Digital Commons Network^™

Adopting An International Convention On Surrogacy - A Lesson From Intercountry Adoption, Seema Mohapatra

Loyola University Chicago International Law Review

No abstract provided.

Insights Into The Possible Mechanisms By Which Platelet-Activating Factor And Paf-Receptors Function In Vascular Smooth Muscle In Magnesium Deficiency And Vascular Remodeling: Possible Links To Atherogenesis, Hypertension And Cardiac Failure, Burton M. Altura, Nilank C. Shah, Gatha J. Shah, Jose Luis Perez-Albela, Bella T. Altura

The School of Health Sciences Publications and Research

The authors discuss different studies concerning the relationship between platelet-activating factor (PAF) and PAF-receptors with atherosclerosis and hypertension.

Dining With The Cyborgs: Disembodied Consumption And The Rhetoric Of Food Media In The Digital Age, Maggie Cotto

Electronic Theses and Dissertations

This project explores digital media productions based specifically on food and cooking in order to demonstrate that new communication technologies are increasingly incorporating all five of the bodily senses. In doing so, they contribute significantly to the emergence of new ideological apparatuses appropriate for a global community. These apparatuses – including the formation of a posthumanist subject, the use of technology to support embodied cognition, and the establishment of entertainment as an ideological institution – have become the harbingers of a rhetorical evolution. Based on the work of Gregory Ulmer, along with Jacques Derrida, N. Katherine Hayles, Donna Haraway, and …

Kind Girls, Evil Sisters, And Wise Women: Coded Gender Discourse In Literary Fairy Tales By German Women In The 19th Century, Julie Koehler

Wayne State University Dissertations

This dissertation is an analysis of fairy tales by German women in late eighteenth and nineteenth century. Although hundreds of women published fairy tales in Germany in the nineteenth century, they remain absent from current scholarship. Recent work by scholars Shawn Jarvis and Jeannine Blackwell have brought these fairy tales back into print, but there remains very little critical work on them. This dissertation takes the focus of retellings of the Kind and Unkind Girls tale type, also known as “Frau Holle.” At first glance, the women’s variants depict modest, passive, and hardworking Kind Girls who are very similar to …

The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis, Safa Beydoun

Wayne State University Dissertations

Aging is a multifactorial process associated with alterations in several physiological functions. It increases susceptibility to disease and ultimately results in mortality. Since the associated diseases of aging are highly prevalent in the geriatric population, targeting the aging process as a whole may provide a better way to delay these age related diseases, in turn delaying aging. Various interventions have been shown to delay aging and age related diseases. They impact a major nutrient sensing pathway, mTOR. mTOR signaling is altered in many cancers and its downregulation was shown to delay aging. Other interventions extend lifespan by altering the one …

The Unusual Substrate Specificity Of A Virulence Associated Serine Hydrolase From The Highly Toxic Bacterium, Francisella Tularensis, Alexander M. Farberg, Whitney K. Hart, R. Jeremy Johnson

Scholarship and Professional Work - LAS

Francisella tularensis is the causative agent of the highly, infectious disease, tularemia. Amongst the genes identified as essential to the virulence of F. tularensis was the proposed serine hydrolase FTT0941c. Herein, we purified FTT0941c to homogeneity and then characterized the folded stability, enzymatic activity, and substrate specificity of FTT0941c. Based on phylogenetic analysis, FTT0941c was classified within a divergent Francisella subbranch of the bacterial hormone sensitive lipase (HSL) superfamily, but with the conserved sequence motifs of a bacterial serine hydrolase. FTT0941c showed broad hydrolase activity against diverse libraries of ester substrates, including significant hydrolytic activity across alkyl ester substrates from …

The Anaphase-Promoting Complex (Apc) Ubiquitin Ligase Affects Chemosensory Behavior In C. Elegans, Julia Wang, Alexandra K. Jennings, Jennifer R. Kowalski

Scholarship and Professional Work - LAS

The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex (APC) is a multi-subunit E3 ubiquitin ligase that controls diverse developmental and signaling processes in post-mitotic neurons; however, potential roles for the APC in sensory function have yet to be explored. In this study, we examined the effect of the APC ubiquitin ligase on chemosensation in Caenorhabditis elegans by testing chemotaxis to the volatile odorants, diacetyl, pyrazine, and isoamyl alcohol, to which wild-type …

Oscar Carleton Mcculloch, Jason Lantzer

Scholarship and Professional Work - LAS

Jason Lantzer's essay on Oscar Carleton McCulloch, a Contribution to The Indiana Historical Society's publication: Indiana's 200: The People Who Shaped the Hoosier State.

Invasive Species In An Urban Flora: History And Current Status In Indianapolis, Indiana, Rebecca W. Dolan

Scholarship and Professional Work - LAS

Invasive plant species are widely appreciated to cause significant ecologic and economic damage in agricultural fields and in natural areas. The presence and impact of invasives in cities is less well documented. This paper characterizes invasive plants in Indianapolis, Indiana. Based on historical records and contemporary accounts, 69 of the 120 species on the official Indiana state list are reported for the city. Most of these plants are native to Asia or Eurasia, with escape from cultivation as the most common mode of introduction. Most have been in the flora of Indianapolis for some time. Eighty percent of Indianapolis’ invasive …

"Introduction" To Theology And Science Fiction, James F. Mcgrath

Scholarship and Professional Work - LAS

What is the difference between a god and a powerful alien? Can an android have a soul, or be considered a person with rights? Can we imagine biblical stories being retold in the distant future on planets far from Earth? Whether your interest is in Christianity in the future, or the Jedi in the present--and whether your interest in the Jedi is focused on real-world adherents or the fictional religion depicted on the silver screen--this book will help you explore the intersection between theology and science fiction across a range of authors and stories, topics and questions.

Throughout this volume, …

2016 Otterbein Football Game Day Program, Otterbein University

Football Programs

Otterbein University continues its proud tradition of athletic and academic excellence and has enjoyed over 100 years of intercollegiate competition. During that time, the University’s mission has been to balance academics and athletic competition. Our commitment has been to the whole person, both in and out of the classroom. Our coaches are teachers first, mentors who make deep and lasting impressions on their students. While the drive to win is important, our real commitment lies in developing leadership traits and the competitive spirit, which will aid our scholar-athletes throughout their lives. On behalf of Otterbein’s faculty, students and administration, we …

From Three Little Words To A Brilliant Future, Ben Pace

Maroon Edition: MSU’s First Year Reading Experience

Third place winner of the MSU Maroon & White QEP/Maroon Edition Essay Competition (Upperclassmen) for 2016/2017.

My Untold Story, Windie Jenkins

Maroon Edition: MSU’s First Year Reading Experience

First place winner of the MSU Maroon & White QEP/Maroon Edition Essay Competition (Upperclassmen) for 2016/2017.

The Moment My Life Changed Forever, Emily Tingle

Maroon Edition: MSU’s First Year Reading Experience

Third place winner of the MSU Maroon & White QEP/Maroon Edition Essay Competition (Freshmen) for 2016/2017.

Joint Mouse–Human Phenome-Wide Association To Test Gene Function And Disease Risk, Xusheng Wang, Ashutosh K. Ciobanu, Megan K. Mulligan, Evan G. Williams, Khyobeni Mozhui, Zhengsheng Li, Virginija Jovaisaite, L. Darryl Quarles, Zhousheng Xiao, Jinsong Huang, John A. Capra, Zugen Chen, William L. Taylor, Lisa Bastarache, Xinnan Niu, Katherine S. Pollard, Daniel C. Ciobanu, Alexander O. Reznik, Artem V. Tishkov, Igor B. Zhulin, Junmin Peng, Stanley F. Nelson, Joshua C. Denny, Johan Auwerx, Lu Lu, Robert W. Williams

Department of Animal Science: Faculty Publications

Phenome-wide association is a novel reverse genetic strategy to analyze genome-tophenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for ~5 million sequence variants, and we compare our results to those extracted from a matched analysis of gene variants in a large human cohort. For the mouse cohort, we amassed a deep and broad open-access phenome consisting of ~4,500 metabolic, physiological, pharmacological and behavioural traits, and more than 90 independent expression quantitative trait locus (QTL), transcriptome, proteome, metagenome and metabolome data sets—by far the largest coherent phenome for any experimental cohort (www.genenetwork.org). …

Bigtooth And Quaking Aspen Propagation From Roots Versus Seed, Joseph M. Vande Hey

Aspen Bibliography

No abstract provided.

Zebra Mussel (Dreissena Polymorpha) Affects The Feeding Ecology Of Early Stage Striped Bass (Morone Saxatilis) In The Hudson River Estuary, Michael G. Smircich, David L. Strayer, Eric T. Schultz

EEB Articles

Variability in the feeding ecology of young fishes over short and long time scales in estuaries is likely to affect population dynamics. We studied 14 years of early stage Striped Bass feeding ecology in the Hudson River Estuary over a 25-year time span, including years in which invasive zebra mussels markedly altered energy flow within the estuary. We predicted that feeding success would be low and that diet composition would be altered during years of high zebra mussel impact, particularly in upriver locations where mussels occur. Feeding success in the short term was indicated by volume of gut contents and …

Thermodynamics And Kinetics Of The Three-Way Junction Of Phi29 Motor Prna And Its Assembly Into Nanoparticles For Therapeutic Delivery To Prostate Cancer, Daniel W. Binzel

Theses and Dissertations--Pharmacy

The emerging field of RNA nanotechnology necessitates creation of functional RNA nanoparticles, but has been limited by particle instability. Previously, it was found the three-way junction (3WJ) of the Phi29 DNA packaging motor pRNA was found to be ultra-stable and assemble in solution without the presence of metal ions. The three-way junction is composed of three short oligo RNA strands and proven to be thermodynamically stable. Here the assembly mechanism, thermodynamic and enzymatic stabilities, and kinetics are examined in order to understand the stability behind this unique motif. Thermodynamic and kinetics studies found that the pRNA 3WJ formed out of …

The Clean Water Rule- A Clarification Of The Definition Of 'Waters Of The United States' Or Agency Overreach, April Collaku

Fordham Environmental Law Review

No abstract provided.

Resource Map Of Expenditures For Tennessee Children, Annual Report - April 2016, Tennessee Commission On Children And Youth

Resource Mapping Reports

This report compiles the federal and state expenditures for services across all departments and agencies for Tennessee children from the previous fiscal year.

Annual Report, State Fiscal Year July 2015 - June 2016, Tennessee. Department Of Children's Services

Annual Reports

This annual report records the progress made by the Department of Children's Services during the fiscal year.

Anda Reverse Payments And The Post-Actavis Landscape, Michele M. Kang

UC Law Science and Technology Journal

Pharmaceutical companies spend much of their time and resources in conducting clinical trials for developing new drugs. Under the Hatch- Waxman Act, generic drugs can refer to the same clinical trials that the initial pharmaceutical companies have done, if they prove similarities in the biological makeup of both drugs. A trend that has developed in response to the Hatch- Waxman Act is that pharmaceutical companies have been paying off generic companies not to enter into their market — this is referred to as a reverse payment patent settlement. While proving to be beneficial to the pharmaceutical industry, reverse payments create …

Analysis Of Slot Height Accuracy And Precision Of Stainless Steel Orthodontic Brackets Manufactured By Metal Injection Molding And Computer Numerical Control Milling Using Stereomicroscopy, Mark D. Angeloni

MUSC Theses and Dissertations

Objective: It is the objective of this study to determine the dimensional accuracy and precision that is achievable by two manufacturing methods of stainless steel orthodontic brackets, CNC milling and metal-injection molding. To determine this, we propose the following specific aims: 1) to determine the actual dimensions of the slots in both milled and MIMed orthodontic bracket and standard deviations. 2) Using mathematical models to determine if the dimensional difference, if one exists, between milled and MIMed brackets will result in a difference in third order tooth movement (torque) realization (effective torque vs nominal torque). The actual bracket slot dimensions …

The Family History Of Reed W. Phillips, Reed W. Phillips

Your Family in History: HIST 550/700

This is five generations of the family of Reed W. Phillips of Missouri. Family names include Phillips, Bybee, Johnson, Schmidt, Jeffries, Ross, Foster, and Hergemueller. It includes personal stories and genealogical data.

Improving Treatment Of Neurodevelopmental Disorders: Recommendations Based On Preclinical Studies, Judith R. Homberg, Evan J. Kyzar, Adam Michael Stewart, Michael Nguyen, Manoj K. Poudel, David J. Ecchevaria, Adam D. Collier, Siddharth Gaikwad, Viktor M. Klimenko, William Norton, Julian Pittman, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi, Sergey A. Apryatin, Maria Luisa Scattoni, David M. Diamond, Jeremy F.P. Ullmann, Matthew O. Parker, Richard E. Brown, Cai Song, Allan V. Kalueff

Faculty Publications

Introduction: Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature and reliance on both genetic and environmental factors makes studying NDDs and their treatment a challenging task.Areas covered: Herein, the authors discuss the neurobiological mechanisms of NDDs, and present recommendations on their translational research and therapy, outlined by the International Stress and Behavior Society. Various drugs currently prescribed to treat NDDs also represent a highly diverse group. Acting on various neurotransmitter and physiological systems, these drugs often lack specificity of action, and are commonly used to treat multiple other psychiatric conditions. There has also been relatively little progress …

Images Of History: Kant, Benjamin, Freedom, And The Human Subject, Richard Thomas Eldridge

Philosophy Faculty Works

Developing work in the theories of action and explanation, Eldridge argues that moral and political philosophers require accounts of what is historically possible, while historians require rough philosophical understandings of ideals that merit reasonable endorsement. Both Immanuel Kant and Walter Benjamin recognize this fact. Each sees a special place for religious consciousness and critical practice in the articulation and revision of ideals that are to have cultural effect, but they differ sharply in the forms of religious-philosophical understanding, cultural criticism, and political practice that they favor. Kant defends a liberal, reformist, Protestant stance, emphasizing the importance of liberty, individual rights, …

Validity Assessment Of Biometrics For The First-Generation Apple Watch And Microsoft Band During Steady-State Exercise, William Constantine Kalamaras

Graduate Research Theses & Dissertations

In recent years, wearable technology equipped with advanced biometric sensors has grown in both market share and consumer popularity. With these devices depending heavily upon the use of algorithms to estimate physiological parameters, the validation of biometric readings from these devices is paramount in establishing the credibility necessary to substitute conventionally-used equipment. PURPOSE: To assess the biometric validity and reliability of heart rate (HR) and energy expenditure (EE) recorded by the first-generation Apple Watch (42mm) and Microsoft Band during submaximal aerobic exercise on a treadmill at steady-state. METHODS: Twenty-three participants (16 males, 7 females; mean age: 22.7 +/- 3.8 years …

The Material Ethics Of Juana Manuela Gorriti’S Peregrinaciones De Una Alma Triste, Elisabeth L. Austin

Decimonónica

Juana Manuela Gorriti’s novella Peregrinaciones de una alma triste (1876) opens in a most Romantic vein: Laura, the protagonist, suffers from tuberculosis and is subjected to arsenic poisoning by her doctor in an attempt to cure her.¹ As her doctor prescribes “mañana doble dosis; triple, pasado mañana” (4), he declares, with the zeal of a true believer, “niña mía [. . .] desde hoy comienza usted a tomar para curarse aquello que a otros da la muerte: el arsénico. Arsénico por la mañana, arsénico en la tarde, arsénico en la noche…¡Horrible! ¿no es cierto?” (4). The lovesick Laura promptly …

The View From Ventress - 2016, University Of Mississippi. College Of Liberal Arts

Liberal Arts Newsletters

Special Section: Collabortions. To better understand the world and to tackle its complex problems, collaboration between disciplines offers a critical path forward. Faculty research and teaching interests to give students multidisciplinary educational opportunities. In this special section, we present the latest offerings in the College—two new minors, a new integrated fine arts course, and integrated science courses—along with a glimpse of the other multidisciplinary majors and minors.

Rnaseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation As A Major Abnormality In Als Spinal Cord, David G. Brohawn, Laura C. O'Brien, James P. Bennett Jr.

Physiology and Biophysics Publications and Presentations

ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and upper motor neurons. No meaningful therapies exist to slow ALS progression, and molecular insights into pathogenesis and progression are sorely needed. In that context, we used high-depth, next generation RNA sequencing (RNAseq, Illumina) to define gene network abnormalities in RNA samples depleted of rRNA and isolated from cervical spinal cord sections of 7 ALS and 8 CTL samples. We aligned >50 million 2X150 bp paired-end sequences/sample to the hg19 human genome and applied three different algorithms (Cuffdiff2, DEseq2, …