Digital Commons Network^™

Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis And Liver X Receptor Activation In The Pander Transgenic Model., Mark G. Athanason, Whitney A. Ratliff, Dale Chaput, Catherine B. Marelia, Melanie N. Kuehl, Stanley M. Stevens Jr., Brant R. Burkhardt

Molecular Biosciences Faculty Publications

PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. Our PANDER transgenic (PANTG) mouse displays a selective hepatic insulin resistant (SHIR) phenotype whereby insulin signaling is blunted yet lipogenesis is increased, a phenomena observed in type 2 diabetes. To examine the complex PANDER-induced mechanism of SHIR, we utilized quantitative mass spectrometry-based proteomic analysis using Stable Isotope Labeling by Amino Acids in Cell …

Sleep Disturbances Among Older Adults In The United States, 2002–2012: Nationwide Inpatient Rates, Predictors, And Outcomes, Alyssa A. Gamaldo, May A. Beydoun, Hind A. Beydoun, Hailun Liang, Rachel E. Salas, Alan B. Zonderman, Charlene E. Gamaldo, Shaker M. Eid

Aging Studies Faculty Publications

Objective/Background: We examined the rates, predictors, and outcomes [mortality risk (MR), length of stay (LOS), and total charges (TC)] of sleep disturbances in older hospitalized patients.

Patients/Methods: Using the U.S. Nationwide Inpatient Sample database (2002–2012), older patients (≥60 years) were selected and rates of insomnia, obstructive sleep apnea (OSA) and other sleep disturbances (OSD) were estimated using ICD-9CM. TC, adjusted for inflation, was of primary interest, while MR and LOS were secondary outcomes. Multivariable regression analyses were conducted.

Results: Of 35,258,031 older adults, 263,865 (0.75%) had insomnia, 750,851 (2.13%) OSA and 21,814 (0.06%) OSD. Insomnia rates increased significantly (0.27% in …

Learning And Memory Abnormalities In Mice Deficient In The Rna-Binding Protein Ksrp, Sarah L. Olguin

Biomedical Sciences ETDs

Post-transcriptional regulation plays a critical role in the function and development of the nervous system; especially in the control of specific subsets of mRNAs localized to dendrites and axons. One such regulatory mechanism is the stabilization or disruption of mRNA through association of RNA binding proteins (RBPs) such as the KH-type splicing regulatory protein (KSRP). We have previously shown that loss of KSRP results in dysregulation of GAP-43 and increased growth of hippocampal neurons in vitro. Therefore, KSRP-/- and KSRP+/- animals were subjected to a battery of behavioral tests including Novel Object Recognition and Trace Fear Conditioning to assess hippocampal …

General Education Subcommittee Agenda, November 15, 2016, Utah State University

Educational Policies Committee

Depth Requirement for Teacher Education Majors

Course Approvals/Removals/Syllabi Approvals

Business

• Data collection for writing/communication committee
• Lack of adequate writing/communication skills in students
• Should a meeting be held in December?

Robert Patel V. Meridian Health Systems Inc

2016 Decisions

USDC for the District of New Jersey

Interaction Between The Stress Phase Angle (Spa) And The Oscillatory Shear Index (Osi) Affects Endothelial Cell Gene Expression, Ronny Amaya, Limary M. Cancel, John M. Tarbell

Publications and Research

Hemodynamic forces play an important role in the non-uniform distribution of atherosclerotic lesions. Endothelial cells are exposed simultaneously to fluid wall shear stress (WSS) and solid circumferential stress (CS). Due to variations in impedance (global factors) and geometric complexities (local factors) in the arterial circulation a time lag arises between these two forces that can be characterized by the temporal phase angle between CS and WSS (stress phase angle±SPA). Asynchronous flows (SPA close to -180Ê) that are most prominent in coronary arteries have been associated with localization of atherosclerosis. Reversing oscillatory flows characterized by an oscillatory shear index (OSI) that …

Correlation Of Hearing Impairment And Communication Disorder Among Geriatric In Geriatric Clinic, Dr. Soetomo Hospital Surabaya, A Ratna Kartika M, Nyilo Purnami, Paulus Liben

Folia Medica Indonesiana

The objective of this study was to analyze correlation between hearing impairment and communication disorder among geriatrics in Geriatric Clinic, Dr. Soetomo Hospital. A randomized cross-sectional study design has been used in this study. Analysis was done by filling in some questionnaire and interview to some patients who were randomly selected according to predetermined condition. The data were collected and reviewed for the factors, which were assumed as risk factors of hearing disorder and life's quality deterioration. Statistical analysis was performed using Fisher's Exact Test using SPSS program version 17. Results showed correlation between hearing impairment and the quality of …

Proteasome Inhibitors, Kyung Bo Kim, Venod Kasam, Wooin Lee, Dong-Eun Kim, Zachary Miller, Chang-Guo Zhan, Do-Min Lee

Pharmaceutical Sciences Faculty Patents

To see this patent's abstract, please download it.

Volume 90, Issue 6 (2016)

Obiter Dicta

No abstract provided.

Gwu Hunt School Of Nursing Celebrates Contributions Of Nurse Practitioners, Office Of University Communications

Gardner-Webb NewsCenter Archive

In recognition of the 51st anniversary of the inaugural Nurse Practitioner (NP) program, the American Association of Nurse Practitioners (AANP) is honoring these health care providers during National Nurse Practitioners Week, Nov. 13-19. The first nurse practitioner program was established at the University of Colorado (Boulder, Colo.), and now there are over 222,000 NPs licensed to practice in the U.S., with an additional 20,000 graduating each year. In 2013, Gardner-Webb University established the Family Nurse Practitioner (FNP) program track as part of the Hunt School of Nursing’s Master of Science in Nursing.

WGWG: National Nurse Practitioners Week, Nov. 13-19

Inhibitors Of Pfkfb3 For Cancer Therapy, Yong-Hwan Lee, Jeong Do Kim

College of Science Patents

Compounds used to inhibit glycolytic pathway small molecule kinase 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB) are set forth; these inhibitors can be used in the treatment of certain diseases in which cells or tumors rely on glycolytic metabolism, such as many cancer cells.

Searching Neuroimaging Biomarkers In Mental Disorders With Graph And Multimodal Fusion Analysis Of Functional Connectivity, Hao He

Electrical and Computer Engineering ETDs

Mental disorders such as schizophrenia (SZ), bipolar (BD), and major depression disorders (MDD) can cause severe symptoms and life disruption. They share some symptoms, which can pose a major clinical challenge to their differentiation. Objective biomarkers based on neuroimaging may help to improve diagnostic accuracy and facilitate optimal treatment for patients. Over the last decades, non-invasive in-vivo neuroimaging techniques such as magnetic resonance imaging (MRI) have been increasingly applied to measure structure and function in human brains. With functional MRI (fMRI) or structural MRI (sMRI), studies have identified neurophysiological deficits in patients’ brain from different perspective. Functional connectivity (FC) analysis …

Stressed Out And Vulnerable, Larry Clow

UNH Today Archive

No abstract provided.

November 15, 2016, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Protecting The Imperfect Victim: Expanding “Safe Harbors” To Adult Victims Of Sex Trafficking, Christine Anchan

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Voting To End Vulnerability: Understanding The Recent Proliferation Of State-Level Child Sex Trafficking Legislation, Kate Price, Keith Gunnar Bentele

William & Mary Journal of Race, Gender, and Social Justice

This Article first focuses on the history of CSEC (commercially sexually exploited children) legislation in the United States by contextualizing the history of state anti-trafficking laws within the larger anti-trafficking policy framework of federal U.S. statutes and United Nations’ (U.N.) protocols. The second and third sections address the variables, statistical model, and results of our data analysis. The fourth section discusses the implications of these findings. The Article concludes with practical considerations for future CSEC legislative efforts on the state level.

When Sex Trafficking Victims Turn Eighteen: The Problematic Focus On Force, Fraud, And Coercion In U.S. Human Trafficking Laws, Julianne Siegfriedt

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Sex Workers And Human Rights: A Critical Analysis Of Laws Regarding Sex Work, Rachel Marshall

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Family Communication Concerning End-Of-Life Care Preferences, Lindsay Jo Peterson

USF Tampa Graduate Theses and Dissertations

Communication concerning the care one wishes to receive at the end of life (EOL) is central to ensuring that wishes are honored. Many studies have examined doctor-patient or doctor-family EOL communication. However, relatively few studies have focused on the occurrence of EOL care discussions among family members. This is an important topic, as research suggests that advance directives (ADs) are ineffective if patients have not involved surrogate decision-makers, most of whom are family members. This study examined EOL care discussions among family members. It used quantitative and qualitative data from a diverse sample of older adults from West Central Florida …

Minutes, Curriculum Committee Meeting, Tuesday, November 15, 2016, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Isscm Newsletter, Volume 14, November 15, 2016, Raj Soin College Of Business, Wright State University

ISSCM Newsletters

An eleven page newsletter from the Department of Information Systems and Supply Chain Management in the Raj Soin College of Business at Wright State University.

A Retrospective Study Of Handwriting Skills Of Kindergarten Students, Danielle Benter, Dawn Fields, Catherine Nichols

Pediatrics

OBJECTIVE: The purpose of this study was to guide teachers and occupational therapist in recognizing handwriting needs in order to provide appropriate early intervention support for handwriting.

METHOD: 218 kindergarten students in a public school district were screened for handwriting ability using the Handwriting Without Tears and the Public School’s copy screeners. Students were assessed three times during the 2014 to 2015 school year on letter memory, line placement, letter orientation, copy legibility, and copy placement skills.

RESULTS: The results indicated that winter scores were a better predictor of spring scores. Significant effects in four out of five variables were …

University Launches Livesafe Mobile App, Christina Steube

University of Mississippi News

Resource available for free download for all students, faculty and staff

Garnet & Black Winter 2016, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.

The Sun Star Vol 70 No 12 ( November 15th, 2016), N/A N/A

Sun Star

No abstract provided.

Advances In Research Using The C-Span Archives, Robert X. Browning

The Year in C-SPAN Archives Research

This book is a guide to the latest research using the C-SPAN Archives. In this book, nine authors present original work using the video archives to study presidential debates, public opinion and Congress, analysis of the Violence Against Women Act and the Great Lakes freshwater legislation, as well as President Clinton’s grand jury testimony. The C-SPAN Archives contain over 220,000 hours of first run digital video of the nation’s public affairs record. These and other essays serve as guides for scholars who want to explore the research potential of this robust public policy and communications resource.

Habitual Coffee Consumption And Risk Of Type 2 Diabetes, Ischemic Heart Disease, Depression And Alzheimer’S Disease: A Mendelian Randomization Study, Man Ki Kwok, Gabriel M. Leung, C. Mary Schooling

Publications and Research

Observationally, coffee is inversely associated with type 2 diabetes mellitus (T2DM), depression and Alzheimer’s disease, but not ischemic heart disease (IHD). Coffee features as possibly protective in the 2015 Dietary Guidelines for Americans. Short-term trials suggest coffee has neutral effect on most glycemic traits, but raises lipids and adiponectin. To clarify we compared T2DM, depression, Alzheimer’s disease, and IHD and its risk factors by genetically predicted coffee consumption using two-sample Mendelian randomization applied to large extensively genotyped case-control and cross-sectional studies. Childhood cognition was used as a negative control outcome. Genetically predicted coffee consumption was not associated with T2DM (odds …

Bank Investment Programs: Program Purpose And Overview, United States: Department Of The Treasury

Documents

No abstract provided.

Plan Ej 2014: Fact Or Fiction? A Critique Of The Obama Administration’S Efforts On Environmental Justice, Jeanne Zokovitch Paben

William & Mary Environmental Law and Policy Review

As President Obama’s tenure in office draws to a close, environmental injustices continue to proliferate in communities across this country. During the Obama Administration, there has been a strong government voice on combating these injustices, yet under their watch we see travesties like Flint, Michigan. Flint is the latest example of how our laws and government processes are not only inadequate in protecting overburdened communities, but also how they are complicit in perpetuating harm. This Article aims to answer how that happens, first, by cataloging the environmental justice efforts under the Obama Administration, most notably through Plan EJ 2014, then …

When States’ Legislation And Constitutions Collide With Angry Locals: Shale Oil And Gas Development And Its Many Masters, Heidi Gorovitz Robertson

William & Mary Environmental Law and Policy Review

This Article explores the nationally common problem of tension and conflict among state oil and gas statutes, constitutional home rule, and local control by considering intersections and tensions among the Ohio Constitution’s home rule authority, the Ohio oil and gas law’s preemption provision, and the many regulatory efforts of Ohio’s local governments. It explores the scope of the Ohio Constitution’s home rule authority, in part, by evaluating courts’ statements on the validity of several types of local ordinances, as they confront home rule and a legislative attempt at preemption. Types of local ordinances evaluated include those that prohibit or ban …