Digital Commons Network^™

Nampt-Mediated Nad+ Biosynthesis In Adipocytes Regulates Adipose Tissue Function And Multi-Organ Insulin Sensitivity In Mice, Kelly L. Stromsdorfer, Shintaro Yamaguchi, Myeong Jin Yoon, Anna C. Moseley, Michael P. Franczyk, Shannon C. Kelly, Nathan Qi, Shin-Ichiro Imai, Jun Yoshino

Open Access Publications

No abstract provided.

Impact Of Time To Appropriate Therapy On Mortality In Patients With Vancomycin-Intermediate Staphylococcus Aureus Infection, Jason P. Burnham, Carey-Ann D. Burnham, David K. Warren, Marin H. Kollef

Open Access Publications

No abstract provided.

Personality Polygenes, Positive Affect, And Life Satisfaction, Andrew C. Heath, Et Al

Open Access Publications

No abstract provided.

Structural Basis Of Control Of Inward Rectifier Kir2 Channel Gating By Bulk Anionic Phospholipids, Sun-Joo Lee, Feifei Ren, Eva-Maria Zangerl-Plessl, Sarah Heyman, Anna Stary-Weinzinger, Peng Yuan, Colin G. Nichols

Open Access Publications

No abstract provided.

Mapping Rare, Deleterious Mutations In Factor H: Association With Early Onset, Drusen Burden, And Lower Antigenic Levels In Familial Amd, Erin K. Wagner, Soumya Raychaudhuri, Mercedes B. Villalonga, Anuja Java, Michael P. Triebwasser, Mark J. Daly, John P. Atkinson, Johanna M. Seddon

Open Access Publications

No abstract provided.

Tubular Overexpression Of Angiopoietin-1 Attenuates Renal Fibrosis, Sudhir Singh, Scott R. Manson, Heedoo Lee, Yeawon Kim, Tuoen Liu, Qiusha Guo, Julio J. Geminiani, Paul F. Austin, Ying Maggie Chen

Open Access Publications

No abstract provided.

An Ultrasensitive Electrogenerated Chemiluminescence-Based Immunoassay For Specific Detection Of Zika Virus, Dhiraj Acharya, Pradip Bastola, Linda Le, Amber M. Paul, Estefania Fernandez, Michael S. Diamond, Wujian Miao

Open Access Publications

No abstract provided.

Mir-15a/16 Regulates Apoptosis Of Lung Epithelial Cells After Oxidative Stress, Yong Cao, Duo Zhang, Hyung-Geun Moon, Heedoo Lee, Jeffrey A. Haspel, Kebin Hu, Lixin Xie, Yang Jin

Open Access Publications

No abstract provided.

Broadly Neutralizing Activity Of Zika Virus-Immune Sera Identifies A Single Viral Serotype, Kimberly A. Dowd, Christina R. Demaso, Rebecca S. Pelc, Scott D. Speer, Alexander R.Y. Smith, Leslie Goo, Derek J. Platt, John R. Mascola, Barney S. Graham, Mark J. Mulligan, Michael S. Diamond, Julie E. Ledgerwood, Theodore C. Pierson

Open Access Publications

No abstract provided.

Triggering Receptor Expressed On Myeloid Cells (Trem)-2 Impairs Host Defense In Experimental Melioidosis, Tassili A. F. Weehuizen, Tijmen J. Hommes, Jacqueline M. Lankelma, Hanna K. De Jong, Joris J. T. H. Roelofs, Alex F. De Vos, Marco Colonna, Tom Van Der Poll, W. Joost Wiersinga

Open Access Publications

No abstract provided.

Reprogrammable Crispr/Cas9-Based System For Inducing Site-Specific Dna Methylation, James I. Mcdonald, Hamza Celik, Lisa E. Rois, Gregory Fishberger, Tolison Fowler, Ryan Rees, Ashley Kramer, Andrew Martens, John R. Edwards, Grant A. Challen

Open Access Publications

No abstract provided.

Protocol For The Electroencephalography Guidance Of Anesthesia To Alleviate Geriatric Syndromes (Engages) Study: A Pragmatic, Randomised Clinical Trial, T. S. Wildes, A. C. Winter, H. R. Maybrier, A. M. Mickle, E. J. Lenze, S. Stark, N. Lin, S. L. Mckinnon, M. R. Muench, M. R. Murphy, R. T. Upadhyayula, B. A. Fritz, K. E. Escallier, G. P. Apakama, D. A. Emmert, T. J. Graetz, T. W. Stevens, B. J. Palanca, R. Hueneke, S. Melby, B. Torres, M. S. Avidan, Et Al

Open Access Publications

No abstract provided.

Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms Of Eye Fatigue, Jonathan B. Lin, Blair W. Gerratt, Carl J. Bassi, Rajendra S. Apte

Open Access Publications

No abstract provided.

Regulators Of Complement Activity Mediate Inhibitory Mechanisms Through A Common C3b‐Binding Mode, Federico Forneris, Jin Wu, Xiaoguang Xue, Daniel Ricklin, Zhuoer Lin, Georgia Sfyroera, Apostolia Tzekou, Elena Volokhina, Joke Cm Granneman, Richard Hauhart, Paula Bertram, M. Kathryn Liszewski, John P. Atkinson, John D. Lambris, Piet Gros

Open Access Publications

No abstract provided.

Maternal Glucose And Fatty Acid Kinetics And Infant Birth Weight In Obese Women With Type 2 Diabetes, W. Todd Cade, Rachel A. Tinius, Dominic N. Reeds, Bruce W. Patterson, Alison G. Cahill

Open Access Publications

No abstract provided.

Eis Database Technical Considerations: Geospatial, Kytt Macmanus

Sabin Center for Climate Change Law

This presentation outlines possible methods of adding geospatial data to a database of environmental impact statements.

Using Online Databasing To Unlock The Full Value Of Environmental Impact Assessments, Jessica A. Wentz

Sabin Center for Climate Change Law

Government agencies are often required to conduct some form of environmental impact assessment (EIA) before approving a major project or proposal. The documents generated during these assessments contain a wealth of information about baseline environmental conditions, impact assessment methodologies, predicted impacts, and mitigation measures, among other things. This information is compiled at great effort and expense and is valuable in many different applications. Unfortunately, the challenge of locating and searching through these documents poses a serious impediment to effectively harnessing the information contained therein.

Granted, public access to EIA documents has improved considerably in the past decade. Environmental Impact Statements …

Ontario’S Climate Change Mitigation And Low Carbon Economy Act: Pious Aspirations Or New Dawn?, Damilola Olawuyi

Sabin Center for Climate Change Law

This paper assess Ontario's proposed cap and trade program for effectiveness; comprehensiveness; transparency and fairness; and offset eligibility. It identifies its areas of innovation and strengths, key implementation and logistical questions that may arise, and offers perspectives on how to address such gaps.

Hud Doesn't Need New Legislative Authority To Better Integrate Climate Change Resilience Into Its Disaster Recovery Program, Justin Gundlach, Channing R. Jones

Sabin Center for Climate Change Law

This article examines the interaction between the Department of Housing and Urban Development (HUD)’s community development block grant disaster recovery program (CDBGDR) and the federal and state governments' resilience and climate adaptation priorities. It identifies and analyzes the statutes that have guided HUD's approach to date, by considering both key statutory language and legislative history. It also examines forms of "soft guidance" issued by HUD for use by various stakeholders, including both HUD CDBG-DR program officers and the state and local officials that interact with them. In reviewing this material, the article identifies a tension between the requirement that all …

Eis Database Design Considerations, Sritharan Vinayagamoorthy

Sabin Center for Climate Change Law

This presentation provides an overview of design considerations for a new online database of environmental impact statements.

A Mitigation Based Rationale For Incorporating A Climate Change Impacts Fee Into The Federal Coal Leasing Program, Michael Burger

Sabin Center for Climate Change Law

This paper describes the legal and policy rationale for imposing a fee on federal coal that reflects the costs of the climate change impacts generated by that coal. It notes that the federal government has a duty to mitigate climate impacts from the federal coal leasing program, and that the Department of Interior (“Interior”) and the Bureau of Land Management (“BLM”) have ample authority to impose a climate change impacts fee on coal leases as a form of compensatory mitigation for those coal leases. The paper also discusses technical issues that should be considered when assessing the effectiveness of this …

Local Law Provisions For Climate Change Adaptation, Justin Gundlach, P. Dane Warren

Sabin Center for Climate Change Law

In September 2014, New York enacted the Community Risk and Resiliency Act (CRRA), which requires in part that the New York Department of State (DOS) and the Department of Environmental Conservation (DEC) create model local laws relating to climate change adaptation for use by local governments. In an effort to assist the State with drafting model local laws for adaptation; to encourage the State to incorporate a broad range of adaptation strategies, including retreat from areas of high flood risk; and to assist local governments with implementation of these programs. The Sabin Center for Climate Change Law has assembled existing …

Federal Implementation Plans And The Path To Clean Power, Daniel Selmi

Sabin Center for Climate Change Law

Promulgated under the Clean Air Act in October 2015, the Clean Power Plan (“CPP”) requires states to significantly reduce carbon emissions from existing power plants and is the centerpiece of the Environmental Protection Agency’s (“EPA”) response to global warming. Many states have filed lawsuits challenging the CPP and some states have vowed that, if those suits are unsuccessful, they will refuse to implement it. In turn, EPA has proposed rules that would implement the CPP by imposing a “federal implementation plan” (“FIP”) upon those recalcitrant states under the authority of the Clean Air Act. Thus, the success of the CPP …

State Responsibility To Respect, Protect And Fulfill Human Rights Obligations In Cyberspace, Gabor Rona, Lauren Aarons

Articles

The article argues that international human rights law applies to cyberspace, obligating States to protect individuals' rights online, including privacy, freedom of expression, and assembly. While the legal framework exists, its application remains unsettled, requiring further development to address challenges like balancing security with liberty and regulating non-State actors. The article emphasizes the need for States to adopt a "Golden Rule" approach, prioritizing human rights and security over short-term competitive advantages.

Introduction To Analytics, Information Systems And Decision Technologies For Sustainability Minitrack, Omar F. El-Gayar, Arno Scharl, Pingsun Leung

Research & Publications

No abstract provided.

Discovering Design Principles For Persuasive Systems: A Grounded Theory And Text Mining Approach, Mohammad Al-Ramahi, Omar F. El-Gayar, Jun Liu

Research & Publications

Persuasive systems aim to change users' behavior and lifestyle. These systems have been gaining popularity with the proliferation of wearable devices and recent advances in information technology. In that regard, recent research aims at identifying system design principles that are specific to persuasive systems. In this article we extend the existing literature by discovering design principles for persuasive systems from a systematic analysis of users feedback from the actual use of persuasive systems. Specifically, we use grounded theory and text mining (topic modeling) to extract design concepts from online user reviews of mobile diabetes applications. Overall, the results extend existing …

Using Semi-Supervised Learning For The Creation Of Medical Systematic Review: An Exploratory Analysis, Prem Timsina, Jun Liu, Omar F. El-Gayar, Yanyan Shang

Research & Publications

In this research, we explore semi-supervised learning based classifiers to identify articles that can be included when creating medical systematic reviews (SRs). Specifically, we perform comparative study of various semi-supervised learning algorithm, and identify the best technique that is suited for SRs creation. We also aim to identify whether semisupervised learning technique with few labeled samples produce meaningful work saving for SRs creation. Through an empirical study, we demonstrate that semi-supervised classifiers are viable for selecting articles for systematic reviews and situations when only a few numbers of training samples are available.

Health Literacy: Exploring Health Knowledge Transfer In Online Healthcare Communities, Yanyan Shang, Jun Liu

Research & Publications

The knowledge-intensive nature of healthcare enables health literacy playing a key role on the quality of healthcare. This study aims at understanding the factors that affect the effectiveness of health knowledge transfer in online healthcare communities. The findings can be used as guidelines for the development and management of the online healthcare communities to improve user experience, and to provide a means to disseminate healthcare information, to enhance healthcare education, and to facilitate a wide range of interactions between patients and healthcare delivery system.

Assessment Of The Environmental And Genetic Factors Influencing Prevalence Of Metabolic Syndrome In Saudi Arabia, Ibrahim M. Gosadi

Saudi Medical Journal

Metabolic syndrome (MS) is a combination of factors that increases the risk of cardiovascular atherosclerotic diseases including diabetes, obesity, dyslipidemia, and high blood pressure. Cardiovascular diseases are one of the leading causes of death in the adult Saudi population where the increase in cardiovascular-related mortality is augmented by the rise in the prevalence of MS. Metabolic syndrome is a multi-factorial disorder influenced by interactions between genetic and environmental components. This review aims to provide a comprehensive assessment of studied environmental and genetic factors explaining the prevalence of MS in the Kingdom of Saudi Arabia. Additionally, this review aims to illustrate …

Kleine-Levin Syndrome: Familial Cases And Comparison With Sporadic Cases

Saudi Medical Journal

Objectives: To highlight the occurrence of familial cases and addresses, whether familial Kleine-Levine syndrome (KLS) presents the same spectrum of disease, as that seen in sporadic KLS. Methods: Between September and December 2014, reports of familial cases of KLS were identified by searching the Library of Congress, PubMed, and Web of Science databases restricted to the English language, with no restriction on date of publication. All cases were reviewed to identify familial cases consistent with current diagnostic criteria for sporadic KLS. Results: Six reviews and 11 case reports describing cases of familial KLS were identified. In 17 of the 29 …