Digital Commons Network^™

A Study Of The Action Of Risperidone At 5-Ht2a Receptors, Supriya A. Gaitonde

Theses and Dissertations

Risperidone is an ‘atypical’ antipsychotic and is approved by the USFDA mainly for the treatment of schizophrenia and symptoms of bipolar disorder. Risperidone (an SDA or serotonin-dopamine antagonist) has ~20-fold higher affinity at 5-HT_2A receptors over dopamine D₂ receptors, which makes it more efficacious against the negative symptoms of schizophrenia and less liable to causing extrapyramidal side effects than ‘typical’ antipsychotics.

The major goal of the current investigation was to study the structure of risperidone and to identify the minimum structural features required for 5-HT_2A receptor affinity that retain antagonist action. The structure of risperidone was systematically …

A Mapping System As A Method In Experiential Culture Learning And Engagement, Faisal Mohammad

Theses and Dissertations

From my observation as a new resident in Education City, I recognize a need for cultural awareness and communication amongst those studying and working in this particular area. With this project I propose a different experience, a new way to use experiential learning as a mechanism to change people’s predetermined opinions about one another and disrupt personal biases in order to foster cultural awareness and friendship.

A mapping system or wayfinding strategy to navigate a new city is the beginning of a visitor’s experience in a new place. This new experience is one way for users to identify locations through …

Adornment And Modesty A Symbiotic Relationship Between Surface Design And Social Behavior, Hawa Stwodah

Theses and Dissertations

The impulse to beautifying clothing through acts of adornments or embellishments is an innate characteristic of humans. The added decorative details are used for identification and visual communication by the wearer and comprehension and visual appreciation by the viewer.

This thesis investigates the recent attention to female modesty, labeled as the Modesty Movement--the community that has developed around the apparel segment of the Movement and the framework of the behavior encompassing the participants within Movement. Additionally, the thesis focuses on adornment through the lens of textile/surface design (embellishment) specific to the Greater Middle East and the northern provinces of India …

Everywhere And Nowhere: Public Art Interventions In Qatar, Barbara Charrue

Theses and Dissertations

Qatar is rapidly becoming an internationally renowned art hub not only through the construction of numerous museums and galleries, but also through the development of public art projects.

I strongly believe that Qatar can be more than a place to work; it can be a space where art is part of public spaces. But how can we fully and effectively integrate art into public space in Qatar? How can Qatar be more than a place where we work, eat, sleep, and go to the mall from time to time? How can public art involve / benefit the community and local …

Gender And Sexual Health: Applying Gender Role Theory To Men And Women’S Intention To Engage In Sexual Health Information Seeking Behaviors, Ariella R. Tabaac

Theses and Dissertations

The purpose of the present study is to examine the pathways between gender and behavioral intention to engage in sexual HISB through application of the Theory of Planned Behavior (TPB). It was found that feminine and masculine gender role stress differentially influence perceived behavioral control and behavioral attitudes, and that intention to engage in HISB was higher among women than men. Attitudes and PBC significantly predicted behavioral intention in this model. Further, women in the sample were more likely to search for sexual health information, with online sources being the most frequently reported resource. Additionally, past HISB was a significant …

A Longitudinal Study Of The Motivations For The Non-Medical Use Of Prescription Drugs In A National Sample Of Young Adults, Tess K. Drazdowski

Theses and Dissertations

Young adults are most at-risk for the non-medical use of prescription drugs (NMUPD) and many of its associated negative consequences. Understanding this population’s motivations for use can help to inform efforts to reduce NMUPD. Past research has been limited in scope, consisting primarily of cross-sectional work with college students focusing on prescription stimulants. The current study researched how motivations for NMUPD changed over young adulthood using three waves of data from a longitudinal, nationally representative sample of 14,990 19 to 24 year olds in the Monitoring the Future study cohorts collected between 1976 to 2013. Prescription stimulants, central nervous system …

A Comparative Case Study Of The Relationships Between Policy Context, Design, And Implementation Of P-20 Educational Reform Movements In Texas And Tennessee, Stefani L. Thachik

Theses and Dissertations

More people are striving for increased levels of educational attainment as a result of a global shift towards a more knowledge based economy. Schools and communities have adjusted to this societal change by seeking alignment along the educational pipeline from preschool (P) to graduate school (20), otherwise known as P-20 reform. This reform often develops with the collaboration and guidance of specific P-20 leadership councils that exist at both the local and state levels. The main purpose of this qualitative study was to go beyond the mere descriptions of P-20 councils to examine the policy pathways chosen by P-20 councils, …

Embodiment Of Empathy: Experiencing Disease Through Design, Noha Fouad

Theses and Dissertations

Today, more than 400 million individuals around the world have diabetes. This number is expected to grow to more than 600 million by 2023. However, diabetes is more than just a statistic. It is an incurable, psychologically nuanced disease, with daily battles and far-reaching complications. The lives of those afflicted undergo permanent physical and psychological changes.

Reading the stories of diabetics, or hearing them share their experience may elicit an immediate yet often fleeting sense of realization. How, then, can this brief moment of awareness be prolonged? How can a non-diabetic feel diabetes? More importantly, why should they? This research …

Adaptability In A State Of Flux, Yasmeen Suleiman

Theses and Dissertations

“[that] which does not change does not endure” – Henri Bergson

Numbers only quantify the development Qatar is experiencing. In Doha, the city is a physical manifestation of these changes. The general approach to development follows a ‘tear down, build new’ model. Potential value is lost in what is discarded, despite necessity and convenience. This study addresses the topic by dispelling the assumed need to destroy in order to build. In doing so, it examines existing vernacular spaces that are often overlooked. The main application is analyzed through agents of space, such as buildings and the urban environment with varied …

Design And Structure-Activity Relationship Of Small Molecule C-Terminal Binding Protein (Ctbp) Inhibitors And Investigation Of The Scope Of Palladium Multi-Walled Carbon Nanotubes (Pd-Mwcnt) Catalyst In C–H Activation Reactions, Sudha Korwar

Theses and Dissertations

C-terminal binding proteins (CtBPs) are transcriptional co-repressors involved in developmental processes, and also implicated in a number of breast, ovarian, colon cancers, and resistance against cancer chemotherapy. CtBP is a validated novel potential anti-cancer target. In this project we sought to develop potent and selective small-molecule inhibitors of CtBP. Using a combination of classical medicinal chemistry and modern computational approaches, we designed a potent inhibitor HIPP (hydroxyimino-3-phenylpropanoic acid) that showed an IC₅₀ of 0.24 μM against recombinant CtBP. Further elucidation of the structure-activity relationship (SAR) of HIPP led to the design of more potent inhibitors 3-Cl HIPP (CtBP IC …

Perception Of Profile Appearance As Judged By Peers Using 3d Video Imaging, Megan G. Schuler

Theses and Dissertations

The purpose of this study was to investigate the social perceptions of subjects with differing lip position and facial convexity in three dimensions. A 3dMD camera (3dMD, Atlanta, GA) was used to capture 3D images of 9 subjects’ faces. The images were altered to have ideal lip position and ideal convexity, ideal lip position and Class II convexity, Class II lip position and ideal convexity, and Class II lip position and Class II convexity. 400 laypersons rated their perceptions of the subjects’ athletic ability, popularity, leadership, and intelligence on a VAS scale. Subjects with ideal lip position relative to the …

"They Believe That Because They Are Women, It Should Be Easier For Them." Subtle And Overt Sexism Toward Women In Stem From Social Media Commentary, Katherine Hall

Theses and Dissertations

This study implemented a social media based content analysis to examine the subjective experiences and the current public perceptions of sexism in STEM fields. Participants included men and women who a) identified as either in STEM or not identified as in STEM and b) commented through Facebook on HuffPost Women articles about women in STEM. The analysis indicated that sexism remains an issue for women in STEM careers. Women in STEM identified several gender-based challenges that they have experienced; some participants discussed how they handled those challenges. Men both in and not in STEM were less likely to acknowledge and …

Role Of Free Fatty Acid Receptors In The Regulation Of Brain-Derived Neurotrophic Factor Levels In The Enteric Glial And Endocrine Cells, Reem M. Alkahtani

Theses and Dissertations

Recent deorphanization of several G-protein-coupled receptors (GPRs) as endogenous receptors for free fatty acids (FFAs) has increased our understanding of these nutrients as signaling molecules and the integral role of gut microbiota in the regulation of host defense mechanisms, energy metabolism, gastrointestinal motility and secretion. There are five distinct FFA receptors (FFRAs: FFAR1, FFAR2, FFAR3, FFAR4 and GPR84) that differ in molecular structure, ligand specificity, expression pattern, and functional properties. FFARs are grouped according to the chain length of FFAs that activate each FFAR.

Enteric glial cells and enteroendocrine cells play a pivotal role in the secretion of gliotransmitters and …

Resolution Of Inflammation Rescues Axon Initial Segment Disruption, Nicholas M. George

Theses and Dissertations

Axonal domains are required for proper neuron function. These domains are unstable and degenerate concurrent with the inflammation in multiple sclerosis (MS) and the inflammatory disease models experimental autoimmune encephalomyelitis (EAE) and lipopolysaccharide (LPS) induced inflammation. Previous studies from our laboratory have shown that the axon initial segment (AIS) is maintained independently of the presence of myelin, but that AIS disruption is seen in MS as well as EAE and LPS-mediated inflammation. AIS loss can be interrupted in the early stage of EAE using the anti-inflammatory drug Didox. However, the potential for Didox directed repair of the AIS in later …

Longitudinal Relations Between Parental And Peer Support For Violent And Nonviolent Responses To Conflict And Early Adolescent Dating Aggression, Rachel C. Garthe

Theses and Dissertations

High prevalence and the negative legal, health, and psychological consequences of adolescent dating aggression underscore the need to identify risk and protective processes associated with this type of aggression. Studying dating aggression in early adolescence is important, as this is the developmental time frame when most youth are establishing attitudes, beliefs, and norms for dating behaviors. The current study investigated longitudinal associations between perceived parental and peer support for violent and nonviolent responses to conflict and dating aggression perpetration among middle school students. Participants included 1,399 adolescents (52% female) in the sixth (n = 466), seventh (n = …

Hidden In Plain Sight: Image, Text, And Social Commentary In Victor Ekpuk's Cartoons For The Daily Times Of Nigeria, 1989-1998, Kaleb W. Jewell

Theses and Dissertations

This thesis provides an analysis of the cartoons produced by Victor Ekpuk for The Daily Times newspaper of Nigeria from 1989 through 1998 and the artist’s use of ancient nsibidi script to “hide in plain sight” his social commentaries on sociopolitical and economic issues in Nigeria. Victor Ekpuk’s original cartoons within the permanent collection of the Smithsonian Institution’s National Museum of African Art are examined in the context of indigenous masking practices and other indirect methods employed by indigenous comedians to protect themselves. Moreover, the cartoons’ use of caricature and their nsibidi scripts within are argued to provide a connotative …

Redskins Revisited: Competing Constructions Of The Washington Redskins Mascot, Eean Grimshaw

Graduate Student Theses, Dissertations, & Professional Papers

This project looks at how synecdoche and ideographs function in the construction of competing position in the controversy surrounding the Washington Redskins mascot. I examined the rhetoric produced by both the Washington Redskins organization and its fans, as well as the rhetoric of Change the Mascot, the Oneida Indian Nation of New York and other opponents between the years of 2013 and 2015. Based in part on Moore’s (1993, 1994, 1997) argument that synecdoche and ideographs often prevent resolution and produce irreconcilable conflict, I extend this notion insofar as the controversy surrounding the Redskins mascot appears to be shifted towards …

Queen Of Kings: Beyoncé Politics And Pedagogy In The Juvenile Detention Center Classroom, Sarah Kahn

Graduate Student Theses, Dissertations, & Professional Papers

In 2016, the cultural conversation around feminism and intersectionality has shifted towards new problems of inclusion and change. Feminists are beginning to ask whether the commodification of female sexuality and objectification are extricable, whether a hypersexualized mainstream identity and a feminist one are mutually exclusive, how to integrate female experiences of different socioeconomic backgrounds, races, and cultures into a new feminism, and how to define feminism as we begin to move away from binary gendering. Increased visibility of trans issues has brought genderqueerness and femmephobia into the feminist conversation, and technology and globalization have forced that conversation to open up …

More Than Zero: Variation In The Tattooed Population, Zachary Reiter

Graduate Student Theses, Dissertations, & Professional Papers

Sociological research treats all individuals with more than zero tattoos as being part of the tattooed population. This type of categorization fails to capture the significant differences between tattooed individuals. For example, a gang member with a criminal insignia tattooed on his or her neck would be part of the same research population as long term tattoo artists with their entire body covered in tattoos or even a middle aged man with a single tattoo on his bicep. By interviewing tattoo artists, this thesis details the unique nature of tattooing as an occupation, the changing nature of the modern tattooing …

Twitter Analysis Of The Orthodontic Patient Experience With Braces Versus Invisalign, Daniel A. Noll

Theses and Dissertations

The purpose of this study was to examine the orthodontic patient experience with braces compared to Invisalign^® by means of a large-scale Twitter sentiment analysis. A custom data collection program was created to collect tweets containing the words “braces” or “Invisalign.” A hierarchal Naïve Bayes sentiment classifier was developed to sort the tweets into one of five categories: positive, negative, neutral, advertisement, or not applicable. Among the 419,363 tweets applicable to orthodontics collected, users posted significantly more positive tweets (61%) than negative tweets (39%) (p-value = ^® tweets (p-value=0.4189). In conclusion, Twitter users express more positive than negative sentiment …

Interhouse: A Place For Growing Up And Growing Adults, Nilufar Makhamatova

Theses and Dissertations

Society has become increasingly segregated by age which lessens the opportunities for communication between generations. Before the Internet, children and adolescents typically learned through traditional means - their parents, school teachers, and life experiences. Adults believed they were capable of recognizing and addressing the needs of children and adolescents. (Strom & Strom, 2012) Now, the global media is widely accessed by people of all ages which gives it the ability to influence a large population in different ways. This has led to children and adolescents being more heavily influenced and educated by the media than other traditional sources. Adolescents, in …

Novel Small Airway Model Using Electrospun Decellularized Lung Extracellular Matrix, Bethany M. Young

Theses and Dissertations

Chronic respiratory diseases affects many people worldwide with little known about the mechanisms diving the pathology, making it difficult to find a cure. Improving the understanding of smooth muscle and extracellular matrix (ECM) interaction is key to developing a remedy to this leading cause of death. With currently no relevant or controllable in vivo or in vitro model to investigate diseased and normal interactions of small airway components, the development of a physiologically relevant in vitro model with comparable cell attachment, signaling, and organization is necessary to develop new treatments for airway disease. The goal of this study is to …

Climbing Mt. Rainier, Kathleen O'Connor

Theses and Dissertations

My work addresses notions of the American landscape through image, memory, and experience. Using found images, video, and a variety of materials to make objects I investigate the intersection of external representations of landscape in American culture and internalized desires of landscapes.

Nonlinear Model And Qualitative Analysis For Coupled Axial/Torsional Vibrations Of Drill String, Fushen Ren, Baojin Wang, Suli Chen, Zhigang Yao, Baojun Bai

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

A nonlinear dynamics model and qualitative analysis are presented to study the key effective factors for coupled axial/torsional vibrations of a drill string, which is described as a simplified, equivalent, flexible shell under axial rotation. Here, after dimensionless processing, the mathematical models are obtained accounting for the coupling of axial and torsional vibrations using the nonlinear dynamics qualitative method, in which excitation loads and boundary conditions of the drill string are simplified to a rotating, flexible shell. The analysis of dynamics responses is performed by means of the Runge-Kutta-Fehlberg method, in which the rules that govern the changing of the …

Publication Of Government-Funded Research, Open Access, And The Public Interest, Julie Kimbrough, Laura N. Gasaway

Faculty Publications

Public access to government-funded research is an issue of tremendous importance to researchers, librarians, and ordinary citizens around the world. Based on the notion that taxpayers finance research through their tax dollars, research data should be available to them. Rapid, unfettered access to research publications provides access to medical research to patients, encourages further exploration and inquiry by other researchers, informs citizens, and advances scientific research. Scientists typically write articles that divulge the results of their government-funded research. Prior to the open access movement, these articles were published in commercially produced journals. Subscriptions to these journals are expensive, and cost …

Shaping Expectations About Dads As Caregivers: Toward An Ecological Approach, Holning S. Lau

Faculty Publications

No abstract provided.

Presidential Executive Action: Unilaterally Changing The World’S Critical Technology And Infrastructure, Steven Ferrey

Suffolk University Law School Faculty Works

Can the President, through executive action with no approval of Congress whatsoever, change the world? Declared President Obama: “If Congress won't act soon to protect future generations, I will.” What is considered the second most important invention in history—electricity—has had its legal regulation and technological foundation fundamentally changed by unilateral executive action in
the past two years. As a result of this unilateral executive action, critical technology and modern society are changing fundamentally.

This is not without legal challenge: Shortly after the Obama Administration announced its Clean Power Plan, House of Representatives Speaker John Boehner announced that he and others …

Tuolumne Meadow: Conservation Of Yosemite's Meadows Through Recreational And Educational Planning, Gretchen Hinz

Landscape Architecture Theses

Alpine meadows are delicate ecosystems that are being damaged and declining. In Yosemite only 3% of the park is considered meadow habitat. Through this thesis I am exploring the question; how can we conserve these alpine meadows? To discover this I will research and collect data to understand these underlying questions. What is the major cause of alpine meadow decline? What are the aspects of a healthy alpine meadow? Can there be human interaction with alpine meadows without further destruction, and if so how? These questions cumulatively help show what is needed to restore an alpine meadow, and what is …

Nitrogen Gas Flooding For Naturally Fractured Carbonate Reservoir: Visualisation Experiment And Numerical Simulation, Zhaojie Song, Jirui Hou, Zhongchun Liu, Fenglan Zhao, Shijun Huang, Yong Wang, Jieheng Wu, Baojun Bai

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Tahe Naturally Fractured Carbonate Reservoir has implemented nitrogen gas flooding since 2013, with daily oil production of 7580 bbls and oil recovery increment of 0.83% by the end of 2015. However, the presence of fractures significantly affects gas swept volume and production performance, so large amount of oil reserves is poorly flooded due to gas channeling through fractures. The fluid flow mechanisms in fractured models were discussed in order to improve field gas flooding efficiency. Based on the geological constrains of Tahe Oilfield, fractured models with different apertures were fabricated using acrylic glass to model carbonate matrix wettability and for …

Sometimes They Come Back: Examining The Threat Of Associated And Non-Associated And/Or Mentally Ill School Violence Perpetrators, Gordon A. Crews

Criminal Justice Faculty Publications

In this chapter it is argued that school violence and its potential in K-12 schools cannot be dealt with by simply removing the troublesome/problematic students from classrooms and/or school grounds. The expelling, suspending, incarcerating, or placing of a juvenile in an alternative school setting may only increase their anger against their former school and teachers. An anger which may continue to grow throughout their lives. Moreover, there is a growing trend of students who have failed to achieve in life returning to their former school and committing acts of violence. The author focuses on two types of these perpetrators. First, …