Digital Commons Network^™

Development Of Cxcr4-Inhibiting Nanoparticles For The Treatment Of Metastatic Cancer, Yan Wang

Theses & Dissertations

Metastasis is the main cause of cancer mortality and morbidity, leading to several million deaths every year. Less than 20% of pancreatic cancer (PC) patients are candidates for surgery due to spread beyond the pancreas. Desmoplasia presents substantial barriers to perfusion, diffusion, and convection of antitumor therapeutics into the PC tissues. We focus on developing novel therapies that regulates tumor microenvironment, chemosensitizing tumor to therapeutics and preventing metastasis.

Gene therapy is emerging as a promising new therapeutic agents for cancer treatment. A targeted, systemic, effective and safe gene delivery system should be developed. CXCR4/SDF-1 axis plays a crucial role in …

Chimerscope: A Novel Alignment-Free Algorithm For Fusion Gene Prediction Using Paired-End Short Reads, You Li

Theses & Dissertations

Fusion genes are those that result from the fusion of two or more genes, and they are typically generated due to the perturbations in the genome structure in cancer cells. In turn, fusion genes can contribute to tumor formation and progression by promoting the expression of an oncogene, deregulation of a tumor-suppressor, or producing much more active abnormal proteins. More importantly, oncogenic fusion genes are specifically expressed in the tumor cells, which provide enormous diagnostic and therapeutic advantages for cancer treatment. With the development of next-generation sequencing (NGS) technology, RNA-Seq becomes increasingly popular for transcriptomic study because of its high …

The Effect Of Agricultural Exposures And Genetics On Respiratory Phenotypes, Lisa W. Boyd

Theses & Dissertations

Agricultural workers are at risk for respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and chronic bronchitis, due to exposures and inflammatory agents found in their work environment. While previous studies have been conducted to examine agricultural effects of chronic respiratory diseases more closely, there are still several significant gaps in the existing literature.

This dissertation explores the relationship between agricultural exposures and respiratory diseases. Utilizing two populations, the Keokuk Country Rural Health Study and the AgLung Study, this research: 1) used principal factor analysis (PFA) to distill exposure data into essential variables characterizing long-term agricultural exposures in order …

The Use Of Electroacupuncture For Cervical Ripening In Pregnant Women, Becky A. Nauta

Theses & Dissertations

The purpose of this study was to compare cervical ripening outcomes, based on Bishop scoring methodology, of pregnant women receiving usual care treatment (UC) with those receiving electroacupuncture plus UC. A sample of 36 pregnant women completing their 39^th week of gestation was randomized into one of the two groups. The women in the UC group continued to meet with their provider on a weekly basis until delivery. The women in the electroacupuncture plus usual care group met with their provider on a weekly basis and also received electroacupuncture treatments: three in the 39th gestational week and two in …

Cervical Spine Angles, Craniocervical Posture, Neck Length, And Oropharyngeal Airway Analyses Of Sleep Apnea Patients In Both Supine And Upright Positions: A Retrospective 3-D Imaging Study, Brian Tuan Luong

Theses & Dissertations

Obstructive sleep apnea (OSA) is one of the most common respiratory disorders. Previous airway studies of OSA subjects have largely relied on 2-D radiographs.

The purpose of this study is to use 3-D imaging to the analyze the relationships among cervical spine angles, craniocervical posture, cervical spine length and the oropharyngeal airway volume in OSA patients in both the supine and upright positions.

Twenty-eight OSA subjects with 3-D imaging were included. Airway, craniocervical posture, spine angles, and spine length were assessed using Dolphin 11.8. Correlation analyses were utilized to detect associations among the recorded and measured variables. Mean differences were …

Adoption Of Medication Management Technologies By U.S. Acute Care Hospitals After The Hitech Act, Aastha Chandak

Theses & Dissertations

Medication errors and adverse drug events (ADEs) are a significant public health concern in the United States as they pose a threat to patient safety. The medication management process is a complicated process in U.S. acute care hospitals, consisting of a series of steps such as ordering, transcribing, dispensing and administration and each step is prone to medication errors.The use of technology is considered to be an important intervention in improving the medication management process and thereby reducing medication errors and ADEs and further improve patient safety. The Health Information Technology for Economic and Clinical Health (HITECH) Act, implemented in …

Barriers To Pediatric Triage Guideline Compliance: A Survey Of Nebraska Emergency Departments, Jonathon J. Gruba

Theses & Dissertations

Nebraska emergency departments may be underprepared for a mass casualty event involving a large number of children, as indicated by the results from the 2013 Emergency Medical Services for Children’s (EMSC) Pediatric Readiness Project (PRP) report. This was primarily evident by the lack of existence of a pediatric triage policy among Nebraska emergency departments. Utilizing a survey, this study attempted to identify the emergency departments in Nebraska that followed the EMSC guideline of having a pediatric triage policy, as well as to identify possible barriers to guideline adherence among those that did not have the policy.

It was found that …

Mitogen And Morphogen Signaling Dysregulation: Pathophysiological Influence In Pancreatic Cancer And Alzheimer’S Disease, Eric Cruz

Theses & Dissertations

Although the etiology of a particular disease will vary, there are genetic and epigenetic bottlenecks that frequently converge resulting in dysregulation of mitogenic and morphogenetic signaling. This propensity is acutely experienced in malignancy and neurodegenerative disease.

Here, we have first investigated the role of dysregulated signaling in the context of pancreatic cancer (PC). Morphogenetic signaling has been regarded as a pleiotropic pathway with the potential to promote and inhibit metastatic features. Our investigation of bone morphogenetic protein 2 (BMP-2), an archetypical member of the BMP superfamily, has revealed the presence of extracellular, intracellular, and long non-coding RNA products. Our findings …

Primer On Perspectives And Practices Of Trauma, Trevor P. Haase

Educational Specialist, 2009-2019

A large majority of the general population has endured at least one traumatic event in their lifetime and many will seek counseling services to process and resolve the impact from the traumatic experience. Counselors and mental health providers will likely encounter trauma survivors in a high frequency in the majority of therapeutic settings. Practicum and internship level counselors are often not prepared for navigating the complexities that arise working with trauma survivors. This paper outlines the various perspectives and practices of the works of Dr. Bessel van der Kolk, Narrative Therapy, and Trauma Focused-Cognitive Behavioral Therapy. These orientations were designed …

Occurrence, Antibiotic Resistance, And Survival Of Fecal Enterococci In Turkey Litter, Steven Glynn Mcbride Ii

Masters Theses, 2010-2019

The United States Environmental Protection Agency’s National Water Quality Inventory and the Commonwealth of Virginia’s 305(b)/303(d) Water Quality Assessment Integrated Report show fecal bacteria to be the most common cause of impairment for both streams and estuaries. Human and animal sources have both been identified as significant contributors of pathogenic bacteria to surface waters. In this study, turkey litter from a farm in Shenandoah County, VA was surveyed for total culturable bacteria and total culturable enterococci before and after a transition to organic rearing practices. The enterococci were identified to species phenotypically using the Biolog Microbial Identification System and resistance …

Gender Inequity Within Public Accounting, Paige Petersen

Honors Thesis

Traditionally a male-dominated field, the public accounting industry has seen recent progress in the presence and advancement of women in the profession. Today, women comprise half of accounting students, Certified Public Accountant test-takers, and employees at public accounting firms. However, women in public accounting face an invisible barrier when it comes to reaching the level of partner, where they represent only nineteen percent of partners. Uneven distribution of female representation should be of concern to public accounting firms seeking to maximize the potential of their talent pool and gain the benefits of diverse leadership. Traditional viewpoints on this issue promote …

The Inter- And Intra-Rater Reliability Of Athletic Trainers At Identifying Acl Injury Risk Factors Using The Cutting Screening Tool, Kelly Buckholz Smallbeck

Master's Theses

Background: ACL injuries are a frequently talked about injury in sports and have a multitude of negative side effects. A majority of injuries occur during single-leg cutting motions. Clinical screening tools are an effective way to identify those demonstrating more ACL injury risk factors. Recent research has created a variety of clinical screening tools to identify ACL injury risk factors, however none screen athletes during a single-leg cutting motion.

Hypothesis: A clinical screening tool using a single-leg cutting motion (the Cutting Screening Tool, or CST) will reliably identify ACL injury risk factors when used by athletic trainers.

Methods: Six currently …

The History Of Sociology Teaching In United Kingdom (Uk) Undergraduate Medical Education: An Introduction And Rallying Call!, T Collett, L Brooks, S Forrest

Peninsula Medical School

Based on a review of the literature, this article provides an introduction to the history of sociology teaching in UK undergraduate medical education. Aimed at an international community and at individuals either new to the field or with a general interest, our objectives are to situate sociology teaching in UK medical education within its broader historical and political setting, to highlight the work of past social science teachers, to draw attention to the modern day context and to ask: ‘what now’? We are particularly interested in the changing role of the sociologist in teaching medical sociology. The behavioral and social …

It’S Just Common Sense! Why Do Negative Perceptions Of Sociology Teaching In Medical Education Persist And Is There Any Change In Sight?, L Brooks, T Collett, S Forrest

Peninsula Medical School

Based on a review of the literature pertaining to sociology teaching in medical education, this paper asks why does the problem of relevance with regards to sociology teaching in medical education still persist? And is there any change in sight? The literature suggests that epistemological understandings of medicine as represented by the biomedical model are deeply entrenched with far reaching consequences for sociology teaching. Notions of the social components of medicine as ‘irrelevant’ or ‘common sense’ have over time been reinforced by students’ expectations of medicine on entering medical education; by the attitudes of clinical and biomedical staff members who …

Utilizing Pre-Education Assessment And A Targeted Education Module To Enhance Nurse Knowledge Of Standard And Transmissible Precautions, Deborah A. Ard

Master's Projects and Capstones

Abstract

The aim of this project was to protect patient safety and prevent healthcare acquired infections by improving nurses’ knowledge of infection prevention practices. A second practical benefit was creating a pilot for an RN education program.

I propose that the reason compliance with hand hygiene is low at any facility can be explained by Rosenstock’s Health Belief Model. Nurses may not believe that 1) There is a high chance of spreading or themselves contracting infectious illness, 2) That the illnesses they are exposed to would be just as serious in them as they are seeing in patients, 3) They …

Improving Cal Nagpra: Honoring Native American Rights, Kim Turner

Master's Projects and Capstones

The California Native American Graves Protection and Repatriation Act (Cal NAGPRA) became state law in 2001. Its purpose was to create a process whereby California tribes could seek to repatriate human remains and objects from their cultural heritage from museums and custodial institutions. Cal NAGPRA includes a number of shortcomings that have impeded the ability of tribes to successfully reclaim objects from their heritage. The ethical implications of museums retaining cultural objects and human remains, often confiscated from Native peoples or their tribal lands, has been a principal social justice topic of USF’s museum studies program. This capstone describes a …

Inside The Juvenile Justice System, Megan Phalon

Master's Projects and Capstones

The United States of America is known for freedom and integrity and being a nation that stands for justice and equality for all. Within the United States there are systems in place to better the people and communities in order to provide safety and order. However, just as any nation, there is a struggle with violent behavior and tendencies among adults and adolescents. Within the last three decades, the United States has created a correctional system that specifically targets adolescents, and that acknowledges the differences between adult and juvenile development and deviant behavior. Within this literature review, academic databases were …

Move-Hf: An Internet-Based Pilot Study To Improve Adherence To Exercise In Patients With Heart Failure, Pallav Deka

Theses & Dissertations

Background Although the use of internet-based exercise interventions to improve physical activity has become popular and useful, such approaches to improve exercise adherence in patients with heart failure (HF) are lacking. It is also unknown whether the delivery of objective feedback on physical activity can impact exercise adherence.

Purpose The purpose of the Move on Virtual Engagement (MOVE-HF) study was to i) test the feasibility of delivering an internet-based face-to-face group discussion/education intervention using a software called “Vidyo” and monitoring of physical activity using the Fitbit Charge HR (FCHR) in community dwelling patients with heart failure; ii) compare the MOVE-HF …

The Political Economy Of Conflict In Liberia, Sierra Leone, And Côte D'Ivoire: Foreign Economic Intervention And The Spatial Distribution Of Violent Conflict, Sarai-Anne N. Ikenze

Master's Theses

Between 1989 and 2011, the three neighboring West African countries of Liberia, Sierra Leone, and Côte d’Ivoire each experienced at least one major civil conflict; and the combined devastation of the conflicts claimed over a million lives, generated millions of refugees, and crippled infrastructure in ways that continue to impact the development of the sub-region today. The occurrence of conflict in the three countries and the fact that they share borders has raised questions about whether the conflicts were caused by domestic factors or were the result of transborder processes of conflict diffusion. This paper will assess the causes of …

Adobe Medicus 2016 5 September-December, Unm Hslic

adobe medicus

No abstract provided.

Teaching Place: Heritage, Home And Community, The Heart Of Education, Judy Kay Lorenzen

Department of English: Dissertations, Theses, and Student Research

This dissertation examines the implementation of a Place-conscious pedagogy as a means to teach heritage and sense of place. This pedagogy is framed upon the premise that trying to understand our heritage and place—ourselves—are crucial elements in our ability to live well as individuals who are connected school/community members, who help our schools/communities thrive, becoming Place-conscious citizens. I argue that in teaching in such a culturally diverse community, tensions rise as immigration has become a main focus. Our school/community has experienced many ethnic groups with vast social differences for which Place-conscious education offers practical solutions. These students have a great …

Implementing Strategies To Improve Patient Perception Of Nursing Communication, Ghada Dunbar, Stacey Nagar

DNP and Student Works

According to the Joint Commission (TJC), effective communication and patient and family centered care impacts quality and safety (2014). The aim of this project was to improve patients' perception of nurse communication in an adult inpatient telemetry unit in California by creating a training module for nurses on caring behaviors and implementing a structured rounding tool (SRT) to evaluate patient perception of nursing caring behaviors. The SRT was implemented prior to nurse education and responses before the training were compared with those after. The nurses attending a training session on caring behaviors completed the Caring Assessment for Caregivers (CACG) survey …

A Green Oasis: What Makes Community Gardens Worth Saving? While Researchers Amass Evidence Of Benefits, Advocates Develop New Strategy To Prove Their Value., Joel Wolfram

Capstones

Green Valley Community Garden in Brownsville, Brooklyn, is one of about a dozen gardens on land owned by the New York City Department of Housing Preservation and Development that are being uprooted by plans to build affordable housing. The gardeners are fighting back to prevent the garden’s destruction, saying that the food-producing green space is a source of healthy eating in a community with high rates of health problems, like diabetes and obesity. Researchers are attempting to tease out the public health benefits of community gardens as one metric of their value, but the science is still catching up with …

Increasing Patient Satisfaction And Decreasing Hospital Readmission Due To Deep Venous Thrombosis By Providing Anticoagulation Education For Orthopedic Patients, Margaret Gniewosz

Master's Projects and Capstones

Abstract

Improving Process on Oral Anticoagulant Education for Orthopedic Patients

The aim of this project is to improve anticoagulation education for orthopedic patients to increase patient satisfaction. The microsystem for this project is a medical-surgical (MS), 50-bed unit in a medium size hospital. Because orthopedic patients are at high risk to develop DVT postoperatively, proper anticoagulants and anticoagulation education is an important aspect of patient care. By implementing a well-designed and easy-to-read patient handout on anticoagulants with instructional script for nurses will empower patients to achieve higher level of anticoagulant knowledge and in result, increase patient satisfaction. A preliminary round …

Jackson Creek Arts And Trails, Llc: Museum Travel Immersion Programs, Else C. Trygstad-Burke

Master's Projects and Capstones

Museums have become increasingly oriented towards reaching new audiences, encouraging visitor loyalty, and informing the public about their overall relevance. Innovation in programming is a centerpiece of this effort, including a provision of programs for all age groups and demographics. At the same time that this transformation occurs in the museum world, similar changes are taking place in the leisure, travel and tourism industries. A continuously rapid increase in globalism and cultural access contributes to an atmosphere in which travelers can expand their goals and purposes within the context of a travel experience. This report will demonstrate that these trends …

Admission Handoff Between Emergency Department And Inpatient Units, Amanda A. Briones

Master's Projects and Capstones

When admitting a patient from the emergency department (ED) to an inpatient unit, a handoff report is conducted. There are many ways the ED nurse can go about delivering this report to the inpatient or floor nurse. Each ED nurse tends to this task in their own way, providing the information they deem important. Due to the absence of standardization, handoff reports have the ability to lack important information regarding the patient and can even lead to compromising the safety of the patient.

The purpose of this project was to gain a comprehensive understanding of the current handover process of …

Sorption And Metabolism Of Explosives In Sediment Of Coastal Marine Ecosystems, Thivanka S. Ariyarathna

Doctoral Dissertations

The lack of knowledge on fate and transport of explosive compounds, 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in marine ecosystems limits the ability to predict toxicological impacts and natural attenuation of these suspected carcinogens in contaminated coastal sites. This study focuses on improving our understanding of the sorption and transformation of TNT and RDX in coastal ecosystems by using stable nitrogen isotopes.

Abiotic and biotic bench-top experiments using sediment slurries evaluated sorption kinetics and anaerobic biotransformation. Marine silt showed higher compound-uptake rates (> ~100) than freshwater silt for both compounds though equilibrium partition constants (Kp’s) were on the same order of …

Assessing Epigenetic Features Of Gaba(A) Receptor Genes In Ipscs, Ipsc-Derived Neuroepithelial Cells, And Ipsc-Derived Neural Cell Cultures, Maegan Watson

Doctoral Dissertations

Alcohol use disorders (AUDs) affect approximately 13.9% of the population in the United States. Many groups have found a correlation between AUDs and a synonymous SNP in exon 5 of the GABRA2 gene (rs279858 T to C; C allele associated with AUDs). However, the biological effects of this and other SNPs in this region are unknown.

Our lab has been using iPSC technology for the past few years to study AUDs. The lab has shown, using qPCR of mRNA, that a cluster of GABA_A receptor subunit genes on chromosome 4p12 is expressed at minimal levels in neural cells derived …

Intolerance Of Uncertainty, Worry, And Problem-Solving: Implications For Generalized Anxiety Disorder, Melissa Patrick

Electronic Theses & Dissertations

This study was conducted to examine the correlations between Generalized Anxiety Disorder (GAD), worry, intolerance of uncertainty (IU), and problem-solving. The Generalized Anxiety Disorder Questionnaire for DSM-IV (GADQ-IV), the Penn State Worry Questionnaire (PSWQ), the Intolerance of Uncertainty Scale (IUS), and the Problem-Solving Inventory (PSI) were used to assess the relationship between GAD, worry, IU, and problem-solving. While the GADQ-IV, PSWQ, and the IUS assessed generalized anxiety, worry, and intolerance of uncertainty as single constructs, the PSI assessed problem-solving in terms of problem-solving confidence, approach avoidance style, and personal control. Data of 86 students in general psychology classes at Pittsburg …

Facial Microbiota And Antibiotic Resistance: A Comparative Study Observing The Presence Of Resistance Genes And Diminished Susceptibility, Kayla R. Stricklan

Electronic Theses & Dissertations

The looming threat of increased antibiotic resistance leading to a post-antibiotic world is progressively becoming a reality. A significant portion of the fight against antibiotic resistance development is slowing down the prescribing of antibiotics for unnecessary conditions while simultaneously encouraging stricter adherence to antibiotic course completion. One of the often-unnecessary conditions is acne vulgaris. Though the disease may be unsightly and discouraging, it does little to affect overall health of the individual with the exception of psychosocial affects. Utilizing facial swabs from 144 participants, samples were tested for the colonization of Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis as …