Digital Commons Network^™

A Metallomics Study On Protein Function Assignment Using Promol, Venkata Aditya Kovuri

Theses

Metal ions are an integral part in both the structural and functional stability of enzymes. The function of an enzyme is exhibited through its active site region, which carries out the reaction for that particular protein. When a metal ion is present in an active site, it not only acts as a structural support for the active site but is often plays a critical role in the functional behavior of the protein. An exhaustive screening for proposed metal ion active sites was performed through online resources including Metal MACiE, Metal PDB, the Catalytic site Atlas and Metal Mine. A total …

Designing A Suite Of Measurements To Understand The Critical Zone, Susan L. Brantley, Roman A. Dibiase, Tess A. Russo, Yuning Shi, Henry Lin, Kenneth J. Davis, Margot Kaye, Lillian Hill, Jason Kaye, David M. Eissenstat, Beth Hoagland, Ashlee L.D. Dere, Andrew L. Neal, Kristen M. Brubaker, Dan K. Arthur

Geography and Geology Faculty Publications

Many scientists have begun to refer to the earth surface environment from the upper canopy to the depths of bedrock as the critical zone (CZ). Identification of the CZ as an integral object worthy of study implicitly posits that the study of the whole earth surface will provide benefits that do not arise when studying the individual parts. To study the CZ, however, requires prioritizing among the measurements that can be made – and we do not generally agree on the priorities. Currently, the Susquehanna Shale Hills Critical Zone Observatory (SSHCZO) is expanding from a small original focus area (0.08 …

There’S A Dragon In My Classroom, Sarah O'Leary-Driscoll

Nature of Science

What makes science, science?

How do we help students make sense of the science they are learning and how it fits in with preconceived notions and misconceptions, social perspectives, and potential controversy?

March 4-5, 2016, Vs. Western Michigan, University Of North Dakota

UND Athletics Publications: Men's Hockey

Program for the March 4-5, 2016, weekend series against the Western Michigan Broncos.

Overview Of Bladder Heating Technology: Matching Capabilities With Clinical Requirements., Paul R. Stauffer, Gerard C. Van Rhoon

Department of Radiation Oncology Faculty Papers

Moderate temperature hyperthermia (40-45°C for 1 h) is emerging as an effective treatment to enhance best available chemotherapy strategies for bladder cancer. A rapidly increasing number of clinical trials have investigated the feasibility and efficacy of treating bladder cancer with combined intravesical chemotherapy and moderate temperature hyperthermia. To date, most studies have concerned treatment of non-muscle-invasive bladder cancer (NMIBC) limited to the interior wall of the bladder. Following the promising results of initial clinical trials, investigators are now considering protocols for treatment of muscle-invasive bladder cancer (MIBC). This paper provides a brief overview of the devices and techniques used for …

Parasitic Diseases Of The Central Nervous System: Lessons For Clinicians And Policy Makers, Arturo Carpio, Matthew L. Romo, R.M.E. Parkhouse, Brooke Short, Tarun Dua

Publications and Research

Parasitic diseases of the central nervous system are associated with high mortality and morbidity, especially in resource-limited settings. The burden of these diseases is amplified as survivors are often left with neurologic sequelae affecting mobility, sensory organs, and cognitive functions, as well as seizures/epilepsy. These diseases inflict suffering by causing lifelong disabilities, reducing economic productivity, and causing social stigma. The complexity of parasitic life cycles and geographic specificities, as well as overlapping clinical manifestations in the host reflecting the diverse pathogenesis of parasites, can present diagnostic challenges. We herein provide an overview of these parasitic diseases and summarize clinical aspects, …

Hoxd Expression In The Fin-Fold Compartment Of Basal Gnathostomes And Implications For Paired Appendage Evolution, Frank J. Tulenko, Gaius J. Augustus, James L. Massey, Seth E. Sims

Faculty Articles

The role of Homeobox transcription factors during fin and limb development have been the focus of recent work investigating the evolutionary origin of limb-specific morphologies. Here we characterize the expression of HoxD genes, as well as the cluster-associated genes Evx2 and LNP, in the paddlefish Polyodon spathula, a basal ray-finned fish. Our results demonstrate a collinear pattern of nesting in early fin buds that includes HoxD14, a gene previously thought to be isolated from global Hoxregulation. We also show that in both Polyodon and the catsharkScyliorhinus canicula (a representative chondrichthyan) late phaseHoxD transcripts are present in cells of the fin-fold …

Analysis Of Lung Microbiota In Bronchoalveolar Lavage, Protected Brush And Sputum Samples From Subjects With Mild-To-Moderate Cystic Fibrosis Lung Disease, Deborah A. Hogan, Sven D. Willger, Emily L. Dolben, Thomas H. Hampton, Bruce A. Stanton, Hilary G. Morrison, Mitchell L. Sogin, Julianna Czum, Alix Ashare, Michael Tunney

Dartmouth Scholarship

Individuals with cystic fibrosis (CF) often acquire chronic lung infections that lead to irrevers- ible damage. We sought to examine regional variation in the microbial communities in the lungs of individuals with mild-to-moderate CF lung disease, to examine the relationship between the local microbiota and local damage, and to determine the relationships between microbiota in samples taken directly from the lung and the microbiota in spontaneously expectorated sputum. In this initial study, nine stable, adult CF patients with an FEV1>50% underwent regional sampling of different lobes of the right lung by bronchoalveolar lavage (BAL) and protected brush (PB) sampling …

Organic Synthesis As A Platform For Mentoring Undergraduates, Steven L. Castle

Journal of Undergraduate Research

This report summarizes the results that were generated under the auspices of the mentoring environment in my laboratory from January 2014 to the present. A total of six undergraduates participated in the mentoring environment during this period. Their names and accomplishments are listed below.

The Parthenon, March 4, 2016, Megan Osborne

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2015 Fall semester, the newspaper is only published four days a week. There is no issue on Mondays, physical issues are printed on Tuesdays and Fridays, and online issues only are published on Wednesdays and Thursdays. The editorial staff is responsible for the news and the editorial content.

Objective Research? Information Literacy Instruction Perspectives, Terry Dwain Robertson

Faculty Publications

Common understandings of “objective” research include values such as “factual” and “interpretive neutrality”. There is a growing consensus that the person, the “subject”, doing the research counts as much as if not more in the interpretive outcomes than the “facts” alone, and that “interpretive neutrality” is not possible.

The presentation offers an alternative framing of “objective research” as the grounded, intentional and savvy analysis of an “object” in conversation with a community of peers/experts for the purpose of creating knowledge.

Following Ferraris’ ontology, three classes of “objects” exist (1) Natural objects: exist whether or not a person notices them. Example: …

“It’S Not Like A Movie. It’S Not Hollywood:” Competing Narratives Of A Youth Mentoring Organization, Carley Geiss

USF Tampa Graduate Theses and Dissertations

Direct social service workers face a variety of difficulties including low pay, limited upward mobility, role ambiguity, and emotional exhaustion. This study adds to the understanding of the complexities of front-line service work with an analysis of the storytelling of case managers working with Big Brothers Big Sisters. Interview participants describe a problem of “volunteer expectations,” which they define as related to the organizational storytelling of the program: the images that entice people to volunteer do not match actual volunteer experiences. I argue that glamorized storytelling through marketing and recruitment tactics creates unintended, negative consequences for volunteers and case managers. …

March 4, 2016, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Noradrenaline Effects On Social Behaviour, Intergroup Relations, And Moral Decisions, S Terbeck, J Savulescu, P Cowen

School of Psychology

Recent research has begun to elucidate the neural basis of higher order social concepts, such as the mechanisms involved in intergroup relations, and moral judgments. Most theories have concentrated on higher order emotions, such as guilt, shame, or empathy, as core mechanisms. Accordingly, psychopharmacological and neurobiological studies have investigated the effects of manipulating serotonin or oxytocin activity on moral and social decisions and attitudes. However, recently it has been determined that changes in more basic emotions, such as fear and anger, might also have a significant role in social and moral cognition. This article summarizes psychopharmacological and fMRI research on …

Supplementation Of Formulated Diets For Tilapia (Oreochromis Niloticus) With Selected Exogenous Enzymes: Overall Performance And Effects On Intestinal Histology And Microbiota, A. A. Adeoye, A. Jaramillo-Torres, S. W. Fox, D. L. Merrifield, S. J. Davies

School of Biomedical Sciences

Abstract This study was conducted to evaluate the effects of exogenous enzymes on Nile tilapia (Oreochromis niloticus) growth and general health status. Tilapia (38.7 g) were fed one of four plant-based diets (408 g kg−1protein, 78 g kg−1 lipid); one of which was a control and the remaining three were supplemented with exogenous enzymes (phytase, protease and carbohydrase at 300 mg kg−1, 200 mg kg−1, and 300 mg kg−1, respectively). Tilapia fed the phytase supplemented diet displayed higher final body weight, FBW (94.9 g fish−1) and specific growth rate, SGR (2.48% day−1) compared to tilapia fed the control diet (82.6 …

Functional Biomaterials Via Supramolecular Assembly Of Biomolecule Fusions, Gregory Hudalla

Amgen Seminar Series in Chemical Engineering

Research in the Hudalla lab creates functional materials for therapeutic or diagnostic applications via “self-assembly”, the spontaneous organization of molecules into supramolecular structures. In general, we first develop synthetic peptides that self-assemble into a desired nano-scale architecture, and then use these peptides as “fusion tags” to organize biologically active molecules into functional materials. One aspect of my research program focuses on creating biomaterials that can recognize carbohydrate-binding proteins, or “lectins”, via self-assembly of synthetic glycopeptides. This talk will present examples of biomaterials that can inhibit lectin bioactivity via non-covalent capture within lectin-rich environments, or harness lectin bioactivity via controlled release …

Rocky Mountain Population Of Trumpeter Swans

United States Fish and Wildlife Service: Publications

Trumpeter swans (Cygnus buccinator) are native only to North America. Although no historical estimates of their abundance are available, by 1900 they had been eliminated from most of their historical range in the U.S. and Canada. Through habitat conservation, protection from illegal shooting, supplemental winter feeding, and re-introduction and translocation efforts, trumpeter swans have increased from a few hundred birds to nearly 35,000. To facilitate monitoring and management, the U.S. Fish and Wildlife Service (FWS) and Canadian Wildlife Service (CWS) designated three populations: the Pacific Coast (PCP), the Rocky Mountain (RMP), and Interior (IP). The Rocky Mountain Population (RMP) …

Pino Gate Prairie Dog Study: Mound-Scale Vegetation Plot Data From The Sevilleta National Wildlife Refuge, New Mexico (2000-2002), Ana Davidson, David Lightfoot

Sevilleta LTER Program Data

Prairie dogs (Cynomys spp.) and banner-tailed kangaroo rats (Dipodomys spectabilis) are considered keystone species of grassland ecosystems, and co-occur in the arid grasslands of the southwestern United States and in Mexico. Their keystone status is attributed primarily to the effects of their burrowing and foraging behavior, but they differ ecologically in several important respects. We studied the comparative functional roles of these species where they co-occur at the Sevilleta National Wildlife Refuge, New Mexico, focusing on their impacts on grassland vegetation. We found that vegetation cover, structure, and species richness varied across a gradient extending out from the mound centers, …

Lanthorn, Vol. 50, No. 47, March 3, 2016, Grand Valley State University

Volume 50, July 13, 2015 - June 6, 2016

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

The Firece Green Fire: Vol. 6 Issue 17, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Characterization Of Α‑Synuclein Multimer Stoichiometry In Complex Biological Samples By Electrophoresis, Bryan A. Killinger, Anna Moszczynska

Pharmaceutical Sciences Faculty Publications

The aberrant aggregation of α-synuclein in the brain is a hallmark of Parkinson’s disease (PD). In vivo soluble α-synuclein occurs as a monomer and several multimers, the latter of which may be important for the biological function of α-synuclein. Currently, there is a lack of reproducible methods to compare α-synuclein multimer abundance between complex biological samples. Here we developed a method, termed “multimer-PAGE,” that combines in-gel chemical cross-linking with several common electrophoretic techniques to measure the stoichiometry of soluble α-synuclein multimers in brain tissue lysates. Results show that soluble α-synuclein from the rat brain exists as several high molecular weight …

03-03-2016 Swosu Biology Club Gearing Up For Plant Sale In April, Southwestern Oklahoma State University

THE BARK ARCHIVE 2016

There are nights when lots of activity takes place at the Southwestern Oklahoma State University Greenhouse on the north side of the Weatherford campus.

Cwu Curriculum Committee Minutes - 03/03/16, Janet Shields

All Faculty Committee Minutes

These are the official Central Washington University Curriculum Committee minutes for the March 3, 2016 meeting.

Application Of Life Table Technique To Estimate The Fecundability Through First Birth Interval Data, Brijesh P. Singh, Gunjan Singh, K. K. Singh

Journal of Statistics Applications & Probability

The term fecundability is an important biological determinant of fertility, which regulate the actual number of children produced by the female. Since fecundability is the monthly chance of conception thus it can be defined as inverse of the waiting time required for a conception, but this time cannot be measured directly and due to this reason birth interval can be used. The paper deals with the estimation of fecundability from the data of waiting time to first conception, i.e., 9 months smaller (on average) than the first birth interval through life table technique. The relevant data is extracted from the …

Reliability Estimation For Negative Binomial Distribution Under Type-Ii Censoring Scheme, Jitendra Kumar, Sanjeev K. Tomer

Journal of Statistics Applications & Probability

The negative binomial distribution is a well recognized lifetime model. In this paper, we consider estimation of reliability measures of this model using type-II censored data. We obtain maximum likelihood and Bayes estimates of parameter, reliability function and hazard rate of this model. We also provide asymptotic, bootstrap and Bayesian credible intervals for the parameter. Finally, we give numerical illustration based on simulation study.

The Inverse Burr Negative Binomial Distribution With Application To Real Data, Abdullahi Yusuf, Badamasi Bashir Mikail, Aliyu Isah Aliyu, Abdurrahaman L. Sulaiman

Journal of Statistics Applications & Probability

We introduce in this paper a four-parameter lifetime model, called the inverse burr negative binomial distribution.We derive some statistical properties of the proposed model that includes moments, quantile functions, median, reliability and entropy. The method of maximum likelihood is used for estimating the model parameters and the observed information matrix is obtained. Simulation study is performed to investigate the performance of the estimation of the model parameters. Two real data sets are used to demonstrate the flexibility of the new proposed model in comparison with other popular lifetime models.

V. 83, Iss. 14, March 3, 2016

Archway (1946-2020)

No abstract provided.

Molecular Mechanisms Of Squamous Cell Carcinoma Tumor Stem Cell Creation Via High Nitric Oxide (Hno) Adaptation, Niresh T. Kuganeswaran '16, Krishi Korrapati '17, Thomas Wan '16, Timothy Tamas, James A. Radosevich

Student Publications & Research

Cancer relapse or recurrence is defined as the return of cancer or its signs/symptoms after a period of improvement. Surgery may not remove all cancer cells and leave behind a few which cannot be detected by scans or other tests. It is also possible that some tumor cells are resistant to chemotherapy or radiation. Although many cancer cells are killed by these treatments, there may exist a few which contain a different genetic makeup which allows them to survive. These hypermalignant cancer cells, or cancer stem cells (CSCs), have been associated with causing cancer relapse. It has also been predicted …

Role Of Pseudogenes In Cancer Stem Creation Via High Nitric Oxide (Hno) Adaptation, Krishi Korrapati '17, Niresh T. Kuganeswaran '16, Thomas Wan '16, Timothy Tamas, James A. Radosevich

Student Publications & Research

Gene chip analysis of ten HNO adapted cell lines (Squamous cells: SCC-016, SCC-040, SCC-056, SCC-114, SCC-116; Adenocarcinomas: A549, BT20, Hs578, MCF7, and T47D) was carried out. Known pseudogenes were identified in each line, as well as their coding counterparts.

The adenocarcinoma cell lines had no up regulated pseudogenes, while they had the following down regulated pseudogenes: RP6-159A1.2, RP11-255N24.3, AC004490.1, LDHBP, RP11-572H4.2. The squamous cell carcinomas (SCCs) had the following up regulated pseudogenes: RPL37AP1, AC138972.1, RP11-641D5.1, AC005534.6, AC022431.1, RPL26P12, and they had these down regulated pseudogenes: RP6-159A1.2, RP11-255N24.3, RBMXP1, RP11-20O23.1, RP11-551G24.2. All cell lines adhered to the hypothesis that an increase …

2014-15 Annual Accountability Report: University Of South Florida St. Petersburg, University Of South Florida St. Petersburg

Academic Learning Compacts

The 2014-2015 Annual Accountability Report for the University of South Florida St. Petersburg approved by the Board of Trustees on March 3, 2016. Includes sections on financial resources, personnel, enrollment, undergraduate education, graduate education, and research and economic development.