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Evaluating The Therapeutic Effect Of An Hsp90 Inhibitor In Mouse Models Of Alzheimer’S Disease, Bin Wang

Theses and Dissertations (ETD)

The excessive accumulation of amyloid peptides (Aβ) represents one major pathological hallmark of Alzheimer’s disease (AD), which is most notably characterized by synaptic dysfunction. Strategies targeting heat shock protein 90 (Hsp90) inhibition have been widely investigated in the treatment of cancer for over two decades. Its application in the treatment of neurodegenerative diseases however, has emerged more recently in the last decade. The role of the Hsp90 chaperone in clearing misfolded protein aggregates has been well established (in vitro only), but its function in synaptic activity remains elusive.

In our study, we utilized a widely used Hsp90 inhibitor, 17-AAG …

Repeated Zolpidem Treatment Effects On Sedative Tolerance, Withdrawal, Mrna Levels, And Protein Expression, Brittany T. Wright

Theses and Dissertations (ETD)

Zolpidem and benzodiazepines (BZs) potentiate the inhibitory action of gamma-Aminobutyric acid (GABA) by allosterically binding to GABAA receptors (GABAAR). Prolonged use of GABAAR positive allosteric modulators (PAM) can lead to behavioral tolerance, the diminished response to the same drug dose with repeated use, and withdrawal, a group of symptoms that occur due to abrupt end of drug treatment. Zolpidem is a short-acting, non-BZ GABAAR PAM whose potential for tolerance and withdrawal is unclear. Zolpidem demonstrates sedative efficacy similar to BZs and has become a main treatment of insomnia in lieu of BZs. Zolpidem replaced BZs due to lower incidences of …

Discoveries Of Targets And Novel Agents For The Treatment Of Ischemic Retinopathy And Neovascular Disease, Jordan Javad Toutounchian

Theses and Dissertations (ETD)

Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are among the most common causes of blindness in adults. Vision loss can occur during the advanced stages of DR and AMD as a consequence of unregulated and dysfunctional growth of new blood vessels, or neovascularization (NV) in the retina or choroid. NV can also be triggered by numerous other ocular insults and diseases including radiation retinopathy (RR) and retinal vein occlusion. These latter cases are generally less common but, like DR and AMD, they are characterized by an initial injury, chronic inflammation, and ischemia which perpetuates episodes of retinal neovascularization (RNV). …

Black Male Emerging Adults: Investigating Inequalities In Adult Transitions, Social Learning, And Criminality, De Andre' Terrell Beadle

Graduate Theses and Dissertations

Emerging adulthood is a life stage that developed as a result of numerous macro-structural changes in recent decades (Arnett 2015), and which has implications for life course criminality and identity formation (Massoglia & Uggen 2010). Much research has been done in the area of the new life stage known as “emerging adulthood,” however little to no research has been done on how emerging adulthood relates to or changes classic findings in criminology, especially about the importance of disadvantages embedded in racial inequalities. This mixed method study analyzes data from the National Study of Youth and Religion (NSYR) to examine Social …

Antibacterial Activity Of Pluchea Indica And Piper Betle Ethanol Extract On Staphylococcus Epidermidis And Pseudomonas Aeruginosa, Nela Simanjuntak, Umi Yuniarni, Diki Prayugo

Pharmacology and Clinical Pharmacy Research

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonas aeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 …

The Challenge To Multiculturalism: Hate Speech Ban In Japan

UBC Law Review

No abstract provided.

Common Property Redux

UBC Law Review

No abstract provided.

The Proteomic Response Of Gill Tissue In Tidally And Subtidally-Acclimated California Mussels, Mytilus Californianus, To Acute Emersion-Induced Anoxia, Aubrie N. Fowler, Lars Tomanek

Master's Theses

Intertidal mussels regularly experience emersion-induced anoxia, in contrast to normoxic conditions experienced during submersion. We therefore hypothesized that acclimation to a tidal rhythm, as opposed to a rhythm of constant submersion, preconditions the proteome of the California mussel, Mytilus californianus, to respond differently to emersion-induced anoxia. Following acclimation, mussels either continued to receive the acclimation conditions (control) or were exposed to 100% nitrogengas (anoxia) during aerial emersion. We collected gill tissue for subsequent analysis of protein abundance with 2D gel electrophoresis and protein identification with tandem mass spectrometry. Relative to subtidally-acclimated mussels, tidally-acclimated mussels showed a greater propensity to …

Tithing: A Biblical Principle For The Sustenance Of Pastor Of The Evangelical Lutheran Church Of Liberia, Simon Dapaye

Master of Art Theology Thesis

Tithing: A Biblical Principle for the Sustenance of Pastor of the Evangelical Lutheran Church of Liberia Dapaye, Simon Tenyen, “Tithing: A Biblical Principle for the Sustenance of Pastor of the Evangelical Lutheran Church of Liberia.” Master of Arts Thesis. Concordia Seminary, 2016. 115pp.

This thesis discusses the implication of Numbers 18:22–32 and Malachi 3:6–12 regarding the sustenance of the priesthood and its bearing on New Testament stewardship and giving with an emphasis on a pastor's sustenance. These Old Testament texts set the basis for the Levite tithe, instituted for the sustenance of the priests and Levites, whose function was to …

Validating Laboratory Techniques That Influence Estimates Of Intake And Performance In Beef Cattle, Hannah C. Hamilton

Department of Animal Science: Dissertations, Theses, and Student Research

Two experiments were conducted to evaluate effects of inoculum source on in vitro and in situ digestion procedures performed on grass hay and corn residue samples. Steers were fed 70% brome or 70% corn residue. Inoculum from each steer was used to perform in vitro procedures to determine IVDMD, organic matter digestibility (OMD), and neutral detergent fiber (NDF) digestibility and for in situ procedures to determine NDF digestibility. There were no interactions for inoculum source and IVDMD, OMD, or NDF digestibility.

Three cattle digestion studies were used to evaluate the relationship between TDN and digested OM (DIGOM). Total tract collection …

Consumerism, Social Practice, And Slavery: Consumer Practices Among Enslaved Laborers At Poplar Forest Plantation (1828-1861), Lori Ann Lee

Dissertations - ALL

This dissertation is a study of the intersections of slavery, daily practice, and consumerism of enslaved laborers at antebellum Poplar Forest plantation in Central Virginia. Key developments in the antebellum period, including expanded transportation options, industrialization, and increased slave leasing shaped the enslaved laborer’s lives. These factors resulted in increased access to the market economy for many enslaved laborers, which transformed social and economic relationships between whites and African Americans and among African Americans as well. The conditions that shaped this process varied according to regional differences, the forms of labor in which the enslaved were engaged, and the individual …

New Wine In Old Wineskins: Metaphor And Legal Research, Amy E. Sloan, Colin Starger

All Faculty Scholarship

We construct our conceptual world using metaphors. Yet sometimes our concepts are flawed and our metaphors do damage. This Article examines a set of metaphors currently doing damage in law – those for legal research. It shows that while technology has radically altered the material world of legal research, our dominant metaphors have remained static, and thus, become outmoded. Conceptualizing today’s reality using old metaphors fails; it is like pouring new wine in old wineskins. To address this problem, this Article first surfaces unwarranted assumptions buried in the metaphors we use when talking about research and then proposes new metaphors …

Training Needs Of Licensed Veterinary Technicians Employed In Augusta County, Virginia, Jeannie Kay Skelton

OTS Master's Level Projects & Papers

The problem of this study was to determine the training needs of Licensed Veterinary Technicians in Augusta County, Virginia to improve their knowledge and skills in the veterinary field. The study was guided by research questions that were developed to determine what the training needs of Licensed Veterinary Technicians are, what their preferred method is for obtaining continuing education credits, what methods they use to obtain new knowledge and skills, and if on the job training is effective. A survey was designed to determine what training methods are being used, what is preferred, and what training is needed in the …

Sentence Structure: Prohibiting “Second Or Successive” Habeas Petitions After Patterson V. Secretary, Christina M. Frohock

University of Miami Law Review

The Eleventh Circuit’s recent opinion in Patterson v. Secretary includes a heated dispute over the prohibition against “second or successive” habeas corpus petitions in 28 U.S.C.§ 2244(b). Considering an amended criminal sentence from Florida state court, the majority and dissenting opinions structure that sentence differently and, thus, apply the prohibition differently. This Article argues that both the majority and the dissent conceal policy judgments beneath the surface of legal decision-making. First, the Article analyzes the statutory prohibition against “second or successive” habeas petitions, as applied previously by the U.S. Supreme Court in Magwood v. Patterson and by the Eleventh Circuit …

Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson

Biomedical Engineering

Peripheral arterial occlusive disease (PAOD) occurs when there is narrowing or blockage of the peripheral arteries that carry blood to the extremities, most commonly the legs. The most common symptom of PAOD is intermittent claudication, or ischemic pain during exercise. Women with PAOD experience a greater extremity functional impairment than men. Since impaired vasodilation might cause the ischemic pain from PAOD, we should evaluate vasodilation post ligation in males and females in collateral vessels, which connect two arterial segments to maintain blood flow to an otherwise hypoxic area. First, we need to examine collateral vasodilation in unoperated male and female …

Evaluation Of High Sugar Ryegrass Varieties, Mariano Alende

All Dissertations

Annual ryegrass (Lolium multiflorum) is an important forage in Southeastern US. However, as in other winter annuals, concern exists about the balance between water soluble carbohydrates (WSC) and protein, which can lead to ruminal nutrient asynchrony. Lately, efforts have been done to increase the WSC content of ryegrass, and cultivars known as “high sugar varieties” have been released to the market. Several productive and environmental advantages have been suggested for these cultivars. The objective of our research was to compare conventional versus high sugar varieties under several conditions and from different approaches, to evaluate the potential of the high sugar …

Neighborhood Revitalization In A Coal Region Community: Developing A Public Green Space In Mount Carmel, Pennsylvania, Dominic Scicchitano

Coal Region Field Station Student Projects

Neighborhood revitalizationthough at times costly and otherwise challengingis a powerful method for preserving the integrity and beauty of large urban areas and small towns alike. The conversion of previously derelict sites into thriving urban green spacesoften in the form of public parks that contain a segment of living greenerypresents a concrete strategy for revitalizing these locations. Aside from neighborhood beautification, the development and presence of green space has been found to contribute to increased mental and physical health, create a stronger sense of social inclusion, and promote ecological sustainability among a myriad of other benefits within the populations they serve …

Effects Of Glyceollin On Mrna Expression In The Female Mouse Brain., Sanaya Firdaus Bamji

Electronic Theses and Dissertations

Glyceollins (Glys), produced by soy plants in response to stress, have anti-estrogenic activity in breast and ovarian cancer cell lines in vitro and in vivo. In addition to known anti-estrogenic effects, Glys exhibit mechanisms of action not involving estrogen receptor (ER) signaling. To date, effects of Glys on brain physiology and function are unknown. The purpose of the experiments summarized in this dissertation was to gain an understanding of the effects of Gly on brain-related functions in the female mouse brain through the observation of changes in gene expression. For our initial studies, we treated ovariectomized Swiss Webster (CFW) …

A Social Marketing Plan For The Lester C. Howick Animal Shelter, Joseph Michael Spiegelhoff

Graduate Theses and Dissertations

The Lester C. Howick Animal Shelter (Howick) is a non-profit organization serving Washington County, Arkansas and the Northwest Arkansas community. This thesis offers Howick a comprehensive Social marketing plan. The goal of the animal shelter is to increase the total number of cats and dogs adopted, increase the total amount of donations, and increase the number of volunteers helping at the facility and various events. In order to accomplish these goals for 2016, a Social marketing plan was developed through research on other non-profit organizations, other animal shelters, communication with the shelter employees, crafting a public service announcement (PSA), and …

Evaluation Of Long-Acting Eprinomectin Compared To Conventional Anthelmintics In Cow/Calf Production, Elizabeth Ann Backes

Graduate Theses and Dissertations

Experiment 1, 83, newly weaned, fall-born crossbred heifer calves were allocated randomly to 1 of 3 anthelmintic treatments: 1) control (CON); 2) combination pour-on moxidectin and oxfendazole (MO); and 3) long-acting eprinomectin (LAE). Two preplanned orthogonal contrast statements were used: 1) to compare CON to treated cattle; and 2) to compare OXF to LAE. Heifer BW and BCS were greater (P≤0.02) from MO and LAE on d 112, 140, 154, 168, 182 compared to CON. Heifer cyclicity, estrous detection, natural service and overall pregnancy rates were greater (P≤0.02) for MO and LAE compared to CON. Cattle fecal egg counts (FEC) …

Cracking The Code: Implementing Internet Accessibility Through The Americans With Disabilities Act, Carly Schiff

Cardozo Law Review

No abstract provided.

Intervention Strategies For The Participation Of People With Autism Spectrum Disorder In Communal Worship Experiences, James Thomas Lowery Iii

ATS Dissertations

No abstract provided.

Northwest Coast Native American Art: The Relationship Between Museums, Native Americans And Artists, Karrie E. Myers

Museum Studies Theses

Museums today have many responsibilities, including protecting and understanding objects in their care. Many also have relationships with groups of people whose items or artworks are housed within their institutions. This paper explores the relationship between museums and Northwest Coast Native Americans and their artists. Participating museums include those in and out of the Northwest Coast region, such as the Museum of Anthropology at the University of British Columbia, the Burke Museum, the Royal British Columbia Museum, the American Museum of Natural History and the Smithsonian Museum. Museum professionals who conducted research for some of these museums included Franz Boas, …

Female Veterans Transition To College, Diane Recinos

Education Doctoral

The purpose of this qualitative phenomenological study was to examine the transition experience of female veterans into college. The participants of the study were eight female veterans, receiving veteran benefits and that have completed at least one year of college. Four of the participants were combat veterans. Female veterans bring with them not only their individual experiences, but also challenges and problems they observed or experienced in the military. The female veteran population attending college continues to increase and there is limited research regarding their transition experience as they pursue their college degree. The researcher utilized Schlossberg’s (1988) transition theory …

Investigating The Effects Of Aqueous Treatment On Selected Sheets From A 17th Century Printed Book With Tideline Staining, Liane Naauao

Art Conservation Master's Projects

The ultimate goal of this project will be to stabilize and treat this copy of the Riflessioni Geografiche2 so that it can be handled and made available as a book model within the department in order to demonstrate the potential for aqueous treatment of historic books. The research component for this project will focus on generating a washing and drying protocol for aqueous treatment of select pages. The present volume, a 17th century book printed in Italy on handmade paper and laced into a paper case, has been previously water damaged and there is tide line staining on a number …

Decorating With Dna: Analysis And Treatment Of A Victorian-Era Hairwork Wreath, Janelle Batkin-Hall

Art Conservation Master's Projects

A framed hairwork wreath in the style of mourning art, and belonging to the author, was initially investigated through a Buffalo State College Independent Research Project (CNS-615) to identify and characterize the fabrication materials used in its construction. Thirty-one material samples were collected and analyzed using Scanning Electron Microscopy (SEM), Polarized Light Microscopy (PLM), X-Ray Fluorescence Spectroscopy (XRF), and X-radiography. Fabrication materials include human hair; textiles are cotton, silk, cuprammonium rayon, and possibly polyester Dacron; dyes contain aluminum, iron, tin, and copper mordants; colorants and pigments are zinc, copper, arsenic, manganese, iron, and smalt. As part of a Senior Specialization …

The Skinny House, Leo August Jilk

UNLV Theses, Dissertations, Professional Papers, and Capstones

The title of my thesis is The Skinny House, a phrase which might indicate: 1) The body of a human or other animal, 2) A coffin or grave, and 3) A residence in Mamaroneck, New York built of recycled materials (e.g. railroad ties and a chicken coop) by an African-American carpenter named Nathan T. Seely in 1932. Seely and his brother ran a business that thrived for several years prior to the Great Depression, catering specifically to Southern blacks moving north. While only a few pages of my thesis are directly concerned with the Mamaroneck residence and its social implications, …

Pansori, Bomi Kang

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Korean Cultural Preservation Law of 1962 designated Pansori an important intangible cultural artifact and a symbol of the national culture of the Korean people. The fundamental objective of Korea government’s policy was to promote and to preserve Pansori. However, the pervasiveness of western-style performing arts in Korea undermined the achievement of this objective, especially for the younger generation. The purpose of this study is to explore Pansori, to understand its history, its importance, the reasons underlying its declining popularity, and the reasons behind the need for preserving and promoting its use in modern Korean society. The methodology of this …

Development And Testing Of An Assessment To Measure Spatial Thinking About Enhanced Greenhouse Effect, Heather Jean Skaza

UNLV Theses, Dissertations, Professional Papers, and Capstones

Americans, in general, do not behave in environmentally sustainable ways. We drive cars and fly in planes that emit planet-warming carbon. We purchase food in nearly indestructible packaging that is not recycled or repurposed. We do not consider the environmental impact of the “stuff” stuffed into our grocery and department stores, most of which is made of materials that had to be dug out of the ground, leaving rivers and skies full of pollution in its place. Citizens have a responsibility to understand complex global and local environmental problems. A person’s ability to think about the way that an environmental …

The Effect Of Moderate Consumption Of Non-Nutritive Sweeteners On Glucose Tolerance And Body Composition In Rats, Ashley Power Tovar

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Effect of Moderate Consumption Of Non-Nutritive Sweeteners On Glucose Tolerance And Body Composition In Rats

by Ashley Tovar

John C. Young, Ph.D., Examination Committee Chair Professor, Kinesiology and Nutrition Sciences University of Nevada, Las Vegas

Introduction: A comorbidity often seen with obesity is the development of impaired glucose tolerance. Abnormalities in the ability to metabolize glucose can lead to increased risk of developing pre-diabetes and if continued, diabetes mellitus type 2. To combat the effects of excess energy intake on obesity and glucose intolerance, low- energy and non-nutritive sweeteners have been introduced as a replacement for traditional sucrose and …