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Haematococcus: A Successful Air-Dispersed Colonist In Ephemeral Waters Is Rarely Found In Phytoplankton Communities, Savvas Genitsaris, Natasa Stefanidou, Matina Katsiapi, Elisabeth Vardaka, Konstantinos Ar. Kormas, Ulrich Sommer, Maria Moustaka-Gouni

Turkish Journal of Botany

In a literature search, the presence of Haematococcus in phytoplankton communities and its biogeography were investigated. Haematococcus, although showing a wide biogeographical distribution, has been rarely found in phytoplankton communities. Simultaneously, the colonization potential of air-dispersed Haematococcus in ephemeral waters and its interactions with coexisting phytoplankton taxa were examined by microscopy and molecular methods. Haematococcus was a successful colonist, appearing among the first taxa in the experimental containers. According to principal component analysis, Haematococcus growth rate was negatively correlated with the abundance and species richness of the other autotrophs. Furthermore, a negative correlation between Haematococcus and Chlamydomonas and a positive …

Simvastatin's Effects On Survival And Outcome In Traumatic Braininjury Patients: A Comparative Study, Taraneh Naghibi, Sara Madani, Saideh Mazloomzadeh, Faramarz Dobakhti

Turkish Journal of Medical Sciences

Background/aim: Mortality and morbidity still remain high in patients with traumatic brain injuries. Understanding the role of new treatments in these patients is critical. The aim of this study was to determine the effect of simvastatin on survival and outcome in traumatic brain injury patients. Materials and methods: Forty-four patients were assigned to receive either simvastatin or a placebo. The serum interleukin-6 and C-reactive protein levels were measured at the first 24 h and 48 h after trauma. All data, including the Glasgow Coma Scale score, survival at discharge, length of intensive care unit stay, and duration of mechanical ventilation, …

Mucormycosis: A 10-Year Experience At A Tertiary Care Center In Turkey, Süheyla Kömür, Ayşe Seza İnal, Behi̇ce Kurtaran, Aslihan Ulu, Aysun Uğuz, Hasan Sali̇h Zeki̇ Aksu, Yeşi̇m Taşova

Turkish Journal of Medical Sciences

Background/aim: Mucormycosis is a rare invasive fungal infection most commonly encountered in the immunocompromised host. We analyzed 51 adult patients treated for mucormycosis between 2003 and 2013 and recorded at a tertiary university hospital in Turkey. Materials and methods: We examined the following data for all patients: age, sex, predisposing disease, symptoms, treatment, surgical procedure, concomitant infections, intensive care requirement, and outcomes. Results: During the study period 51 cases of mucormycosis were documented; 54.9% of the patients were female. The mean age was 44.2 ± 18.2 years. Rhinocerebral presentation was reported in 94.1% of patients. Almost all patients (88.2%) had …

Plasma Lipoprotein(A) Levels Are Associated With The Severity Of Coronaryheart Disease In Han Chinese People, Li Zhu, Zhan Lu, Liren Zhu, Xiaoxiao Ouyang, Yang Yang, Yanping Feng, Ping Li, Wenjing Ye, Xiaoming Zhang, Xiuyun Zhang, Yongyan Song

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the association of lipoprotein(a) [Lp(a)] with the severity of coronary heart disease (CHD) in Han Chinese people. Materials and methods: Six hundred and seventy-nine patients with angiographically defined CHD were enrolled in this cross-sectional study. Fasting lipids were measured, and the severity of CHD was quantitatively assessed for each patient according to the number of stenotic coronary branches and the Gensini scoring system. Results: The levels of Lp(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and apolipoprotein (apo) B100 increased, while high-density lipoprotein cholesterol (HDL-C) and …

The Efficacy Of Kaolin Clay In Reducing The Duration And Severity Of `Heat' Diarrhea In Foals, Magdalena Pieszka, Jaroslaw Luszczynski, Magdalena Hedrzak, Katerina Goncharova, Stefan G. Pierzynowski

Turkish Journal of Veterinary & Animal Sciences

'Heat' diarrhea in foals is an onerous but not life-threatening ailment, which indicates that it may be of osmotic origin. This was confirmed by a successful attempt, presented in this paper, to alleviate the severity and duration of foal heat diarrhea with the use of a typical absorbent, kaolin clay, as a feed additive, usually applied in feed production as an anticaking agent. Based on the present results, it can be concluded that treatment of foals maintained on different stud farms with a kaolin paste reduced the duration of heat diarrhea and alleviated its severity (P < 0.05 and P = 0.001). The observed action of kaolin clay, an excellent absorbent, suggests that the so-called heat diarrhea can be caused by disturbances in the intestinal osmotic balance at this specific age of foals. The use of this preparation can reduce the risk of secondary pathological viral or bacterial diarrhea and the requirement for veterinary intervention in foal management. It can also shorten the care period and increase foal well-being, essential for the normal development of a young horse. In addition, prophylactic application of an antidiarrheal preparation based on an industrial by-product, i.e. A cheap component, will reduce the costs of foal care.

Effect Of Retinol And Retinol Esters On Performance, Egg Quality, And Blood And Egg Vitamin A Levels In Laying Quails, Murat İlhan, Tuba Bülbül

Turkish Journal of Veterinary & Animal Sciences

This study aimed to determine the effects of retinol and retinol ester supplementation on performance, egg quality, serum and egg oxidative status, and vitamin A levels in laying quails. Three hundred quails were divided into 5 groups. The control group received a basal diet that contained vitamin premix without vitamin A or vitamin A precursors. The treatment groups received dietary supplementation with retinol and retinol esters [retinyl acetate (R-acetate), retinyl palmitate (R-palmitate), retinyl propionate (R-propionate), 3300 IU/kg]. Egg production and feed conversion ratio improved in all experimental groups. Serum β-carotene and malondialdehyde (MDA) levels decreased and serum retinol levels increased …

The Problematic Applicability Of Subsidiarity To International Law, Paolo G. Carozza

Journal Articles

This article seeks to explore some of the reasons why the principle of subsidiarity, although applicable in some sectors of international law and particularly in the field of international human rights law, has difficulty in serving as a general principle of public international law more broadly. The obstacles to advancing a more robust understanding of subsidiarity's place in the current structure of global norms and institutions include: the normative and institutional fragmentation of international law; the continuing centrality of state sovereignty in the international legal system; and the endemic weaknesses and incapacity of states and sub-state communities with respect to …

The Future Of Abortion Law In The United States, Gerard V. Bradley

Journal Articles

In 1971, Judith Jarvis Thomson published what was then and still often is regarded as a trailblazing philosophical defense of a woman’s right to have a lawful abortion. It is time to revisit Thomson’s paper. The aim here is not to engage Thomson’s pro-choice conclusions, which are indeed mistaken, but to show that her question—to what extent can abortion be morally justified, assuming that it is the deliberate killing of one person by his or her mother—is the question today in American law concerning abortion. Pro-life people and groups argue among themselves about the prudence of political efforts to roll …

Affirmatively Furthering Neighborhood Choice: Vacant Property Strategies And Fair Housing, James J. Kelly Jr.

Journal Articles

When many of us think about fair housing enforcement, scenes involving undercover apartment applicants ferreting out racially biased landlords come to mind. Indeed, fair housing "testers" have been and continue to be an important element of civil rights accountability.' However, implementation of the Fair Housing Act of 1968 has had at least as much to do with increasing the supply of decent, affordable housing options to members of protected groups as with assuring those individuals that they will not be denied a particular housing unit because of the color of their skin or a disability.

This macro aspect of fair …

A Code-Based Approach To Unauthorized Access Under The Computer Fraud Abuse Act, Patricia L. Bellia

Journal Articles

Thirty years ago, Congress passed the Computer Fraud and Abuse Act (CFAA) to combat the emerging problem of computer crime. The statute’s core prohibitions targeted one who “accesses” a computer “without authorization” or who “exceeds authorized access.” Over time, incremental statutory changes and large-scale technical changes have dramatically expanded the potential scope of the CFAA. The question of what constitutes unauthorized access has taken on far greater significance than it had thirty years ago, and courts remain deeply divided on this question. This Article explores the text, purpose, and history of the CFAA, as well as a range of normative …

Modern-Day Monitorships, Veronica Root

Journal Articles

When a sexual abuse scandal rocked Penn State, when Apple engaged in anticompetitive behavior, and when servicers like Bank of America improperly foreclosed upon hundreds of thousands of homeowners, each organization entered into a Modern-Day Monitorship. Modern-Day Monitorships are utilized in an array of contexts to assist in widely varying remediation efforts. They provide outsiders a unique source of information about the efficacy of the tarnished organization’s efforts to remediate misconduct. Yet despite their use in high-profile and serious matters of organizational wrongdoing, they are not an outgrowth of careful study and deliberate planning. Instead, Modern-Day Monitorships have been employed …

Guidance For The Practical Management Of The Heparin Anticoagulants In The Treatment Of Venous Thromboembolism., Maureen A. Smythe, Jennifer Priziola, Paul P. Dobesh, Diane Wirth, Adam Cuker, Ann K. Wittkowsky

Journal Articles: Pharmacy Practice

Venous thromboembolism (VTE) is a serious and often fatal medical condition with an increasing incidence. Despite the changing landscape of VTE treatment with the introduction of the new direct oral anticoagulants many uncertainties remain regarding the optimal use of traditional parenteral agents. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance based on existing guidelines and consensus expert opinion where guidelines are lacking. This specific chapter addresses the practical management of heparins including low molecular weight heparins and fondaparinux. For each anticoagulant a list of the most common practice related questions were created. Each question was addressed using a …

Low-Dose Aronia Melanocarpa Concentrate Attenuates Paraquat-Induced Neurotoxicity, Adam J. Case, Daniel Agraz, Iman M. Ahmad, Matthew C. Zimmerman

Journal Articles: Cellular & Integrative Physiology

No abstract provided.

Angiotensin Ii-Induced Hypertension Is Attenuated By Overexpressing Copper/Zinc Superoxide Dismutase In The Brain Organum Vasculosum Of The Lamina Terminalis., John P. Collister, Heather Taylor-Smith, Donna Drebes, David Nahey, Jun Tian, Matthew C. Zimmerman

Journal Articles: Cellular & Integrative Physiology

Angiotensin II (AngII) can access the brain via circumventricular organs (CVOs), including the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), to modulate blood pressure. Previous studies have demonstrated a role for both the SFO and OVLT in the hypertensive response to chronic AngII, yet it is unclear which intracellular signaling pathways are involved in this response. Overexpression of copper/zinc superoxide dismutase (CuZnSOD) in the SFO has been shown to attenuate the chronic hypertensive effects of AngII. Presently, we tested the hypothesis that elevated levels of superoxide (O2 (∙-)) in the OVLT contribute to the hypertensive effects …

Low-Dose Aronia Melanocarpa Concentrate Attenuates Paraquat-Induced Neurotoxicity., Adam J. Case, D Agraz, Iman M. Ahmad, Matthew C. Zimmerman

Journal Articles: Cellular & Integrative Physiology

Herbicides containing paraquat may contribute to the pathogenesis of neurodegenerative disorders such as Parkinson's disease. Paraquat induces reactive oxygen species-mediated apoptosis in neurons, which is a primary mechanism behind its toxicity. We sought to test the effectiveness of a commercially available polyphenol-rich Aronia melanocarpa (aronia berry) concentrate in the amelioration of paraquat-induced neurotoxicity. Considering the abundance of antioxidants in aronia berries, we hypothesized that aronia berry concentrate attenuates the paraquat-induced increase in reactive oxygen species and protects against paraquat-mediated neuronal cell death. Using a neuronal cell culture model, we observed that low doses of aronia berry concentrate protected against paraquat-mediated …

Access And Barriers To Care During Transition From Active Duty To Veteran Status In Veterans With Diabetes: A Look At Health Literacy, Change, And Ongoing Diabetes Self-Management Education, Mark R. Malebranche

Dissertations

Background and Rationale: Transition from active duty to veteran status may be a challenging time, especially for veterans with diabetes. These veterans face multiple changes that can cause distress. Most veterans with diabetes have type 2 diabetes, however a diagnosis of type 1 diabetes on active duty is cause for discharge for active duty.

Purposes and Aims: The purpose of this study was to describe the transition experience of veterans diagnosed with diabetes while on active duty from active duty to veteran status. The study describes barriers and facilitators to healthcare and diabetes self-care management. The four aims of the …

In-Hospital Factors Associated With Supplementation Among Healthy, Full-Term, Breastfed Infants, Jodi Kae O'Brien

Dissertations

Background: Formula supplementation of healthy, term, breastfed infants born to mothers who plan to exclusively breastfeed persists at high rates, in spite of global reduction efforts. The identification of modifiable risk factors for supplementation and effective nursing care for successful breastfeeding is understudied.

Purpose: This study aimed to better understand the obstetrical, hospital, and nursing factors associated with supplementation during the hospital stay. The aims were: (1) examine the relationships between aspects of hospital care of infants who are supplemented compared to infants exclusively breastfed and (2) determine what in-hospital risk factors increase the odds of formula supplementation among a …

Guardians Of Municipal Public Trees: Commonwealth Of Massachusetts Tree Wardens’ Authority And Accountability, Julie E. Steiner

Faculty Scholarship

Today’s tree wardens are continually called upon to strike a balance between preservation of public trees and protection of the public from hazardous tree conditions. The Commonwealth of Massachusetts has been a pioneer in tree protection legislation, including the enactment of the first state legislation requiring a municipal tree warden. As guardians of the municipal landscape, tree wardens decide whether and when to plant new public shade trees, or to permit those that already exist to be cut, trimmed, or removed. This Article describes the important historical role the Commonwealth of Massachusetts has played in protecting public trees, the legal …

Symposium: Environmental Accountability In An Age Of Consequences: Foreword, Julie E. Steiner

Faculty Scholarship

The five articles in this Symposium issue each take a different approach to addressing environmental accountability. There is unequivocal evidence that the climate system is warming, caused mainly by the measurable increase in anthropogenic greenhouse gas emissions. The Symposium authors include Denis Binder, Susan Stark, Julie E. Steiner, Chris Erchull, Laura Fisher, and Daniel DePasquale. These Authors challenge all to think broadly about utilization of different accountability mechanisms to ensure more efficient environmental outcomes.

What Legal Writers Can Learn From Paint Nite, Beth Cohen, Pat Newcombe

Faculty Scholarship

Paint Nite activities and adult coloring have captured the nation’s interest and gone mainstream. Creating something on our own is what drives similar trends like the popular Do It Yourself movement and the resurgence of knitting after 9/11. At the same time, these fun, creative activities can provide us with a window into the process of legal writing. Using Paint Nite as a reference point throughout a legal writing course allows faculty to present a holistic view of the writing process and provides a useful analogy for faculty as well as an accessible context for students. Legal writing instructors share …

Quaking Aspen In Utah: Integrating Recent Science With Management, Paul C. Rogers, Samuel B. St. Clair

Wildland Resources Faculty Publications

Quaking aspen is widely regarded as a key resource for humans, livestock, and wildlife with these values often competing with each other, leading to overuse of aspen in some locations and declines. We review trends in aspen science and management, particularly in Utah. Historically, research conducted here holds a prestigious place in international aspen circles. We highlight recent studies continuing the tradition to keep rangeland managers informed of important developments, focusing on aspen functional types, historical cover change and climate warming, ungulate herbivory, and disturbance interactions.

Evaluation Of Total Daily Dose And Glycemic Control For Patients Taking U-500 Regular Insulin Admitted To The Hospital, Andrew O/ Paulus, Jeffrey A. Colburn, Mark W. True, Darrick J. Beckman, Richard P. Davis, Jana L. Wardian Phd, Sky D. Graybill, Irene Folaron, Jack E. Lewi

Journal Articles: Hospital Medicine

OBJECTIVE: Patients using U-500 regular insulin are severely insulin resistant, requiring high doses of insulin. It has been observed that a patient's insulin requirements may dramatically decrease during hospitalization. This study sought to systematically investigate this phenomenon.

METHODS: We performed a retrospective chart review of patients with U-500 insulin outpatient regimens who were admitted to the San Antonio Military Medical Center over a 5-year period. Each patient's outpatient total daily dose (TDD) of insulin was compared to the average inpatient TDD. The outpatient estimated average glucose (eAG) was calculated from the glycated hemoglobin (HbA1c) and compared to the average inpatient …

Validation Of Metabolic Alterations In Microscale Cell Culture Lysates Using Hydrophilic Interaction Liquid Chromatography (Hilic)-Tandem Mass Spectrometry-Based Metabolomics, Venugopal Gunda, Fang Yu, Pankaj K. Singh

Journal Articles: Eppley Institute

By standard convention, in order to increase the efficacy of metabolite detection from cell culture lysates, metabolite extracts from a large quantity of cells are utilized for multiple reaction monitoring-based metabolomic studies. Metabolomics from a small number of cell extracts offers a potential economical alternative to increased cell numbers, in turn increasing the utility of cell culture-based metabolomics. However, the effect of reduced cell numbers on targeted metabolomic profiling is relatively unstudied. Considering the limited knowledge available of the feasibility and accuracy of microscale cell culture metabolomics, the present study analyzes differences in metabolomic profiles of different cell numbers of …

Effect Of Tiotropium On Night-Time Awakening And Daily Rescue Medication Use In Patients With Copd, Peter M.A. Calverley, Stephen I. Rennard, Emmanuelle Clerisme-Beaty, Norbert Metzdorf, Valentina Bayer Zubek, Richard Zuwallack

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Several small studies found night-time awakenings due to COPD symptoms were associated with decreased health status. In this study, night-time awakenings in patients with COPD were examined and effects of tiotropium therapy evaluated.

METHODS: This study was a post hoc, exploratory, pooled analysis of twin, multicenter, double-blind, randomized, placebo-controlled, parallel-group trials. Patients with stable moderate-to-severe COPD were randomized to tiotropium HandiHaler® (n = 550) or placebo (n = 371) and followed for 13 weeks. During a 2-week, pre-treatment baseline period and for 13 weeks on treatment, self-reported night-time awakenings due to COPD symptoms, rescue medication (albuterol) use, and morning …

Who Leads Nonprofit Organizations And What Does It Matter? A Mixed Methods Study Of The Impact Of Different Sector Experience On Nonprofit Leadership, Darrent Robert Tune

Dissertations

The nonprofit sector serves an important economic and community-building role in California and the rest of the United States. However, the nonprofit sector may be facing a leadership deficit due to inadequate succession planning and training of future leaders. Given that nonprofit organizations are often pressured to become more business-like and that many nonprofit organizations may need to adhere to regulations imposed upon them by government funders, nonprofit organizations may be able to find qualified leaders from the for-profit and public sectors.

The purpose of this explanatory sequential mixed methods study was to build on prior research on the sector …

Implementation Of Operational Excellence: Challenges Related To Employee Perception And Organizational Culture, Ruben Fontes

Dissertations

Industries that are traditionally technical and hierarchical present a variety of challenges for today’s leaders, particularly given the rapidly evolving, technology-driven global business environment. In addition, the movement toward more collaborative and horizontal work environments encourages a uniquely collective perspective comprised of individuals who are expected to continually shift between innovation and conformance. Success in the contemporary business environment largely depends on a firm’s speed and efficiency in relation to its competitors, which challenges leaders to not only remain on the cutting edge of their respective industries, but also stay “in tune” with the inner workings of their organizations in …

Dysfunctional Epileptic Neuronal Circuits And Dysmorphic Dendritic Spines Are Mitigated By Platelet-Activating Factor Receptor Antagonism, Alberto E. Musto, Robert F. Rosencrans, Chelsey P. Walker, Surjyadipta Bhattacharjee, Chittalsinh M. Raulji, Ludmila Belayev, Zhide Fang, William C. Gordon, Nicolas G. Bazan

Journal Articles: Pediatrics

Temporal lobe epilepsy or limbic epilepsy lacks effective therapies due to a void in understanding the cellular and molecular mechanisms that set in motion aberrant neuronal network formations during the course of limbic epileptogenesis (LE). Here we show in in vivo rodent models of LE that the phospholipid mediator platelet-activating factor (PAF) increases in LE and that PAF receptor (PAF-r) ablation mitigates its progression. Synthetic PAF-r antagonists, when administered intraperitoneally in LE, re-establish hippocampal dendritic spine density and prevent formation of dysmorphic dendritic spines. Concomitantly, hippocampal interictal spikes, aberrant oscillations, and neuronal hyper-excitability, evaluated 15-16 weeks after LE using multi-array …

How Should The Law Think About Robots?, Neil M. Richards, William D. Smart

Scholarship@WashULaw

The robots are coming. We don’t mean this in a scary, apocalyptic way, like in The Terminator or Battlestar Galactica, or in a tongue-in-cheek way, like in the Flight of the Conchords song “The Humans are Dead.” What we mean is this: Robots and robotic technologies are now mature enough to leave the research lab and come to the consumer market in large numbers. These early technologies are just the start, and we might soon be witnessing a personal robotics revolution. These systems have the potential to revolutionize our daily lives and to transform our world in ways even more …

Representation On The Courts? The Effects Of Trial Judges' Sex And Race, Christina L. Boyd

Scholarship@WashULaw

Scholars have long sought to resolve whether and to what degree political actor diversity influences the outputs of political institutions like legislatures, administrative agencies, and courts. When it comes to the judiciary, diverse judges may greatly affect outcomes. Despite this potential, no consensus exists for whether judicial diversity affects behavior in trial courts -- i.e., the stage where the vast majority of litigants interact with the judicial branch. After addressing the research design limitations in previous trial court-diversity studies, the statistical results here indicate that a trial judge's sex and race have very large effects on his or her decision …

Big Data And The Future For Privacy, Neil M. Richards, Jonathan H. King

Scholarship@WashULaw

In our inevitable big data future, critics and skeptics argue that privacy will have no place. We disagree. When properly understood, privacy rules will be an essential and valuable part of our digital future, especially if we wish to retain the human values on which our political, social, and economic institutions have been built. In this paper, we make three simple points. First, we need to think differently about "privacy." Privacy is not merely about keeping secrets, but about the rules we use to regulate information, which is and always has been in intermediate states between totally secret and known …