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2016

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Multiscale Mechanics Of Bone: Examining The Influence Of Genetic Alterations, Brendyn James Miller Dec 2016

Multiscale Mechanics Of Bone: Examining The Influence Of Genetic Alterations, Brendyn James Miller

Theses and Dissertations

This MSc thesis investigates how genetic alterations involved in the synthesis of proteins or in the regulation of tissue remodeling affects the composition, structure and mechanics of bone at the multiscale levels. This was accomplished by performing two mouse model studies. In the first study, bone properties of TIMP-3 knock-out (Timp-3⁻ˊ⁻) mice were examined by performing mechanical testing, µCT analysis, and FTIR analysis. Results demonstrated that the mechanical integrity of the Timp-3⁻ˊ⁻ bone was compromised. Decreased values for the yield and ultimate load, stress capacity, and fracture toughness were observed in both the TIMP-3 deficient bones. These reductions in the …

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Multi-Axial Fiber Optic Reference Strain Sensor For Flexible Dynamics Of Structures, Gabriel Lapilli Dec 2016

Multi-Axial Fiber Optic Reference Strain Sensor For Flexible Dynamics Of Structures, Gabriel Lapilli

Theses and Dissertations

Launch vehicles are in an ever-decreasing weight trend, with bodies becoming more slender to reduce aerodynamic loading. Mass and stiffness tend to be opposing concepts when designing launch vehicles: a stiffer structure means it is usually heavier. Lower stiffness on launch vehicles may produce excessive vibrations during flight, reducing the performance, operating characteristics and safety margins of the vehicle. It also impacts flight dynamics: as the vehicle flies, the orientation of its thrusters and actuators are impacted by the vibrations, creating potential instabilities in the control schemes. This is currently accounted for by using single-point inertial measurements and feeding the …

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Exploring The Role Of Biofilms In The Transport And Establishment Of Invasive Marine Macrofoulers, Lynn Holly Sweat Dec 2016

Exploring The Role Of Biofilms In The Transport And Establishment Of Invasive Marine Macrofoulers, Lynn Holly Sweat

Theses and Dissertations

Biofilms dominated by bacteria and diatoms universally colonize submerged surfaces and mediate larval recruitment in benthic marine systems. The ability for macrofoulers to be transported by vessels and become globally established is likely affected by cues from the biofilm organisms they encounter. This study investigates how macrofoulers respond to biofilms shaped by local geography, transport processes and relocation. Biofilm assemblages in neighboring ports were largely unique to the site at which they were developed. Bacteria were primary drivers of variations among sites, and overall bacterial richness was an order of magnitude higher than has been reported for other marine environments. …

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Improving Transitions Of Care From Hospital To Community Provider For Patients With Type Ii Diabetes Mellitus, Laura Dale Thompson Dec 2016

Improving Transitions Of Care From Hospital To Community Provider For Patients With Type Ii Diabetes Mellitus, Laura Dale Thompson

Doctor of Nursing Practice

Poorly coordinated care transitions result in nearly half of discharged patients’ experiencing at least 1 medication error and 1 in 5 Medicare beneficiaries readmitted within 30 days. Repercussions of suboptimal transitions of care greatly impact the nation’s economy costing between $12 billion and $44 billion annually. Ineffective handoffs between providers at hospital discharge contribute to suboptimal patient outcomes; therefore, strategies to improve transitions of care are necessary to provide quality care while decreasing health care expenditure. A quality improvement project was conducted on an inpatient surgical unit to decrease hospital readmissions and emergency department visits. Proposed interventions for patients with …

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Improving Provider Adherence To Guidelines In Addressing Childhood Overweight And Obesity In A Primary Care Setting, David Hernandez Dec 2016

Improving Provider Adherence To Guidelines In Addressing Childhood Overweight And Obesity In A Primary Care Setting, David Hernandez

Doctor of Nursing Practice

The purpose of the quality improvement project was to improve BMI measurement, screening, identification, documentation, and assessment of childhood overweight and obesity among children ages 3 to 18 years old in a primary care setting. Primary care providers continue to fail to address childhood overweight and obesity and have a positive impact on this issue. Delay in early identification and assessment of childhood obesity and overweight may affect patients’ qualify of life and the efficiency of health care. Over the last 30 years, the rates of childhood overweight and obesity have consistently escalated despite the existence of recommended guidelines and …

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Improving The Assessment And Care Management Of Patients With Diabetes At Risk For Foot Ulcers And Amputations, Karen Architect Dec 2016

Improving The Assessment And Care Management Of Patients With Diabetes At Risk For Foot Ulcers And Amputations, Karen Architect

Doctor of Nursing Practice

Purpose: To implement guidelines set in 2016, by the American Diabetes Association (ADA), which recommend annual and periodic foot exams for patients with type II diabetes mellitus (T2DM). Background: Uncontrolled diabetes and foot complications can lead to permanent disability, loss of employment often leading to depression and increased morbidities (Szpunar, Minnick, Dako, & Saravolatz, 2014). Significance of Problem: Individuals who are diagnosed with diabetes are at risk for foot ulcers and amputations if not properly managed. Implementation of a foot screening program has been shown to reduce foot ulcers and amputations (Peterson & Virden, 2013). Methods: Annual and periodic foot …

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Love-Bombing: A Narcissistic Approach To Relationship Formation, Claire Strutzenberg Dec 2016

Love-Bombing: A Narcissistic Approach To Relationship Formation, Claire Strutzenberg

Human Development and Family Sciences Undergraduate Honors Theses

The current study examined the relationship between attachment style, self-esteem, and narcissism as they pertain to behavioral tendencies termed Love-Bombing behaviors among a sample of young adult Millennials. Love-Bombing was identified as the presence of excessive communication at the beginning of a relationship in order to passively obtain power and control over another’s life as a means of narcissistic self-enhancement. The sample consisted of 484 college students from a large southern university who ranged in age 18-30. The results indicated that Love-Bombing was positively correlated with narcissistic tendencies, avoidant attachment, anxious attachment, and negatively correlated with self-esteem. Love-Bombing was also …

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Environmental Signaling Through The Target Of Rapamycin Complex 1 (Torc1) And The Regulation Of Epigenetic Mechanisms, Jason J. Workman Dec 2016

Environmental Signaling Through The Target Of Rapamycin Complex 1 (Torc1) And The Regulation Of Epigenetic Mechanisms, Jason J. Workman

Theses and Dissertations (ETD)

The gene expression profile of a eukaryotic cell is responsive to a variety of extracellular stimuli, including nutrient availability, which allows cells to toggle between anabolism and catabolism based on the favorability of their environment. Much of this information is relayed through signaling complexes, such as the target of rapamycin complex 1 (TORC1), to downstream chromatin modifying enzymes. These enzymes impact the gene regulatory process through altered histone post-translation modifications, changes in chromatin structure, and docking of chromatin regulatory complexes. Yet, despite preliminary studies suggesting that TORC1 affects epigenetic mechanisms, including histone H3 lysine 56 acetylation (H3K56ac), almost nothing is …

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Endosomal Trafficking As A Determinant Of Antifungal Tolerance In The Pathogenic Fungus Candida Albicans, Arturo Luis Luna Dec 2016

Endosomal Trafficking As A Determinant Of Antifungal Tolerance In The Pathogenic Fungus Candida Albicans, Arturo Luis Luna

Theses and Dissertations (ETD)

Several important antifungal drugs inhibit the synthesis of ergosterol, a lipid that modulates the thickness, fluidity and permeability of fungal cell membranes. These include the azole antifungals, which block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of ‘toxic’ sterol intermediates are both thought to cause plasma membrane dysfunction and ultimately growth arrest. However, the effects of ergosterol depletion upon the function of intracellular membranes and organelles are not well described. The purpose of this study was to characterize the effects of azole treatment upon the integrity of the Candida albicans vacuole, …

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Dissecting The Physiological Roles Of Ulk1/2 In The Mouse Brain, Bo Wang Dec 2016

Dissecting The Physiological Roles Of Ulk1/2 In The Mouse Brain, Bo Wang

Theses and Dissertations (ETD)

Mammalian UNC-51–like kinases 1 and 2 (ULK1 and ULK2), Caenorhabditis elegans UNC-51 and Drosophila melanogaster Atg1 are redundant serine/threonine kinases that regulate flux through the autophagy pathway in response to various types of cellular stress. C. elegans UNC-51 and D. melanogaster Atg1 also promote axonal growth and defasciculation, and disruption of these genes results in defects in axon guidance in invertebrates. Germline Ulk1/2-deficient mice die perinatally. Therefore, we used a conditional-knockout approach to investigate the roles of ULK1/2 in the brain. Mice lacking Ulk1 and Ulk2 in their central nervous systems (CNS) showed defects in axonal pathfinding and defasciculation affecting …

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Regulation Of Cancer Metastasis By Protein Kinase D1: A Global Regulatory Cascade, Aditya Ganju Dec 2016

Regulation Of Cancer Metastasis By Protein Kinase D1: A Global Regulatory Cascade, Aditya Ganju

Theses and Dissertations (ETD)

Protein Kinase D1 (PKD1) is a serine threonine kinase which is downregulated in Prostate, Breast and Colon Cancer. It functions as a tumor suppressor in different cancer cells. Downregulation of PKD1 is known to be associated with aggressiveness of the cancer. PKD1 is known to regulate many key oncogenic signaling pathways such as E-cadherin, β-catenin and Androgen Receptor signaling pathways. Aberrant expression of these oncogenic pathways leads to transformation of cells from normal to malignant phenotype, thereby leading to increased proliferation, growth and metastasis to distant organs of these cancer cells. Literature evidence also points to the fact that E-cadherin …

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Examining The Associations Between Depressive Symptoms, Body Mass Index, And Physical Activity Self-Efficacy In African American Mother-Child Dyads, Y'Esha Vonyae Williams Dec 2016

Examining The Associations Between Depressive Symptoms, Body Mass Index, And Physical Activity Self-Efficacy In African American Mother-Child Dyads, Y'Esha Vonyae Williams

Theses and Dissertations (ETD)

In recent decades the prevalence of childhood and adult depression and obesity has increased worldwide. Multiple factors influence the onset of both depression and obesity. Individual manifestations of depressive symptomatology and health-related problems associated with obesity vary; however, genetics and environmental and psychological factors have been implicated as correlates. Consequently, both disorders can ultimately interfere with individuals’ activities of daily living and decrease their quality of life. African American women are known to have a higher prevalence of obesity and more severe depressive symptoms in comparison to Caucasian women. Likewise, African American children are more obese and experience many factors …

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The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation With Arginine-Rich Nucleolar Proteins Through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika Dec 2016

The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation With Arginine-Rich Nucleolar Proteins Through Weak, Multivalent Electrostatic Interactions, Jaclyn Alicia Cika

Theses and Dissertations (ETD)

Nucleoli are nuclear membrane-less organelles that are the sites for ribosome biogenesis and serve as sensors of cellular stress. Weak, multivalent protein-protein interactions and interactions between disordered, low complexity domains (LCDs) and rRNA have been shown to promote liquid-liquid phase separation (LLPS) in vitro, suggesting a basis for the liquid-like behavior of nucleoli. Nucleophosmin (NPM1), a multifunctional and highly abundant nucleolar protein, exhibits structural features associated with LLPS suggesting a role in nucleolar organization. Specifically, NPM1 forms a pentamer through its N-terminal oligomerization domain and can bind to rRNA through its C-terminal nucleic acid binding domain. Multiple acidic tracts throughout …

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Maximinimalism, Jamal Greene Dec 2016

Maximinimalism, Jamal Greene

Cardozo Law Review

The article explores Chief Justice John Roberts' judicial approach, characterizing it as "maximinimalism"—a blend of narrow decision-making with deep, impactful reasoning. While Roberts is often seen as a minimalist for his emphasis on deciding cases narrowly, his rulings in significant cases like Citizens United v. FEC, Shelby County v. Holder, and NFIB v. Sebelius reveal a deeper, more substantive approach that challenges the law, thus embodying maximalist tendencies. This duality allows the Court to influence the law profoundly while maintaining judicial restraint.

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Decisional Involvement And Professional Practice: Relation And Outcomes, Carolyn L. Davidson Rn, Phd, Kim S. Hitchings Msn, Rn, Nea-Bc, John W. Nilson Phd, Msn, Rn, Debra Peter Msn, Rn-Bc, Cathy Schwartz Ms, Rn Dec 2016

Decisional Involvement And Professional Practice: Relation And Outcomes, Carolyn L. Davidson Rn, Phd, Kim S. Hitchings Msn, Rn, Nea-Bc, John W. Nilson Phd, Msn, Rn, Debra Peter Msn, Rn-Bc, Cathy Schwartz Ms, Rn

Patient Care Services / Nursing

No abstract provided.

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Modeling And Analysis Of A Novel Imbedded Organic Thermal Cycle, Joel Maker Faure Dec 2016

Modeling And Analysis Of A Novel Imbedded Organic Thermal Cycle, Joel Maker Faure

Theses and Dissertations

A thermal cycle is a device that converts thermal energy into work energy. There is a strong need in the United States and the world for a cycle that can have viable performances with low-grade temperature heat sources to increase the supply of power generation. There are many cycles with different configurations, however most do not involve mixing. Generally speaking this is due to modeling difficulties with multiple constituents, phases, and the technology available that lose performance under these mixed conditions. The gap in technology for mixed flow and phase components is getting smaller due to the need. Current cycles …

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The Effects Of Shade On Growth, Development And Yield Of A Primocane Fruiting Blackberry, ‘Prime-Ark 45’ To Extend The Market Season, Olivia C. Caillouet Dec 2016

The Effects Of Shade On Growth, Development And Yield Of A Primocane Fruiting Blackberry, ‘Prime-Ark 45’ To Extend The Market Season, Olivia C. Caillouet

Horticulture Undergraduate Honors Theses

This thesis examines the effects of shade on ‘Prime-Ark 45’ blackberries (Rubus spp.) in greenhouse (GH) and field (FD) experiments aimed at improving fruit production in the southern United States Ozark Plateau region. Primocane blackberry production in the southern United States is limited in acreage of production as well as low yields by high temperatures during the bloom and early fruiting period, resulting in poor fruit set and poor fruit quality. Shade may have the potential to delay bloom and flowering to a more favorable season or by reducing temperatures that cause a poor fruit set and quality. Both …

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Analysis Of Synthetic Cannabinoids And Drugs Of Abuse Amongst Hiv-Infected Individuals, Jillian M. Wetzel Dec 2016

Analysis Of Synthetic Cannabinoids And Drugs Of Abuse Amongst Hiv-Infected Individuals, Jillian M. Wetzel

Student Theses

Synthetic cannabinoids are man-made mind-alternating chemicals. Law enforcement and legislation have attempted to classify many of these synthetic cannabinoids as schedule I controlled substances, however, they are continuously being modified by dealers at the retail end of the distribution chain. Addiction and moderate use of illicit drugs have been identified as major reasons for non-adherence to antiretroviral therapy among HIV patients. However, there is no data regarding the impact of synthetic cannabinoid exposure in this population and how this affects their compliancy with taking antiretroviral therapy. A total of 72 authentic urine specimens were collected weekly from 13 individuals with …

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In Your Region December 2016, Department Of Primary Industries And Regional Development, Western Australia Dec 2016

In Your Region December 2016, Department Of Primary Industries And Regional Development, Western Australia

Newsletters

No abstract provided.

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The Alestle - Vol. 69. No. 19 - 12/01/2016, Southern Illinois University Edwardsville Dec 2016

The Alestle - Vol. 69. No. 19 - 12/01/2016, Southern Illinois University Edwardsville

The Alestle

Vol. 69 No. 18

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Barriers Related To Prenatal Care Utilization Among Women, Nasibeh Roozbeh, Fatemeh Nahidi, Sepideh Hajiyan Dec 2016

Barriers Related To Prenatal Care Utilization Among Women, Nasibeh Roozbeh, Fatemeh Nahidi, Sepideh Hajiyan

Saudi Medical Journal

Objectives To investigate barriers related to prenatal care utilization among women. Methods Data was collected in both English and Persian databases. English databases included: the International Medical Sciences, Medline, Web of Science, Scopus, Google Scholar. The Persian databases included: the Iranmedex, the State Inpatient Databases (SID) with the use of related keywords, and on the basis of inclusion-exclusion criteria. The keywords included are barrier, prenatal care, women, access, and preventive factors. OR and AND were Boolean operators. After the study, articles were summarized, unrelated articles were rejected, and related articles were identified. Inclusion criteria were all published articles from 1990 …

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Open Globe Eye Injury Characteristics And Prognostic Factors In Jazan, Saudi Arabia, Mashaal A. Makhrash, Ibrahim M. Gosadi Dec 2016

Open Globe Eye Injury Characteristics And Prognostic Factors In Jazan, Saudi Arabia, Mashaal A. Makhrash, Ibrahim M. Gosadi

Saudi Medical Journal

Objectives To evaluate characteristics and prognostic factors of open globe injuries (OGI) presented to King Fahad Specialist Hospital in the Jazan region, Saudi Arabia. Methods This study is a retrospective review of medical records of OGI patients who underwent operative repair of their injuries in King Fahad Central Hospital, Jazan, Saudi Arabia between January 2011 and December 2013. Demographic information, eye injury, preoperative, and postoperative visual acuity were collected. The initial and final visual acuity outcomes were compared to identify subjects who witnessed any improvement in their visual acuity. Logistic regression was used to assess characteristics associated with improvements in …

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Discipleship And Suffering: The Christian Response To Persecution, Conrad Vine Dec 2016

Discipleship And Suffering: The Christian Response To Persecution, Conrad Vine

Journal of Adventist Mission Studies

No abstract provided.

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The Elusive Disciple: Cross-Cultural Perceptions Of Discipleship, Cristian Dumitrescu Dec 2016

The Elusive Disciple: Cross-Cultural Perceptions Of Discipleship, Cristian Dumitrescu

Journal of Adventist Mission Studies

No abstract provided.

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Toward A Biblical Model Of Discipleship: A Case Study Of The Willow Creek Community Church, Boubakar Sanou Dec 2016

Toward A Biblical Model Of Discipleship: A Case Study Of The Willow Creek Community Church, Boubakar Sanou

Journal of Adventist Mission Studies

No abstract provided.

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The Importance Of Worldview Change In The Discipling Process, Bruce L. Bauer Dec 2016

The Importance Of Worldview Change In The Discipling Process, Bruce L. Bauer

Journal of Adventist Mission Studies

No abstract provided.

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Discipleship Structures, Movements, And The Role Of Multipliers, Laurence G. Burn Dec 2016

Discipleship Structures, Movements, And The Role Of Multipliers, Laurence G. Burn

Journal of Adventist Mission Studies

No abstract provided.

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Principles And Strategies For Reaching And Discipling Nomads: A Case Study Of The Pokot Of East Africa, Haron N. Matwetwe Dec 2016

Principles And Strategies For Reaching And Discipling Nomads: A Case Study Of The Pokot Of East Africa, Haron N. Matwetwe

Journal of Adventist Mission Studies

No abstract provided.

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The Impact Of Video Gaming On Managers' Adaptive Leadership Skills: Do Millennials Have An Advantage?, John W. Harbison Dec 2016

The Impact Of Video Gaming On Managers' Adaptive Leadership Skills: Do Millennials Have An Advantage?, John W. Harbison

Masters Theses and Doctoral Dissertations

The aging Baby Boomer Generation, coupled with the large coming of age Millennial Generation and the need for more adaptive and flexible employees in business, is presenting companies with a challenge of how to develop individuals in leadership positions within their organizations to properly demonstrate and implement adaptive leadership attributes. This study compared data previously gathered by the participating organization from individuals composed of multiple generations currently in leadership positions attending a leadership orientation course. Data were collected using a selected instrument measuring adaptive leadership skills. The focus of this study was to determine if the Millennial Generation has gained …

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The Role Of Leed Certification In Consumer Major Purchase Decisions: A Case Study Of The Chattanooga Volkswagen Manufacturing Facility, Amy E. Katcher-Dunne Dec 2016

The Role Of Leed Certification In Consumer Major Purchase Decisions: A Case Study Of The Chattanooga Volkswagen Manufacturing Facility, Amy E. Katcher-Dunne

Masters Theses and Doctoral Dissertations

The Leadership in Energy and Environmental Design (LEED) certification program serves as a benchmark for ‘green’ construction in the U.S. Although considerable research has investigated the marketability of LEED-certified buildings, no direct attention has been given to assessing if the benefits of LEED certification filter down to the profitability of products manufactured in those buildings. To investigate this potential influence, I conducted a large-scale survey of regional owners of the Volkswagen Passat, which is manufactured in the world's first automobile plant to achieve LEED Platinum status. Results suggest that manufacturing facility LEED certification does not influence product purchasing decisions regardless …

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