Digital Commons Network^™

Epidemiology And Impact Of Campylobacter Infection In Children In 8 Low-Resource Settings: Results From The Mal-Ed Study, Shahida Qureshi, Aneeta Hotwani, Sadia Shakoor, (Mal-Ed) Network Investigators, Imran Ahmed, Didar Alam, Syed Asad Ali, Zulfiqar Ahmed Bhutta, Muneera Rasheed, Sajid Bashir Soofi, Ali Turab, Anita K. M. Zaidi

Department of Paediatrics and Child Health

Background: Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life.
Methods: Children were actively followed up until 24 months of age. Diarrheal and nondiarrheal stool samples were collected and tested by enzyme immunoassay for Campylobacter Stool and blood samples were assayed for markers of intestinal permeability and inflammation.
Results: A total of 1892 children had 7601 diarrheal and 26 267 nondiarrheal stool samples tested for Campylobacter We describe a high …

Parental Attitudes/ Locus Of Health Control And Caries Experience In Their 3-5 Year Old Children, Cassandra Garcia

Dental Hygiene ETDs

ABSTRACT

Purpose: Childhood caries represents a public health issue especially for the Head Start population due to many disadvantages. Behavioral risk factors such as locus of health control (LoC) could act as indirect casual agents in the development of dental disease, but has not been fully studied. This research was to assess the relationship between parental attitudes/ health locus of control, parental age, and parental marital status with caries experience in their preschool children by using a validated survey.

Methods: The target population assessed in this study was the parents of children enrolled in Head Start Programs, in Santa Fe …

A Dna Methylation Biomarker Of Alcohol Consumption, C. Liu, R. E. Marioni, Å. K. Hedman, L. Pfeiffer, P. -C. Tsai, L. M. Reynolds, A. C. Just, Q. Duan, C. G. Boer, T. Tanaka, C. E. Elks, S. Aslibekyan, J. A. Brody, B. Kühnel, C. Herder, L. M. Almli, D. Zhi, Y. Wang, T. Huan, C. Yao, M. M. Mendelson, R. Joehanes, L. Liang, S. -A. Love, W. Guan, S. Shah, A. F. Mcrae, A. Kretschmer, H. Prokisch, K. Strauch, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (n_total=13 317; 54% women; mean age across cohorts 42–76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples. We performed meta-analysis and variable selection in …

V-Src Oncogene Induces Trop2 Proteolytic Activation Via Cyclin D1., Xiaoming Ju, Xuanmao Jiao, Adam Ertel, Mathew C. Casimiro, Gabriele Disante, Shengqiong Deng, Zhiping Li, Agnese Di Rocco, Tingting Zhan, Adam Hawkins, Tanya Stoyanova, Sebastiano Andò, Alessandro Fatatis, Michael P. Lisanti, Leonard G. Gomella, Lucia R. Languino, Richard G. Pestell

Department of Cancer Biology Faculty Papers

Proteomic analysis of castration-resistant prostate cancer demonstrated the enrichment of Src tyrosine kinase activity in approximately 90% of patients. Src is known to induce cyclin D1, and a cyclin D1-regulated gene expression module predicts poor outcome in human prostate cancer. The tumor-associated calcium signal transducer 2 (TACSTD2/Trop2/M1S1) is enriched in the prostate, promoting prostate stem cell self-renewal upon proteolytic activation via a γ-secretase cleavage complex (PS1, PS2) and TACE (ADAM17), which releases the Trop2 intracellular domain (Trop2 ICD). Herein, v-Src transformation of primary murine prostate epithelial cells increased the proportion of prostate cancer stem cells as characterized by gene expression, …

Nutritional Status Affects Incidence Of Pneumonia In Underfives, Henry Wicaksono

Folia Medica Indonesiana

Pneumonia is an acute infection disease which remains the main killer of children under 5 years old worldwide. Based on Unicef's report, 17% of all children death is caused by pneumonia. Indonesia was in 10th position of the highest incidence of pneumonia and diarrhea which caused the death of children under 5 years old in 2013. In Gane Luar Public Health Center, there were at least 3 patients with pneumonia every month during 2014. The risk factors are less exclusive breastfeeding, malnutrition, low birth weight, less coverage of measles vaccine, indoor air pollution, and the high level of occupation density. …

Habitual Coffee Consumption And Risk Of Type 2 Diabetes, Ischemic Heart Disease, Depression And Alzheimer’S Disease: A Mendelian Randomization Study, Man Ki Kwok, Gabriel M. Leung, C. Mary Schooling

Publications and Research

Observationally, coffee is inversely associated with type 2 diabetes mellitus (T2DM), depression and Alzheimer’s disease, but not ischemic heart disease (IHD). Coffee features as possibly protective in the 2015 Dietary Guidelines for Americans. Short-term trials suggest coffee has neutral effect on most glycemic traits, but raises lipids and adiponectin. To clarify we compared T2DM, depression, Alzheimer’s disease, and IHD and its risk factors by genetically predicted coffee consumption using two-sample Mendelian randomization applied to large extensively genotyped case-control and cross-sectional studies. Childhood cognition was used as a negative control outcome. Genetically predicted coffee consumption was not associated with T2DM (odds …

Quantitative And Qualitative Nutritional Analysis Of Gvsu Managed Honey Bee Colonies, Emily Noordyke, Anne Marie Fauvel

Student Summer Scholars Manuscripts

Managed honeybee colonies are in significant decline worldwide. The interaction between poor nutrition, pests and diseases, and pesticide use are most cited as potential culprits for the precarious state of the beekeeping industry. By evaluating food coming into the hive, conclusions can be drawn about the quality of hive location and forage availability. Pollen from an apiary with historically low honey production and poor colony health was compared to pollen from an apiary with high honey production and good colony health. Pollen was collected weekly in a 24-hour period, hive weight was monitored, and colonies were assessed for overall growth …

The Future Of Indiana: Reducing Risky Behavior Of Our Youth, Center For Families

Center for Families Publications

No abstract provided.

Papaya Seed Extract Lowers Sperm Concentrations, Motility And Viability In Male Mice, Reryd Arindany Wiryawan, Reny I'Tishom, Sri Purwaningsih

Folia Medica Indonesiana

Indonesia is a developing country with a dense population, so the government carry on KB (Family Planning) program in which the targets are mostly women. Contraceptives are intended for women are birth control pills and IUD (Intra Uterine Device), whereas until now the contraceptive for men who are considered well-established are condom and vasectomy. Thus, the development of herbal medicine, which is cheap and affordable, makes it possible to be consumed in a long term with less meaningful side effects. Papaya seeds (Carica papaya) is one of the many plants used by communities to eradicate intestinal worms, menstrual laxative, and …

Worldwide Trends In Blood Pressure From 1975 To 2015: A Pooled Analysis Of 1479 Population-Based Measurement Studies With 19·1 Million Participants, Bin Zhou, James Bentham, Mariachiara Di Cesare, Honor Bixby, Goodarz Danaei, Melanie J. Cowan, Christopher J. Paciorek, Gitanjali Singh, Kaveh Hajifathalian, James E. Bennett, Cristina Taddei, Con Burns, Tara Coppinger, Ver Bilano, Rodrigo M. Carrillo-Larco, Shirin Djalalinia, Shahab Khatibzadeh, Charles Lugero, Niloofar Peykari, Wan Zhu Zhang, Yuan Lu, Gretchen A. Stevens, Leanne M. Riley, Pascal Bovet, Paul Elliott, Dongfeng Gu, Nayu Ikeda, Rod T. Jackson, Michel Joffres, Andre Pascal Kengne, Tiina Laatikainen, Tai Hing Lam, Avula Laxmaiah, Jing Liu

Publications

Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean …

Developing A New Specialty Multi-Disciplinary Clinic While Orienting As A Novice Nurse Navigator, Angela Miller Rn, Jeanne Kenna Rn, Ocn, Laura Beaupre Bsn, Ocn, Cbpn-Ic, Jane Zubia Rn, Ocn, Cbpn I-C, Martiza Y. Chicas Rn, Pccn, Raizalie Roman-Rosado Bsn, Ocn, Cmsrn, Cynthia Smith Rn, Alyssa Pauls, Kathy Sevedge Rn, Ma, Aocn

Patient Care Services / Nursing

No abstract provided.

Characteristics Of Hellp Syndrome In Severe Preeclampsia Patients In Dr. Soetomo Hospital Surabaya, Warih Angesti P, Ernawati Ernawati, Dwi Susanti

Folia Medica Indonesiana

Hemolysis, elevated liver enzyme, and low platelet count syndrome (HELLPs) is complication following severe preeclampsia which is one of the three leading causes of maternal mortality in Indonesia. The purpose of this study was to understand the prevalence, characteristics, and post-partum outcome of HELLPs patients who deliver in Dr. Soetomo Hospital in July 2012-June 2013. This study was observational-descriptive, cross sectional study. The population observed was the severe preeclampsia patients who deliver in Dr. Soetomo Hospital and have complete medical data in July 2012-June 2013. study subject taken by total sampling. HELLPs follow the 7% of severe preeclampsia patients. The …

Epoxyeicosatrienoic Acids Regulate Adipocyte Differentiation Of Mouse 3t3 Cells, Via Pgc-1Α Activation, Which Is Required For Ho-1 Expression And Increased Mitochondrial Function, Maayan Waldman, Lars Bellner, Luca Vanella, Joseph Schragenheim, Komal Sodhi, Shailendra P. Singh, Daohong Lin, Anand Lakhkar, Jiangwei Li, Edith Hochhauser, Michael Arad, Zbigniew Darzynkiewicz, Attallah Kappas, Nader G. Abraham

Biochemistry and Microbiology

Epoxyeicosatrienoic acid (EET) contributes to browning of white adipose stem cells to ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET altered preadipocyte function, enhanced peroxisome proliferation-activated receptor γ coactivator α (PGC-1α) expression, and increased mitochondrial function in the 3T3-L1 preadipocyte subjected to adipogenesis. Cells treated with EET resulted in an increase, P < 0.05, in PGC-1α and a decrease in mitochondria-derived ROS (MitoSox), P < 0.05. The EET increase in heme oxygenase-1 (HO-1) levels is dependent on activation of PGC-1α as cells deficient in PGC-1α (PGC-1α knockout adipocyte cell) have an impaired ability to express HO-1, P < 0.02. Additionally, adipocytes treated with EET exhibited an increase in mitochondrial superoxide dismutase (SOD) in a PGC-1α-dependent manner, P < 0.05. The increase in PGC-1α was associated with an increase in β-catenin, P < 0.05, adiponectin expression, P < 0.05, and lipid accumulation, P < 0.02. EET decreased heme levels and mitochondria-derived ROS (MitoSox), P < 0.05, compared to adipocytes that were untreated. EET also decreased mesoderm-specific transcript (MEST) mRNA and protein levels (P < 0.05). Adipocyte secretion of EET act in an autocrine/paracrine manner to increase PGC-1α is required for activation of HO-1 expression. This is the first study to dissect the mechanism by which the antiadipogenic and anti-inflammatory lipid, EET, induces the PGC-1α signaling cascade and reprograms the adipocyte phenotype by regulating mitochondrial function and HO-1 expression, leading to an increase in healthy, that is, small, adipocytes and a decrease in adipocyte enlargement and terminal differentiation. This is manifested by an increase in mitochondrial function and an increase in the canonical Wnt signaling cascade during adipocyte proliferation and terminal differentiation.

The Utah Statesman, November 14, 2016, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Occupational Therapy Services And Clinical Decision Making In Oncology Care: A Mixed Methods Approach, Sheila M. Longpre'

Occupational Therapy Program Student Theses, Dissertations and Capstones

The purpose of this study was to explore the types and patterns of occupational therapy services implemented with clients who are cancer survivors, which utilized a mixed methods approach, specifically an explanatory sequential design. The Occupational Therapy Practice Inventory (OTPI) was used to gather information regarding the type and patterns of occupational therapy services provided for clients receiving oncology care. The results of the OTPI were analyzed and used to further develop semi-structured questions for exploring the perspectives of occupational therapy practitioners who practice in the area of oncology in the United States. The data were analyzed to generate a …

The Impact Of Rural Poverty On Women’S Health Outcomes In Ethiopia: A Review Of A Walk To Beautiful, Christine A. Wernet Ph.D

Societies Without Borders

No abstract provided.

Current And Emerging Uses Of Statins In Clinical Therapeutics: A Review, Jonathan T. Davies, Spencer F. Delfino, Chad E. Feinberg, Meghan F. Johnson, Veronica L. Nappi, Joshua T. Olinger, Anthony P. Schwab, Hollie I. Swanson

Pharmacology and Nutritional Sciences Faculty Publications

Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular disease. Statin use may expand considerably given its potential for treating an array of cholesterol-independent diseases. However, the lack of conclusive evidence supporting these emerging therapeutic uses of statins brings to the fore a number of unanswered questions including uncertainties regarding patient-to-patient variability in response to statins, the most appropriate statin to be used for the desired effect, and the efficacy of statins in treating cholesterol-independent diseases. In this review, the adverse effects, costs, and drug–drug and drug–food interactions associated with statin …

Photovoice Of Obesity On Murray State University's Campus, Karley Wray, Melissa Godby

Scholars Week

The issue we decided to discuss on campus using Photovoice was obesity. Obesity is becoming a very big topic that we all need to start focusing on. Obesity is defined as having a BMI at or above 30. This is becoming more common with our cultural change. We are becoming more fast food eaters and are not exercising as much as we should. It is even getting worse on college campuses. We all knew of what was called the freshmen 15, but now it is becoming a four year 15. It is becoming more common for college students to become …

The Acute Effects Of Weighted Vest Running On Substrate Utilization And Energy Expenditure, Troy M. Purdom Mr.

Health, Exercise, and Sports Sciences ETDs

This study evaluated the effect of weighted vest running (WVR) on fatty acid oxidation (FAox) and caloric expenditure at pre-designated exercise intensities (60,65,70,75,80% VO_2max). Seventeen recreationally trained runners (9 men and 8 women) performed four separate graded exercise tests (GXT) separated by 24 hours each. The first graded exercise test (GXT) was performed to establish the workloads at specific exercise intensities. The following three GXTs tested WVR with a control (no vest), 5% body mass (BM) vest, and 10%BM vest, using 3-minute incrementally increasing steady rate stages. Indirect calorimetry was used to measure both FAox (g/min) and caloric …

Development Of Domain Specific Cluster : An Integrated Framework For College Libraries Under The University Of Burdwan, Sukumar Mandal

Library Philosophy and Practice (e-journal)

This paper discusses the development of six domain specific cluster software in the college libraries under the University of Burdwan. Library is the heart of educational institutions. So, as to select the open source relevant with comprehensive software and global parameters on the basis of global recommendations like IFLA-Working Group, Integrated Library System for Discovery Interface (ILS-DI), Request for Proposals (RFP), Request for Comments (RFC), Service Oriented Architectre (SOA) and Open Library Environment Projects (OLE) including the areas like integrated library system cluster, digital media archiving cluster, content management system cluster, learning content management system cluster, federated search system cluster …

Obesity Due To Poor Snack Choices And Lack Of Physical Activity, Kaleb S. Adams

Scholars Week

Obesity Due to Poor Snack Choices and Lack of Physical Activity

A chronic issue in my immediate community, Murray State University, is obesity due to unhealthy diets and a generally lethargic lifestyle. The muffin picture represents the average healthiness of snacks available on campus. While students are working towards their education on campus it has become increasingly difficult to acquire snacks that are both convenient and health conscious. Places such as the T-Room cater towards less healthy foods by making them far more available and also making them much less expensive. For a student to get a quick lunch consisting …

Lighten Up, Brittany G. Burress

Scholars Week

Looking at the effects of fast food restaurant convenience as well as physical activity opportunities and how the two contrast in the community of Murray, Kentucky.

Constituting Agricultural And Food Policy In Malawi: The Role Of The State And International Donors In The Farm Input Subsidy Program (Fisp), Peter Rock Nkhoma

USF Tampa Graduate Theses and Dissertations

Numerous studies have been undertaken on the political economy of agricultural policies in developing countries. These studies have explained agricultural policies in terms of urban bias, economic reforms, and domestic politics. Recently, the emphasis has been on explanations that reference the existence of a rational-legal and patronage element within the African state. Such explanations tend to underplay the extent to which agricultural policies are devised in a context of power asymmetries between the state and international donors or financial institutions. In the Malawian context specifically, limited attention has been paid to the possibility that policies are a negotiated outcome of …

“We Know The Taste Of Sugar Because Of Cardamom Production”: Links Among Commercial Cardamom Farming, Women’S Involvement In Production And The Feminization Of Poverty, Sony Kc, Bishnu Raj Upreti, Bashu Prasad Subedi

Journal of International Women's Studies

This paper analyses the impact of commercial cardamom farming on the livelihoods of women, revisiting the concept of the “feminization of poverty”. For the analysis of cash crop farming in Eastern Nepal, both quantitative and qualitative approaches have been used. A quantitative survey was conducted in 513 households in Ilam district between November and December 2015 followed by qualitative data collection. A literature review on the feminization of poverty and cash crop farming has also been included. A descriptive data analysis has been conducted from the perspective of the feminization of poverty against the background of cash crop farming. The …

Fetishizing Women: Advertising In Indian Television And Its Effects On Target Audiences, Madhusmita Das, Sangeeta Sharma

Journal of International Women's Studies

Advertising today has become the major driving force behind the various definitions of beauty. It is not “size-zero” models who are responsible for one version of female beauty, but models with skimpy clothes, fair skin, and bare midriffs who assume influential paradigmatic roles in society. Such practices become problematic for India as the standard of beauty appropriated by the media is highly westernized. With this background, the purpose of this study is to explore young girls’ perceptions of media pressure through the portrayal of ultra-thin beautiful models in Indian TV advertisements; and to discover the factors responsible for the internalization …

Learning From The Past, Planning For The Future: Empowering Future Generations Of Women And Girls: A Keynote Address For The Second World Conference On Women’S Studies, Colombo, Sri Lanka, May 5, 2016, Diana Fox

Journal of International Women's Studies

No abstract provided.

The Faithful Flyer, 11-13-2016, University Of Dayton. Campus Ministry

Chapel Bulletins

No abstract provided.

Research Support Study: Agriculture; University Of Connecticut Local Report, Carolyn V. Mills, Sharon Giovenale

Published Works

The local University of Connecticut report of a 19 institution ethnographic agriculture research support study done with Ithaka S+R.

Dreams, Aspirations And Related Behavior In Children And Adolescents: Impacts On Child Developmental Outcomes, Florence K. Y. Wu, Daniel T. L. Shek, Hildie Leung

Pediatrics Faculty Publications

“Dreams”, “aspirations” and related constructs are traditionally regarded as facilitators of adolescent educational attainment in the Chinese context. Besides, there is an emergent need to widen the understanding of such constructs and their impact on children and adolescent developmental outcomes. This paper discusses the developmental outcomes of dreams, aspiration and related concepts based on a thorough review of the literature. Besides outlining the impacts of aspirations, dreams and related constructs on children and adolescents, features of related intervention programs, including themes of the intervention programs, program participants, methods of implementation and evaluation in both Western and Chinese contexts are also …

An Integrated Risk And Vulnerability Assessment Framework For Climate Change And Malaria Transmission In East Africa, Esther Achieng Onyango, Oz Sahin, Alex Awiti, Cordia Chu, Brendan Mackey

East Africa Institute

Background: Malaria is one of the key research concerns in climate change-health relationships. Numerous risk assessments and modelling studies provide evidence that the transmission range of malaria will expand with rising temperatures, adversely impacting on vulnerable communities in the East African highlands. While there exist multiple lines of evidence for the influence of climate change on malaria transmission, there is insufficient understanding of the complex and interdependent factors that determine the risk and vulnerability of human populations at the community level. Moreover, existing studies have had limited focus on the nature of the impacts on vulnerable communities or how well …