shown that the negative effects of density of Ae. albopictus on Ae. aegypti exceed those of Ae. aegypti on Ae. albopictus for population growth, adult size, survivorship, and developmental rate. This competitive superiority has been invoked to explain the displacement of Ae. aegypti by Ae. albopictus in the southeastern USA. In Brazil, these species coexist in many vegetated suburban and rural areas. We investigated a related, but less-well-studied question: do effects of Ae. albopictus on Ae. aegypti larval development and survival occur under field conditions at realistic densities across …

The Law Of 180-Day Exclusivity, Erika Lietzan, Julia Post

Faculty Publications

In 1984, Congress created a statutory pathway for approval of generic drug applications and included an incentive for generic applicants to challenge the patents claiming the reference drugs on which they based their applications. The first generic applicant to file an ANDA with a patent challenge is eligible for 180 days of generic market exclusivity. This article is the fourth in a series of articles describing the resulting body of law, as interpreted and applied by FDA (in regulations, guidances, citizen petition responses, and individual decisions awarding and denying exclusivity) and the courts. The heart of the article is section …

International Intellectual Property Shelters, Sam F. Halabi

Faculty Publications

The battle over the reach and strength of international protections for intellectual property rights is one of the critical flashpoints between wealthy and low-income countries: those protections are perceived to obstruct access to essential medicines, thwart regulatory efforts to promote individual and population health, and undermine traditional forms of agriculture and food production. While scholars have thoroughly tracked the bilateral and multilateral trade and investment treaties responsible for the expansion of international intellectual property rights worldwide, they have paid significantly less attention to the strength and form that opposition to international intellectual property expansion has taken. This Article examines the …

Molecular Mechanisms Of Suberoylanilide Hydroxamic Acid In The Inhibition Of Tgf-Β1-Mediated Canine Corneal Fibrosis, Kristina M. Gronkiewicz, Elizabeth A. Giuliano, Ajay Sharma, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

Objective—To investigate molecular mechanisms mediating anti-fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad-dependent and, to a lesser extent, Smad-independent signaling pathways activated by TGF-β1, as well as matrix metalloproteinase (MMP) activity.

Methods—Cultured canine corneal fibroblasts (CCF) were incubated in the presence/absence of TGF-β1 (5ng/ml) and SAHA (2.5μM) for 24hrs. Western blot analysis was used to quantify non-phosphorylated and phosphorylated isoforms of Smad2/3, p38 MAP kinase (MAPK), ERK1/2 and JNK1. Real-time PCR and zymography were utilized to quantify MMP1, MMP2, MMP8 and MMP9 mRNA expression and …

Target Dose Conversion Modeling From Pencil Beam (Pb) To Monte Carlo (Mc) For Lung Sbrt, Dandan Zheng, Xiaofeng Zhu, Qinghui Zhang, Xiaoying Liang, Weining Zhen, Chi Lin, Vivek Verma, Shuo Wang, Andrew Wahl, Yu Lei, Sumin Zhou, Chi Zhang

School of Biological Sciences: Faculty Publications

Background: A challenge preventing routine clinical implementation of Monte Carlo (MC)-based lung SBRT is the difficulty of reinterpreting historical outcome data calculated with inaccurate dose algorithms, because the target dose was found to decrease to varying degrees when recalculated with MC. The large variability was previously found to be affected by factors such as tumour size, location, and lung density, usually through sub-group comparisons. We hereby conducted a pilot study to systematically and quantitatively analyze these patient factors and explore accurate target dose conversion models, so that large-scale historical outcome data can be correlated with more accurate MC dose without …

South Dakota State University Undergraduate General Catalog 2016-2017, South Dakota State University

South Dakota State University Catalogs and Bulletins: 1935 to present

No abstract provided.

Texas Advance Directives Act: Nearly A Model Dispute Resolution Mechanism For Intractable Medical Futility Conflicts, Thaddeus Pope

Faculty Scholarship

Increasingly, clinicians and commentators have been calling for the establishment of special adjudicatory dispute resolution mechanisms to resolve intractable medical futility disputes. As a leading model to follow, policymakers both around the United States and around the world have been looking to the conflict resolution provisions in the 1999 Texas Advance Directives Act (‘TADA’). In this article, I provide a complete and thorough review of the purpose, history, and operation of TADA. I conclude that TADA is a commendable attempt to balance the competing goals of efficiency and fairness in the resolution of these time-sensitive life-and-death conflicts. But TADA is …

Kids Count: The State Of The Child In Tennessee, 2016, Tennessee Commission On Children And Youth

Kids Count/State of the Child in Tennessee Reports

This report provides an overview of information on healthy infants, children and teens; child/teen well-being; education; economic security; and demographics.

The Influence Of Safety, Efficacy, And Medical Condition Severity On Natural V. Synthetic Drug Preference, Brian P. Meier, Courtney M. Lappas

Psychology Faculty Publications

Research indicates that there is a preference for natural v. synthetic products, but the influence of this preference on drug choice in the medical domain is largely unknown. We present 5 studies in which participants were asked to consider a hypothetical situation in which they had a medical issue requiring pharmacological therapy. Participants ( N = 1223) were asked to select a natural, plant-derived, or synthetic drug. In studies 1a and 1b, approximately 79% of participants selected the natural v. synthetic drug, even though the safety and efficacy of the drugs were identical. Furthermore, participants rated the natural drug as …

A Reckless Disregard For The Truth? The Constitutional Right To Lie In Politics, Jason Zenor

Campbell Law Review

In the first presidential campaign following the controversial United States Supreme Court decision in Citizens United, much attention was given to the record amount of money spent on the election - close to $3 billion. Ideally, more money spent on campaigning would permit more speech and add to the public discourse, and allowing more speech would encourage and permit bad speech to be countered with good speech. In 2012, however, claims arose that the candidates were being more negative than ever, including resorting to outright deception.

Many states have laws on the books that prohibit knowingly false campaign speech on …

Social Media, Public Discourse And Civic Engagement In Modern China, Yinjiao Ye, Ping Xu, Mingxin Zhang

Political Science Faculty Publications

Drawing on the theoretical view of cyberspace’s role in engagement in public discourse and civic activities, the current study investigates how social media use is related to public discourse and civic engagement in mainland China. Moreover, we examine how political interest, general trust in people, and life satisfaction modify the interdependence of social media use and public discourse and civic engagement. Data analyses based on a survey of 1, 202 online Chinese show that social media use is significantly related to both public discourse and civic engagement. In addition, political interest has a consistent, strong modification on the role of …

Correlation Between Sleep And Lifespan In Drosophila Melanogaster, Courtney H. Fiebelman

Masters Theses

”Sleep has previously been associated with lifespan. Monitoring sleep in any given fly over their lifetime facilitates the ability to predict the lifespan of that given fly. Using this estimate, lifespan can potentially correlate with biological age to identify when health parameters have declined.

To confirm that the prediction algorithm could identify short and long-lived flies, glutathione levels in heads and bodies were compared between two groups. The results showed this to be consistent in the bodies of wild-type Canton S male flies, and showed that glutathione was decreased in the predicted biologically older flies. These data show that glutathione …

Hpc Enabled Data Analytics For High-Throughput High-Content Cellular Analysis, Ross A. Smith, Rhonda J. Vickery, Jack Harris, Sara Gharabaghi, Thomas Wischgoll, David Short, Robert Trevino, Steven A. Kawamoto, Thomas J. Lamkin, Kevin Schoen, Eric E. Bardes, Scott C. Tabar, Bruce J. Aronow

Computer Science and Engineering Faculty Publications

Biologists doing high-throughput high-content cellular analysis are generally not computer scientists or high performance computing (HPC) experts, and they want their workflow to support their science without having to be. We describe a new HPC enabled data analytics workflow with a web interface, HPC pipeline for analysis, and both traditional and new analytics tools to help them transition from a single workstation mode of operation to power HPC users. This allows the processing of multiple plates over a short period of time to ensure timely query and analysis to match potential countermeasures to individual responses.

Portland State Magazine, Portland State University. Office Of University Communications

Portland State Magazine

PSU’s alumni magazine, published 2-3 times a year. In this issue: Seven alumni who are making a difference in their communities; LinkedIn list of top employers of alumni and students in Oregon; looking at the link between urban trees and health; Gates scholar is committed to improving the lives of her people; researchers discover a potential knockout punch against malaria; Bruce Barnum makes winners out of a struggling PSU football program; and more.

When There Are No Borders Between Art And Teaching, Patricia Vázquez Gómez, José Miguel González Casanova, Harrell Fletcher

Reference Points

English version.

This book is part of the Reference Points series published through Portland State University Art and Social Practice MFA Program. The series is an evolving pedagogical framework in which graduate students formulate and research a significant topic or practitioner(s) related to socially engaged art. Because the series is designed to shift and respond to the concerns of the program's current students and faculty, mode, structure, and content are open-ended.

Cosmopolitanism, Custom And Complexity: Kant's Cosmopolitan Norms In Action, Tracey Leigh Dowdeswell

Osgoode Legal Studies Research Paper Series

Immanuel Kant's Cosmopolitanism has come to stand alongside Political Realism and Liberal Internationalism as one of three broad theories of ethics in international relations. Yet Cosmopolitanism has been subjected to criticisms that the universal norms identified by Kant - including such norms as hospitality, reciprocity, and publicity (transparency and free political participation) - are Western and Eurocentric in nature, incompatible with cultural pluralism, and lack the justification and legitimacy for the broad-based consensus required for a Cosmopolitan politicalsphere to emerge among the world’s diverse peoples. This paper seeks to address these criticisms of Cosmopolitanism by studying examples of Cosmopolitan norms …

The ‘Objectives’ And ‘Principles’ Of The Wto Trips Agreement: A Detailed Anatomy, Alison Slade

Osgoode Legal Studies Research Paper Series

Articles 7 and 8 of the WTO Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) are entitled ‘Objectives’ and ‘Principles’ respectively. These provisions occupy a prominent position within the text of the Agreement, yet have figured sparingly in the legal reasoning of the WTO Dispute Settlement Body (DSB). The illogical nature of this discrepancy is accentuated when considered in light of four key factors. First, the pioneering step taken by the negotiators of the TRIPS Agreement to include broad declarations of intent within the legally operative text. Second, the 2001 reinforcement given to the authority of these provisions through …

Dueling Interpretations: The Conflict Arising From Ptab’S Use Of Broadest Reasonable Interpretation For Claim Construction, 16 J. Marshall Rev. Intell. Prop. L. 134 (2016), Andrew Martin

UIC Review of Intellectual Property Law

Claim Construction is the first hurdle in patent litigation to invalidate a patent. Traditionally, federal courts have interpreted claims in their plain and obvious meaning to a person skilled in the art. But a new avenue through post-grant proceedings at the patent office, such as inter-partes review, has created a worrying trend of increased patent invalidation. This comment will explore the consequences of the higher rate of invalidation, proposals suggested to solve the problem, and the actions of those who exploit it.