Digital Commons Network^™

Human Neural Progenitor Cells Are Productively Infected By R5-Tropic Hiv-1: Opiate Interactions On Infection And Function Involve Cdk5 Signaling, Joyce Magat Balinang

Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1) is known to cause a spectrum of neurological, behavioral and motor deficits collectively termed as HIV-1 associated neurocognitive impairments (HAND). Opiates augment HIV-related CNS complications through both direct and indirect mechanisms that disrupt glial and neuronal function. All CNS macroglia and neurons derive from neural progenitor cells (NPCs) during development, and NPCs in the adult brain contribute to repair processes. Since disruptions in NPC function are known to impact CNS populations and brain function in a number of disease/injury conditions, we determined whether HIV ± opiate exposure affected the maturation and fate of human …

Information Needs And Information Sources Of Patients Diagnosed With Rare Cancers, Dana L. Ladd

Theses and Dissertations

Abstract

INFORMATION NEEDS AND INFORMATION SOURCES OF PATIENTS DIAGNOSED WITH RARE CANCERS

By Dana L. Ladd, Ph.D., MS, SLIS

BACKGROUND: Approximately 25% of all cancers diagnosed are considered rare. Patients may face many significant challenges including difficulty obtaining information about their rare conditions. Patients often have high information needs and may seek desired information from a variety of informational sources including healthcare providers, media, print, government and non-profit organizations in order to meet their needs. Accessing reliable consumer-level information can be challenging and often information needs are unmet. Dissatisfaction with health information provision can result in negative health-related outcomes and …

Behaviorally Induced Insufficient Sleep Syndrome And Insomnia: Prevalence And Relationship To Depression In College Students, Allison Baylor

Theses and Dissertations

Background: College students are at increased risk for general sleep issues as well as specific disorders, including Behaviorally Induced Insufficient Sleep Syndrome (BISS) and insomnia. These disorders can have deleterious daytime consequences, which can be compounded by exacerbating depression. The present study aims to establish college prevalence of BISS/insomnia, to characterize sleep characteristics in this sample, and to compare depression across BISS/insomnia.

Methods: Data from a college risk behaviors and health study (n=989) was used. Insomnia and BISS were defined as mutually exclusive disorders, using ICD-10/DSM-5 criteria, and Pittsburg Sleep Quality Index items.

Results: Overall, the results of this study …

Genetic And Epigenetic Mechanisms Of Complex Reproductive Disorders, Bhavi P. Modi

Theses and Dissertations

Common, complex disorders are polygenic and multifactorial traits representing interactions between environmental, genetic and epigenetic risk factors. More often than not, contributions of these risk factors have been studied individually and this is especially true for complex reproductive traits where application of genomic technologies has been challenging and slow to progress. This thesis explores the potential of genetic and epigenetic components contributing to a better understanding of the biological pathways underlying disease risk in two specific female complex reproductive traits - polycystic ovary syndrome (PCOS) and preterm premature rupture of membranes (PPROM). The PCOS projects focus on characterization of a …

Black Feminist Discourse Analysis Of Portrayals Of Gender Violence Against Black Women: A Social Work Dissertation, Avina Ross

Theses and Dissertations

This study explored media discourse of gender violence against Black women in Black contemporary films. Four Tyler Perry films were examined using a novel, qualitative and analytical framework: Black Feminist Discourse Analysis. Discourses that were studied include, but were not limited to: portrayals of gender violence and victims, character dispositions and interactions, stereotypes, relationship dynamics as well as portrayals of race, gender, sexuality and religion. The use of new and existing controlling images based on systems of race, gender, sexuality and religion were revealed in a transitional and systemic model. Common themes across the films are provided. This research closes …

Adopting Sustainability Innovations In Restaurants: An Evaluation Of The Factors Influencing Owner-Managers’ Decisions In Richmond, Virginia, Anna Salzberg

Theses and Dissertations

The purpose of this study is to investigate the factors influencing restaurant Owner-Managers’ decisions to adopt sustainability innovations in restaurants. A cross-sectional survey research design is used for this study, which entails distributing a survey to restaurants in the City of Richmond, Virginia, to gain an understanding of the factors influencing sustainability innovation adoption. Drawing from both the innovation adoption theory and the theory of planned behavior, the researcher contributes a baseline of the restaurants’ sustainability and the Owner-Managers’ intrinsic motivations. By integrating innovation adoption theory’s perceived innovation characteristics and measuring restaurants’ past sustainability behavior, this study increases the overall …

Curcumin/Melatonin Hybrids As Neuroprotective Agents For Alzheimer's Disease, John Saathoff

Theses and Dissertations

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting ~5.2 million Americans. Current FDA approved medications provide mainly symptomatic relief and there are no agents available to delay or cure this disease. Multiple factors such as amyloid-β aggregates, dyshomeostasis of biometals, oxidative stress, and neuroinflammation have been implicated in the development of AD. Even though significant advances have been made in understanding the mechanisms leading to AD, the exact etiology still remains elusive. Given AD’s multifactorial nature, a multifunctional strategy of small molecule design would help to identify novel chemical templates. Recently our lab …

A Qualitative Study Of Woodland County Public Schools’ Social Media Policy For Employees: Its Development, Interpretation, And Significance, Greenlee B. Naughton

Theses and Dissertations

The popularity of social networking sites on the World Wide Web has exploded during the past two decades. As more and more K-12 public school teachers choose to actively participate on social networking sites, school leaders and school boards face the increasingly difficult decision about whether or not to enact policies which will enable them to discipline teachers for their online behavior. The purpose of this qualitative case study was to explore the development, interpretation, and significance of one such policy.

The Instructional Technology Resource Teacher: A Descriptive Case Study Of Deployment, Use, And Perceptions, Mary Sepelyak

Theses and Dissertations

This case study describes one professional development approach to support technology integration at all public schools in one large county in central Virginia. Using data obtained from daily time logs, the frequency of Instructional Technology Resource Teacher (ITRT) use by classroom teachers was analyzed. Descriptive statistics were used to describe overall percentage of ITRT use, the various types of professional development requested by teachers, the consistency of those activities over time, and if the frequencies of activities varied as a function of school level, Title I status at the elementary level, or subject area taught by teachers at the secondary …

Women At The Crossroads, Women At The Forefront, American Women In Letterpress Printing In The Nineteenth Century, Dianne L. Roman Ms

Theses and Dissertations

The significant role of the female printer in the American home-based print shops during the colonial and early republic periods has been documented in print history, socioeconomic, labor, and women studies, yet with the industrialization of the printing trade, women’s presence is thought to have disappeared. Contrary to the belief that industrialization of the print shop eradicated women’s involvement in skilled employments such as typesetting, the creation of the Women’s Cooperative Printing Union in California and the creation and chartering of the Women’s Typographical Union in New York, both in the late 1860s, clearly indicate that women continued to work …

Write To Work: The Use And Importance Of Writing As Perceived By Business Leaders, Clay Aschliman

Theses and Dissertations

The relation of English Language Arts (ELA) to the economy has played a historic role in educational policy, persisting to today’s corporate reform movement. It is, however, an area that remains under-researched. This study builds upon the limited existing literature base with a systematic replication of the College Board’s National Commission on Writing for America’s Families, Schools, and Colleges’ (NCW) 2004 report, “Writing: A Ticket to Work…Or a Ticket Out.” The guiding research questions for this study are 1) How important is writing in the workplace? 2) Is writing an important hiring consideration? 3) What kind of writing is expected …

The Role Of Procedural Justice Within Police-Citizen Contacts In Explaining Citizen Behaviors And Other Outcomes, Shana M. Mell

Theses and Dissertations

American policing is shaped by an array of challenges. Police are expected to address crime and engage the community, yet police are held to higher expectations of accountability, effectiveness, and efficiency than ever before. Police legitimacy is the ability of the police to exercise their authority in the course of maintaining order, resolving conflicts, and solving problems (PERF, 2014). The procedural justice and police legitimacy literature suggest that by exhibiting procedurally just behaviors within police-citizen encounters, officers are considered legitimate by the public (PERF, 2014; Tyler, 2004, Tyler & Jackson, 2012).

This study examines procedural justice through systematic observations of …

Is Your Student Fit For That College? A Study Of The Factors That Contribute To Students’ Academic Performance In College, Abdulaziz A. Alotaibi

Theses and Dissertations

The purpose of this study was to expand the extent of available literature in regard to the factors that contribute to students’ academic performance in college. It focused on a neglected segment of the student population, which is Saudi Arabian students studying in the United States. This study utilized a nonexperimental quantitative research design in order to investigate the relationship between the independent variables (the characteristics of the student, the characteristics of the program, and the academic and social integration between the student and the program) and the dependent variables (degree GPA, ability to graduate within academic program time frame, …

Measurement Of Rare Earth And Uranium Elements Using Laser-Induced Breakdown Spectroscopy (Libs) In An Aerosol System For Nuclear Safeguards Applications, Ammon N. Williams

Theses and Dissertations

The primary objective of this research is to develop an applied technology and provide an assessment for remotely measuring and analyzing the real time or near real time concentrations of used nuclear fuel (UNF) elements in electrorefiners (ER). Here, Laser-Induced Breakdown Spectroscopy (LIBS) in UNF pyroprocessing facilities was investigated. LIBS is an elemental analysis method, which is based on the emission from plasma generated by focusing a laser beam into the medium. This technology has been reported to be applicable in solids, liquids (includes molten metals), and gases for detecting elements of special nuclear materials. The advantages of applying the …

What’S Real? What’S Not? : Reality Tv’S Effect On Relational Aggression Among Black College Women, Ashley N. Hill

Theses and Dissertations

Relational aggression, behaviors that manipulate social relationships, is a pressing issue among Black college women (Dahlen, Czar, Prather, & Dyess, 2013). As a result of experiencing and using relational aggression, Black women may experience diminished interpersonal interactions and poorer overall psychological well-being (Gomes, Davis, Baker, & Servonsky, 2009). The present study examined how Black reality television (BRTV) models relationally aggressive behaviors for viewers. According to Cultivation theory, television has the power to influence the social reality (i.e. attitudes and perceptions) of individuals who consume high amounts of television (Gerbner et al, 2002), while Identification theory suggests that deep cognitive and …

Nostalgia And Iphone Camera Apps: An Ethnographic Visual Approach To Iphoneography, Maria L. De Panbehchi

Theses and Dissertations

The iPhone is the most popular smartphone and camera on social media. iPhoneography, the photography taken or edited with the iPhone, has set the trend of nostalgic photography on social media during the 2010s; thus, the iPhone, a high-tech camera, produces low-tech-looking images. This dissertation attempts to find out why iPhone photographers (iPhoneographers) take, edit, and share images that mimic photographs taken with analog photographic equipment. I argue that nostalgia allows iPhoneographers to use the iPhone as a creative tool and to belong to a community. Based on the arguments of Vilém Flusser—who suggested that photographers are more interested in …

Characterization Of Poly(Dimethylsiloxane) Blends And Fabrication Of Soft Micropillar Arrays For Force Detection, Thomas J. Petet Jr

Theses and Dissertations

Diseases involving fibrosis cause tens of thousands of deaths per year in the US alone. These diseases are characterized by a large amount of extracellular matrix, causing stiff abnormal tissues that may not function correctly. To take steps towards curing these diseases, a fundamental understanding of how cells interact with their substrate and how mechanical forces alter signaling pathways is vital. Studying the mechanobiology of cells and the interaction between a cell and its extracellular matrix can help explain the mechanisms behind stem cell differentiation, cell migration, and metastasis. Due to the correlation between force, extracellular matrix assembly, and substrate …

Wreading, Performing, And Reflecting: The Application Of Narrative Hypertext And Virtual World Experiences To Social Work Education, Linda Ayscue Gupta Phd

Theses and Dissertations

In this dissertation I propose the use of a new media composition of narrative hypertext, performances in a virtual world, and a dialogic process of writing to provide a continuum of learning opportunities in social work education. I suggest that the structure of the hypertext narrative, embedded with hypermedia, mirrors the dissociative aspects of traumatic memory. I argue that work with the multivocality and multisequentiality of narrative hypertext emulates the process of discovery in the clinical interview. The immersive component of work in a virtual world deepens the realism and affective impact of simulations and creates opportunities to practice and …

Atm Phosphorylates Subunit A Of Pp2a Resulting In Its Nuclear Export And Spatiotemporal Regulation Of The Dna Damage Response, Amrita D. Sule

Theses and Dissertations

Ataxia telangiectasia mutated (ATM) is a serine-threonine protein kinase and major regulator of the DNA damage response (DDR). One critical ATM target is protein phosphatase 2A (PP2A) known to regulate diverse cellular processes such as mitosis and cell growth as well as dephosphorylation of many proteins during the recovery from the DDR while returning the cell to normalcy. Interestingly, ATM and PP2A are known to form an auto-regulatory yin-yang kinase-phosphatase relationship. Herein, we show that the phosphorylation of the PP2A-Aα structural subunit at S401 by ATM results in nuclear export, which regulates the DDR at multiple levels and affects genomic …

Rethinking Counterterrorism In The Age Of Isis: Lessons From Sinai, Sahar F. Aziz

Nebraska Law Review

I. Introduction

II. Economic Deprivation and Political Marginalization in the Sinai … A. The Sinai’s Strategic Significance ... B. Neglect and Criminalization of the Bedouin

III. Bringing the Sinai into the National Fold ... A. Long-Term Investment in Development ... B. De-Securitizing Development in Sinai ... C. Political Inclusion and Integrating Bedouin into Security Services

IV. Contextualizing Sinai’s Transition into a Failing Sub-State ... A. Festering Grievances and Militants in Sinai before the 2011 Uprising ... B. 2011 Uprisings Create a Security and Political Vacuum ... C. Violence in Sinai Reaches New Heights after Morsi Is Deposed

V. Conclusion

Saltine Box Full Of Dreams: One Mexican Immigrant Woman's Journey To Academic Success, Adriana C. Sanchez

EWU Masters Thesis Collection

"This auto-ethnography/literacy narrative examines the journey of a first-generation Mexican immigrant woman from birth through completion of the master's degree at Eastern Washington University. The purpose of this single case study is to examine how one first-generation Mexican immigrant college student was able to succeed in higher education despite being part of the least academically successful minority group. It is also important for teachers from diverse linguistic and cultural backgrounds to tell their stories about overcoming hardships and barriers to academic success-such as discrimination, low socioeconomic levels (Reeves, 1997; 2012), low levels of education. The author includes photos and written …

Differences In Physical Activity Participation, Screen Time, And Body Mass Index For Children With Learning Disabilities And Typically Developing Children, Andrew Q. Pawlick

Cal Poly Humboldt theses and projects

TOPIC: There is a vast body of research revealing low levels of physical activity, excessive use of electronic media, and increasing obesity rates for children in the United States and Europe. This study measures differences in physical activity, screen time, and Body Mass Index (BMI) between typically developing (TD) children and children with learning disabilities (LD). METHODS: The study included 404, thirteen year old Irish children with an LD diagnosis and 440 randomly selected 13 year olds that are typically developing. Children self-reported on how many days in the past two weeks they participated in moderate to vigorous …

Access To Capital Or Just More Blues? Issuer Decision-Making Post Sec Crowdfunding Regulation, Patricia Hureston Lee

All Faculty Scholarship

Crowdfunding is an alternative for Issuers seeking funds for their businesses. On October 2015, the Securities Exchange Commission (SEC) released final crowdfunding regulations that became effective May 20162 as a charge of the Jobs Act, Title III (the “Crowdfund Act”). Issuers can now secure crowdfunded investments without a securities registration.

This article evaluates investment-based crowdfunding from the perspective of one group that has been neglected from the crowdfunding scholarship — Issuers that seek financing under this new framework. In Section I, the author summarizes the new crowdfund regulations, which create a new financing opportunity vastly different from previous types of …

Imprisonment Inertia And Public Attitudes Toward "Truth In Sentencing", Michael M. O'Hear, Darren Wheelock

Social and Cultural Sciences Faculty Research and Publications

In the space of a few short years in the 1990s, forty-two states adopted truth in sentencing (“TIS”) laws, which eliminated or greatly curtailed opportunities for criminal defendants to obtain parole release from prison. In the following decade, the pendulum seemingly swung in the opposite direction, with thirty-six states adopting new early release opportunities for prisoners. However, few of these initiatives had much impact, and prison populations continued to rise. The TIS ideal remained strong. In the hope of developing a better understanding of these trends and of the prospects for more robust early release reforms in the future, the …

Annual Report 2016, Tennessee. Department Of General Services

Annual Reports

This annual report briefly describes the business units in General Services and financial transactions made during the fiscal year.

Annual Report 2015-2016, Tennessee. Board Of Paroles

Annual Reports

This document is the annual report for the Tennessee Board of Parole during the fiscal year.

Evaluation Of Itunes University Courses Through Instructional Design Strategies And M-Learning Framework, Hungwei Tseng, Yingqi Tang, Betty Morris

Research, Publications & Creative Work

As mobile learning technology promotes learning accessibility and flexibility, students benefit from social interactivity and connective learning process which will also foster students’ performance and satisfaction on learning content. The primary purpose of this research was to evaluate iTunes U courses based on instructional design strategies and the m-learning framework. A total of 27 iTunes U courses were selected and evaluated based on the following criteria: (a) The course is provided by institutions of higher education; (b) the course should include instructional design components. The results revealed that all courses scored notably higher means on Content Chunking and Objective and …

Comparison Of The Efficiency Of Concentrated Soluble Recombinant Phospholipase D And Natural Phospholipase D Enzymes, Asli Sakmanoğlu, Osman Ergani̇ş

Turkish Journal of Veterinary & Animal Sciences

Phospholipase D (PLD) is a major virulence determinant of Corynebacterium pseudotuberculosis. Various studies have focused on the expression of recombinant PLD (rPLD) enzyme in different Escherichia coli strains, but generally a high yield of insoluble protein was reported. The aims of this study were to express soluble rPLD by different methods in E. coli. The rPLD and natural PLD (dPLD) enzymes were concentrated using an ultramembrane cassette system after the efficiencies of these concentrated enzymes were compared. The rPLD enzyme was expressed in One Shot®BL21(DE3) E. coli when induced by IPTG in TY medium. Soluble dPLD and rPLD enzyme hemolytic …

Effect Of Capacitating Agents On Sperm Pretreatment During In Vitrofertilization For Blastocyst Production In Caprines, Puja Goel, Anil Kumar Goel, Ashok Kumar Bhatiya, Suresh Dinkar Kharche

Turkish Journal of Veterinary & Animal Sciences

The present study aimed at comparing the relative efficacy of different capacitating agents used for sperm pretreatment during in vitro fertilization (IVF) and subsequent embryo development of caprine oocytes. In experiment 1, the effect of different concentrations of heparin (0, 20, and 50 μg/mL) on sperm pretreatment for different periods of time (30 and 60 min) was studied. In experiment 2, the dose-dependent effect of calcium ionophore (0, 0.1, 0.2, and 0.5 μM) on sperm pretreatment was assessed. Experiment 3 validated and compared the effects of both capacitating agents on sperm pretreatment for capacitation based on the results of the …

Bacteria Associated With Clinical Postpartum Dysgalactia Syndrome In Farmed Sows In The Republic Of Macedonia, Branko Angjelovski, Aleksandar Cvetkovikj, Slavcho Mrenoshki, Miroslav Radeski, Iskra Cvetkovikj, Marija Ratkova, Toni Dovenski

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to gather information about the prevalence of bacterial species in farmed sows, with special focus on the clinical manifestation of postpartum dysgalactia syndrome (PDS). One hundred and sixteen sows from 5 pig farms in the Republic of Macedonia were clinically examined for PDS 12?24 h after farrowing. Milk samples and vaginal swabs for bacteriological testing were taken from PDS-affected (PDSA, n = 30) and PDS-unaffected (PDSU, n = 86) sows. Escherichia coli, staphylococci, and streptococci were the predominant bacteria isolates. Escherichia coli was the most frequently found isolate, with a prevalence of 73.3% in …