Digital Commons Network^™

Optimization Of Rgd Containing Cyclic Peptides Against Αvβ3 Integrin, Yan Wang, Wenwu Xiao, Yonghong Zhang, Leah Meza, Harry Tseng, Yoshikazu Takada, James B. Ames, Kit S. Lam

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity (Mol Cancer Ther, 9:2714–23, 2010). αvβ3 integrin is known to be over-expressed in many cancers and in tumor vasculature, and it has been established as a cancer therapeutic target. To further optimize LXW7, we have performed systematic structure activity relationship (SAR) studies. Based on the results, two highly focused OBOC peptide libraries were designed, synthesized and screened against αvβ3 integrin transfected K562 cells. One of the best …

Justice And Accountability: Activist Judging In The Light Of Democratic Constitutionalism And Democratic Experimentalism, William H. Simon

Faculty Scholarship

This essay examines the charge that activist judging is inconsistent with democracy in the light of two recent perspectives in legal scholarship. The perspectives – Democratic Constitutionalism and Democratic Experimentalism – suggest in convergent and complementary ways that the charge ignores or oversimplifies relevant features of both judging and democracy. In particular, the charge exaggerates the pre-emptive effect of activist judging, and it implausibly conflates democracy with electoral processes. In addition, it understands consensus as a basis for judicial legitimacy solely in terms of pre-existing agreement and ignores the contingent legitimacy that can arise from the potential for subsequent agreement.

Preserving The Corporate Superego In A Time Of Activism: An Essay On Ethics And Economics, John C. Coffee Jr.

Faculty Scholarship

This essay focuses on the impact of recent changes in corporate governance on ethical behavior within the public corporation. It argues that a style of corporate behavior – one characterized by a risk tolerant, even reckless, pursuit of short-term profits and a disregard for the interests of non-shareholder constituencies – is attributable in significant part to recent changes in corporate governance, including the rise of hedge fund activism, greater use of incentive compensation, and the appearance of blockholder directors. It then surveys feasible responses intended to strengthen the role of the boards as the corporation’s conscience and superego. Given the …

The Challenges Of Fitting Principled Modern Government – A Unified Public Law – To An Eighteenth Century Constitution, Peter L. Strauss

Faculty Scholarship

The papers presented at a fall 2016 conference at Cambridge University, The Unity of Public Law?, generally addressed issues of judicial review in the UK, Canada, Australia and New Zealand, often from a comparative perspective and the view that unifying impulses in “public law” arose from the common law. Accepting what Justice Harlan Fisk Stone once characterized as the ideal of “a unified system of judge-made and statute law woven into a seamless whole by [judges],” The Common Law in the United States, 50 Harvard L Rev 4 (1936), this paper considers a variety of issues that have complicated maintaining …

Apps In Higher Education: Criteria And Evaluation, Rebecca Arzola, Stefanie Havelka

Publications and Research

In this article, the authors will consider different evaluation methods for mobile applications. A closer look is taken at app criteria and benchmarks by librarians, by topic, accessibility, and rubrics.

Afroreggae And Grupo Cultural Afro Reggae: A Study Of The Early Years, Sarah S. Ohmer

Publications and Research

The following study of AfroReggae and Grupo Cultural Afro Reggae (GCAR) calls attention to Brazilian presence and community organizing in the field of Hip Hop studies with a long memory framework: placing AfroReggae and GCAR in a long history of Africana resistance through music in Latin America. !990s GCAR group arises when reggae and Hip Hop music had become new global forms of solidarity among urban marginalized youths worldwide, making use of old and new strategies of social healing (Fernandes 2011). A close look at lyrics from the Hip Hop fusion band and the associated nonprofit organization shape the concepts …

Clara Barton National Historic Site (Glen Echo, Maryland), Janet Butler Munch

Publications and Research

The home of Clara Barton, founder of the American Red Cross, is part of a national historic site managed by the National Park Service. This site interprets the contributions of Barton and the Red Cross.

Driverless Cars And The Much Delayed Tort Law Revolution, Andrzej Rapaczynski

Faculty Scholarship

The most striking development in the American tort law of the last century was the quick rise and fall of strict manufacturers’ liability for the huge social losses associated with the use of industrial products. The most important factor in this process has been the inability of the courts and academic commentators to develop a workable theory of design defects, resulting in a wholesale return of negligence as the basis of products liability jurisprudence. This article explains the reasons for this failure and argues that the development of digital technology, and the advent of self-driving cars in particular, is likely …

Wide-Scale Small Unmanned Aircraft System Access To The National Airspace System, John Robbins, Brent Terwilliger, David Ison, Dennis Vincenzi

Publications

Expected revisions of federal policies and regulations for the operation and certification of small unmanned aircraft systems (sUAS) are anticipated to significantly increase the volume of traffic in the National Airspace System (NAS). By investigating critical needs of regulatory compliance and safety, as well as new advancements, it may be possible to identify strategies to address the most pressing concerns of sUAS integration. Findings and recommendations from this research are presented to highlight implications and possible solutions to urgent needs of UAS stakehold-ers, including industry, government, and academia.

Project Execution: A Research Agenda To Explore The Phenomenon, James Walter Marion, Tracey Richardson, Matthew Earnhardt

Publications

It is observed in the literature that although project management is considered to be an execution-oriented discipline, the Project Management Body of Knowledge developed by the Project Management Institute provides relatively little detail in the Executing process group compared with other process groups such as the Planning and Monitoring and Controlling process groups. It is further observed that project elements considered essential to the success of the project including project Scope, Cost, Schedule, and Risk are not included within the Executing process group. Likewise, the coverage of project execution in the Project Manager Competency Development Framework authored by the Project …

Understanding The Sunni Awakening With Complexity Theory, Diane Maye Zorri

Publications

Concurrent to the surge of U.S. forces in Iraq between 2006 and 2008, Sunni tribesmen in the U.S. Marine‐controlled western Anbar province of Iraq experienced an “awakening” movement, which led them to side with U.S. and coalition forces. The Sunni Awakening demonstrates that individuals will often realign because of betrayal and opportunities for advancement. It also demonstrates that individual motives can have macrolevel social consequences. Complexity theory suggests that political factions will realign based on individual considerations that then develop into macrolevel movements. Complexity theory also combines both agency (in terms of microbehaviors) and structure (in terms of initial conditions). …

How Undergraduates' Involvement Affects Sense Of Belonging In Courses That Use Technology, Leroy L. Long Iii

Publications

In order to increase the number of American degree recipients in science, technology, engineering and mathematics (STEM), academics must continually develop ways to improve students’ interest, retention, and success in fields like engineering. Prior researchers have studied the use of educational technology as a way to improve student outcomes and skills. Previous scholars have also investigated students’ perceptions of the usefulness of technology. However, it is unclear if a statistically significant relationship exists between students’ involvement in courses that use technology and their sense of belonging to others on campus. The present study addressed this gap by examining the relationship …

Emulating The Wright State Model For Engineering Mathematics Education: Improving First-Year Engineering Student Retention, Leroy L. Long Iii, Lisa M. Abrams, Lisa Barclay, Jamie Paulson

Publications

In 2004, Wright State University developed an innovative mathematics course for first-year engineering undergraduates in order to increase student retention, motivation and academic success. To date, the Wright State model has had a positive impact on student retention, motivation and academic success by increasing graduation rates and GPAs among participants. During the fall of 2014 and 2015, one large public university in the Midwest with more selective admission criteria decided to pilot a course based on the Wright State Model for Engineering Mathematics Education. Using the Wright State model, a mathematics for engineering course was offered to prospective students so …

From Enrollment To Employment: A Dacum Approach To Information Systems And Information Security And Assurance Curriculum Design, Leila Halawi, Wendi M. Kappers, Aaron Glassman

Publications

Issues associated with information security are numerous and diverse. Since the majority of organizational actions rely greatly on information and communication technologies, Information Systems (IS) security is now a main concern for firms, governments, institutes, and society as a whole. As a result, a plethora of graduate programs have been created, covering nearly every aspect of IS security. The authors review the current state of the IS industry presented in the literature, and identify a panel of IS experts in which to explore current job skill needs using a “Developing a Curriculum,” DACUM, process to support curriculum design for two …

Constitutional Bad Faith, David E. Pozen

Faculty Scholarship

The concepts of good faith and bad faith play a central role in many areas of private law and international law. Typically associated with honesty, loyalty, and fair dealing, good faith is said to supply the fundamental principle of every legal system, if not the foundation of all law. With limited exceptions, however, good faith and bad faith go unmentioned in constitutional cases brought by or against government institutions. This doctrinal deficit is especially striking given that the U.S. Constitution twice refers to faithfulness and that insinuations of bad faith pervade constitutional discourse.

This Article investigates these points and their …

Teaching Innovation And Creativity: Turning Theory Into Practice, Aaron M. Glassman, Rose Opengart

Publications

Innovation and creativity are the lifeblood of organizations. As such, businesses expect college graduates to exhibit the skills necessary to engage in these behaviors. This research explores the concept of innovation, whether it is innate, or if the skill can be taught within the university setting, and how universities are addressing the need for, and teaching innovation. A search of the word “innovation” within educational courses found that most courses are theoretically-oriented or are efforts to cultivate entrepreneurs and/or new inventions, though some appear more practical in nature. A sampling of 50 ACBSP and AACSB accredited universities offering courses in …

Interactomics-Based Functional Analysis: Using Interaction Conservation To Probe Bacterial Protein Functions, J. Harry Caufield

Theses and Dissertations

The emergence of genomics as a discrete field of biology has changed humanity’s understanding of our relationship with bacteria. Sequencing the genome of each newly-discovered bacterial species can reveal novel gene sequences, though the genome may contain genes coding for hundreds or thousands of proteins of unknown function (PUFs). In some cases, these coding sequences appear to be conserved across nearly all bacteria. Exploring the functional roles of these cases ideally requires an integrative, cross-species approach involving not only gene sequences but knowledge of interactions among their products. Protein interactions, studied at genome scale, extend genomics into the field of …

Electrochemical Studies Of Cerium And Uranium In Licl-Kcl Eutectic For Fundamentals Of Pyroprocessing Technology, Dalsung Yoon

Theses and Dissertations

Understanding the characteristics of special nuclear materials in LiCl-KCl eutectic salt is extremely important in terms of effective system operation and material accountability for safeguarding pyroprocessing technology. By considering that uranium (U) is the most abundant and important element in the used nuclear fuel, measurements and analyses of U properties were performed in LiCl-KCl eutectic salt. Therefore, the electrochemical techniques such as cyclic voltammetry (CV), open circuit potential (OCP), Tafel, linear polarization (LP), and electrochemical impedance spectroscopy (EIS) were conducted under different experimental conditions to explore the electrochemical, thermodynamic, and kinetic properties of U in LiCl-KCl eutectic. The ultimate goal …

Beyond The Single Story: How Analog Hypertext Facilitates Representation Of Multiple Critical Perspectives In An Art Museum Object Study Gallery, Aimee D. Hunt

Theses and Dissertations

This project utilized a form of arts based educational research described as analog hypertext to develop interpretative material representing multiple critical, theoretical, and disciplinary perspectives on objects in a university art museum’s object study gallery. Drawing on scholars’ recommendations for postcolonial interpretation of non-Western art, the project created a web of information, which simultaneously revealed and critiqued the underlying ideologies and power structures shaping the museum’s display in an effort to change existing interpretive practice. The project developed five color-coded thematic self-guided tours—art as commodity, spiritual practice, technology and cultural evolutionism, mortuary rituals, and postcolonial perspectives—presented to the public as …

Toward Epistemological Diversity In Stem-H Grantmaking: Grantors’ And Grantees’ Perspectives On Funding Indigenous Research, Programming, And Evaluation, Jessica C. Venable

Theses and Dissertations

Mainstream institutions have, historically, dismissed Indigenous worldviews, knowledges, and research approaches (Bowman-Farrell, 2015; Harrington & Pavel, 2013). However, in recent years, a literature has emerged articulating Indigenous research methodologies (IRMs), and their distinctiveness from Western, Eurocentric perspectives on inquiry (Denzin, Lincoln, & Smith, 2008; Kovach, 2009; Smith, 1999 & 2012; Wilson, 2008). This has coincided with increased need for IRM scholars and practitioners to secure extramural funds to support their activities. But questions remain as to how the U.S. federal grant making enterprise has accommodated Indigenous frameworks. This research explores synergies in the ways that grantees, grant makers, and other …

Liability For Mobile Health And Wearable Technologies, Lindsay Wiley, Nicolas Terry

Scholarly Articles in Law Reviews & Journals

Most of the legal commentary regarding mobile health has focused on direct regulation leveraging existing laws and regulators such as HIPAA privacy through HHS-OCR or device regulation by the FDA. However, much of the mobile health revolution likely will play out in lightly regulated spaces bereft of most of the privacy, security, and safety rules associated with traditional health care. This article examines the potential for common law liability models to bridge these gaps (even on a temporary basis). Part II of this paper provides an introduction to the terminology used, and presents a brief typology of the apps appearing …

Modern Art Of Pakistan: Lahore Art Circle 1947-1957, Samina Iqbal

Theses and Dissertations

This dissertation focuses on the modern art of Pakistan from 1947-57, more specifically, the role of six important artists who founded the Lahore Art Circle (LAC) in 1952. The group played a pivotal role in the formulation of modernism in Pakistan after its establishment as an Islamic Republic. Framed within postcolonial theories and criticism, this study will address the role of modern art in developing new artistic sensibilities in the nation of Pakistan. In order to understand the context of LAC’s framing of “modernism” and “nationalism” in terms of specific historic and hybrid nexus,my research will provide an investigation of …

Family Defense And The Disappearing Problem-Solving Court, Jane M. Spinak

Faculty Scholarship

Problem-solving courts began to flourish in the early 1990s with the creation of criminal drug courts as alternatives to standard criminal court practices. In the drug courts, defendants would receive treatment rather than incarceration and be monitored closely within the court. Family Court Treatment Parts (FCTPs) were developed in the late 1990s in New York State, fully embracing the three key components of the problem-solving drug court model: (1) an activist judge who helps to fashion, and then closely monitor, dispositions; (2) a team of lawyers, social workers, and court personnel who try to identify and then work toward commons …

Using Semiphysiologically-Based Pharmacokinetic (Semi-Pbpk) Modeling To Explore The Impact Of Differences Between The Intravenous (Iv) And Oral (Po) Route Of Administration On The Magnitude And Time Course Of Cyp3a-Mediated Metabolic Drug-Drug Interactions (Ddi) Using Midazolam (Mdz) As Prototypical Substrate And Fluconazole (Flz) And Erythromycin (Ery) As Prototypical Inhibitors, Mengyao Li

Theses and Dissertations

The purpose of the project was to investigate the impact of IV and PO routes difference for MDZ, a prototypical CYP3A substrate, and two CYP3A inhibitors (CYP3AI) -FLZ and ERY-, on the magnitude and time course of their inhibitory metabolic DDI.

Individual semi-PBPK models for MDZ, FLZ and ERY were developed and validated separately, using pharmacokinetic (PK) parameters from clinical/in-vitro studies and published physiological parameters. Subsequently, DDI sub-models between MDZ and CYP3AIs incorporated non-competitive and mechanism-based inhibition (MBI) for FLZ and ERY, respectively, on hepatic and gut wall (GW) CYP3A metabolism of MDZ, using available in-vitro/in-vivo information. Model-simulated MDZ …

A Correlational Analysis Of Secondary Data For Factors Influencing Graduation From Adult Drug Court, David N. Masri

Theses and Dissertations

The proliferation of drug courts throughout the world over the last two decades presents an opportunity and a challenge. The drug court approach involves a combination of treatment and judicial supervision which is a diversion from incarceration and/or ‘traditional’ criminal justice supervision. Despite widespread study of drug courts, there is much that researchers still do not know and there is still controversy as to how and why drug courts work. This research study is an examination of secondary data from an urban, mid-Atlantic drug court to attempt to correlate factors that contribute to success (as defined by graduation) in drug …

Automated Conjecturing Approach To The Discrete Riemann Hypothesis, Alexander Bradford

Theses and Dissertations

This paper is a study on some upper bounds of the Mertens function, which is often considered somewhat of a ``mysterious" function in mathematics and is closely related to the Riemann Hypothesis. We discuss some known bounds of the Mertens function, and also seek new bounds with the help of an automated conjecture-making program named CONJECTURING, which was created by C. Larson and N. Van Cleemput, and inspired by Fajtowicz's Dalmatian Heuristic. By utilizing this powerful program, we were able to form, validate, and disprove hypotheses regarding the Mertens function and how it is bounded.

From Seed To Sky: Impacts Of Explosive Compounds On Vegetation Across Spatial And Developmental Scales, Stephen M. Via

Theses and Dissertations

Explosive compounds are broadly distributed across the globe as a result of nearly two centuries of munitions use in warfare and military activities. Two explosive compounds have seen disproportionate use; RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) and TNT (2-methyl- 1,3,5-trinitrobenzene), being the most commonly found explosives in the environment. The effects of explosives on biota have been studied in great detail; however, there is a general lack of understanding with regard to broader ecological impacts of these contaminants. My dissertation objective was to follow the impacts of explosive compounds on vegetation across scales. Impacts on vegetation at the species scale alter community composition via …

The Molecular And Mechanical Mechanisms Of The Age-Associated Increase In The Severity Of Experimental Ventilator Induced Lung Injury, Joseph Ames Herbert

Theses and Dissertations

Abstract

Background

The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and mortality. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood.

Pulmonary edema is a hallmark of VILI and the severity of edema increases with age. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress (ARDS) patients, but has not been investigated in VILI. We hypothesized that age-associated increases in pulmonary edema promote age-related increases in ventilator-associated mortality. Endoplasmic reticulum (ER) …

Law In The Shadow Of Violence: Can Law Help To Improve Doctor-Patient Trust In China?, Benjamin L. Liebman

Faculty Scholarship

Can law help to address the lack of trust in doctor-patient relationships in China? This essay examines the role that law, on the books and in practice, has played in the rise and resolution of patient-doctor disputes and conflict in China. Law has generally played a secondary role in medical disputes: most patient claims never make it to court, and there is little evidence that negotiated outcomes are influenced by legal standards. Yet a legal framework weighted in favor of hospitals and doctors almost certainly exacerbated doctor-patient conflict in the 2000s. Patients facing legal procedures and rules that appeared to …

The Painful Long Head Of The Biceps Brachii: Nonoperative Treatment Approaches, Kevin E. Wilk, Todd R. Hooks

Physical Therapy Faculty Research and Publications

Pain associated with the long head of the biceps (LHB) brachii seems to be increasingly recognized in the past 4 to 5 years. The LHB has long been considered a troublesome pain generator in the shoulder. Abnormality involving the LHB brachii has long been an area of debate, with Codman in 1934 even questioning the specificity of the diagnosis of biceps tendinitis. Biceps tendon abnormality is often associated with rotator cuff impingement. Shoulder pain originating from the biceps tendon can be debilitating, causing a severe decrease in shoulder function. As a result of the frequent clinical presentation of biceps pain, …