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Study Of The Seasonal And Interannual Variability Of Phytoplankton Bloom In Arabian Gulf Using Modisdata, Malik Mutasim Malik Gasim

Theses

The Arabian Gulf is a semi enclosed large water body that experiences seasonal

variations and reversal of it water currents flow circulation. The Gulf waters are characterized by having high primary productivity and strong phytoplankton blooms at particular seasons within the year. Phytoplankton is a base of the food chain for marine species, providing an essential food resource for aquatic life. Marine phytoplankton affects the diversity of any marine ecosystem and drives its functioning and is strongly correlated with fishery yields. The primary

objectives of this research study are to answer key research questions related to phytoplankton blooms in the …

Synthesis And Mechanistic Investigations Of Transition Metal Complexes And Ligands For Chemotherapeutic Applications, Jimmie Lee Bullock Jr.

Chemistry & Biochemistry Theses & Dissertations

Transition metal complexes have played a critical role in antitumor therapy with many complexes incorporating platinum, ruthenium, and lanthanum having been investigated in preclinical and clinical trials. The best known transition metal therapeutic is cisplatin, which is utilized in nearly 50% of all cancer therapies, despite its significant toxic side effects. The toxic side effects of current FDA approved platinum-based chemotherapeutics are often overlooked due to the “special status” granted to these drugs due to their ability to fight, what is often considered an incurable disease with life expectancies often measured in months. Oncology drug development has therefore now focused …

Killing Two Birds With One Stone: The Concurrent Development Of The Novel Alignment Free Tree Building Method, Scrawkov-Phy, And The Extensible Phyloinformatics Utility, Emu-Phy., J. Nick Fisk

Theses

Many components of phylogenetic inference belong to the most computationally challenging and complex domain of problems. To further escalate the challenge, the genomics revolution has exponentially increased the amount of data available for analysis. This, combined with the foundational nature of phylogenetic analysis, has prompted the development of novel methods for managing and analyzing phylogenomic data, as well as improving or intelligently utilizing current ones. In this study, a novel alignment tree building algorithm using Quasi-Hidden Markov Models (QHMMs), Scrawkov-Phy, is introduced. Additionally, exploratory work in the design and implementation of an extensible phyloinformatics tool, EMU-Phy, is described. Lastly, features …

Analysis Of Region-Specific Transcriptomic Changes In The Autistic Brain, Dmitry Velmeshev

Open Access Dissertations

Autism is a highly prevalent neurodevelopmental disorder that affects 1 in every 68 children in the US. Autism comprises a spectrum of highly heterogeneous disorders defined by characteristic deficits of communication and by presence of repetitive and stereotyped behavior. At the same time the disease is highly heritable and genetically heterogeneous, with hundreds of genetic variants that have been associated with it. Previous systems biology studies have provided first insights into convergence of various disease-associated genetic variants onto specific pathways, developmental windows and cell types in the brain. Additionally, transcriptomic and epigenetic studies have identified genes and pathways affected by …

An Entrepreneurial Perspective On The Business Of Being In Our Profession, Steven H. Hobbs

Fordham Urban Law Journal

No abstract provided.

Integrative Analyses Reveal Signaling Pathways Underlying Familial Breast Cancer Susceptibility, Stephen R. Piccolo, Laura M. Hoffman, Thomas Conner, Gajendra Shrestha, Adam L. Cohen, Jeffrey R. Marks, Leigh A. Neumayer, Cori A. Agarwal, Mary C. Beckerle, Irene L. Andrulis, Avrum E. Spira, Philip J. Moos, Saundra S. Buys, William Evan Johnson, Andrea H. Bild

Faculty Publications

The signaling events that drive familial breast cancer (FBC) risk remain poorly understood. While the majority of genomic studies have focused on genetic risk variants, known risk variants account for at most 30% of FBC cases. Considering that multiple genes may influence FBC risk, we hypothesized that a pathway‐based strategy examining different data types from multiple tissues could elucidate the biological basis for FBC. In this study, we performed integrated analyses of gene expression and exome‐sequencing data from peripheral blood mononuclear cells and showed that cell adhesion pathways are significantly and consistently dysregulated in women who develop FBC. The dysregulation …

Session C-1: Ecosystem Disruption: Using Lab And Real-World Examples To Bring Changes In Earth’S Ecosystems To Life, Crystal Randall, Sarah O'Leary-Driscoll, Sowmya Anjur, Don Dosch

Professional Learning Day

The magnitude of the changes occurring in Earth’s ecosystems seems difficult to tackle in the classroom and lab. Here we explore ways to demonstrate the changes in the Earth’s water and carbon cycles in the lab and bring them to life in real-world ecosystems in the classroom.

The Inverse Burr Negative Binomial Distribution With Application To Real Data, Abdullahi Yusuf, Badamasi Bashir Mikail, Aliyu Isah Aliyu, Abdurrahaman L. Sulaiman

Journal of Statistics Applications & Probability

We introduce in this paper a four-parameter lifetime model, called the inverse burr negative binomial distribution.We derive some statistical properties of the proposed model that includes moments, quantile functions, median, reliability and entropy. The method of maximum likelihood is used for estimating the model parameters and the observed information matrix is obtained. Simulation study is performed to investigate the performance of the estimation of the model parameters. Two real data sets are used to demonstrate the flexibility of the new proposed model in comparison with other popular lifetime models.

Genome Engineering: Drosophila Melanogaster And Beyond, Kjt Venken, A Sarrion-Perdigones, Pj Vandeventer, Ns Abel, Ae Christiansen, Kl Hoffman

Faculty, Staff and Students Publications

A central challenge in investigating biological phenomena is the development of techniques to modify genomic DNA with nucleotide precision that can be transmitted through the germ line. Recent years have brought a boon in these technologies, now collectively known as genome engineering. Defined genomic manipulations at the nucleotide level enable a variety of reverse engineering paradigms, providing new opportunities to interrogate diverse biological functions. These genetic modifications include controlled removal, insertion, and substitution of genetic fragments, both small and large. Small fragments up to a few kilobases (e.g., single nucleotide mutations, small deletions, or gene tagging at single or multiple …

The Pipeline Project: Pre-Publication Independent Replications Of A Single Laboratory's Research Pipeline., Martin Schweinsberg, Nikhil Madan, Michelangelo Vianello, S.Amy Sommer, Jennifer Jordan, Et. Al.

Research Collection Lee Kong Chian School Of Business

This crowdsourced project introduces a collaborative approach to improving the reproducibility of scientific research, in which findings are replicated in qualified independent laboratories before (rather than after) they are published. Our goal is to establish a non-adversarial replication process with highly informative final results. To illustrate the Pre-Publication Independent Replication (PPIR) approach, 25 research groups conducted replications of all ten moral judgment effects which the last author and his collaborators had “in the pipeline” as of August 2014. Six findings replicated according to all replication criteria, one finding replicated but with a significantly smaller effect size than the original, one …

Cd33 Expression And Its Association With Gemtuzumab Ozogamicin Response: Results From The Randomized Phase Iii Children's Oncology Group Trial Aaml0531., Jessica A. Pollard, Michael Loken, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Richard Aplenc, Irwin D. Bernstein, Alan S. Gamis, Todd A. Alonzo, Soheil Meshinchi

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: CD33 is variably expressed on acute myeloid leukemia (AML) blasts and is targeted by gemtuzumab ozogamicin (GO). GO has shown benefit in both adult and pediatric AML trials, yet limited data exist about whether GO response correlates with CD33 expression level.

PATIENTS AND METHODS: CD33 expression levels were prospectively quantified by multidimensional flow cytometry in 825 patients enrolled in Children's Oncology Group AAML0531 and correlated with response to GO.

RESULTS: Patients with low CD33 expression (lowest quartile of expression [Q1]) had no benefit with the addition of GO to conventional chemotherapy (relapse risk [RR]: GO 36% v No-GO 34%, …

The Transcriptional Landscape Of The Photosynthetic Model Cyanobacterium Synechocystis Sp. Pcc6803, Miguel A. Hernández-Prieto, Trudi Ann Semeniuk, Joaquín Giner-Lamia, Matthias E. Futschik

School of Biomedical Sciences

AbstractCyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium Synechocystis sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditions is lacking. Here, we report a meta-analysis of 756 individual microarray measurements conducted in 37 independent studies-the most comprehensive study of the Synechocystis transcriptome to date. Using stringent statistical evaluation, we characterized the coordinated adaptation of Synechocystis’ gene expression on systems level. Evaluation of the data revealed that the photosynthetic apparatus is subjected to greater changes in expression …

Direct Measurements Of Oxygen Gradients In Spheroid Culture System Using Electron Parametric Resonance Oximetry, Laura M. Langan, Nicholas J.F. Dodd, Stewart F. Owen, Wendy M. Purcell, Simon K. Jackson, Awadhesh N. Jha

School of Biomedical Sciences

No abstract provided.

Conversations With Gunanurang, Lawrence Smith

Landscapes: the Journal of the International Centre for Landscape and Language

Gunanurang (the Ord River) nurtured some of the original Australians productively for millennia. In less than 150 years, their relationship with the river valley and surrounding land was almost destroyed by the effects of the east Kimberley cattle industry commenced in the 1880s. The biological and archaeological surveys before and during the filling of the Lake Argyle dam were a belated attempt to understand what was being lost in the way of ecosystems and aboriginal sites. This short essay encapsulates the impact of the pastoral industry in the Ord valley.

Hydrodynamic Loading In Concomitance With Exogenous Cytokine Stimulation Modulates Differentiation Of Bovine Mesenchymal Stem Cells Towards Osteochondral Lineages, Stephen M. Goldman, Gilda A. Barabino

Publications and Research

Background: Mesenchymal stem cells (MSCs) are viewed as a having significant potential for tissue engineering and regenerative medicine therapies. Clinical implementation of MSCs, however, demands that their preparation be stable and reproducible. Given that environmental and bioprocessing parameters such as substrate stiffness, seeding densities, culture medium composition, and mechanical loading can result in undirected differentiation of the MSC population, the objective of this study was to systematically investigate how hydrodynamic loading influences the differentiation of bone marrow-derived mesenchymal stem cells (MSCs) towards the osteochondral lineages both in the presence and absence of exogenous, inductive factors.

Methods: Expanded bovine MSCs were …

The Conflicts Of Coexistence: Contested Meanings Of Carnivore Management And Conservation In The Greater Yellowstone Ecosystem, Hannah F. Jaicks

Dissertations, Theses, and Capstone Projects

The Greater Yellowstone Ecosystem (GYE) encompasses urbanizing areas adjacent to essential conservation habitat with an inimitable capacity to support carnivore populations, including grizzly bears, wolves, and cougars. This geography has resulted in divisive social conflicts about these animals’ management as well as physical conflicts when they come into contact with people over the course of daily life in the region. Employing a qualitative methodology with semi-structured interviews, participant observation, wilderness treks, and archival work, this study examines the context, social processes, and decision-making processes that underlie the predator conflicts and produce management challenges in the GYE. This approach integrates theory …

05. Chemistry, Northeastern State University

Oklahoma Research Day Abstracts

No abstract provided.

The Effect Of In Vitro Cultivation On The Transcriptome Of Adult Brugia Malayi, Cristina Ballesteros, Lucienne Tritten, Maeghan O'Neill, Erica Burkman, Weam I. Zaky, Jianguo Xia, Andrew Moorhead, Steven A. Williams, Timothy G. Geary

Biological Sciences: Faculty Publications

Filarial nematodes cause serious and debilitating infections in human populations of tropical countries, contributing to an entrenched cycle of poverty. Only one human filarial parasite, Brugia malayi, can be maintained in rodents in the laboratory setting. It has been a widely used model organism in experiments that employ culture systems, the impact of which on the worms is unknown.

The Effect Of In Vitro Cultivation On The Transcriptome Of Adult Brugia Malayi, Cristina Ballesteros, Lucienne Tritten, Maeghan O’Neill, Erica Burkman, Weam I. Zaky, Jianguo Xia, Andrew Moorhead, Steven A. Williams, Timothy G. Geary

Biological Sciences: Faculty Publications

Infections with filarial worms cause serious physical impairment and affect tens of millions of people in tropical and subtropical countries. To better understand the biology and phar- macology of these parasites, Brugia malayi is often used as a model. This parasite can be maintained in the laboratory in Mongolian jirds, enabling researchers to test drugs in vivoand in vitro, among other studies. The effects of removing worms from their hosts and cul- turing them may affect many aspects of their physiology, including response to drugs, but the extent to which the worms undergo changes during culture has remained unknown. Using …

03. Biology, Northeastern State University

Oklahoma Research Day Abstracts

No abstract provided.

Virus–Host Interactions: Insights From The Replication Cycle Of The Large Paramecium Bursaria Chlorella Virus, Elad Milrot, Yael Mutsafi, Yael Fridmann-Sirkis, Eyal Shimoni, Katya Rechav, James Gurnon, James L. Van Etten, Abraham Minsky

James Van Etten Publications

The increasing interest in cytoplasmic factories generated by eukaryotic-infecting viruses stems from the realization that these highly ordered assemblies may contribute fundamental novel insights to the functional significance of order in cellular biology. Here, we report the formation process and structural features of the cytoplasmic factories of the large dsDNA virus Paramecium bursaria chlorella virus 1 (PBCV-1). By combining diverse imaging techniques, including scanning transmission electron microscopy tomography and focused ion beam technologies, we show that the architecture and mode of formation of PBCV-1 factories are significantly different from those generated by their evolutionary relatives Vaccinia and Mimivirus. Specifically, PBCV-1 …

Lycium Barbarum L. (Goji Berry) Fruits Improve Anxiety, Depression-Like Behaviors, And Learning Performance: The Moderating Role Of Sex, Fatma Pehli̇van Karakaş, Hami̇t Coşkun, Kadi̇r Sağlam, Bi̇hter Gökçe Bozat

Turkish Journal of Biology

The aim of this research was to investigate the effects of the methanol extract obtained from Lycium barbarum fruits on anxiety, depression-like behaviors, and spatial memory in Wistar albino rats. A total of 28 rats were selected, randomly assigned to four experimental groups, and tested by means of the open field and elevated plus maze tests for anxiety-like behaviors, the forced swim test for depression-like behaviors, and the Morris water maze test for spatial memory. The findings demonstrated that in the open field, L. Barbarum-administered rats spent more time at the center and showed more mobility and velocity than controls. …

Underlying Mechanisms And Prospects Of Heart Regeneration, Gali̇p Servet Aslan, Dudu Gonca Misir, Fati̇h Kocabaş

Turkish Journal of Biology

Findings in the last decade suggest that there is a considerable amount of cardiomyocyte turnover in the human heart throughout life, albeit not sufficient for heart regeneration following myocardial infarctions. Only a few species are known to be remarkably efficient in cardiac regeneration. They restore lost cardiomyocytes via a process of cardiomyocyte dedifferentiation, which is followed by robust proliferation of cardiomyocytes and incorporation into the myocardium. Similarly, neonatal mice have been recently shown to regenerate their heart following myocardial injuries. Studies with a neonatal cardiac regeneration mouse model suggest that the major source of new cardiomyocytes is likely to be …

Histopathological And Biochemical Changes In The Liver, Kidney, And Bloodof Amphibians Intoxicated With Cadmium, Marcela Fátima Medina, Maria Elina González, Sandra Maria Roxana Klyver, Iris Maria Aybar Odstrcil

Turkish Journal of Biology

The worldwide decline in amphibian populations has made heavy metal pollution a subject of interest. The aim of this work was to analyze the effect of sublethal doses of cadmium (Cd) on the liver, kidney, and blood of Rhinella arenarum specimens. Serum markers indicative of hepatic injury (gamma glutamyltransferase, alkaline phosphatase, pseudo cholinesterase, and total cholesterol) and markers of renal dysfunction (blood urea nitrogen, serum creatinine, calcium, and glucose) showed variation in animals treated with a 0.5 mg/kg dose compared to controls. Histopathological images revealed alterations in the liver (hepatocyte ballooning and hyperplasia of Kupffer cells) and kidney (renal tubular …

Mandibular Morphology And Dietary Preferences In Two Pygmy Molecrickets Of The Genus Xya (Orthoptera: Tridactylidae), Katerina Kuravova, Petr Kocarek

Turkish Journal of Zoology

Pygmy mole crickets (Tridactylidae) are an interesting but little-known group of Orthoptera; their food biology and dietary preferences have not been adequately studied. Our study focused on the diet composition and associated functional morphology of the mandibles in two European species: Xya pfaendleri Harz, 1970 and X. variegata (Latreille, 1809). Based on postmortem gut content analyses, the studied species feed mainly on detritus (decaying organic particles), representing 91% and 97% of the diet in X. pfaendleri and X. variegata, respectively. The mandibular structures are associated with the processing of such food. The incisor area is equipped with three robust and …

Fact Book 2015- 2016, Office Of Institutional Research, Seton Hall University

Fact Books

No abstract provided.

“Do No Harm”: An Exploration Of Medicine In William Shakespeare’S Writings And Modern Filmic Adaptations, Nicholas A. Shortreed

Conspectus Borealis

No abstract provided.

Effect Of Cranberry (Vaccinium Macrocarpon) Oligosaccharides On The Formation Of Advanced Glycation End-Products, Jiadong Sun, Weixi Liu, Hang Ma, Jannie P.J. Marais, Christina Khoo, Joel A. Dain, David C. Rowley, Navindra P. Seeram

Biomedical and Pharmaceutical Sciences Faculty Publications

Background: The formation and accumulation of advanced glycation end-products (AGEs) are implicated in several chronic human illnesses including type-2 diabetes, renal failure, and neurodegenerative diseases. The cranberry (Vaccinium macrocarpon) fruit has been previously reported to show anti-AGEs effects, attributed primarily to its phenolic constituents. However, there is lack of similar data on the non-phenolic constituents found in the cranberry fruit, in particular, its carbohydrate constituents. Herein, a chemically characterized oligosaccharide-enriched fraction purified from the cranberry fruit was evaluated for its potential anti-AGEs and free radical scavenging effects.

Objective: The aim of this study was to evaluate …

Exploration Of Bivalent Ligands Targeting Putative Mu Opioid Receptor And Chemokine Receptor Ccr5 Dimerization, Christopher K. Arnatt, Bethany A. Falls, Yunyun Yuan, Thomas J. Raborg, Ruturaj R. Masvekar, Nazira El-Hage, Dana E. Selley, Anthony V. Nicola, Pamela E. Knapp, Kurt F. Hauser, Yan Zhang

Medicinal Chemistry Publications

Modern antiretroviral therapies have provided HIV-1 infected patients longer lifespans and better quality of life. However, several neurological complications are now being seen in these patients due to HIV-1 associated injury of neurons by infected microglia and astrocytes. In addition, these effects can be further exacerbated with opiate use and abuse. One possible mechanism for such potentiation effects of opiates is the interaction of the mu opioid receptor (MOR) with the chemokine receptor CCR5 (CCR5), a known HIV-1 co-receptor, to form MOR-CCR5 heterodimer. In an attempt to understand this putative interaction and its relevance to neuroAIDS, we designed and synthesized …

Synthesis Of Cd-Free Inp/Zns Quantum Dots Suitable For Biomedical Applications, Matthew A. Ellis, Giovana Grandinetti, Katye M. Fichter

College of Natural and Applied Sciences

Fluorescent nanocrystals, specifically quantum dots, have been a useful tool for many biomedical applications. For successful use in biological systems, quantum dots should be highly fluorescent and small/monodisperse in size. While commonly used cadmium-based quantum dots possess these qualities, they are potentially toxic due to the possible release of Cd2+ ions through nanoparticle degradation. Indium-based quantum dots, specifically InP/ZnS, have recently been explored as a viable alternative to cadmium-based quantum dots due to their relatively similar fluorescence characteristics and size. The synthesis presented here uses standard hot-injection techniques for effective nanoparticle growth; however, nanoparticle properties such as size, emission wavelength, …