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2016

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The Second Quantized Approach To The Study Of Model Hamiltonians In Quantum Hall Regime, Li Chen Dec 2016

The Second Quantized Approach To The Study Of Model Hamiltonians In Quantum Hall Regime, Li Chen

Arts & Sciences Graduate Student Theses and Dissertations

The study of model Hamiltonians, whose exact ground states are well known quantum Hall states, have been investigated solely in the literature from the point of view of first quantized approach in the last few decades. However, a second quantized approach to such Hamiltonians has not been taken in the same measure. In this dissertation, we study Haldane pseudopotential, which is the parent Hamiltonian of 1/M Laughlin state, and Trugman-Kivelson pseudopotential, which is the parent Hamiltonian of 2/5 unprojected Jain state. We find that the study of these Hamiltonians in their second quantized forms not only reproduces all properties of …


Investigating The Life-Cycle Of Photosystem Ii Using Mass Spectrometry, Daniel Avram Weisz Dec 2016

Investigating The Life-Cycle Of Photosystem Ii Using Mass Spectrometry, Daniel Avram Weisz

Arts & Sciences Graduate Student Theses and Dissertations

Photosystem II (PSII) is a protein complex found embedded in the thylakoid membranes of all organisms that perform oxygenic photosynthesis. PSII converts sunlight into chemical energy, filling our atmosphere with molecular oxygen in the process and supporting nearly all life on Earth. PSII undergoes frequent light-induced damage as an unavoidable result of the electron transfer reactions it catalyzes. When damaged, PSII is disassembled, repaired, and reassembled in an intricate, tightly regulated process. The structure and mechanism of function of active PSII are relatively well-understood, due to the available crystal structures of the active complex and many years of biochemical and …


New Techniques And Optimizations Of Short Echo-Time 1h Mri With Applications In Murine Lung, Jinbang Guo Dec 2016

New Techniques And Optimizations Of Short Echo-Time 1h Mri With Applications In Murine Lung, Jinbang Guo

Arts & Sciences Graduate Student Theses and Dissertations

Although x-ray computed tomography (CT) is a gold standard for pulmonary imaging, it has high ionizing radiation, which puts patients at greater risk of cancer, particularly in a longitudinal study with cumulative doses. Magnetic resonance imaging (MRI) doesn't involve exposure to ionizing radiation and is especially useful for visualizing soft tissues and organs such as ligaments, cartilage, brain, and heart. Many efforts have been made to apply MRI to study lung function and structure of both humans and animals. However, lung is a unique organ and is very different from other solid organs like the heart and brain due to …


Getting Road Expansion On The Right Track: A Framework For Smart Infrastructure Planning In The Mekong, Andrew Balmford, Huafeng Chen, Ben Phalan, Mingcheng Wang, Christine S. O'Connell, Cath Tayleur, Jianchu Xu Dec 2016

Getting Road Expansion On The Right Track: A Framework For Smart Infrastructure Planning In The Mekong, Andrew Balmford, Huafeng Chen, Ben Phalan, Mingcheng Wang, Christine S. O'Connell, Cath Tayleur, Jianchu Xu

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The current unprecedented expansion of infrastructure promises to enhance human wellbeing but risks causing substantial harm to natural ecosystems and the benefits they provide for people. A framework for systematically and proactively identifying the likely benefits and costs of such developments is badly needed. Here, we develop and test at the subregional scale a recently proposed global scheme for comparing the potential gains from new roads for food production with their likely impact on biodiversity and ecosystem services. Working in the Greater Mekong—an exceptionally biodiverse subregion undergoing rapid development—we combined maps of isolation from urban centres, yield gaps, and the …


Wsu Board Of Trustees Meeting Minutes, December 15-16, 2016 Dec 2016

Wsu Board Of Trustees Meeting Minutes, December 15-16, 2016

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 15-16, 2016.


Preliminary Study Of Internal Solitary Wave Amplitude Off The East Coast Of Korea Based On Synthetic Aperture Radar Data, Dan-Bee Hong, Chan-Su Yang, Kazuo Ouchi Dec 2016

Preliminary Study Of Internal Solitary Wave Amplitude Off The East Coast Of Korea Based On Synthetic Aperture Radar Data, Dan-Bee Hong, Chan-Su Yang, Kazuo Ouchi

Journal of Marine Science and Technology–Taiwan

This paper presents a method of retrieving the amplitude of oceanic internal solitary wave (ISW), from synthetic aperture radar (SAR) data, and preliminary results obtained in the East/ Japan Sea off the east coast of Korean Peninsula. The retrieval algorithms include the small perturbation method (SPM) for microwave backscatter, the action balance equation (ABE) for describing the interaction between wind-generated ocean waves and varying surface current, and also the Korteweg-deVries (KdV) (non-linear partial differential) equation for describing the surface current variation induced by an internal soliton. The radar cross section (RCS) was computed, and the ISW amplitude was estimated by …


Underwater Linear Feature Extraction With Multispectral Band Images: An Evaluation With Level-Set Method In Dongsha Atoll And Zengmu Shoal, Peter Tian-Yuan Shih, Jian-Wei Lin, Cheng-Gi Wang Dec 2016

Underwater Linear Feature Extraction With Multispectral Band Images: An Evaluation With Level-Set Method In Dongsha Atoll And Zengmu Shoal, Peter Tian-Yuan Shih, Jian-Wei Lin, Cheng-Gi Wang

Journal of Marine Science and Technology–Taiwan

Optical remote sensing satellite images are a useful and convenient source to provide underwater features, particularly for shallow water areas because light, dependent on wavelength, has the capability to penetrate water. In this study, the information richness of underwater features is investigated for each spectral band of the optical images, and also several derived bands. This assessment is performed with the level-set method for segmentation. Two cases are analyzed in this study. The first study site is the Dongsha atoll, which is composed of Dongsha island, lagoon, and surrounding reefs. The water depth ranges from zero to less than 3 …


Capability Of Geostationary Satellite Imagery For Sea Ice Monitoring In The Bohai And Yellow Seas, Hwa-Seon Lee, Kyu-Sung Lee Dec 2016

Capability Of Geostationary Satellite Imagery For Sea Ice Monitoring In The Bohai And Yellow Seas, Hwa-Seon Lee, Kyu-Sung Lee

Journal of Marine Science and Technology–Taiwan

On a regional scale, sea ice monitoring is important for marine transportation, fishery, harbor and offshore structures, and weather forecast. In this study, we attempt to analyze the potential of Geostationary Ocean Color Imager (GOCI) images for regional-scale sea ice monitoring. GOCI images obtained from December 2011 to March 2012 were analyzed to evaluate the frequency that sea ice can be observed in the Bohai Sea and the northern Yellow Sea. In this season, the sea ice distribution varies greatly both temporally and spatially. During the approximate 100-day ice period, GOCI provided relatively cloud-free daily images over sea ice 86% …


A Computational Study On Sensor Localization For Underwater Acoustic Sensor Network In The East Sea Environmental Model, Jinyoung Choi, Kiseon Kim, Sung Chan Jun Dec 2016

A Computational Study On Sensor Localization For Underwater Acoustic Sensor Network In The East Sea Environmental Model, Jinyoung Choi, Kiseon Kim, Sung Chan Jun

Journal of Marine Science and Technology–Taiwan

An underwater acoustic sensor network (UASN) is a promising method for surveillance or monitoring underwater environments. This network may be most applicable as a disaster alarm system against tsunamis and red tides. Sensor measurement data and sensor location information from these networks are important elements for the UASN system. However, global positioning system (GPS) information is not yet available because the electromagnetic signal has high attenuation under the water. Thus, new methods for sensor localization are of great importance to UASN systems. In this paper, an event-driven localization scheme using the constant arrival time surface (ELSUCATS) is proposed to achieve …


Interpretation Of Sar Image Modulation By The Interaction Of Current And Bottom Topography In Gyeonggi Bay With Microwave Scattering Models, Tae-Ho Kim, Chan-Su Yang, Kazuo Ouchi Dec 2016

Interpretation Of Sar Image Modulation By The Interaction Of Current And Bottom Topography In Gyeonggi Bay With Microwave Scattering Models, Tae-Ho Kim, Chan-Su Yang, Kazuo Ouchi

Journal of Marine Science and Technology–Taiwan

The effect of the interaction between surface currents and bottom topography to the radar cross section (RCS) is investigated using theoretical and numerical scattering models and synthetic aperture radar (SAR) data. First, the ocean waveheight spectrum perturbed by a varying surface current is computed under the wind condition at the time of SAR data acquisition. The surface current data are extracted from the tidal current models. The RCS modulations are then computed using the small perturbation method (SPM) and the numerical scattering model based on the method of moments (MoM) with undulated surface height profiles simulated from the perturbed wave …


Reconstruction And Analysis Of Surface Velocity From Drifters In The Kuroshio Region East Of Taiwan, Kai-Ho Cheng, Chen-Chih Lin, Po-Chun Hsu, Shih-Jen Huang Dec 2016

Reconstruction And Analysis Of Surface Velocity From Drifters In The Kuroshio Region East Of Taiwan, Kai-Ho Cheng, Chen-Chih Lin, Po-Chun Hsu, Shih-Jen Huang

Journal of Marine Science and Technology–Taiwan

In this study, sea surface velocities derived from drifters were gridded to 0.25 latitude by 0.25 longitude for analysis of the Kuroshio region east of Taiwan. The data for each grid that were originally missing were obtained using the Data Interpolating Empirical Orthogonal Functions (DINEOF) method, which can precisely reconstruct missing data. Compared with the original data, the error of the reconstructed Kuroshio velocity is 0.18  0.03 m/s. By analyzing the reconstructed data, we defined the Kuroshio axis at its maximum surface velocity in the zonal direction of 0.25 latitude along the east coast of Taiwan. The results indicate …


A Preliminary Examination Of Elevated Blood Lead Levels In A Rural Georgia County, R. Christopher Rustin, Yu Sun, Chris Calhoun, Christy Kuriatnyk Dec 2016

A Preliminary Examination Of Elevated Blood Lead Levels In A Rural Georgia County, R. Christopher Rustin, Yu Sun, Chris Calhoun, Christy Kuriatnyk

Environmental Health Sciences: Faculty Publications

Background: Rural areas are often viewed as lower risk for lead poisoning and toxic exposures seriously impacting development of the brain and central nervous system; this report examines the prevalence of elevated blood lead levels for children <6 years of age in rural Ben Hill County, GA.

Methods: Lead surveillance data from the Georgia Department of Public Health (DPH) were analyzed using SAS®v-9.3 to calculate the prevalence of elevated blood lead levels (≥5ug/dL) among those children in Ben Hill County who had been tested for lead; the results were compared to Georgia and national data.

Results: A preliminary analysis of 2010-2015 screening data for Ben Hill County indicates that 8.73% …


Outlining A Sustainable Campus Garden: A Proposal To Revive The Bates Garden, Allison Berman, Zsofia Duarte, Emma Marchetti Dec 2016

Outlining A Sustainable Campus Garden: A Proposal To Revive The Bates Garden, Allison Berman, Zsofia Duarte, Emma Marchetti

Community Engaged Research Reports

Reviving the Bates Garden on the corner of College and Vale Streets is in the institution's best interest, for a campus garden would synthesize Bates College’s ideals of academic rigor, intellectual curiosity, and freedom. Through extensive 1 research, we - students in ENVR 417: Community-Engaged Research - have pinpointed why past attempts at the Garden have failed, and how a revival would succeed. Past engagement with the Garden failed to engage it as a functioning system and put all leadership responsibilities on an existing, full-time staff member, Bill Bergevin the College’s Landscape Architect, which lead to the Garden’s demise. Accordingly, …


Predicting The Catch Potential Of Skipjack Tuna In The Western And Central Pacific Ocean Under Different Climate Change Scenarios, Kuo-Wei Yen, Nan-Jay Su, Tooreka Teemari, Min-An Lee, Hsueh-Jung Lu Dec 2016

Predicting The Catch Potential Of Skipjack Tuna In The Western And Central Pacific Ocean Under Different Climate Change Scenarios, Kuo-Wei Yen, Nan-Jay Su, Tooreka Teemari, Min-An Lee, Hsueh-Jung Lu

Journal of Marine Science and Technology–Taiwan

Skipjack tuna (Katsuwonus pelamis) constitute an important migratory species that contributes significantly to the economy and the global fishery industry. Skipjack tuna play a vital role in the marine ecosystem, particularly in tropical waters of the western and central Pacific Ocean (WCPO). However, climate change may affect the characteristics of fishery resources, leading to substantial reallocation and reduction of the biomass of this species in the WCPO. In this study, catch and effort data for skipjack tuna were collected from a purse seine fishery and subsequently analyzed in combination with remote-sensing environmental variables and simulation data from climate models under …


Scatterometry Of 50 Nm Half Pitch Features, Ruichao Zhu Dec 2016

Scatterometry Of 50 Nm Half Pitch Features, Ruichao Zhu

Optical Science and Engineering ETDs

Metrology technologies are an essential adjunct to Integrated Circuit (I.C.) Semiconductor manufacturing. Scatterometry, an optical metrology, was chosen to measure 50 nm half pitch feature structures. A bread-board scatterometry system has been assembled to provide a non-contact, non-destructive, accurate and flexible measurement. A real-time, on-line scatterometry system has also been demonstrated and proven to provide a high throughput measurement.

Three different types of samples have been measured using the scatterometry setup. The wire-grid polarizer (WGP) sample has been made by Jet and Flash Nanoimprint Lithography with ~100 nm pitch and ~50 nm wide ~200 nm tall Al gratings on fused …


Integrating Information Into The Engineering Design Process, Michael Fosmire, David Radcliffe Dec 2016

Integrating Information Into The Engineering Design Process, Michael Fosmire, David Radcliffe

Purdue Information Literacy Handbooks

Engineering design is a fundamental problem-solving model used by the discipline. Effective problem-solving requires the ability to find and incorporate quality information sources. To teach courses in this area effectively, educators need to understand the information needs of engineers and engineering students and their information gathering habits. This book provides essential guidance for engineering faculty and librarians wishing to better integrate information competencies into their curricular offerings. The treatment of the subject matter is pragmatic, accessible, and engaging. Rather than focusing on specific resources or interfaces, the book adopts a process-driven approach that outlasts changing information technologies.

After several chapters …


Tumor-Derived Factors And Reduced P53 Promote Endothelial Cell Centrosome Over-Duplication, Zhixian Yu, Kevin P. Mouillesseaux, Erich J. Kushner, Victoria L. Bautch Dec 2016

Tumor-Derived Factors And Reduced P53 Promote Endothelial Cell Centrosome Over-Duplication, Zhixian Yu, Kevin P. Mouillesseaux, Erich J. Kushner, Victoria L. Bautch

Biological Sciences: Faculty Scholarship

Approximately 30% of tumor endothelial cells have over-duplicated (>2) centrosomes, which may contribute to abnormal vessel function and drug resistance. Elevated levels of vascular endothelial growth factor A induce excess centrosomes in endothelial cells, but how other features of the tumor environment affect centrosome over-duplication is not known. To test this, we treated endothelial cells with tumor-derived factors, hypoxia, or reduced p53, and assessed centrosome numbers. We found that hypoxia and elevated levels of bone morphogenetic protein 2, 6 and 7 induced excess centrosomes in endothelial cells through BMPR1A and likely via SMAD signaling. In contrast, inflammatory mediators IL-8 …


Web-Based Integrated Development Environment, Hien T. Vu Dec 2016

Web-Based Integrated Development Environment, Hien T. Vu

Master's Projects

As tablets become more powerful and more economical, students are attracted to them and are moving away from desktops and laptops. Their compact size and easy to use Graphical User Interface (GUI) reduce the learning and adoption barriers for new users. This also changes the environment in which undergraduate Computer Science students learn how to program. Popular Integrated Development Environments (IDE) such as Eclipse and NetBeans require disk space for local installations as well as an external compiler. These requirements cannot be met by current tablets and thus drive the need for a web-based IDE. There are also many other …


Implementing Partial Blind Estimation Of Alamouti Space-Time Coding In Software-Defined Radios, Sai Gautham Peesapati Dec 2016

Implementing Partial Blind Estimation Of Alamouti Space-Time Coding In Software-Defined Radios, Sai Gautham Peesapati

Theses

The aim of this thesis is to develop and study the performance of an algorithm to perform blind estimation of Alamouti space-time coding (STC) on Zedboard’s ARM core and FPGA, and propose improvements based on the collected data. In the first part, previous methods to accomplish blind estimation of Alamouti STC are presented, and a new method that is simple enough for hardware implementation is proposed. The system of linear equations in the final step of the proposed method is not mathematically solvable. Hence, in the next part, the thesis proposes a method to accomplish partial blind estimation of Alamouti …


Classification Of Intertidal Sediment Using A Two-Step Principal Component Analysis (Pca) Of Optical Reflectance: A Case Study In Ganghwa Tidal Flats, Dong-Jae Kwon, Wook Park, Joong-Sun Won Dec 2016

Classification Of Intertidal Sediment Using A Two-Step Principal Component Analysis (Pca) Of Optical Reflectance: A Case Study In Ganghwa Tidal Flats, Dong-Jae Kwon, Wook Park, Joong-Sun Won

Journal of Marine Science and Technology–Taiwan

Sediment distribution within intertidal flats varies widely, ranging from mud-dominant to sand-dominant, with extensive seasonal changes. However, retrieving grain size information from remotely sensed data is difficult because the optical reflectance of intertidal sediment is not a function of a single parameter but varies according to water content, grain size, topography, surface water, benthic algae, and halophytes. Among these, grain size and water content are two important parameters. The fact that intertidal sediments are always affected by tide necessitates the development of a water-independent grain size retrieval model. Mud and sand sediment are known to be well distinguished under dry …


Mixed-Integer Optimization Problems With Applications To Manufacturing Scheduling And Distributed Energy System Operation, Bing Yan Dec 2016

Mixed-Integer Optimization Problems With Applications To Manufacturing Scheduling And Distributed Energy System Operation, Bing Yan

Doctoral Dissertations

Archival abstract submitted


An Efficient Solution Methodology For Mixed-Integer Programming Problems Arising In Power Systems, Mikhail Bragin Dec 2016

An Efficient Solution Methodology For Mixed-Integer Programming Problems Arising In Power Systems, Mikhail Bragin

Doctoral Dissertations

For many important mixed-integer programming (MIP) problems, the goal is to obtain near-optimal solutions with quantifiable quality in a computationally efficient manner (within, e.g., 5, 10 or 20 minutes). A traditional method to solve such problems has been Lagrangian relaxation, but the method suffers from zigzagging of multipliers and slow convergence. When solving mixed-integer linear programming (MILP) problems, the recently adopted branch-and-cut may also suffer from slow convergence because when the convex hull of the problems has complicated facial structures, facet-defining cuts are typically difficult to obtain, and the method relies mostly on time-consuming branching operations. In this thesis, the …


Population And Trophic Dynamics Of Striped Bass And Blueback Herring In The Connecticut River, Justin P. Davis Dec 2016

Population And Trophic Dynamics Of Striped Bass And Blueback Herring In The Connecticut River, Justin P. Davis

Doctoral Dissertations

Case studies of the ramifications of predator management for prey population dynamics can play a valuable role in developing ecosystem fisheries management. My dissertation focuses on the predator-prey interaction between Striped Bass (Morone saxatilis), an abundant predatory finfish, and an imperiled prey population of anadromous Blueback Herring (Alosa aestivalis). Annual returns of Blueback Herring to the Holyoke Dam on the Connecticut River in southern New England collapsed during the 1980-2000s, coincident with Striped Bass recovery. I studied the abundance and demography of both species in the Connecticut River during 2005-08, measured predation levels, and surveyed the …


Differentiating Instruction Through Math Stations And Literacy Centers, Olivia Bates Dec 2016

Differentiating Instruction Through Math Stations And Literacy Centers, Olivia Bates

Faculty Curated Undergraduate Works

Differentiating instruction based on students’ readiness, interests, and learning profiles is essential for creating effective and meaningful learning activities. Identifying these characteristics allows teachers to meet students’ needs and engage them in learning. By differentiating instruction, educators target specific students’ strengths and challenges in developing lessons to support their understanding of content. Two useful strategies for differentiating math and literacy instruction include stations and centers. In stations and centers, students work on specific skills catered to their educational needs while rotating activities in flexible groups. This guide supports teachers in identifying strategies and understanding the benefits of differentiating math and …


Electropolymerization Of B–Cyclodextrin Onto Multi–Walled Carbon Nanotube Composite Films For Enhanced Selective Detection Of Uric Acid, Mulugeta B. Wayu, Luke T. Dipasquale, Margaret A. Schwarzmann, Samuel D. Gillespie, Michael C. Leopold Dec 2016

Electropolymerization Of B–Cyclodextrin Onto Multi–Walled Carbon Nanotube Composite Films For Enhanced Selective Detection Of Uric Acid, Mulugeta B. Wayu, Luke T. Dipasquale, Margaret A. Schwarzmann, Samuel D. Gillespie, Michael C. Leopold

Chemistry Faculty Publications

An amperometric uric acid (UA) sensor incorporating a multi-walled carbon nanotubes (MWCNT) network in Nafion and electropolymerized β-cyclodextrin (β-CD) layer is investigated. The electrochemical sensor is comprised of a glassy carbon electrode modified with Nafion-MWCNT nanocomposite film, a β-CD polymer inner selective layer, and a Hydrothane polyurethane (HPU) outer selective coating. The surface morphology and electronic structure of the electrode material are characterized using transmission electron microscopy (TEM), scanning electron microscope (SEM), and Fourier transform infrared (FTIR) spectroscopy. The electrocatalytic activity of the sensor is studied using cyclic voltammetry (CV), chronocoulometry (CC) and differential pulse voltammetry (DPV). Analytical performance of …


The Interaction Of Mercury And Methylmercury With Reduced Sulfur: Implications For The Transformation Of Mercury And Methylmercury In The Environment, Nashaat M. Mazrui Dec 2016

The Interaction Of Mercury And Methylmercury With Reduced Sulfur: Implications For The Transformation Of Mercury And Methylmercury In The Environment, Nashaat M. Mazrui

Doctoral Dissertations

Archival abstract submitted


An Intercomparison Of Dissolved Iron Speciation At The Bermuda Atlantic Time-Series Study (Bats) Site: Results From Geotraces Crossover Station A, Kristen N. Buck, Loes J. A. Gerringa, Micha J. A. Rijkenberg Dec 2016

An Intercomparison Of Dissolved Iron Speciation At The Bermuda Atlantic Time-Series Study (Bats) Site: Results From Geotraces Crossover Station A, Kristen N. Buck, Loes J. A. Gerringa, Micha J. A. Rijkenberg

Marine Science Faculty Publications

The organic complexation of dissolved iron (Fe) was determined in depth profile samples collected from GEOTRACES Crossover Station A, the Bermuda Atlantic Time-series Study (BATS) site, as part of the Dutch and U.S. GEOTRACES North Atlantic programs in June 2010 and November 2011, respectively. The two groups employed distinct competitive ligand exchange-adsorptive cathodic stripping voltammetry (CLE-AdCSV) methods, and resulting ligand concentrations and conditional stability constants from each profile were compared. Excellent agreement was found between the total ligand concentrations determined in June 2010 and the strongest, L1-type, ligand concentrations determined in November 2011. Yet a primary distinction between …


Ongoing And Visually-Evoked Cortical Activity Measured Across Multiple Spatial Scales, Nathaniel Caleb Wright Dec 2016

Ongoing And Visually-Evoked Cortical Activity Measured Across Multiple Spatial Scales, Nathaniel Caleb Wright

Arts & Sciences Graduate Student Theses and Dissertations

The visual cortex is a densely-interconnected network of neurons, which receives sensory input from the early visual pathway, and represents information about the visual world in the resulting spatiotemporal activity patterns. These patterns are mediated by cortical interactions that span multiple spatial scales (i.e., neuron-neuron, neuron-population, and population-population). Such interactions are a fundamental property of cortical function, and capture the contribution of the cortex to sensory coding. Yet these interactions are only beginning to be understood, in part because of the challenge of recording ongoing and visually-evoked activity across multiple spatial scales in individual studies. In this thesis, we present …


Understanding The Role Of Dynamics In Brain Networks: Methods, Theory And Application, Mohammadmehdi Kafashan Dec 2016

Understanding The Role Of Dynamics In Brain Networks: Methods, Theory And Application, Mohammadmehdi Kafashan

McKelvey School of Engineering Graduate Student Theses & Dissertations

The brain is inherently a dynamical system whose networks interact at multiple spatial and temporal scales. Understanding the functional role of these dynamic interactions is a fundamental question in neuroscience. In this research, we approach this question through the development of new methods for characterizing brain dynamics from real data and new theories for linking dynamics to function. We perform our study at two scales: macro (at the level of brain regions) and micro (at the level of individual neurons).

In the first part of this dissertation, we develop methods to identify the underlying dynamics at macro-scale that govern brain …


Characterizing Nonmodel Microorganisms And Reconstructing Catabolic Pathways For Bio-Productions, Whitney Hollinshead Dec 2016

Characterizing Nonmodel Microorganisms And Reconstructing Catabolic Pathways For Bio-Productions, Whitney Hollinshead

McKelvey School of Engineering Graduate Student Theses & Dissertations

In the 1970s, spikes in oil prices sparked early interests into first-generation biofuels (i.e., the production of ethanol from corn). Four decades later, biofuel manufacturing has under-performed as developed industrial strains suffer from poor performance and high costs of feedstocks. While the advancement in molecular biology has greatly benefited pathway engineering, synthetic biology hosts still cannot overcome the obstacles for profitable microbial bio-production. One approach may be to study non-model organisms and employ their metabolic features towards an improved bio-production pipeline. Here, this thesis aims to develop 13C-metabolism analysis tools to characterize novel organisms and re-program cell metabolism using novel …