Digital Commons Network^™

2016-02-15-Live-Streaming Of Local American Bald Eagle, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

Gut Immunity In A Protochordate Involves A Secreted Immunoglobulin-Type Mediator Binding Host Chitin And Bacteria, Larry J. Dishaw, Brittany Leigh, John P. Cannon, Assunta Liberti, M. Gail Mueller, Diana P. Skapura, Charlotte R. Karrer, Maria R. Pinto, Rosaria De Santis, Gary W. Litman

Marine Science Faculty Publications

Protochordate variable region-containing chitin-binding proteins (VCBPs) consist of immunoglobulin-type V domains and a chitin-binding domain (CBD). VCBP V domains facilitate phagocytosis of bacteria by granulocytic amoebocytes; the function of the CBD is not understood. Here we show that the gut mucosa of Ciona intestinalis contains an extensive matrix of chitin fibrils to which VCBPs bind early in gut development, before feeding. Later in development, VCBPs and bacteria colocalize to chitin-rich mucus along the intestinal wall. VCBP-C influences biofilm formation in vitro and, collectively, the findings of this study suggest that VCBP-C may influence the overall settlement and colonization of bacteria …

Role Of Deubiquitinating Enzymes In Dna Repair, Younghoon Kee, Tony T. Huang

Molecular Biosciences Faculty Publications

Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.

2016-02-15-New Empoyees, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

2016-02-15-Nsa Grant, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

Constructing Modular And Universal Single Molecule Tension Sensor Using Protein G To Study Mechano-Sensitive Receptors, Xuefeng Wang, Zainab Rahil, Isaac T. S. Li, Farhan Chowdhury, Deborah E. Leckband, Yann R. Chemla, Taekjip Ha

Articles

Recently a variety of molecular force sensors have been developed to study cellular forces acting through single mechano-sensitive receptors. A common strategy adopted is to attach ligand molecules on a surface through engineered molecular tethers which report cell-exerted tension on receptor-ligand bonds. This approach generally requires chemical conjugation of the ligand to the force reporting tether which can be time-consuming and labor-intensive. Moreover, ligand-tether conjugation can severely reduce the activity of protein ligands. To address this problem, we developed a Protein G (ProG)-based force sensor in which force-reporting tethers are conjugated to ProG instead of ligands. A recombinant ligand fused …

Pdid: Database Of Molecular-Level Putative Protein-Drug Interactions In The Structural Human Proteome, Chen Wang, Gang Hu, Kui Wang, Michal Brylinski, Lei Xie, Lukasz Kurgan

Faculty Publications

© 2015 The Author 2015. Published by Oxford University Press. All rights reserved. Motivation: Many drugs interact with numerous proteins besides their intended therapeutic targets and a substantial portion of these interactions is yet to be elucidated. Protein-Drug Interaction Database (PDID) addresses incompleteness of these data by providing access to putative protein-drug interactions that cover the entire structural human proteome. Results: PDID covers 9652 structures from 3746 proteins and houses 16 800 putative interactions generated from close to 1.1 million accurate, all-atom structure-based predictions for several dozens of popular drugs. The predictions were generated with three modern methods: ILbind, SMAP …

Madonnas And Whores In The Workplace, Jessica Fink

William & Mary Journal of Race, Gender, and Social Justice

Much has been written about “lookism”—the preferential treatment given to those who conform to societal standards of beauty. But in a recent case before the Iowa Supreme Court, a sex discrimination plaintiff alleged “reverse-lookism,” claiming that her male employer terminated her long-term employment because she was too physically attractive, thus tempting the employer to consider entering into an extramarital affair. To the great surprise of many who followed this case, the Iowa Supreme Court sided with the employer, declining to find him liable for sex discrimination. As one might expect, uproar ensued, with the media, the public, and the academic …

Jack & Jill Take Lots Of Pills, But Jill Comes Tumbling After: Gender Inequality In Privately Funded Early Phase Clinical Trials, Shana F. Oppenheim

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Cognitive-Behavioral Therapy Augmentation Of Ssri Reduces Cortisol Levels In Older Adults With Generalized Anxiety Disorder: A Randomized Clinical Trial, Christopher B. Rosnick, Julie L. Wetherell, Kamila S. White, Carmen Andreescu, David Dixon, Eric J. Lenze

SIUE Faculty Research, Scholarship, and Creative Activity

Objectives: Elevated cortisol in stress and aging, such as has been seen in late-life anxiety disorders, is postulated to accelerate cognitive and physiological decline in this large and increasing population. Selective serotonin-reuptake inhibitors (SSRIs) and cognitive behavior therapy (CBT) are both effective treatments for Generalized Anxiety Disorder (GAD) in older adults. On the other hand, there is very little research examining the effect of combining these therapies on peak cortisol levels. For the current analyses, we examined the effectiveness of CBT augmentation on peak cortisol levels in older adults diagnosed with GAD.

Methods: The sample consisted of 42 individuals with …

Molecular Evolution And Intraclade Recombination Of Enterovirus D68 During The 2014 Outbreak In The United States., Yi Tan, Ferdaus Hassan, Jennifer E. Schuster, Ari Simenauer, Rangaraj Selvarangan, Rebecca A. Halpin, Xudong Lin, Nadia Fedorova, Timothy B. Stockwell, Tommy Tsan-Yuk Lam, James D. Chappell, Tina V. Hartert, Edward C. Holmes, Suman R. Das

Manuscripts, Articles, Book Chapters and Other Papers

In August 2014, an outbreak of enterovirus D68 (EV-D68) occurred in North America, causing severe respiratory disease in children. Due to a lack of complete genome sequence data, there is only a limited understanding of the molecular evolution and epidemiology of EV-D68 during this outbreak, and it is uncertain whether the differing clinical manifestations of EV-D68 infection are associated with specific viral lineages. We developed a high-throughput complete genome sequencing pipeline for EV-D68 that produced a total of 59 complete genomes from respiratory samples with a 95% success rate, including 57 genomes from Kansas City, MO, collected during the 2014 …

Cogenerative Dialogue: Developing Biology Learning Accommodations For Students With Disabilities, Edward Lehner

Publications and Research

A prominent challenge, at times under-addressed in the science education literature, is considering what types of learning accommodations science teachers should employ for students with disabilities. Outside of science education, researchers have consistently outlined how Universal Design for Learning (UDL) is one efficient means by which to engage students with disabilities in the curriculum. This paper presents the results of a research study in which teachers employed cogenerative dialogue as a learning space where UDL was used to differentiate and individualize instruction in an inclusive biology class. The data originated from a larger, ongoing, longitudinal ethnography of science learning in …

Has Blue Overshadowed Green?: The Ecological Need To Eradicate Hunting Blue Laws, Allie Humphreys

William & Mary Environmental Law and Policy Review

No abstract provided.

Pseudomonas Aeruginosa Exoenzymes U And Y Induce A Transmissible Endothelial Proteinopathy, K. Adam Morrow, Cristhiaan D. Ochoa, Ron Balczon, Chun Zhou, Mikhail Alexeyev, Katherine M. Schmalzer, Dara W. Frank, Troy Stevens

University Faculty and Staff Publications

We tested the hypothesis that Pseudomonas aeruginosa type 3 secretion system effectors exoenzymes Y and U (ExoY and ExoU) induce release of a high-molecular-weight endothelial tau, causing transmissible cell injury characteristic of an infectious proteinopathy. Both the bacterial delivery of ExoY and ExoU and the conditional expression of an activity-attenuated ExoU induced time-dependent pulmonary microvascular endothelial cell gap formation that was paralleled by the loss of intracellular tau and the concomitant appearance of high-molecular-weight extracellular tau. Transfer of the high-molecular-weight tau in filtered supernatant to naïve endothelial cells resulted in intracellular accumulation of tau clusters, which was accompanied by cell …

Emerging Contaminants In Virginia, Peter L. Defur, Laura E. Williams, Sarah D. Sanford

William & Mary Environmental Law and Policy Review

This Article summarizes the rise of emerging contaminants in waterways in Virginia and nationwide, and how they affect ecological and human health. First, we review the scientific discovery of chemicals that alter hormone systems, reproductive and developmental processes and how these were discovered in waterways. We go on to explain the current state of emerging contaminant regulations, noting that few states have a clear understanding of what chemicals are discharged into surface waters. The Environmental Protection Agency (“EPA”) has no national effort in this area, despite congressional interest and action. Finally, we make recommendations for future emerging contaminant control and …

Essay – The Toxic Legacy Of Coal Ash On Southeastern Rivers, Waterways, And Reservoirs, Cale Jaffe

William & Mary Environmental Law and Policy Review

My talk focuses on what I have called the toxic legacy of coal ash pollution in the Southeastern United States, andmy goal today is to give you all an insight into how we in the environmental community—by which I mean the waterkeepers and riverkeepers—are seeing this issue. I also hope to share with you the perspective of the impacted communities and families that live downstream of these coal ash lagoons.

Message In A Water Bottle: The Call For A Tri-State Tmdl For Western Lake Erie, Lauren Coleman

William & Mary Environmental Law and Policy Review

No abstract provided.

Barometer Rising: The Cartagena Protocol On Biosafety As A Model For Holistic International Regulation Of Ocean Fertilization Projects And Other Forms Of Geoengineering, Matthew Hubbard

William & Mary Environmental Law and Policy Review

No abstract provided.

It Is Up To You, Kate Vander Veen

Faculty Work Comprehensive List

"If indeed you desire to be healthy, or to at least try to work toward living a healthier life than you do now, you must first answer one core question: what does healthy living mean to you?"

Posting about life choices that promote health from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/it-is-up-to-you/

Lanthorn, Vol. 50, No. 42, February 15, 2016, Grand Valley State University

Volume 50, July 13, 2015 - June 6, 2016

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

February 15, 2016 Armstrong Faculty Senate Minutes, Armstrong State University

Armstrong Faculty Senate: Minutes (Archived)

February 15, 2016 Armstrong Faculty Senate Minutes

Analyzing The Leadership Skills Of Nurses Through Mentoring Relationships, Barbara Jean Siwula

Theses and Dissertations

Mentoring relationships have the ability to create healthier working environments for nurses by encouraging better communication, teaching necessary leadership skills, and creating unity among nurses. In the same respect, mentoring relationships can instill negative habits, creating a cycle of ineffective leadership. Therefore, it is vital mentoring relationships be analyzed to ensure that nurses are being taught effective leadership skills that will lead to a healthy workplace environment. The purpose of this study is to analyze the leadership skills of nurses though mentoring relationships. Data collection consisted of a mixed methods study completed by student, certified and registered nurses from various …

A High-Resolution Mid-Pleistocene Temperature Record From Arctic Lake El'gygytgyn: A 50 Kyr Super Interglacial From Mis 33 To Mis 31?, Gregory De Wet, Isla S. Castañeda, Robert M. Deconto, Julie Brigham-Grette

Geosciences: Faculty Publications

Previous periods of extreme warmth in Earth's history are of great interest in light of current and predicted anthropogenic warming. Numerous so called "super interglacial" intervals, with summer temperatures significantly warmer than today, have been identified in the 3.6 million year (Ma) sediment record from Lake El'gygytgyn, northeast Russia. To date, however, a high-resolution paleotemperature reconstruction from any of these super interglacials is lacking. Here we present a paleotemperature reconstruction based on branched glycerol dialkyl glycerol tetraethers (brGDGTs) from Marine Isotope Stages (MIS) 35 to MIS 29, including super interglacial MIS 31. To investigate this period in detail, samples were …

The Rider (2016-02-15), Jesus Sanchez

The Rider Archives

Vol.1 No.19

No Effect Of Acute Beetroot Juice Ingestion On Oxygen Consumption, Glucose Kinetics, Or Skeletal Muscle Metabolism During Submaximal Exercise In Males, Scott Betteridge, Raúl Bescós, Miquel Martorell, Antoni Pons, Andrew P. Garnham, Christos C. Stathis, Glenn K. Mcconell

School of Health Professions

Beetroot juice, which is rich in nitrate (NO3−), has been shown in some studies to decrease oxygen consumption (V̇o2) for a given exercise workload, i.e., increasing efficiency and exercise tolerance. Few studies have examined the effect of beetroot juice or nitrate supplementation on exercise metabolism. Eight healthy recreationally active males participated in three trials involving ingestion of either beetroot juice (Beet; ∼8 mmol NO3−), Placebo (nitrate-depleted Beet), or Beet + mouthwash (Beet+MW), all of which were performed in a randomized single-blind crossover design. Two-and-a-half hours later, participants cycled for 60 min on an ergometer at 65% of V̇o2 peak. [6,6-2H]glucose …

Cytomegalovirus-Based Vaccine Expressing Ebola Virus Glycoprotein Protects Nonhuman Primates From Ebola Virus Infection, Andrea Marzi, Aisling A. Murphy, F Feldmann, Christopher J. Parkins, Elaine Haddock, Patrick W. Hanley, Matthew J. Emery, Flora Engelmann, Ilhem Messaoudi, H Feldmann, Michael A. Jarvis

School of Biomedical Sciences

AbstractEbolaviruses pose significant public health problems due to their high lethality, unpredictable emergence, and localization to the poorest areas of the world. In addition to implementation of standard public health control procedures, a number of experimental human vaccines are being explored as a further means for outbreak control. Recombinant cytomegalovirus (CMV)-based vectors are a novel vaccine platform that have been shown to induce substantial levels of durable, but primarily T-cell-biased responses against the encoded heterologous target antigen. Herein, we demonstrate the ability of rhesus CMV (RhCMV) expressing Ebola virus (EBOV) glycoprotein (GP) to provide protective immunity to rhesus macaques against …

Medical School Watercooler Newsletter - February 14, 2016, Lindsey Lyle

Watercooler Newsletter

This is the February 14, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Mark Your Calendar: Match Day 2016
• USA Pediatric Residents Recognized with Trainee Travel Awards
• USA Physicians Group Welcomes Kathleen Ferguson
• First COM Dean, VP Medical Affairs Candidate to Present Feb. 17

Breed Effects And Genetic Parameter Estimates For Calving Difficulty And Birth Weight In A Multibreed Population, C. M. Ahlberg, L. A. Kuehn, R. M. Thallman, S. D. Kachman, W.M. Snelling, Matthew L. Spangler

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Birth weight (BWT) and calving difficulty (CD) were recorded on 4,579 first-parity females from the Germplasm Evaluation Program at the U.S. Meat Animal Research Center (USMARC). Both traits were analyzed using a bivariate animal model with direct and maternal effects. Calving difficulty was transformed from the USMARC scores to corresponding Z-scores from the standard normal distribution based on the incidence rate of the USMARC scores. Breed fraction covariates were included to estimate breed differences. Heritability estimates (SE) for BWT direct, CD direct, BWT maternal, and CD maternal were 0.34 (0.10), 0.29 (0.10), 0.15 (0.08), and 0.13 (0.08), respectively. Calving difficulty …

Orthodontist Parlays Small Town Opportunities Into Big-Time Practice, Alana Bowman

University of Mississippi News

Chandra Minor is an humble trailblazer in the state's health care landscape

Oral Concurrent Session Iii: Biological Sciences Iii: Microbiology, Dayle Daines

Undergraduate Research Symposium

No abstract provided.